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| 1 | Climate change, water resources and sustainable development in the arid and semi-arid lands of Central Asia in the past 30 years显示文摘The countries of Central Asia are collectively known as the five '-stans': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990 s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region. | YU Yang PI Yuanyue YU Xiang TA Zhijie SUN Lingxiao Markus DISSE ZENG Fanjiang LI Yaoming CHEN Xi YU Ruide | 2019 | Journal of Arid Land2019，11，1： | 20 |
| 2 | Role of penehyclidine in acute organophosphorus pesticide poisoning显示文摘BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. | Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li | 2020 | World Journal of Emergency Medicine2020，11，1： | 18 |
| 3 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘Phosphatidylinositol 3 磷酸盐(PI3P ) 在小囊的 trafficking,细胞器生物的续生说和 autophagy 起必要作用。二班 III phosphatidylinositol 3-kinase (PI3KC3 ) 建筑群在哺乳动物, ATG14L 建筑群(PI3KC3-C1 ) 和 UVRAG 建筑群(PI3KC3-C2 ) 被识别了。PI3KC3-C1 为 autophagosome 生物的续生说是关键的,并且 PI3KC3-C2 涉及各种各样的膜 trafficking 事件。这里,我们在亚纳米分辨率报导人的 PI3KC3-C1 和 PI3KC3-C2 的 cryo 他们结构。二结构与不同特征分享普通塑造 L 的全面体系结构。他们检查直接表明 PI3KC3-C1 在类脂化合物单层上站起来,与 ATG14L 蝙蝠领域和 VPS34 C 终端领域(CTD ) 联系膜。生物化学的解剖显示 ATG14L 蝙蝠领域负责膜抛锚,而 VPS34 的 CTD 决定取向。而且, PI3KC3-C2 比 PI3KC3-C1 更微弱地绑在包含 PI liposomes 和净化的 endoplasmic 蜂窝胃(嗯) 泡,被 ATG14L 明确地决定的一个性质打领域。在里面 vivo 嗯本地化分析显示蝙蝠领域被要求为嗯 PI3KC3 的本地化。我们建议不同类脂化合物绑定能力是在 autophagy 区分 PI3KC3-C1 和 PI3KC3-C2 的函数的关键因素。 | Meisheng Ma Jun-Jie Liu Nan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu Hong-Wei Wang | 2017 | Cell Research2017，27，8： | 7 |
| 4 | Determination of erodible particles on cultivated soils by wind tunnel simulation显示文摘The erodible particle size distribution, diameter range and separate content of three soils from semi-arid regions of China were determined at different wind velocities through wind tunnel simulation and dry sieving. It was demonstrated that soil erodibility by wind depends not only on the intrinsic soil properties, but also on the extrinsic erosion effect of the erosive winds. It was supposed that there existed general consistency in the mechanics of wind erosion on different soils. | Lianyou Liu Jianhua Wang Xiaoyan Li Yuzhang Liu Wanquan Ta Haimei Peng | 1998 | Chinese Science Bulletin1998，43，19： | 4 |
| 5 | A Prefix Tree Based n-best List Re-scoring Strategy for Recurrent Neural Network Language Model显示文摘In this paper, issues of speeding up Recurrent neural network language model(RNNLM) in the testing phase are explored so that RNNLMs can be used to re-rank a large n-best list in real-time systems which could obtain better performance. A new n-best list rescoring framework, Prefix tree based n-best list re-scoring(PTNR), is proposed to hundred percent eliminate the repeated computations which makes n-best list re-scoring ineffective. At the same time, the bunch mode technique,widely-used in speeding up the training of Feed-forward neural network language model(FF-NNLM), is combined with PTNR and the speed is further improved. Experimental results show that our approach is much faster than basic n-best list re-scoring. Take 1000-best as an example, our approach is almost 11 times faster than the basic n-best list re-scoring. | SI Yujing LI Ta PAN Jielin YAN Yonghong | 2014 | Chinese Journal of Electronics2014，23，1： | 3 |
| 6 | An Ultrasonic Backscatter Instrument for Cancellous Bone Evaluation in Neonates显示文摘Ultrasonic backscatter technique has shown promise as a noninvasive cancellous bone assessment tool. A novel ultrasonic backscatter bone diagnostic(UBBD) instrument and an in vivo application for neonatal bone evaluation are introduced in this study. The UBBD provides several advantages, including noninvasiveness, nonionizing radiation, portability, and simplicity. In this study, the backscatter signal could be measured within 5 s using the UBBD. Ultrasonic backscatter measurements were performed on 467 neonates(268 males and 199 females) at the left calcaneus. The backscatter signal was measured at a central frequency of 3.5 MHz. The delay(T_1) and duration(T_2) of the backscatter signal of interest(SOI) were varied, and the apparent integrated backscatter(AIB), frequency slope of apparent