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| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA显示文摘 | KORSHUNOVA Y MALONEY R K LAKEY N | 2008 | Genome Res2008，18，1： | 1 |
| 3 | Heterogenous expression of nestin in human pancreatic tissue precludes its use as an islet precursor marker显示文摘 | STREET C N LAKEY J R T SEEBERGER K | 2004 | Journal of Endocrinology2004，180，： | 1 |
| 4 | The current situation in human pancreatic islet transplantation:problems and prospects显示文摘 | Kobayshi N Okitsu T Lakey JR | 2004 | J Artif Organs2004，7，： | 1 |
| 5 | Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA 显示文摘 | Korshunova Y Maloney RK Lakey N | 2008 | Genome Res2008，18，1： | 1 |
| 6 | Naive human T cells devel- op into Th1 effeetors after stimulation with mycobacterium tuberculosis -infected macrophages or recombinant Ag85 proteins显示文摘 | Russo DM Kozlova N Lakey DL | 2000 | Infect Im- mun2000，68，12： | 1 |
| 7 | The current situation in human pancreatic islet transplantation:problems and prospects显示文摘 | Kobayashi N Okitsu T Lakey JR | 2004 | J Artif Organs2004，7，1： | 1 |
| 8 | Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA显示文摘 | KORSHUNOVA Y MALONEY R K LAKEY N | 2008 | Genome Res2008，18，1： | 1 |
| 9 | Naive human T cellsdevelop into Th1 effectors after stimulation withMycobacterium tuberculosis-infected macrophages orrecombinant Ag85 proteins显示文摘 | Russo DM Kozlova N Lakey DL | 2000 | Infect Immun2000，68，12： | 1 |
| 10 | Data-diven and optimal denoising of a signal and recovery of its derivation using multiwavelets显示文摘 | Efromovich S Lakey J Pereyia M Tymes N | 2004 | IEEE Trans Signal Processing2004，52，3： | 1 |
| 11 | Naive human T cells develop into Th1 effectors after stimulation with Mycobacterium tuberculosis infected macrophages or recombinant Ag85 proteins 显示文摘 | Russo DM Kozlova N Lakey DL | 2000 | Infect Immun2000，68，12： | 1 |
| 12 | Naive human T cells de- velop into Thl effectors after stimulation with Mycobacterium tu- berculosis-irffected macrophages or recombinant Ag85 proteins 显示文摘 | Russo DM Kozlova N Lakey DL et o11 | 2000 | Infect Immun2000，68，12： | 1 |
| 13 | Data-diven and optimal denoising of a signal using multiwavelets显示文摘 | EFROMOVICH S LAKEY J PEREYIA M C TYMES N J | 2004 | IEEE Trans Signal Processing2004，52，3： | 1 |
| 14 | Hepatitis C virus replication in mice with chimeric human livers 显示文摘 | Mercer D F Schiller D E Elliott J F Douglas D N Hao C Rinfret A Addison W R Fischer K P Churchill T A Lakey J R Tyrrell D L Kneteman N M | 2001 | Nat Med2001，，08： | 1 |
| 15 | Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-asseciated cytosine-methylation patterns obtained from tissue and serum DNA显示文摘 | Korshunova Y Maloney RK Lakey N | 2008 | Genome Res2008，18，1： | 1 |
| 16 | The current situation in human pancreatic islet transplantation: problems and prospects显示文摘 | Kobayashi N Okitsu T Lakey JR | 2004 | J Artif Organs2004，7，： | 1 |
| 17 | The current situation in human pancreatic islet transplantation:problems and prospects显示文摘 | Kobayshi N Okitsu T Lakey JR | 2004 | J Artif Organs2004，7，： | 1 |
| 18 | Islet graft assessment in the edmonton protocol implications for predicting longt:rm clinical outcome显示文摘 | Street C N Lakey J R T James Shapiro A M | 2004 | Diabetes2004，53，： | 1 |
| 19 | Data-driven and optimal denoising of a signal using multiwavelets显示文摘 | Efromovich S Lakey J Pereyia M C Tymes N J | 2004 | IEEE Trans Signal Processing2004，52，3： | 1 |
| 20 | Islet Graft assessment in the Edmonton Protocol:implications for predicting long-term clinical outcome显示文摘 | Street C N Lakey J R Shapiro A M | 2004 | Diabetes2004，53，12： | 1 |
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