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| 1 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 2 | Effects of dietary protein/energy ratio on growth performance,carcass trait,meat quality,and plasma metabolites in pigs of different genotypes显示文摘Background:The protein/energy ratio is important for the production performance and utilization of available feed resources by animals.Increased protein consumption by mammals leads to elevated feed costs and increased nitrogen release into the environment.This study aimed to evaluate the effects of dietary protein/energy ratio on the growth performance,carcass traits,meat quality,and plasma metabolites of pigs of different genotypes.Methods:Bama mini-pigs and Landrace pigs were randomly assigned to two dietary treatment groups(Chinese conventional diet with low protein/energy ratio or National Research Council diet with high protein/energy ratio;n = 24 per treatment) in a 2x2 factorial arrangement.Blood and muscle samples were collected at the end of the nursery,growing,and finishing phases.Results:We observed significant interactions(P< 0.05) between breed and diet for total fat percentage,intramuscular fat(IMF) content,protein content in biceps femoris(BF) muscle,and plasma urea nitrogen(UN) concentration in the nursery phase;for average daily gain(ADG),average daily feed intake(ADFI),dry matter,IMF content in psoas major(PM) muscle,and plasma total protein and albumin concentrations in the growing phase;and for drip loss and plasma UN concentration in the finishing phase.Breed influenced(P < 0.05) growth performance,carcass traits,and meat quality,but not plasma metabolites.Throughout the trial,Landrace pigs showed significantly higher(P < 0.05) ADG,ADFI,dressing percentage,lean mass rate,and loin-eye area than did Bama mini-pigs,but significantly lower(P< 0.05)feed/gain ratio,fat percentage,backfat thickness,and IMF content.Dietary protein/energy ratio influenced the pH value,chemical composition of BF and PM muscles,and plasma activities of glutamic-pyruvic transaminase and gamma-glutamyl transpeptidase,and plasma concentration of UN.Conclusions:Compared with Landrace pigs,Bama mini-pigs showed slower growth and lower carcass performance,but had better meat quality.Moreover,unlike Landrace pigs,the dietary protein/energy ratio did not affect the growth performance of Bama mini-pigs.These results suggest that,in swine production,low dietary protein/energy ratio may be useful for reducing feed costs and minimizing the adverse effects of ammonia release into the environment. | Yingying Liu Xiangfeng Kong Guoli Jiang Bi'e Tan Jinping Deng Xiaojian Yang Fengna Li Xia Xiong Yulong Yin | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 37 |
| 3 | Development of SSR markers from ESTs of gramineous species and their chromosome location on wheat显示文摘407,663 的一个总数表示了小麦,大麦,玉米,米饭,和蜀黍的顺序标签(EST ) ,从 GenBank/dbEST 获得了,被用来寻找简单顺序重复(SSR ) 。10,253 EST-SSRs 的一个总数,说明了 2.52% 所有 EST,被识别。用教材首相 5.0, 1367 EST-SSR 教材对被设计,哪个 715 与高质量被综合。 715 教材对在五庄稼在一样的 PCR 条件,和有效教材对下面在小麦,米饭,玉米,棉花,和大豆上被测试是 500 (69.93%), 383 (53.57%), 452 (63.22%), 357 (49.93%),并且 388 (56.27%)分别地。这显示了在扩及远距离的种类之间的 EST-SSR 标记的高可转移性。另外,有 240 loci 的 139 EST-SSR 教材对在由使用小麦的中国春天 nulli-tetrasomic 线的所有 21 个小麦染色体上是局部性的。 | Linzhi Li Junjun Wang Ying Guo Fangshan Jiang Yunfeng Xu Yingying Wang Haitao Pan Guanzhu Han Ruijun Li Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 25 |
