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| 1 | The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase ClPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF显示文摘象反应的氧种类(ROS ) 和 Ca2+ 一样的第二个送信人的刺激特定的累积对许多在植物发信号和规定过程中央。然而,管理发信号的 Ca2+ 和 ROS 的相互的相互关系的机制开始仅仅正在出现。呼吸爆炸 oxidase 相当或相同的事物(RBOH ) 的 NADPH oxidases 家庭是当和他们的交往的 kinases (CIPK ) 的 Calcineurin 象 B 一样(CBL )Ca2+ 传感器蛋白质被显示了在表明过程的许多 Ca2+- 工作时,贡献 ROS 的产生的批评部件。在这研究,我们识别在两个都表明系统之间的直接功能的相互作用。我们报导交往 CBL 蛋白质 kinase CIPK26 明确地在酵母与 RBOHF 的 N 终端领域交往二混血儿的分析并且与在植物房间的全身的 RBOHF 蛋白质。另外,在有 CIPK26 的 CBL1 或 CBL9 的 vitro 和合作表示的 CIPK26 phosphorylates RBOHF 强烈在 HEK293T 房间由 RBOHF 提高 ROS 生产。一起,这些调查结果识别在调停 CBLCIPK 的 Ca2+ 在植物发信号并且 ROS 发信号之间的直接互联并且为 NADPH oxidase RBOHF 的 synergistic 激活提供证据由对它由 CBL1/9CIPK26 建筑群的 EF 传递和导致 Ca2+ 的 phosphorylation 直接 Ca2+ 有约束力。 | Maria Magdalena Drerup Kathrin Schlückinga Kenji Hashimoto Prabha Manishankar Leonie Steinhorst Kazuyuki Kuchitsu Jōrg Kudl | 2013 | Molecular Plant2013，6，2： | 35 |
| 2 | Role of E3 ubiquitin ligases in lung cancer显示文摘E3 ubiquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome.Therefore,E3 ubiquitin ligases play an essential role in a variety of biological processes including cell cycle regulation,proliferation and apoptosis.E3 ubiquitin ligases are often found overexpressed in human cancers,including lung cancer,and their deregulation has been shown to contribute to cancer development.However,the lack of specific inhibitors in clinical trials is a major issue in targeting E3 ubiquitin ligases with currently only one E3 ubiquitin ligase inhibitor being tested in the clinical setting.In this review,we focus on E3 ubiquitin ligases that have been found deregulated in lung cancer.Furthermore,we discuss the processes in which they are involved and evaluate them as potential anti-cancer targets.By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis,we can improve the development of specific E3 ubiquitin ligase inhibitors and pave the way for novel treatment strategies for cancer patients. | Barbara C Snoek Leonie HAM de Wilt Gerrit Jansen Godefridus J Peters | 2013 | World Journal of Clinical Oncology2013，4，3： | 5 |
| 3 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 4 | Mechanisms of carvediiol action in human congestive heart failure显示文摘 | David MK Leonie J Gautam V | 2001 | Hypertension2001，37，： | 1 |
| 5 | The use of tenax for the extraction of pesticides and polychlorinated biphenyls from water显示文摘 | Puccetti G Colombo R J | 1976 | J Chromatogr1976，125，： | 1 |
| 6 | A novel and easy method for the production of recombinant peptides for use in the generation of monospecific antisera against Lama glama IgG2b and IgG2c subclasses显示文摘 | Saccodossi N De Simone E Leoni J | 2006 | J Immunol Methods2006，313，12： | 1 |
| 7 | An observational study of nutrition and physical activity behaviours, knowledge, and advice in pregnancy显示文摘 | Susan J J Jan MN Leonie KC | 2013 | BMC Pregnancy Childbirth2013，13，： | 1 |
| 8 | When actions have consequences: Empirically based decision making for intelligent user interfaces显示文摘 | Anthony J Barbara Grobmann Hutter Leonie March | 2001 | Knowledge Based Systems2001，14，12： | 1 |
| 9 | In vivo prediction of response to antiestrogen treatment in estrogen receptor-positive breast cancer显示文摘 | OELOF J B GEERTJANVAN T LEONIE J R | 2004 | J Nucl Med2004，45，1： | 1 |
| 10 | Breast-conserving therapy in patients with a relatively large (T2 or T3) breast cancer:long term local control and cosmetic outcome of a feasibility study显示文摘 | Leonie AE Woerdemaw Hage J Joris Thio Esther A | 2004 | Plast Reconstr Surg2004，113，： | 1 |
| 11 | Mechanism for recoverable power drift in PHEMTs显示文摘 | LEONI III R E BAO J W BU J | 2000 | IEEE Trans Electron Devices2000，47，： | 1 |
| 12 | On the difference between the isoelectric point and the point of zero charge of carbons 显示文摘 | Menendez J A Illan - Gomez M J Leony Leon C A | 1995 | Carbon1995，33，11： | 1 |
| 13 | Effect of Added Carbohydrates on Membrane Phase Behavior and Survival of Dried Lactobacillus plantarum 显示文摘 | LEONIE J M L WIM F W FOLKERT A H | 1997 | Cryobiology1997，35，： | 1 |
| 14 | Symmetries within chaos: a routine to effective mixing 显示文摘 | Franjione J G Leony C W Ottino J M | 1989 | Physics of Fluids A1989，1，11： | 1 |
| 15 | The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits 1L-6 and VEGF production by stromal cells显示文摘 | Golay J Cuppini L Leoni F | 2007 | Leukemia2007，21，： | 1 |
| 16 | EGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer 显示文摘 | Spinola M Leoni VP Tanuma J | 2005 | Oncol Rep2005，14，2： | 1 |
| 17 | Structural analysis of effector functions related motifs, complement activation and hemagglutinating activities in Lama glama heavy chain antibod- ies显示文摘 | Saccodossi N De Simone E A Leoni J | 2012 | Vet Immunol Immunopathol2012，145，12： | 1 |
| 18 | Ocular toxicity after intracameral in- jection of very high doses of cefuroxime during cataract sur- gery显示文摘 | DELYFER MN ROUGIER MB LEONI S ZHANG Q DAL- BON F COLIN J | 2011 | J Cataract Refract Surg2011，37，2： | 1 |
| 19 | Effect of added carbohydrates on membrane phase behavior and survival of dried lactobacillus plantarum显示文摘 | Leonie J M Linders Wim F Wolkers Folkefl A Hoekstra | 1997 | Cryobiology1997，35，： | 1 |
| 20 | ALAS-KA:A learning analytics extension for better understanding the learning process in the Khan Academy platform显示文摘 | Ruipérez-Valiente J A Muoz-Merino P J Leony D | 2014 | Computers in Human Behavior2014，，4： | 1 |
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