|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 3 | Lipophilic statins preventmatrix metalloproteinase-mediated cartilage collagen breakdown by inhib-iting protein geranylgeranylation显示文摘 | Barter M J Hui W Lakey R L | 2010 | Ann Rheum Dis2010，69，21： | 1 |
| 4 | Macromolecular or-ganisation of recombinant Yersinia pestis F1 antigen and the effectof structure on immunogenicity显示文摘 | Miller J Williamson E D Lakey J H | 1998 | FEMS Immunol Med Micro-biol1998，21，3： | 1 |
| 5 | 显示文摘 | Shapiro A Lakey J Ryan E | 2000 | N Engl J Med2000，343，： | 1 |
| 6 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | SHAPIRO A M LAKEY J R RYAN E A | 2000 | N Engl J Med2000，343，4： | 1 |
| 7 | Islet transplantation in seven patients with type I diabetes mellitus using a glucocorti- coid-free immunosuppressive regimen 显示文摘 | Shapiro J Lakey JRT Ryan LEA | 2000 | The New England Journal of Medicine2000，343，4： | 1 |
| 8 | Comparative analysis of the QUTR transcription repressor protein and the three Cterminal domains of the pentafunctional AROM enzyme显示文摘 | LAMB H K MOORE J D LAKEY J H | 1996 | Biochemical Journal1996，313，： | 1 |
| 9 | How people make support judgment:individual differences in the traits used to infer supportiveness in others显示文摘 | LUTZ C J LAKEY B | 2001 | J Pers Soc Psychol2001，81，6： | 1 |
| 10 | Untangling the links between nar-cissism and self - esteem:A theoretical and empirical review显示文摘 | Bosson J K’Lakey C E Campbell W K | 2008 | Social andPersonality Psychology Compass2008，2，3： | 1 |
| 11 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid - free immunosuppressive regimen 显示文摘 | SHAPIRO A M LAKEY J R RYAN E A | 2000 | N Engl J Med2000，343，4： | 1 |
| 12 | Data-di- yen and optimal denoising of a signal using multiwavelets 显示文摘 | EFROMOVICH S LAKEY J PEREYIA M C | 2004 | IEEE Trans Signal Processing2004，52，3： | 1 |
| 13 | Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker显示文摘 | STREET C N LAKEY J R T SEEBERGER K | 2004 | Journal of Endocrinology2004，180，： | 1 |
| 14 | Maeromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity显示文摘 | Miller J WiUiamson E D Lakey J | 1998 | FEMS Immunol Med Microbiol1998，21，： | 1 |
| 15 | Islet transplan- tation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | SHAPIRO A M LAKEY J R RYAN E A | | 0，，04： | 1 |
| 16 | Islet transplant: an option for childhood diabetes显示文摘 | Hathout E Lakey J Shapiro J | 2003 | Arch Dis Child2003，88，7： | 1 |
| 17 | Ita-Diven and Optimal Denoising of a Signal and Recovery of its Deriva- tion Using Multiwavelets 显示文摘 | EFROMOVICH S LAKEY J PEREYIAMC | 2004 | IEEE Trans Signal Processing2004，52，3： | 1 |
| 18 | Portal venous pressure changes after sequential clinical islet transplantation 显示文摘 | Casey J Lakey J Ryan E | 2002 | Transplantation2002，74，7： | 1 |
| 19 | Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct ceils in human islets transplanted in immunodefi- cient diabetic mice 显示文摘 | Suarez-Pinzon W L Lakey J R Rabinovitch A | 2008 | Cell Transplant2008，17，6： | 1 |
| 20 | Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet beta-cells from pancreatic duct cells and an increase in functional beta-cell mass显示文摘 | Suarez-Pinzon WL Lakey JR Brand S J | 2005 | J Clin Endocrinol Metab2005，90，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员