| 4 | An-2 Encodes a Cytokinin Synthesis Enzyme that Regulates Awn Length and Grain Production in Rice显示文摘大量词法、生理的特点在驯服下面在栽培米饭 Oryza sativa 和野米饭 Oryza rufipogon 之间变化了。这里,我们报导 An-2 基因克隆,编码象蛋白质 6 一样的孤独的盖伊(OsLOGL6 ) ,它在 O 催化细胞激动素合成的最后的步。rufipogon。在 theawnless indica Guangluai 4 的基因背景怀有 An-2 的野等位基因的 near-isogenic 线证明 An-2 由由每植物每圆锥花序和 tillers 减少谷物提高房间分割,而是减少谷物生产支持芒延伸。我们表明在 An-2 地点的一个基因变化在减少芒长度并且在驯养的米饭增加 tiller 和谷物数字上有大影响。基因 expressionpatterns 的分析建议 An-1 调整芒的形成初发,并且 An-2 支持芒延伸。在栽培米饭的 theAn-2 地点的核苷酸差异被发现显著地与野米饭的相比被减少,建议 An-2 地点受到人工的选择。我们因此在 An-2 的基因变化的选择由于减少的芒长度并且增加的 proposethat 在栽培米饭的谷物产量。 | Benguo Gu Taoying Zhou Jianghong Luo Hui Liu Yongchun Wang Yingying Shangguan Jingjie Zhu Yan Li Tao Sang Zixuan Wang Bin Han | 2015 | Molecular Plant2015，8，11： | 22 |
| 5 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 6 | Computed tomography-based radiomics for prediction of neoadjuvant chemotherapy outcomes in locally advanced gastric cancer: A pilot study显示文摘Objective: The standard treatment for patients with locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery. The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography(CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy.Methods: Thirty consecutive patients with CT-staged II/III gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017. All patients underwent upper abdominal CT during the unenhanced, late arterial phase(AP) and portal venous phase(PP) before the administration of neoadjuvant chemotherapy. In total, 19,985 radiomics features were extracted in the AP and PP for each patient.Four methods were adopted during feature selection and eight methods were used in the process of building the classifier model. Thirty-two combinations of feature selection and classification methods were examined. Receiver operating characteristic(ROC) curves were used to evaluate the capability of each combination of feature selection and classification method to predict a non-good response(non-GR) based on tumor regression grade(TRG).Results: The mean area under the curve(AUC) ranged from 0.194 to 0.621 in the AP, and from 0.455 to 0.722 in the PP, according to different combinations of feature selection and the classification methods. There was only one cross-combination machine-learning method indicating a relatively higher AUC(>0.600) in the AP, while 12 cross-combination machine-learning methods presented relatively higher AUCs(all >0.600) in the PP. The feature selection method adopted by a filter based on linear discriminant analysis + classifier of random forest achieved a significantly prognostic performance in the PP(AUC, 0.722±0.108; accuracy, 0.793; sensitivity, 0.636; specificity,0.889; Z=2.039; P=0.041).Conclusions: It is possible to predict non-GR after neoadjuvant chemotherapy in locally advanced gastric cancers based on the radiomics of CT. | Zhenhui Li Dafu Zhang Youguo Dai Jian Dong Lin Wu Yajun Li Zixuan Cheng Yingying Ding Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，4： | 18 |
| 7 | PtrHB7, a class III HD-Zip Gene, Plays a Critical Role in Regulation of Vascular Cambium Differentiation in Populus显示文摘在树的第二等的生长的一个关键问题是脉管的形成层房间的区别怎么被指导到 concurrentlyform 二不同纸巾:木部或韧皮部。类 III homeodomain 白氨酸拉链(HD 压缩 III ) 基因被知道在主要、第二等的 growth.However 的进程在脉管的系统的开始, patterning,和区别玩 criticalroles,这些基因怎么控制第二等的脉管的区别的机制是未知的。这里,我们显示出那 Populus 类 III HD 压缩基因, PtrHB7,优先地在 cambial 被表示地区。压制 PtrHB7 的植物在木部与减小在脉管的纸巾显示了重要变化但是韧皮部的增加。Transcriptionalanalysis 表明调整木部区别的基因是下面调整的,而基因调整韧皮部 differentiationwere 起来调整。相应地, PtrHB7 overexpression 向木部房间提高了 cambial 房间的区别,但是禁止了韧皮部区别。cambial 房间区别上的 PtrHB7 规定与它的抄本丰富被联系。一起,结果 demonstratedthat PtrHB7 在在剂量依赖者 manner.Key 在 processof Populus 第二等的生长控制在第二等的木部和韧皮部纸巾之间的平衡区别起一个关键作用词: | Yingying Zhu Dongliang Song Jiayan Sun Xingfen Wang Laigeng Li | 2013 | Molecular Plant2013，6，4： | 13 |
