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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Sleep disordered breathing in interstitial lung disease: A review显示文摘Patients with interstitial lung disease commonly exhibit abnormal sleep architecture and increased sleep fragmentation on polysomnography. Fatigue is a frequent complaint, and it is likely that poor sleep quality is a significant contributor. A number of studies have shown that sleep disordered breathing is prevalent in this population, particularly in the idiopathic pulmonary fibrosis subgroup. The factors that predispose these patients to obstructive sleep apnoea are not well understood, however it is believed that reduced caudal traction on the upper airway can enhance collapsibility. Ventilatory control system instability may also be an important factor, particularly in those with increased chemo-responsiveness, and in hypoxic conditions. Transient, repetitive nocturnal oxygen desaturation is frequently observed in interstitial lung disease, both with and without associated obstructive apnoeas. There is increasing evidence that sleep-desaturation is associated with increased mortality, and may be important in the pathogenesis of pulmonary hypertension in this population. | Lauren K Troy Tamera J Corte | 2014 | World Journal of Clinical Cases2014，2，12： | 2 |
| 3 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 4 | General Practitioners'experiences of bereavement care and their educationalsupport needs:a qualitative study显示文摘 | Moira O ’ Connor Lauren J Breen | 2014 | BMC Med Educ2014，14，1： | 1 |
| 5 | Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes 显示文摘 | Uutela M Lauren J Bergsten E | 2001 | Circulation2001，103，18： | 1 |
| 6 | Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo 显示文摘 | Lindbolm P Voutilainen MH Lauren J | 2007 | Nature2007，448，7149： | 1 |
| 7 | Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers显示文摘 | Lauren J Gimbel DA Nygaard HB | 2009 | Nature2009，457，： | 1 |
| 8 | Intermittent ischemia reduces warm hypoxia-reoxygenation-induced JNK(1)/ SAPK(1) activation and apoptosis in rat hepatocytes 显示文摘 | Crenesse D Laurens M Gugenheim J | 2001 | Hepatology2001，34，： | 1 |
| 9 | Notch activation of Jaggedl Contributes tothe assembly of the arterial wall 显示文摘 | LAUREN J M | 2012 | Circulation2012，125，： | 1 |
| 10 | Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes显示文摘 | Uutela M Lauren J Bergsten E | 2001 | Circulation2001，103，18： | 1 |
| 11 | Cellular prion protein mediates impairment of synaptic plasticity by amylold-beta oligomers 显示文摘 | Lauren J Gimbel DA Nygaard HB | 2009 | Nature2009，457，7233： | 1 |
| 12 | Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells显示文摘 | Hinkula J Walther-Jallow L Lauren A | 2009 | Vaccine2009，27，46： | 1 |
| 13 | Assessment of functional recovery and axonal sprouting in oligodendrocyte myelin glycoprotein(OMgp) null mice after spinal cord injury显示文摘 | Benxiu J Lauren C | 2008 | Mol Cell Neurosci2008，39，2： | 1 |
| 14 | Chromosomal location,exon structure,and vascular expression patterns of the human PDGFC and PDGFD genes显示文摘 | Uutela M Lauren J Bergsten E | 2001 | Circulation2001，103，18： | 1 |
| 15 | C2- and CA-position 17beta-estradiol metabolites and their relation to breast cancer显示文摘 | JOUBERT A VAN Z H LAURENS J | 2009 | Biocell2009，33，3： | 1 |
| 16 | Gas chromatographic-mass spectrometric confirmation of atractyloside in a patient poisoned with Callilepis laureola显示文摘 | Laurens J B Bekker L C Steenkamp V | 2001 | J Chromatogr B2001，765，2： | 1 |
| 17 | Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members显示文摘 | LAUREN J HU F CHIN J | 2007 | J Biol Chem2007，282，8： | 1 |
| 18 | Sensory Properties of Ginseng Solutions Modified by Masking Agents 显示文摘 | Lauren C Tamamoto Shelly J Schmidt Soo-Yeun Lee | 2010 | Journal of Food Science2010，75，7： | 1 |
| 19 | Chromosomal location exon structure,and vascular expression patters of the human PDGFC genes显示文摘 | Uutela M lauren J Bergsten E | 2001 | Circulation2001，103，18： | 1 |
| 20 | Improving hilt report fo CUS and consistency with the situation, background, assess- ment, recommendation protocol 显示文摘 | Paul C Mary T G Lauren Y J | 2013 | Journal of Nursing Ad- ministration2013，43，78： | 1 |
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