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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Novel p19 protein engages IL-12 p40 to form a cytokine from a cytokine,IL-23,with biological activites similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，1： | 1 |
| 3 | Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 4 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 5 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | OPPMANN B LESLEY R BLOM B | 2000 | Immunity2000，13，5： | 1 |
| 6 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | J Exp Med2000，13，5： | 1 |
| 7 | Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 显示文摘 | OPPMANN B LESLEY R BLOM B | 2000 | Immunity2000，13，5： | 1 |
| 8 | Novel p19 protein enga ges IL-12p40 to form a cytokine, IL-23, with biological activi ties similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 9 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23 ,with biological activities simi lar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，： | 1 |
| 10 | A rational basis for mucosal vaccination against HIV infection显示文摘 | LESLEY B YUFEI W | 1999 | Immuno Rev1999，170，： | 1 |
| 11 | Separation of high molecular weight sorghum procyanidins by HPLC显示文摘 | LESLEY J P LARRY G B | 1989 | J Agric Food Chem1989，37，： | 1 |
| 12 | Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 13 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 14 | Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus显示文摘Dear Editor,Severe Acute Respiratory Syndrome(SARS)has beendescribed as the first pandemic of the 21st century andbetween November 2002 and July 2003,over 8000 peo-ple were infected with the SARS-associated coronavirus(SARS-CoV).Polymorphisms in the human leukocyteantigen(HLA)system have been shown to influencesusceptibility to SARS-CoV but here we were unable | Fang Fang Yuan Zlatibor Velickovic Lesley J Ashton Wayne B Dyer Andrew F Geczy Heather Dunckley Garry W Lynch John S Sullivan | 2014 | Virologica Sinica2014，29，2： | 1 |
| 15 | Novel p19 protein engages IL- 12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Biota B | 2000 | Immunity2000，13，5： | 1 |
| 16 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biologi- cal activities similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | Im- munity2000，13，5： | 1 |
| 17 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | OPPMANN B LESLEY R BLOM B | 2000 | Immunity2000，13，： | 1 |
| 18 | Novel p19 protein engages IL- 12p40 to form a cytokine, IL-23,with biological activities similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 19 | Novel p19 protein engages IL-12 p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | OPPMANN B LESLEY R BLOM B | 2000 | Immunity2000，13，5： | 1 |
| 20 | Targeting rat antimouse transferring receptor monoclonal antibodies through blood-brain barrier in mouse显示文摘 | Lee H J Engelhardt B Lesley J | 2000 | J Pharmacol Exp Ther2000，292，3： | 1 |
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