| 8 | Effects of dietary protein restriction on muscle fiber characteristics and m TORC1 pathway in the skeletal muscle of growing-finishing pigs显示文摘Background: To investigate the effects of dietary crude protein(CP) restriction on muscle fiber characteristics and key regulators related to protein deposition in skeletal muscle, a total of 18 growing-finishing pigs(62.30 ± 0.88 kg)were allotted to 3 groups and fed with the recommended adequate protein(AP, 16 % CP) diet, moderately restricted protein(MP, 13 % CP) diet and low protein(LP, 10 % CP) diet, respectively. The skeletal muscle of different locations in pigs, including longissimus dorsi muscle(LDM), psoas major muscle(PMM) and biceps femoris muscle(BFM) were collected and analyzed.Results: Results showed that growing-finishing pigs fed the MP or AP diet improved(P < 0.01) the average daily gain and feed: gain ratio compared with those fed the LP diet, and the MP diet tended to increase(P = 0.09) the weight of LDM. Moreover, the ATP content and energy charge value were varied among muscle samples from different locations of pigs fed the reduced protein diets. We also observed that pigs fed the MP diet up-regulated(P < 0.05) muscular m RNA expression of all the selected key genes, except that myosin heavy chain(My HC) IIb,My HC IIx, while m RNA expression of ubiquitin ligases genes was not affected by dietary CP level. Additionally, the activation of mammalian target of rapamycin complex 1(m TORC1) pathway was stimulated(P < 0.05) in skeletal muscle of the pigs fed the MP or AP diet compared with those fed the LP diet.Conclusion: The results suggest that the pigs fed the MP diet could catch up to the growth performance and the LDM weight of the pigs fed the AP diet, and the underlying mechanism may be partly due to the alteration in energy status, modulation of muscle fiber characteristics and m TORC1 activation as well as its downstream effectors in skeletal muscle of different locations in growing-finishing pigs. | Yinghui Li Fengna Li Li Wu Hongkui Wei Yingying Liu Tiejun Li Bie Tan Xiangfeng Kong Kang Yao Shuai Chen Fei Wu Yehui Duan Yulong Yin | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 13 |
| 9 | Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss显示文摘The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells(BMSCs)characterizes many pathological bone loss conditions.Stromal cell-derived factor-1(SDF1)is highly enriched in the bone marrow for C-X-C motif chemokine receptor 4(CXCR4)-positive hematopoietic stem cell(HSC)homing and tumor bone metastasis.In this study,we displayed CXCR4 on the surface of exosomes derived from genetically engineered NIH-3T3 cells.CXCR4+exosomes selectively accumulated in the bone marrow.Then,we fused CXCR4+exosomes with liposomes carrying antagomir-188 to produce hybrid nanoparticles(NPs).The hybrid NPs specifically gathered in the bone marrow and released antagomir-188,which promoted osteogenesis and inhibited adipogenesis of BMSCs and thereby reversed age-related trabecular bone loss and decreased cortical bone porosity in mice.Taken together,this study presents a novel way to obtain bone-targeted exosomes via surface display of CXCR4 and a promising anabolic therapeutic approach for age-related bone loss. | Yan Hu Xiaoqun Li Qin Zhang Zhengrong Gu Ying Luo Jiawei Guo Xiuhui Wang Yingying Jing Xiao Chen Jiacan Su | 2021 | Bioactive Materials2021，6，9： | 12 |
