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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 3 | Metabolic Pathways and Residue Levels of Thifensulfuron Methyl in Soybeans显示文摘 | HUGH M BROWN LENA B | 1993 | Agric Food Chem1993，41，： | 1 |
| 4 | Investigating the factors affecting blood donation among Israelis显示文摘 | Merav B N Lena G | 2011 | Int Emerg Nuts2011，，19： | 1 |
| 5 | Structure and function of buffer strip s from a water quality perspective in agriculture landscapes显示文摘 | Lena B M Gilles P Ann F | 1995 | Landscape and Urban Planning1995，31，： | 1 |
| 6 | Nutrient Preserving in River Transitional Strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 7 | Azgos vein aneurysm: contribution of transesophageal echography 显示文摘 | Lena H Desrues B Heresbach H | 1996 | Ann Thorac Surg1996，61，4： | 1 |
| 8 | Metabolic pathways and residue levels of thifensulfuron methyl in soybeans显示文摘 | HUGH M BROWN LENA B | 1993 | Journal of Agricultural and Food Chemistry1993，41，： | 1 |
| 9 | Health care professionals ' ex- periences of parental presence and participation in neonatal inten- sive care unit显示文摘 | Helena W Marie B Anna - lena H | 2007 | International Journal of Qualitative Studies on Health and Well - being2007，2，： | 1 |
| 10 | Nutrient preserving in riverine transitional strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 11 | Determination of food constituents based on SFE:applications to vitamins A and E in meat and milk显示文摘 | HANS B CHARLOTTA T LENA D | 2000 | Journal of Biophysics Methods2000，43，： | 1 |
| 12 | Nutrient preserving in riverine transitional strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 13 | Nutrient preserving in riverine transitional strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 14 | Nutrient Preserving in Riverine Transi- tional Strip 显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 15 | Structure and function of buffer strip s from a water quality perspective in agriculture landscapes 显示文摘 | Lena B M Gilles P Ann F | 1995 | Landscape and Urban Planning1995，31，13： | 1 |
| 16 | Nutrient Preserving in Riverine Transitional Strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 17 | Nutrient preserving in riverine transitional Strip 显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 18 | The logic of innovation in construc- tion显示文摘 | LENA E B MALENA I | 2014 | Industrial Marketing Management2014，43，3： | 1 |
| 19 | Nutrent preserving in riverine transitional strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
| 20 | Nutrient preserving in riverine transitional strip显示文摘 | Lena B V | 1994 | Journal of Human Environment1994，3，6： | 1 |
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