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| 1 | Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus显示文摘AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5(PGP9.5), neuronal nitric oxide synthase(n NOS), vasoactive intestinal peptide(VIP), neurokinin-1(NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha,(PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also conducted.RESULTS Twenty-six controls and 35 diabetic patients(21 shortduration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index(BMI)(higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group(P < 0.01). On immunohistochemical staining, c-Kit- and PDGFRα-positive immunoreactivity were significantly decreased in the DM group compared with the control group(P < 0.05). There were no statistically significant differences in PGP9.5, n NOS, VIP, and neurokinin 1 expression. On immunofluorescent staining, cellularity of interstitial cells of Cajal(ICC) was observed to decrease with increasing duration of DM.CONCLUSION Our study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM. | Kyung Sik Park Kwang Bum Cho Il Seon Hwang Jae Hyung Park Byung Ik Jang Kyeong Ok Kim Sung Woo Jeon Eun Soo Kim Chang Sik Park Joong Goo Kwon | 2016 | World Journal of Gastroenterology2016，22，46： | 11 |
| 2 | Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach显示文摘BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient factors.Radiofrequency ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating HCC.The objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous approach.METHODS:Eight patients(male,seven;age,49-67 years) with 8 HCCs in difficult locations were treated by intraoperative RFA.Six of the patients had local tumor progression after initial transarterial chemoembolization or ultrasound(US)guided percutaneous RFA.The locations of the tumors were hepatic dome in six patients,posterior subcapsule in one,and caudate lobe in one.The tumor size was 2.0 to 6.4 cm(mean,3.9 cm).Intraoperative RFA was performed at the tumor itself and an anticipated resection line under US guidance with 3 cm monopolar single or clustered internally cooled electrodes.Tumor resection was performed in six patients.One month later,treatment response was assessed by contrast material-enhanced computed tomography(CT).CT studies were performed every 2 or 3 months after RFA.RESULTS:RFA was technically successful in all tumors,and the contrast-enhanced CT images acquired one month later showed complete disappearance of tumor enhancement.One pneumothorax occurred.After a median follow-up of 18 months(range,6-30 months),no tumors showed local progression.During the follow-up period,four new recurrent tumors were observed in three patients.Four patients were alive at the time of this report and the other four died of hepatorenal syndrome,liver failure,and progression of new recurrent tumors.CONCLUSION:Intraoperative RFA with tumor resection can be an alterative treatment option for HCC in locations difficult for a percutaneous approach. | Hyung Ook Kim Seung Kwon Kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong Kyun Cho Byung Ik Kim | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 9 |
| 3 | Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis显示文摘瞄准:在葡聚糖硫酸盐的发展调查淋巴细胞的角色导致钠的大肠炎。方法:用葡聚糖硫酸盐钠(决策支持系统)的各种各样的剂量,我们在野类型的 B6 控制和 Rag-1 大美人( H-2b haplotype )导致了大肠炎鼠标,并且评估了大肠炎以征兆并且 histologic 参数例如重量损失,幸存,腹泻的严厉,冒号长度和组织学的变化的缺乏。征兆的参数每天被检查,组织学的变化被获得。结果:尽管在 Rag-1 猛烈老鼠的大肠炎的开发与决策支持系统的高剂量(5%) 对待比得上在 B6 控制老鼠,大肠炎前进在 Rag-1 猛烈老鼠与相比是更可容忍的比在与低剂量(1.5%) 对待的 B6 老鼠决策支持系统。征兆的参数以及组织病理学说的变化在 Rag-1 猛烈鼠标被改进。结论:这些结果显示淋巴细胞的存在在决策支持系统刺激的低剂量贡献大肠炎前进。淋巴细胞可以在导致决策支持系统的大肠炎作为一个加重的因素起作用。 | Tae Woon Kim Jae Nam Seo Young Ho Suh Hyo Jin Park Ju Hyun Kim Ji Young Kim Kwon Ik Oh | 2006 | World Journal of Gastroenterology2006，12，2： | 6 |