backscatter(FSAB), zero frequency intercept of apparent backscatter(FIAB), and spectral centroid shift(SCS) were calculated. The results showed that the SOI selection had a direct influence on cancellous bone evaluation. The AIB and FIAB were positively correlated with the gestational age(|R| up to 0.45, P < 0.001) when T_1 was short(< 8 μs), while negative correlations(|R| up to 0.56, P < 0.001) were commonly observed for T_1 > 10 μs. Moderate positive correlations(|R| up to 0.45, P < 0.001) were observed for FSAB and SCS with gestational age when T_1 was long(> 10 μs). The T_2 mainly introduced fluctuations in the observed correlation coefflcients. The moderate correlations observed with UBBD demonstrate the feasibility of using the backscatter signal to evaluate neonatal bone status. This study also proposes an explicit standard for in vivo SOI selection and neonatal cancellous bone assessment. | Chengcheng Liu Rong Zhang Ying Li Feng Xu Dean Ta Weiqi Wang | 2015 | Engineering2015，1，3： | 2 |
| 7 | Severe acute respiratory syndrome(SARS):Infection control显示文摘 | Li TS Buckley TA Yap FH | 2003 | Lancet2003，361，： | 2 |
| 8 | Experiment study on water-rock interaction about gold activation and migration in different solutions显示文摘The interactions on gold active and migratory quantities and rates between tuffaceous slate and solu tions with different compositions were experimentally studied at 200 ℃, 20 MPa, in a high pressure apparatus. After reaction, tuffaceous slate became light colored and soft, and its mass density reduced. The amount of gold extracted from tuffaceous slate ranges widely, from 0 027 to 0 234 μg/g. Chlorine solution may activate appreciable amount of gold, and the gold migratory rate is high enough, from 50 70% to 92 30%, which reveals that sulphur and chlorine work together in solutions to accelerate gold activation and migration, and to realize gold mineralization in favorable places. | DAI Ta gen, GU Li, QIU Dong sheng, XIE Wen bing (College of Resources, Environment and Civil Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，2： | 2 |
| 9 | Optimization of humanized IgGs in glycoengineered Pichia pastoris 显示文摘 | LI H SETHURAMAN N STADHEIM TA | 2006 | Nat Biotechnol2006，24，2： | 1 |
| 10 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance 显示文摘 | Cao X Cai SF Fehniger TA Song J Collins LI Piwnica-Worms DR | 2007 | Immunity2007，27，63： | 1 |
| 11 | Severe acute respiratory syndrome (SAP, S) :infection control显示文摘 | Li Ts ]3uckly TA Yap FH | 2003 | Lancet2003，361，： | 1 |
| 12 | COPD is associat- ed with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype 显示文摘 | Packard TA Li QZ Cosgrove GP | 2013 | Immunol Res2013，55，13： | 1 |
| 13 | Post-synaptic density-95(PSD-95 ) binding capacity of G-protein-coupled receptor 30(GPR30) , an estrogen receptor that can be identified in hippocampaldendritic spines显示文摘 | Akama KT Thompson LI Milner TA | 2013 | J Biol Chem2013，288，9： | 1 |
| 14 | Quantifyingpattern recognition-based myoelectric control ofmultifunctional transcradial prostheses 显示文摘 | Li GL Schultz AE Kuiken TA | 2010 | IEEETransactions on Neural Systems and RehabilitationEngineering: a Publication of the IEEE Engineeringin Medicine and Biology Society2010，18，2： | 1 |
| 15 | DPP-4(CD26)inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1expression by U937 histiocytes显示文摘 | Ta NN Li Y Schuyler CA | 2010 | Atherosclerosis2010，213，2： | 1 |
| 16 | DPP-4(CD26)inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice显示文摘 | Ta NN Schuyler CA Li Y | 2011 | J Cardiovasc Pharmacol2011，58，2： | 1 |
| 17 | DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes 显示文摘 | Ta NN Li Y Schuyler CA | 2010 | Atherosclerosis2010，213，2： | 1 |
| 18 | Numer- ical Simulations of the Solar Transmission Process for a Pressurized Volumetric Receiver 显示文摘 | Cui F Q He Y L Cheng Z D Li D Ta~ Y B | 2012 | Energy2012，46，1： | 1 |
| 19 | Molecular epidemiology of adenovirus infection among pediatric population with diarrhea in Asia显示文摘 | Li L Phan TG Nguyen TA | 2005 | Microbiol hnmuno12005，49，2： | 1 |
| 20 | High mutation frequencies among Escherichia coli and Salmonella pathogens 显示文摘 | LeClerc JE Li B Payne WL Cebula TA | 1996 | Science1996，274，5290： | 1 |
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