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| 1 | Antibody-drug conjugates: recent advances in conjugation and linker chemistries显示文摘抗体药结合(模数转换器) ,一人性化或人的 monoclonal 抗体通过化学连接器与高度细胞毒素的小分子(收费载重) 结合了,是一种新奇治疗学的格式并且有大潜力让一个范例变在癌症化疗。这个新基于抗体的分子的平台启用一个有势力的选择交货指向癌症房间的细胞毒素的收费载重,导致改进功效,减少的全身的毒性,和更好的 pharmacokinetics (PK )/pharmacodynamics (PD ) 和与传统的化疗相比的 biodistribution。由这个药班很快在临床的试用当前与大约 60 个模数转换器一起一直在种的同意食物及药品管理局的 Adcetris ? 和 Kadcyla ?, 的成功增加了。在这篇文章,我们简短考察模数转换器的每个部件(抗体,收费载重,和连接器) 的分子的方面,然后主要为临床上有效的模数转换器的成功的建设讨论变化形式和连接器化学的传统、新的技术。在变化形式和连接器化学愿望的当前的努力从药用的化学和药理学立场为临床上有效的模数转换器提供更大的卓见进分子的设计和策略。为构造同类的模数转换器的地点特定的变化形式方法论的发展是特别答应 ? 路径到改进模数转换器设计治疗学,它将为新奇癌症打开方法。 | Kyoji Tsuchikama Zhiqiang An | 2018 | Protein & Cell2018，9，1： | 37 |
| 2 | Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis显示文摘Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease. | Kazuya Okushin Takeya Tsutsumi Kazuhiko Ikeuchi Akira Kado Kenichiro Enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike | 2018 | World Journal of Gastroenterology2018，24，32： | 15 |
| 3 | Bacteremia in hemodialysis patients显示文摘Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant Staphylococcus aureus infection. The most common site of infection causing bacteremia is internal prostheses; the use of a hemodialysis catheter is the most important risk factor for bacteremia. Although antibiotic lock of hemodialysis catheters and topical antibiotic ointment can reduce catheter-related blood stream infection(CRBSI), their use should be limited to necessary cases because of the emergence of resistant organisms. Systemic antibiotic administration and catheter removal is recommended for treating CRBSI, although a study indicated the advantages of antibiotic lock and guidewire exchange of catheters over systemic antibiotic therapy. An infection control bundle recommended by the Center for Disease Control and Prevention succeeded in reducing bacteremia in hemodialysis patients with either a catheter or arteriovenous fistula. Appropriate infection control can reduce bacteremia in hemodialysis patients. | Masashi Suzuki Nobuhiko Satoh Motonobu Nakamura Shoko Horita George Seki Kyoji Moriya | 2016 | World Journal of Nephrology2016，5，6： | 14 |
| 4 | Water-saving irrigation of paddy field to reduce nutrient runoff显示文摘The purpose of this work is to study the effect of a type of water-saving irrigation (WSI) on nutrient runoff of paddy field.The volume of surface drainage was maintained low by WSI.In particular,WSI effectively reduced surface drainage in rain events.Model simulation indicated that net runoff load of total nitrogen (TN) from the paddy field was increased by WSI.Meanwhile,net runoff loads of total phosphorus (TP) and total organic carbon (TOC) from the paddy field was decreased by WSI.Because ponding waters of the study fields were enriched with TP and TOC,WSI reduced runoff of these nutrients by controlling the volume of surface drainage.WSI could be considered an efficient method for reducing runoff loads and could conserve water quality in an agricultural watershed. | Tadayoshi Hitomi Yusaku Iwamoto Asa Miura Koji Hamada Kyoji Takaki Eisaku Shiratani | 2010 | Journal of Environmental Sciences2010，22，6： | 6 |
| 5 | 蒙特卡罗模拟在区域地震滑坡灾害评价中应用显示文摘2004年10月23日,日本新泻中越地区发生史上最强地震之一,震级达到Mw6.6。这次地震诱发上千个规模大小不一、形式各样的滑坡,造成一定的灾害损失和人员伤亡。因此,为了有效地避免和减轻这方面的灾害,有必要有效地、科学地预测和评价地震诱发滑坡的空间发生规律。为此以一定的地区作为研究对象,提出了蒙特卡罗随机模拟和Newmark滑动体位移分析法在区域地震斜坡失稳概率分析中的应用。该法充分考虑到岩土参数和相关地震参数空间变异性,结合地理信息系统空间分析的优势,以网格模型为基础,分析该区斜坡滑动体位移分布规律,并以2cm为失稳临界值探讨网格斜坡破坏的概率。实例证明,所提出的模型有效地预测了滑坡发生的空间分布规律。 | 汪华斌 Sassa Kyoji | 2007 | 岩土力学2007，28，12： | 5 |
| 6 | Fatal liver failure caused by reactivation of lamivudine-resistant hepatitis B virus:A case report显示文摘We present a case of fetal liver failure caused by the activation of lamivudine-resistant hepatitis B virus (HBV) nine months after lamivudine treatment. A 57-year old man visited our hospital for the treatment of decompensated chronic hepatitis B. Lamivudine was started in December 2001. Subsequently, serum HBV was negative for HBV DNA with seroconversion from HBeAg to anti-HBe and improvement of liver function. However, HBV DNA and HBeAg were again detected in September 2002. He was complicated by breakthrough hepatitis and admitted to our hospital in November for severely impaired liver function. Vidarabine treatment was started and serum HBV DNA and alanine aminotransferase (ALT) decreased transiently. However, after the start of α-interferon treatment, HBV DNA level increased and liver function deteriorated. He died 1 mo after admission. An analysis of amino acid sequences in the polymerase region revealed that rtM204I/V with rtL80I/V occurred at the time of viral breakthrough. After the start of antiviral treatment, rtL180M was detected in addition to rtM204I/V and rtL80I/V, and became predominant in the terminal stage of the disease. HBV clone with a high replication capacity may be produced by antiviral treatment leading to the worsening of liver function. Antiviral therapy for patients with breakthrough hepatitis in advanced liver disease should be carefully performed. | Yuka Suzuki Hiroshi Yotsuyanagi Chiaki Okuse Yoshihiko Nagase Hideaki Takahashi Kyoji Moriya Michihiro Suzuki Kazuhiko Koike Shiro Iino Fumio Itoh | 2007 | World Journal of Gastroenterology2007，13，6： | 4 |