| 10 | Experimental study of partially-cured Z-pins reinforced foam core composites:K-Cor sandwich structures显示文摘This paper presents an experimental study of a novel K-Cor sandwich structure reinforced with partially-cured Z-pins. The influence of pultrusion processing parameters on Z-pins characteristics was studied and the effect of Z-pins on mechanical properties was disclosed.Differential scanning calorimetry(DSC) and optical microscopy(OM) methods were employed to determine the curing degree of as-prepared Z-pins and observe the implanted Z-pins in the K-Cor structure. These partially-cured Z-pins were treated with a stronger bonding link between face sheets and the foam core by means of a hot-press process,thereby decreasing burrs and cracking defects when the Z-pins were implanted into the Rohacell foam core. The results of the out-of-plane tensile tests and the climbing drum peel(CDP) tests showed that K-Cor structures exhibited superior mechanical performance as compared to X-Cor and blank foam core. The observed results of failure modes revealed that an effective bonding link between the foam core and face sheets that was provided from partially-cured Z-pins contributed to the enhanced mechanical performances of K-Cor sandwich structures. | Zheng Yingying Xiao Jun Duan Mufeng Li Yong | 2014 | Chinese Journal of Aeronautics2014，27，1： | 12 |
| 11 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 12 | Three-stage aged refuse biofilter for the treatment of landfill leachate显示文摘A field-scale aged refuse(AR) biofilter constructed in Shanghai Refuse Landfill,containing about 7000 m3 aged refuse inside,was evaluated for its performance in the treatment of landfill leachate. This AR biofilter can be divided into three stages and can manage 50 m3 landfill leachate per day. The physical,chemical,and biological characteristics of AR were analyzed for evaluating the AR biofilter as leachate treatment host. The results revealed that over 87.8%-96.2% of COD and 96.9%-99.4% of ammonia nitrogen were removed by the three-stage AR biofilter when the influent leachate COD and ammonia nitrogen concentration were in the range 5478-10842 mg/L and 811-1582 mg/L,respectively. The final effiuent was inodorous and pale yellow with COD and ammonia nitrogen below 267-1020 mg/L and 6-45 mg/L,respectively. The three-stage AR biofilter had effcient nitrification but relative poor denitrification capacity with a total nitrogen(TN) removal of 58%-73%. The external temperature of AR biofilter did not influence the total ammonia nitrogen removal significantly. It was concluded that the scale-up AR biofilter can work very well and can be a promising technology for the treatment of landfill leachate. | LI Hongjiang ZHAO Youcai SHI Lei GU Yingying | 2009 | Journal of Environmental Sciences2009，21，1： | 11 |
| 13 | DNA microarray analysis of fluconazole resistance in a laboratory Candida albicans strain显示文摘几机制为获得的 fluconazole (FLC ) 负责在 Candida albicans 的抵抗。在这研究,我们开发了 FLC 抵抗的 C。通过 FLC 易受影响的 C 的连续文化的 albicans 紧张。有 FLC 的禁止的集中的 albicans 紧张。赞美 DNA 微数组分析和即时反向的抄写聚合酶链反应被用来在易受影响的父母紧张和抵抗女儿紧张在 azole 抵抗的获得期间调查基因表示变化。表示基因代表了的差别工作象运输 ers 一样多样(例如 CDR1, PDR17 ) ,麦角固醇生合成(例如 ERG2, ERG9 ) ,甾醇新陈代谢(例如 ARE2, IPF6464 ) ,精力新陈代谢(例如 ADH3, AOX2 ) 并且抄写因素(例如 FCR1, ECM22 ) 。功能的分析表明膜运输 ers 的那项精力依赖者流出活动增加了,那个麦角固醇内容作为与易受影响的紧张相比在抵抗紧张与甾醇中介的累积减少了。我们发现在导致了 Tac1 的活动过度的抄写因素 TAC1 的一个点变化(N977K ) 能是原因为在在抵抗紧张的 CDR1, CDR2,和 PDR17 的表示上。而且,在导致的 ERG3 的单个氨基酸差别(D19E ) 在里面 Erg3 的激活能在这抵抗紧张在麦角固醇生合成基因的表示说明两甾醇先锋累积和变化。这些调查结果在临床的 C 扩展 FLC 抵抗的潜在的新奇分子的目标的理解。albicans 孤立。 | Lan Yan Jundong Zhang Miaohai Li Yongbing Cao Zheng Xu Yingying Cao Pinghui Gao Yan Wang Yuanying Jiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 11 |
