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| 1 | Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment显示文摘 | Zhenguang Wang Yelei Guo Weidong Han | 2017 | Protein & Cell2017，8，12： | 24 |
| 2 | Distribution and significance of C~_(40) alkanes in the extracts of Cretaceous source rocks from the Songliao Basin显示文摘Source rock extracts and crude oils from the Songliao Basin were analyzed by high-temperature gas chromatography (HTGC), gas chromatography-mass spectrometry (HTGC-MS) and gas chromatography-isotope ratio-mass spectrometry (GC-IRMS), for high molecular-weight alkanes. The distributions of n-alkanes in the Nenjiang Formation extracts are in the C14―C63 range; a bimodal distribution occurs in the C-21 and C21―40 regions. The C30―C37 n-alkanes are accompanied by C29―C35 hopanes, whereas the high molecular-weight C45―C47 n-alkanes co-occur with abundant isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The high δ 13C values of the n-alkanes and the microscopic maceral compositions indicate a highly diversified organic source input for the Nenjiang Formation source rocks, ranging from aquatic plants, blue alge-bacteria, to land plant material. In contrast, n-alkanes in the rock extracts of the Qingshankou Formation are characterized by a single modal distribution, with relatively low abundances of C29―C35 hopanes, but high molecular-weight isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The relatively low δ 13C values of C22―C44 n-alkanes and organic material compositions indicate that the source rocks in the Qingshankou Formation contain dominantly type I algal organic matter. The relative abundance of C+40 compounds in source rocks changes little at low maturity stage, but decreases drastically at higher maturity levels, with a concurrent reduction in the odd/even carbon predominance. In crude oils, in contrast, the relative abundance of C+40 compounds appears to relate closely with the oil source and oil viscosity. | FENG ZiHui FANG Wei ZHANG JuHe LI ZhenGuang HUANG ChunYan WANG Xue ZHAO QinLing HUO QiuLi | 2007 | Science China Earth Sciences2007，50，10： | 10 |
| 3 | Preliminary analysis of species sensitivity distribution based on gene expression effect显示文摘Species sensitivity analysis is one of the major techniques applied to derive water quality criteria. Presently, the toxicity data used for development of water quality criteria are mainly in the biological individual level. With the increase of ecotoxicogenomics toxicity data, it is worth studying whether the gene expression effect data can be used to derive water quality criteria. Taking cadmium, copper and zinc as examples, we analyzed the toxic effects of the three heavy metals by constructing the species sensitivity distribution curves on the basis of extensive toxicity data. The results showed that the rank of species sensitivity for the acute, chronic and gene expression effect toxicity data of cadmium is 'chronic>gene>acute'. Although the gene expression effect data of copper and zinc are insufficient, the trend of data sensitivity of zinc is similar to cadmium. However, the trend of species sensitivity of copper is different from that of cadmium and zinc with higher sensitivity of gene expression data. It suggested that though the existing data of gene expression effects are not sufficient enough, they have the potential to be used in the development of chronic water quality criteria. For application in the derivation of water quality criteria, illogical test concentration design and insufficient target genes are two main weaknesses in the study of gene expression effects. | YAN ZhenGuang YANG NiYun WANG XiaoNan WANG WanHua MENG ShuangShuang LIU ZhengTao | 2012 | Science China Earth Sciences2012，55，6： | 7 |
| 4 | Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors显示文摘Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell receptor(TCR)deficient mesothelin-specific CAR-T(MPTK-CAR-T)cells using CRISPR-Cas9 technology and evaluated them in a dose-escalation study.A total of 15 patients received one or more infusions of MPTK-CAR-T cells without prior lymphodepletion.No dose-limiting toxicity or unexpected adverse events were observed in any of the 15 patients.The best overall response was stable disease(2/15 patients).Circulating MPTK-CAR-T cells peaked at days 7–14 and became undetectable beyond 1 month.TCR-positive CAR-T cells rather than TCR-negative CAR-T cells were predominantly detected in effusion or peripheral blood from three patients after infusion.We further confirmed the reduced persistence of TCR-deficient CAR-T cells in animal models.Our results establish the preliminary feasibility and safety of CRISPR-engineered CAR-T cells with PD-1 disruption and suggest that the natural TCR plays an important role in the persistence of CAR-T cells when treating solid tumors. | Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han | 2021 | Cellular & Molecular Immunology2021，18，9： | 7 |
| 5 | Relationship between microstructure and hydrogen induced cracking behavior in a low alloy pipeline steel显示文摘Hydrogen induced cracking(HIC) behaviors of a high strength pipeline steel with three different microstructures, granular bainite & lath bainite(GB + LB), granular bainite & acicular ferrite(GB + AF), and quasi-polygonal ferrite(QF), were studied by using corrosion experiment based on standard NACE TM0284. The HIC experiment was conducted in hydrogen sulfide(H_2S)-saturated solution. The experimental results show that the steel with GB + AF and QF microstructure present excellent corrosion resistance to HIC, whereas the phases of bainite lath and martensite/austenite in LB + GB microstructure are responsible for poor corrosion resistance. Compared with ferrite phase, the bainite microstructure exhibits higher strength and crack susceptibility of HIC. The AF + GB microstructure is believed to have the best combination of mechanical properties and resistance to HIC among the designed steels. | Jing Li Xiuhua Gao Linxiu Du Zhenguang Liu | 2017 | Journal of Materials Science & Technology2017，33，12： | 6 |