| 7 | The 4th World Landslide Forum: Landslide Research and Risk Reduction for Advancing the Culture of Living with Natural Hazards显示文摘The World Landslide Forum is a triennial mainstream conference that gathers together the scientific and technological community, policymakers, industry actors, public officials, and other stakeholders, who deal with the understanding and management of landslide disaster risk. The establishment of the ISDR-ICL Sendai Partnerships 2015–2025 for Global Promotion of Understanding and Reducing Landslide Disaster Risk in Sendai during the 2015 World Conference on Disaster Risk Reduction(WCDRR) enabled the landslide science and technology community support the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030 in order to prevent new and reduce existing disaster risk.The 4th World Landslide Forum(WLF4) was held in Ljubljana, Slovenia, from 29 May to 2 June 2017 and discussed the progress of landslide research and risk reduction for advancing the culture of living with natural hazards. A high-level panel composed of United Nations officials, international stakeholders, and national organizations sought to identify the best mechanisms to be developed by the community of the International Consortium on Landslides(ICL). The objective was to advance the implementation of the ISDR-ICL Sendai Partnerships,to achieve a better commitment among partners, and to provide substantive services to developing countries. During the WLF4, the 2017 Ljubljana Declaration on Landslide Risk Reduction was adopted and the concept framework of the Kyoto 2020 Commitment was endorsed. | Irasema Alcntara-Ayala Kyoji Sassa Matjaz Miko Quinli Han Jakob Rhyner Kaoru Takara Satoru Nishikawa Badaoui Rouhban Slvano Briceo | 2017 | International Journal of Disaster Risk Science2017，8，4： | 3 |
| 8 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 9 | Pore-pressure generation and movement of rainfall-induced landslides: effects of grain size and fine-particle content显示文摘 | Gonghui Wang Kyoji Sassa | 2002 | Engineering Geology2002，，1： | 3 |
| 10 | Pore-pressure generation and movement of rainfall-induced landslides: effects of grain size and fine-particle content显示文摘 | Gonghui Wang Kyoji Sassa | 2002 | Engineering Geology2002，，1： | 3 |
| 11 | China's Growth Slowdown: Lessons from Japan's Experience and the Expected Impact on Japan, the USA and Germany显示文摘 | Kyoji Fukao Tangjun Yuan | 2016 | China & World Economy2016，24，5： | 3 |
| 12 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 13 | Frequent β-catenin aberration in human hepatocellular carcinoma显示文摘 | Hajime Fujie Kyoji Moriya Yoshizumi Shintani Takeya Tsutsumi Tadatoshi Takayama Masatoshi Makuuchi Satoshi Kimura Kazuhiko Koike | 2001 | Hepatology Research2001，，1： | 2 |
| 14 | PPAR[alpha] activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice显示文摘 | Tanaka Naoki Moriya Kyoji Kiyosawa Kendo Koike Kazuhiko Gonzalez Frank J Aoyama Toshifumi | 2008 | Journal of Clinical Investigation2008，，2： | 2 |
| 15 | Added value of indocyanine green fluorescence imaging in liver surgery显示文摘Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)hepatectomy.The clinical relevance of this method has been increasing gradually,as new procedures develop in this field.Various important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report. | Nobuyuki Takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，4： | 2 |
| 16 | Characterization of Structural Domains of HumanOsteoclastogenesis Inhibitory Factor显示文摘 | Masahiko Kinosaki Masaaki Goto | 1998 | J Biol Chem1998，273，9： | 1 |
| 17 | Characterization of Sleeping Beauty transposi-tion and its application to genetic screening in mice显示文摘 | Kyoji H Kosuke Y Kojiro Y | 2003 | Mol Cell Biol2003，9189，： | 1 |
| 18 | Backward Vertical Linkages of Foreign Manufacturing Affiliates: Evidence from Japanese Multinationals显示文摘 | Belderbos Rene Giovanni Capannelli Kyoji Fukao | 2001 | World Development2001，29，1： | 1 |
| 19 | Undrained dynamic-loading ring-shear apparatus and its application to landslide dynamics显示文摘 | SASSA Kyoji FUKUOKA Hiroshi WANG Gonghui | 2004 | Landslides2004，1，1： | 1 |
| 20 | Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy显示文摘 | KYOJI KOHCHI SHIGEO TAKEBAYASHI TADAYUKI HIROKI MASAKIYO NOBUYOSHI | 1985 | Circulation1985，，4： | 1 |
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