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| 1 | Distribution and significance of C~_(40) alkanes in the extracts of Cretaceous source rocks from the Songliao Basin显示文摘Source rock extracts and crude oils from the Songliao Basin were analyzed by high-temperature gas chromatography (HTGC), gas chromatography-mass spectrometry (HTGC-MS) and gas chromatography-isotope ratio-mass spectrometry (GC-IRMS), for high molecular-weight alkanes. The distributions of n-alkanes in the Nenjiang Formation extracts are in the C14―C63 range; a bimodal distribution occurs in the C-21 and C21―40 regions. The C30―C37 n-alkanes are accompanied by C29―C35 hopanes, whereas the high molecular-weight C45―C47 n-alkanes co-occur with abundant isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The high δ 13C values of the n-alkanes and the microscopic maceral compositions indicate a highly diversified organic source input for the Nenjiang Formation source rocks, ranging from aquatic plants, blue alge-bacteria, to land plant material. In contrast, n-alkanes in the rock extracts of the Qingshankou Formation are characterized by a single modal distribution, with relatively low abundances of C29―C35 hopanes, but high molecular-weight isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The relatively low δ 13C values of C22―C44 n-alkanes and organic material compositions indicate that the source rocks in the Qingshankou Formation contain dominantly type I algal organic matter. The relative abundance of C+40 compounds in source rocks changes little at low maturity stage, but decreases drastically at higher maturity levels, with a concurrent reduction in the odd/even carbon predominance. In crude oils, in contrast, the relative abundance of C+40 compounds appears to relate closely with the oil source and oil viscosity. | FENG ZiHui FANG Wei ZHANG JuHe LI ZhenGuang HUANG ChunYan WANG Xue ZHAO QinLing HUO QiuLi | 2007 | Science China Earth Sciences2007，50，10： | 10 |
| 2 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
| 3 | Relationship between microstructure and hydrogen induced cracking behavior in a low alloy pipeline steel显示文摘Hydrogen induced cracking(HIC) behaviors of a high strength pipeline steel with three different microstructures, granular bainite & lath bainite(GB + LB), granular bainite & acicular ferrite(GB + AF), and quasi-polygonal ferrite(QF), were studied by using corrosion experiment based on standard NACE TM0284. The HIC experiment was conducted in hydrogen sulfide(H_2S)-saturated solution. The experimental results show that the steel with GB + AF and QF microstructure present excellent corrosion resistance to HIC, whereas the phases of bainite lath and martensite/austenite in LB + GB microstructure are responsible for poor corrosion resistance. Compared with ferrite phase, the bainite microstructure exhibits higher strength and crack susceptibility of HIC. The AF + GB microstructure is believed to have the best combination of mechanical properties and resistance to HIC among the designed steels. | Jing Li Xiuhua Gao Linxiu Du Zhenguang Liu | 2017 | Journal of Materials Science & Technology2017，33，12： | 6 |
| 4 | Depositional environment of terrestrial petroleum source rocks and geochemical indicators in the Songliao Basin显示文摘To determine geochemical indicators for depositional environment favored by terrestrial petroleum source rocks, we selected 40 source rock samples from the Late Cretaceous Qingshankou Formation (K2qn) and the first member of Nenjiang Formation (K2n1) in the Songliao Basin to qualify saturate fraction and aromatic fraction using GC-HRT (gas chromatography high reso lution time-of-flight mass spectrometry) and quantify important biomarkers using GC-MS. The results reveal that source rocks from the 1st member of Qingshankou Formation (K2qn1) are characterized by not only high contents of terpanes, regular ster anes and 4-methylsteranes but also high contents of dinosteranes, C31 steranes and aryl isoprenoids. Presence of specific bi omarkers like elementary sulfur and lanostanes indicates a depositional environment of lagoon characterized by water stratifi cation and high salinity. In the 2nd-3rd members of Qingshankou Formation (K2qn2+3), source rocks contain lower contents of biomarkers, indicating a depositional environment of shallow fresh-water lake delta. Source rocks in the K2n1 contain high contents of terpanes, regular steranes and 4-methylsteranes but lower contents of dinosteranes, C31 steranes and aryl isopre noids, indicating a depositional environment of fresh-brackish open lake characterized by low salinity and poor water stratifi cation, where organic matter is seriously altered by bacteria. Overall analysis shows that primary geochemical indicators for terrestrial petroleum source rocks are as follows: 1) C30 hopanes > 1500 ppm; 2) gammacerane >190 ppm; 3) C27 steranes >200 ppm; 4) 4-methylsteranes >100 ppm; 5) aryl isoprenoids > 3 ppm; 6) dehydroxyl-vitamin E >10 ppm. | FENG ZiHui FANG Wei LI ZhenGuang WANG Xue HUO QiuLi HUANG ChunYan ZHANG JuHe ZENG HuaSen | 2011 | Science China Earth Sciences2011，54，9： | 6 |