| 14 | Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice显示文摘米饭 Eui (伸长最高节间) 基因编码撤销的细胞色素 P450 monooxygenase 简历活跃赤霉素(气体) 。在这研究,我们在植物开发调查了 Eui 基因和它的角色的控制表示。我们发现 Eui 是外长的气体导致的差别并且 Eui 倡导者在维管束举办了最高的活动。eui 异种在在根冠的淀粉小粒开发是有缺点的,在表达式上的 Eui 提高了淀粉小粒产生和严肃回答,揭示为在根淀粉小粒开发和严肃回答的 GA 的一个角色。使用胚胎更少一半种子的实验揭示了那 RAmy1A, GAmyb 是高度起来当外长的 GA 不在时在 eui 糊粉房间调整了。另外, GA 生合成基因 GA3ox1 和 GA20ox2 是调整的 down, GA2ox1 起来在 eui 调整了幼苗。这些结果显示 EUI 涉及 GA 动态平衡,不是在仅仅内部在出发阶段的节点,而且在苗期,根和种子。扰乱 GA 动态平衡影响了表明基因 GID1 (赤霉素感觉迟钝的矮子 1 ) 的 GA 的表示, GID2 和 SLR1。有效地增加的 Eui 基因的转基因的 RNA 干扰种高度和改进标题性能。由对比,在米饭 GA 生合成基因 GA3ox2 和 GA20ox2 的倡导者下面的 Eui 的宫外的表示显著地减少了植物高度。这些结果证明 Eui 表示的细微增加能戏剧性地改变米饭形态学,显示在米饭的 Eui 基因的实际申请为一个高产潜力的分子的繁殖。 | Yingying Zhang Yongyou Zhu Yu Peng Dawei Yan Qun Li Jianjun Wang Linyou Wang Zuhua He | 2008 | Cell Research2008，18，3： | 10 |
| 15 | Evaluation of gas wettability and its effects on fluid distribution and fluid flow in porous media显示文摘The special gas wettability phenomenon of reservoir rocks has been recognized by more and more researchers.It has a significant effect on efficient development of unconventional reservoirs.First,based on the preferentially gas-covered ability and surface free energy changes,definition and evaluation methods have been established.Second,a method for altering rock wettability and its mechanisms have been studied,surface oriented phenomena of functional groups with low surface energy are the fundamental reason for gas wettability alteration of rock.Third,the effect of gas wettability on the surface energy,electrical properties and dilatability are investigated.Last,the effects of gas wettability on capillary pressure,oil/gas/water distribution and flow are investigated with capillary tubes and etchedglass network models.The gas wettability theory of reservoir rocks has been initially established,which provides theoretical support for the efficient production of unconventional reservoirs and has great significance. | Jiang Guancheng Li Yingying Zhang Min | 2013 | Petroleum Science2013，10，4： | 10 |
| 16 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 17 | Development of a daily soil moisture product for the period of2002–2011 in Chinese mainland显示文摘Soil moisture is an essential climate variable(ECV) concerned widely. Due to its high spatial variability, it is costly to measure soil moisture at tens of kilometers scale. In this study, a ten-year(2002–2011) daily soil moisture dataset at 0.25° spatial resolution for Chinese mainland was produced through assimilating the Advanced Microwave Scanning Radiometer for Earth Observing System(AMSR-E) brightness temperature(TB) data into a land surface model(LSM). The obtained soil moisture data was evaluated against soil moisture-measuring networks deployed in two wet areas and one dry area of the Tibetan Plateau.The results show that for the wet areas the accuracy of the soil moisture product obtained from the assimilation is considerably higher than that of both AMSR-E official soil moisture products and land surface simulation results, and for the dry area their accuracy is comparable to each other. The spatial pattern of the soil moisture from the new product is consistent with that of soil porosity from an independent survey-based dataset, further confirming the credibility of the new product. According to this product, the transition regions in China show stronger seasonal variation of soil moisture than dry and wet regions, and drier regions have stronger inter-annual variability of soil moisture than wetter regions, particularly during transitional seasons(spring and autumn). The soil moisture product is accessible at the National Tibetan Plateau Data Center. | Kun YANG Yingying CHEN Jie HE Long ZHAO Hui LU Jun QIN Donghai ZHENG Xin LI | 2020 | Science China Earth Sciences2020，63，8： | 10 |
