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54篇 您的检索式：作者名="LEONI E"

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	题名	作者	年代	出处	被引量
1	Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.	Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz	2012	Hepatobiliary & Pancreatic Diseases International2012，11，4：	3
2	Impact of a Risk Management Plan on Legione/la Contamination of Dental Unit Water 显示文摘	Leoni E Dallolio L Stagni F	2015	lnt J Environ Res Public Health2015，2312，3：	1
3	The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic in- flammation in vivo 显示文摘	LEONI F FOSSATI G LEWIS E C	2005	Molecular Medicine2005，11，123456789101112：	1
4	A novel and easy method for the production of recombinant peptides for use in the generation of monospecific antisera against Lama glama IgG2b and IgG2c subclasses显示文摘	Saccodossi N De Simone E Leoni J	2006	J Immunol Methods2006，313，12：	1
5	Large-scale in vitro expansion of polyclonal C1M^+ CD25b^+isht regulatory T cells human显示文摘	Hoffmann P Ruediger E Leoni AKS	2004	Blood2004，104，：	1
6	Epidemi- ology and risk factors for urinary tract infection in patients with spinal cord ir~iury显示文摘	Esclarin De Ruz A Garcia Leoni E Herruzo Cabrera R	2000	J Urol2000，164，4：	1
7	Epidemiology and risk factors for urinary tract infection in patients with spinal cord injury 显示文摘	Esclarin De Ruz A Garcfa Leoni E Herruzo Cabrera R	2000	J Urol2000，164，：	1
8	Mechanism for recoverable power drift in PHEMTs显示文摘	LEONI III R E BAO J W BU J	2000	IEEE Trans Electron Devices2000，47，：	1
9	Temporal trend in species composition and plant traits in natural grasslands of Uruguay 显示文摘	RODR LEONI E LEZAMA F	2003	J Veg Sei2003，14，3：	1
10	Kinetic investigation on the smouldering combustion ofboreal peat 显示文摘	Cancellieri D Leroy-Cancellieri V Leoni E	2012	Fuel2012，93，：	1
11	Comparison of selective procedures for isolationand enumeration of Legionella species from hot water systems显示文摘	Leoni E Legnani P P	2001	J Appl Microbiol2001，90，1：	1
12	Epide- miology and risk factors for urinary tract infection in pa- tients with spinal cord injuries显示文摘	Esclarin De Ruz A Garcia Leoni E Herruzo Cabrera R	2000	The Journal of Urology2000，164，4：	1
13	Effect of processing and storage conditions on the microbiological quality of minimally processed vegetables显示文摘	Legnani P P Leoni E	2004	International Journal of Food Science and Technology2004，39，：	1
14	Epidemiology and risk factors for urinary tract infection in patients with spinal cord injury显示文摘	Esclarín De Ruz A García Leoni E Herruzo Cabrera R	2000	J Urol2000，164，4：	1
15	Thermal degradation of ligno- cellulosic fuels : DSC and TGA studies 显示文摘	Leroy V Cancellieri B Leoni E	2006	Thermochim Acta2006，451，：	1
16	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+ CD25+ GITR+ Foxp3+ CD62L+ functional regulatory T-cells in patients with graft versus-host disease显示文摘	Biagi E Di Biaso I Leoni V		0，，01：	1
17	Persistence of cruciform structure and preferential location of nucleosomes on some regions of pBR322 and ColE 1 DNAs 显示文摘	Caffarelli E Leoni L Sampaolese B	1986	EurJ Biochem1986，156，2：	1
18	Indoor air climate and microbioligical airbome: contamination in various hospital areas显示文摘	Leoni E	1993	Zentralbl-Hyg-Umweltmed1993，194，4：	1
19	Structural analysis of effector functions related motifs, complement activation and hemagglutinating activities in Lama glama heavy chain antibod- ies显示文摘	Saccodossi N De Simone E A Leoni J	2012	Vet Immunol Immunopathol2012，145，12：	1
20	Impact of a risk management plan on Legionella contamination of dental unit water显示文摘	Leoni E Dallolio L Stagni F	2015	Int J Environ Res Public Health2015，12，3：	1

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