| 5 | Application and Model of Term Structure of Stochastic Interest Rate Based on the Inflation Rate显示文摘 | Yonghong Ma Rongxi Zhou Zhenguang Li | 2007 | Journal of Systems Science and Information2007，5，2： | 5 |
| 6 | Protection of Li metal anode by surface-coating of PVDF thin film to enhance the cycling performance of Li batteries显示文摘Lithium metal, the ideal anode material for next-generation high-energy batteries, suffers from the severe safety problem of Li dendrites. Herein, we report a simple approach to effectively maintain the morphology of Li-metal anode and enhance the cycling performance of Li batteries by surface coating of a porous polyvinylidene fluoride (PVDF) thin film. In symmetrical cells testing, the cells with the Li@PVDF electrode display stable cycling performance more than 1300 h (650 cycles) at the current density of 0.5 mA/cm^2 with a stripping/plating capacity of 0.5 mAh/cm^2. The results with full cells employing Li@PVDF anode and LiFePO_4 cathode show a good cycling ability with a capacity retention of 80.0% after 500 cycles at 4 C and an excellent rate capability with a high capacity of 78.4 mAh/g even at a high rate of 10 C. | Zhenguang Gao Shaojian Zhang Zhigen Huang Yanqiu Lu Weiwei Wang Kai Wang Juntao Li Yao Zhou Ling Huang Shigang Sun | 2019 | Chinese Chemical Letters2019，30，2： | 5 |
| 7 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 8 | CM-Droid: Secure Container for Android Password Misuse Vulnerability显示文摘Android applications are associated with a large amount of sensitive data,therefore application developers use encryption algorithms to provide user data encryption,authentication and data integrity protection.However,application developers do not have the knowledge of cryptography,thus the cryptographic algorithm may not be used correctly.As a result,security vulnerabilities are generated.Based on the previous studies,this paper summarizes the characteristics of password misuse vulnerability of Android application software,establishes an evaluation model to rate the security level of the risk of password misuse vulnerability and develops a repair strategy for password misuse vulnerability.And on this basis,this paper designs and implements a secure container for Android application software password misuse vulnerability:CM-Droid. | Wen Zhang Keyue Li Tianyang Li Shaozhang Niu Zhenguang Gao | 2019 | Computers, Materials & Continua2019，，4： | 1 |
| 9 | Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells显示文摘 | Weihua Yu Zhenguang Chen Jinli Zhang Lirong Zhang Hui Ke Lihua Huang Yanwen Peng Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 10 | An ahemative envelope approach for empirical mode decomposition显示文摘 | Xu Zhenguang Huang Benxiong Li Kewei | 2010 | Digital Signal Pro- cessing2010，20，1： | 1 |
| 11 | Mutations in the genome of the highly pathogenic porcine reproductive and re- spiratory syndrome virus potentially related to attenuation显示文摘 | Leng Xue Li Zhenguang Xia Mingqi | 2012 | Vet Microbiol2012，57，12： | 1 |
| 12 | Localization of calmodulin and calmodulin-like protein and their functions in biomineralization in P. fucata显示文摘Calmodulin (CaM) and calmodulin-like protein (CaLP) are two proteins involved in biomineralization. Their localizations in Pinct- ada fucata mantle epithelia were studied by Western blot (WB) analysis of the nuclear/cytosol fraction of primary cultured P. fucata mantle cells and immunogold electron microscopy. The results showed a completely different distribution of these two proteins at the subcellular level. CaM was distributed throughout both the nucleus and cytoplasm of the mantle epithelium but CaLP was distributed only in the cytoplasm. The functions of these two proteins in biomineralization were investigated by shell regeneration. During this pro- cess, the expressions of CaM and CaLP were greatly enhanced in different organelles of the mantle epithelium. Overexpression of these two proteins and a mutant of calmodulin-like protein (M-CaLP) that lacks an extra C-terminal tail in MC3T3-E1 promoted the mRNA expression of osteopontin, a biomineralization marker for osteoblasts. All of the results indicated that CaM and CaLP have completely different distributions in the mantle epithelium and affect the biomineralization process at different levels. The extra C-terminal tail of CaLP is important for its functions in biomineralization in P. fucata. | Zi Fang Zhenguang Yan Shuo Li Qin Wang Weizhong Cao Guangrui Xu Xunhao Xiong Liping Xie Rongqing Zhang | 2008 | Progress in Natural Science:Materials International2008，18，4： | 1 |
| 13 | Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells显示文摘 | Weihua Yu Zhenguang Chen Jinli Zhang Lirong Zhang Hui Ke Lihua Huang Yanwen Peng Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 14 | Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells显示文摘 | Yanwen Peng Zhenguang Chen Weihua Yu Qifeng Zhou Lin Xu Frank Fuxiang Mao Gang Huang Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Cell Biology International2008，，10： | 1 |
