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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model显示文摘 | Lesley J. Murray Tinya J. Abrams Kelly R. Long Theresa J. Ngai Lisa M. Olson Weiru Hong Paul K. Keast Jacqueline A. Brassard Anne Marie O’Farrell Julie M. Cherrington Nancy K. Pryer | 2003 | Clinical and Experimental Metastasis2003，，8： | 1 |
| 3 | The structures of five new antifungal and hemolytic amphidinol analogs from Amphidinium carterae collected in New Zealand显示文摘 | REIKO E LESLEY R YASSUKATSU O | 2005 | Harmful Algae2005，4，： | 1 |
| 4 | Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry显示文摘 | Lesley A. Howell Aaron Howman Maria A. O’Connell Anja Mueller Mark Searcey | 2009 | Bioorganic & Medicinal Chemistry Letters2009，，20： | 1 |
| 5 | The OECD program to validate the rat uterotrophic bioasay to Screen compounds for in vivo estroqenic responses:phase 1 显示文摘 | Jun K Lesley O Joseph H | 2001 | Environ Health Perspect2001，109，8： | 1 |
| 6 | Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content显示文摘 | Ann M Poynten Seng Khee Gan Adamandia D Kriketos Anthony O'Sullivan John J Kelly Bronwyn A Ellis Donald J Chisholm Lesley V Campbell | 2003 | Metabolism2003，，6： | 1 |
| 7 | How can toxicogenomics inform risk assessment? 显示文摘 | AXEL O LESLEY O URSULA GR | 2005 | Toxicol Appl Pharm2005，207，2： | 1 |
| 8 | A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis显示文摘 | Duncan B. Sparrow Gavin Chapman Allanceson J. Smith Muhammad Z. Mattar Joelene A. Major Victoria C. O’Reilly Yumiko Saga Elaine H. Zackai John P. Dormans Benjamin A. Alman Lesley McGregor Ryoichiro Kageyama Kenro Kusumi Sally L. Dunwoodie | 2012 | Cell2012，，2： | 1 |
| 9 | Outcomes of Medicare Beneficiaries Undergoing Catheter Ablation for Atrial Fibrillation显示文摘 | Jonathan P. Piccini Moritz F. Sinner Melissa A. Greiner Bradley G. Hammill Jo?o D. Fontes James P. Daubert Patrick T. Ellinor Adrian F. Hernandez Allan J. Walkey Susan R. Heckbert Emelia J. Benjamin Lesley H. Curtis | 2012 | Circulation2012，，18： | 1 |
| 10 | The OECD program to validate the rat Uterotrophic Bioassay to Screen Compounds for in vivo estrogenic responses : Phase 1 显示文摘 | Jun K Lesley O Joseph H | 2001 | Environmental Health Perspectives2001，109，8： | 1 |
| 11 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 1 |
| 12 | Dietary Patterns and Incident Type 2 Diabetes in Chinese Men and Women: The Singapore Chinese Health Study显示文摘 | Odegaard Andrew O Koh Woon-Puay Butler Lesley M Duval Sue Gross Myron D Yu Mimi C Yuan Jian-Min Pereira Mark A | 2011 | Diabetes Care2011，，4： | 1 |
| 13 | Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors显示文摘Background and purpose Depression is common after stroke and is often treated with antidepressant medications(AD).ADs have also been hypothesised to improve stroke recovery,although recent randomised trials were neutral.We investigated the patterns of in-hospital AD initiation after ischaemic stroke and association with clinical and readmission outcomes.Methods All Medicare fee-for-service beneficiaries aged 65 or older hospitalised for ischaemic stroke in participating Get With The Guidelines-Stroke hospitals between April and December 2014 were eligible for this analysis.Outcome measures included days alive and not in a healthcare institution(home time),all-cause mortality and readmission within 1-year postdischarge.Propensity score(PS)-adjusted logistic regression models were used to evaluate the associations between AD use and each outcome measure.We also compared outcomes in patients prescribed selective serotonin reuptake inhibitors(SSRIs)AD versus those prescribed non-SSRI ADs.Results Of 21805 AD naive patients included in this analysis,1835(8.4%)were started on an AD at discharge.Patients started on an AD had higher rates of depression and prior ischaemic stroke,presented with higher admission National Institutes of Health Stroke Scale score and were less likely to be discharged home.Similarly,patients started on an SSRI had lower rates of discharge to home.Adjusting for stroke severity,patients started on an AD had worse all-cause mortality,all-cause readmission,major adverse cardiac events,readmission for depression and decreased home-time.However,AD use was also associated with an increased risk for the sepsis,a falsification endpoint,suggesting the presence of residual confounding.Conclusions Patients with ischaemic stroke initiated on AD therapy are at increased risk of poor clinical outcomes and readmission even after PS adjustment,suggesting that poststroke depression requiring medication is a poor prognostic sign.Further research is needed to explore the reasons why depression is associated with worse outcome,and whether AD treatment modifies this risk or not. | Mark R Etherton Shreyansh Shah Xu Haolin Ying Xian Lesley Maisch Deidre Hannah Brianna Lindholm Barbara Lytle Laine Thomas Eric E Smith Gregg C Fonarow Lee H Schwamm Deepak L Bhatt Adrian F Hernandez Emily C O'Brien | 2021 | Stroke & Vascular Neurology2021，6，3： | 0 |
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