| 18 | Terrace dating as an archive of the run-through of the Sanmen Gorges显示文摘Analysis of morphological properties in the Sanmen Gorges region of the Yellow River shows that four river terraces have been developed at the entrance to the gorges. Commonly, thick aeolian loess-paleosol sequence was deposited on the terraces, which makes it easy to date the terraces. The dating of paleomagnetic, loess-paleosol sequence matching and thermoluminescence show that terraces T2, T3 and T4 were formed 0. 129 Ma, 0. 625 Ma and 0. 865 Ma ago, respectively. The formation of these terraces in this region indicates that the Yellow River has experienced four intensive downcutting events during the last 0.9 Ma. The Yellow River cut through the Sanmen Gorges and inpoured into the East China Sea no later than 0. 865 Ma. | PAN Baotian WANG Junping GAO Hongshan CHEN Yingying LI Jijun LIU Xiaofeng | 2005 | Progress in Natural Science:Materials International2005，15，12： | 9 |
| 19 | Hierarchical construction of CNT networks in aramid papers for high-efficiency microwave absorption显示文摘Carbon nanotubes(CNTs)incorporated polymeric composites have been extensively investigated for microwave absorption at target frequencies to meet the requirement of radar cross-section reduction.In this work,a strategy of efficient utilization of CNT in producing CNT incorporated aramid papers is demonstrated.The layer-by-layer self-assembly technique is used to coat the surfaces of meta-aramid fibers and fibrils with CNT,providing novel raw materials available for the large-scale papermaking.The hierarchical construction of CNT networks resolves the dilemma of increasing CNT content and avoiding the agglomeration of CNT,which is a frequent challenge for CNT incorporated polymeric composites.The composite paper,which contains abundant heterogeneous interfaces and long-range conductive networks,is capable of reaching a high permittivity and dielectric loss tangent at a low CNT loading,its complex permittivity is,so far,adjustable in the range of(1.20−j0.05)to(25.17−j18.89)at 10 GHz.Some papers with optimal matching thicknesses achieve a high-efficiency microwave absorption with a reflection loss lower than−10 dB in the entire X-band. | You Wu Li Chen Yixuan Han Panbo Liu Haihong Xu Guanze Yu Yingying Wang Tao Wen Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，5： | 9 |
| 20 | Puerarin prevents high glucose-induced apoptosis of Schwann cells by inhibiting oxidative stress显示文摘Oxidative stress may be the unifying factor for the injury caused by hyperglycemia in diabetic peripheral neuropathy. Puerarin is the major isoflavonoid derived from Radix puerariae and has been shown to be effective in increasing superoxide dismutase activity. This study sought to investigate the neuroprotective effect of puerarin on high glucose-induced oxidative stress and Schwann cell apoptosis in vitro. Intracellular reactive oxygen radicals and mitochondrial transmembrane potential were detected by flow cytometry analysis. Apoptosis was confirmed by TUNEL and oxidative stress was monitored using an enzyme-linked immunosorbent assay for the DNA marker 8-hydroxy-2-deoxyguanosine. The expression levels of bax and bcl-2 were analyzed by quantitative real-time reverse transcriptase-PCR, while protein expression of cleaved caspase-3 and -9 were analyzed by means of western blotting. Results suggested that puerarin treatment inhibited high glucose-induced oxidative stress, mitochondrial depolarization and apoptosis in a dose-dependent manner. Furthermore, puerarin treatment downregulated Bax expression, upregulated bcl-2 expression and attenuated the activation of caspase-3 and -9. Overall, our results indicated that puerarin antagonized high glucose-induced oxidative stress and apoptosis in Schwann cells. | Yingying Wu Bing Xue Xiaojin Li Hongchen Liu | 2012 | Neural Regeneration Research2012，7，33： | 8 |
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