| 15 | Design and calibration of spoke piezoelectric six-dimensional force/torque sensor for space manipulator显示文摘The large manipulator outside the space cabin is a multi-degree of freedom actuator for space operations.In order to realize the automatic control and flexible operation of the space manipulator,a novel spoke structure piezoelectric six-dimensional force/torque sensor with redundancy ability,high stiffness and good decoupling performance is innovatively proposed.Based on the deformation coordination relationship,the redundancy measurement mechanism is revealed.The mathematical models of the sensor with and without branch fault are established respectively.The finite element model is established to verify the feasibility of structure and redundancy measuring principle of the sensor.Depending on the theoretical analysis and simulation analysis,the prototype of the sensor is developed.Static and dynamic calibration experiments are carried out.The actual output voltage signal of the six-dimensional force/torque sensor is collected to establish the equation between the standard input applied load and the actual output voltage signal.Based on ant colony optimized BP algorithm,performance indexes of the sensor with and without branch fault are analyzed respectively.The experimental results show that the spoke piezoelectric sixdimensional force/torque sensor with the eight-point support structure has good accuracy and reliability.Meanwhile,it has strong decoupling characteristic that can effectively shield the coupling between dimensions.The nonlinear errors and maximum interference errors of decoupled data with and without branch faults are less than 1% and 2%,respectively.The natural frequency of the sixdimensional force sensor can reach 2856.45 Hz and has good dynamic characteristics.The research content lays a theoretical and experimental foundation for the design,development and application of the new six-dimensional force/torque sensors with redundancy.Meanwhile,it will significantly improve the research level in this field,and provide a strong guarantee for the smooth implementation of force feedback control of the space station manipulator project. | Yingjun LI Guicong WANG Shuai ZHANG Yuanqin ZHOU Hongyu LI Zhenguang QI | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 16 | Quantitative Inversion of REEs in Ion-Adsorbed Rare Earth Ores from the Liutang Area(South China),Based on Measured Hyperspectral Data显示文摘Rare earth minerals are important strategic resources to economic development all over the world.In this study,multiple linear regression and back propagation(BP) neural network methods are used to invert the contents of ion adsorbed rare earth elements(REEs) and exploring the feasibility of quantitative inversion of REEs through measured hyperspectral data in Liutang rare earth mines,South China.The result shows that the spectral curve of the rare earth ore samples has obvious absorption characteristics around 390,930,1 400,1 900 and 2 200 nm,and continuum removal and the 1st derivative treatment can highlight the absorption characteristics.The modeling accuracies of BP neural network are higher than that of multiple linear regression model.The BP neural network model of the 1st derivative data in 400–1 000 nm bands has the best inversion result of the total content of REEs,R2 reaches 0.98,the ratio of the performance to deviation(RPD) is larger than 3.0.The quantitative inversion model of each REE(except for Ce) has high precision,R2 is greater than 0.90 and RPD is greater than 3.0.The results indicate that quantitative inversion of REEs using measured spectra not only has great potential and feasibility in the exploration of rare earth minerals,but also provides a rapid test method for the content of ion-adsorbed rare earth elements. | Gong Cheng Hongrui Zhang Huan Li Xiaoqing Deng Safiyanu Muhammad Elatikpo Jiaxuan Li Zhenguang Hu Guangqiang Li | 2023 | Journal of Earth Science2023，34，4： | 0 |
| 17 | Research progress on the electrophysiological indicators to predict the efficacy of vagus nerve stimulation for drug-refractory epilepsy显示文摘Vagus nerve stimulation(VNS)is an important treatment option for drug-refractory epilepsy(DRE),with well-established efficacy and safety in clinical practice for more than 20 years.However,it is very difficult to find the optimal electrophysiological indicators for the effectiveness of VNS on DRE because the mechanism of action is unknown.In this review,we provide an update of the potential applications of VNS outcomes in patients with drug-resistant epilepsy.Electroencephalographic(EEG)activity,event-related potentials,EEG synchronization levels,magnetoencephalographic,laryngeal muscle evoked potentials,and heart rate variability are potential biomarkers for VNS outcomes in people with DRE. | Guangli Li Zhenguang Li Yingting Liu | 2024 | Acta Epileptologica2024，7，1： | 0 |
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