| 4 | Predictive risk factors of perforation in gastric endoscopic submucosal dissection for early gastric cancer: a large, multicenter study显示文摘 | Min Kim Seong Woo Jeon Kwang Bum Cho Kyung Sik Park Eun Soo Kim Chang Keun Park Hyang Eun Seo Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Byeong Ik Jang Si Hyung Lee Kyeong Ok Kim Chang Hun Yang | 2013 | Surgical Endoscopy2013，，4： | 3 |
| 5 | Mesoscopic spatial designs of nano-and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques显示文摘 | Kidoaki S Kwon IK Matsuda T | 2005 | Biomaterials2005，26，1： | 1 |
| 6 | Mechanical stretching for tissue engineering:two-dimensional and three-dimensional constructs显示文摘 | Riehl BD ParkJH Kwon IK | | 0，，04： | 1 |
| 7 | Clinical outcomes for perforations during endoscopic submucosal dissection in patients with gastric lesions显示文摘 | Seong Woo Jeon Min Kyu Jung Sung Kook Kim Kwang Bum Cho Kyung Sik Park Chang Keun Park Joong Goo Kwon Jin Tae Jung Eun Young Kim Tae Nyeun Kim Byung Ik Jang Chang Hun Yang | 2010 | Surgical Endoscopy2010，，4： | 1 |
| 8 | Organic Light‐Emitting Diodes with 30% External Quantum Efficiency Based on a Horizontally Oriented Emitter显示文摘 | Sei‐Yong Kim Won‐Ik Jeong Christian Mayr Young‐Seo Park Kwon‐Hyeon Kim Jeong‐Hwan Lee Chang‐Ki Moon Wolfgang Brütting Jang‐Joo Kim | 2013 | Adv Funct Mater2013，，31： | 1 |
| 9 | Expression of tyrosine kinase A in the cerebral cortex of postnatal developing rat 显示文摘 | Kwon HJ Lee KY Park IK | 2005 | J Vet Sci2005，6，3： | 1 |
| 10 | Quantitative monitoring of cor-ticosteroids in cosmetic products manufactured in Korea using LC-MS/MS显示文摘 | Nam YS Kwon IK Lee Y | | 0，，： | 1 |
| 11 | Mesoscopic spatial designs of nanoand microfiber meshes for tissue-engineering matrix and scaffold based on newly devised muhilayering and mixing electrospinning techniques显示文摘 | Kidoaki S Kwon IK Matsuda T | 2005 | Biomaterials2005，26，1： | 1 |
| 12 | In vivo bone for-mation following transplantation of human adipose-derived stromal cells that are not differentiated os-teogenically显示文摘 | Jeon O Rhie JW Kwon IK | | 0，，08： | 1 |
| 13 | Investigation of a nosocomial outbreak of Acinetobacter baumannii producing PER-1 extended-spectrum β-lactamase in an intensive care unit显示文摘 | Jeong S H Bae IK Kwon SB | 2005 | Journal of Hospital Infection2005，59，3： | 1 |
| 14 | The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase Ⅱ alpha by enhancing the rate of ATP hydrolysis 显示文摘 | Kwon Y Shin BS Chung IK | 2000 | J Biol Chem2000，275，18： | 1 |
| 15 | Osteoblastic/cemento-blastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine显示文摘 | Kim BC Bae H Kwon IK | | 0，，03： | 1 |
| 16 | HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability显示文摘 | Mellinghoff IK Vivanco I Kwon A | | 0，，5： | 1 |
| 17 | In vivo bone formation following transplantation of human adipose-derived stromal cells that are not differentiated osteogenically显示文摘 | Jeon O Rhie JW Kwon IK | 2008 | Tissue Engineering2008，14，8： | 1 |
| 18 | Preparation and surface characterization of functional group-grafted and heparin-immobilized polyurethanes by plasma glow discharge显示文摘 | Kang IK Kwon OH Lee YM | | 0，，08： | 1 |
| 19 | Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 β-lactamase in Korea 显示文摘 | Jeon BS Jeong IK Kwon SB | 2005 | J Clin nicrobiol2005，43，5： | 1 |
| 20 | Eleetrospun nano-to mierofiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and eell adhesion potential显示文摘 | Kwon IK Kidoaki S Matsuda T | 2005 | Biomaterials2005，26，18： | 1 |
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