| 6 | Depositional environment of terrestrial petroleum source rocks and geochemical indicators in the Songliao Basin显示文摘To determine geochemical indicators for depositional environment favored by terrestrial petroleum source rocks, we selected 40 source rock samples from the Late Cretaceous Qingshankou Formation (K2qn) and the first member of Nenjiang Formation (K2n1) in the Songliao Basin to qualify saturate fraction and aromatic fraction using GC-HRT (gas chromatography high reso lution time-of-flight mass spectrometry) and quantify important biomarkers using GC-MS. The results reveal that source rocks from the 1st member of Qingshankou Formation (K2qn1) are characterized by not only high contents of terpanes, regular ster anes and 4-methylsteranes but also high contents of dinosteranes, C31 steranes and aryl isoprenoids. Presence of specific bi omarkers like elementary sulfur and lanostanes indicates a depositional environment of lagoon characterized by water stratifi cation and high salinity. In the 2nd-3rd members of Qingshankou Formation (K2qn2+3), source rocks contain lower contents of biomarkers, indicating a depositional environment of shallow fresh-water lake delta. Source rocks in the K2n1 contain high contents of terpanes, regular steranes and 4-methylsteranes but lower contents of dinosteranes, C31 steranes and aryl isopre noids, indicating a depositional environment of fresh-brackish open lake characterized by low salinity and poor water stratifi cation, where organic matter is seriously altered by bacteria. Overall analysis shows that primary geochemical indicators for terrestrial petroleum source rocks are as follows: 1) C30 hopanes > 1500 ppm; 2) gammacerane >190 ppm; 3) C27 steranes >200 ppm; 4) 4-methylsteranes >100 ppm; 5) aryl isoprenoids > 3 ppm; 6) dehydroxyl-vitamin E >10 ppm. | FENG ZiHui FANG Wei LI ZhenGuang WANG Xue HUO QiuLi HUANG ChunYan ZHANG JuHe ZENG HuaSen | 2011 | Science China Earth Sciences2011，54，9： | 6 |
| 7 | Application and Model of Term Structure of Stochastic Interest Rate Based on the Inflation Rate显示文摘 | Yonghong Ma Rongxi Zhou Zhenguang Li | 2007 | Journal of Systems Science and Information2007，5，2： | 5 |
| 8 | Recent advances in enzyme-mediated peptide ligation显示文摘Artificial synthesis and site-specific modification of peptides and proteins has evolved into an indispensable tool for protein engineers and chemical biologists. Chemical and enzymatic approaches to peptide ligation are important alternatives of recombinant DNA technology for protein synthesis and modification. Although as old as that of chemical procedures, enzyme-mediated peptide ligation is far less developed than that of chemical counterpart due to the difficult availability of peptide ligase.Fortunately, this situation has been changed slowly with the fast development of biological techniques. In the past decades, several natural peptide ligases have been discovered. Protein engineering to improve the ligation efficiencies of the natural peptide ligase and to reverse the functionality of protease provide more powerful peptide ligases. In this review, the advances of enzyme-mediated peptide ligation and their application in protein synthesis and modification will be discussed. | Silin Xu Zhenguang Zhao Junfeng Zhao | 2018 | Chinese Chemical Letters2018，29，7： | 5 |
| 9 | Protection of Li metal anode by surface-coating of PVDF thin film to enhance the cycling performance of Li batteries显示文摘Lithium metal, the ideal anode material for next-generation high-energy batteries, suffers from the severe safety problem of Li dendrites. Herein, we report a simple approach to effectively maintain the morphology of Li-metal anode and enhance the cycling performance of Li batteries by surface coating of a porous polyvinylidene fluoride (PVDF) thin film. In symmetrical cells testing, the cells with the Li@PVDF electrode display stable cycling performance more than 1300 h (650 cycles) at the current density of 0.5 mA/cm^2 with a stripping/plating capacity of 0.5 mAh/cm^2. The results with full cells employing Li@PVDF anode and LiFePO_4 cathode show a good cycling ability with a capacity retention of 80.0% after 500 cycles at 4 C and an excellent rate capability with a high capacity of 78.4 mAh/g even at a high rate of 10 C. | Zhenguang Gao Shaojian Zhang Zhigen Huang Yanqiu Lu Weiwei Wang Kai Wang Juntao Li Yao Zhou Ling Huang Shigang Sun | 2019 | Chinese Chemical Letters2019，30，2： | 5 |
| 10 | Gene-lndexed Mutations in Maize显示文摘 | Xiaoduo Lu Jisheng Liu Wen Ren Qun Yang Zhenguang Chai Rumei Chen Lei Wang Jun Zhao Zhihong Lang Haiyang Wang Yunliu Fan Jiuran Zhao Chunyi Zhang | 2018 | Molecular Plant2018，11，3： | 4 |
| 11 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 12 | CM-Droid: Secure Container for Android Password Misuse Vulnerability显示文摘Android applications are associated with a large amount of sensitive data,therefore application developers use encryption algorithms to provide user data encryption,authentication and data integrity protection.However,application developers do not have the knowledge of cryptography,thus the cryptographic algorithm may not be used correctly.As a result,security vulnerabilities are generated.Based on the previous studies,this paper summarizes the characteristics of password misuse vulnerability of Android application software,establishes an evaluation model to rate the security level of the risk of password misuse vulnerability and develops a repair strategy for password misuse vulnerability.And on this basis,this paper designs and implements a secure container for Android application software password misuse vulnerability:CM-Droid. | Wen Zhang Keyue Li Tianyang Li Shaozhang Niu Zhenguang Gao | 2019 | Computers, Materials & Continua2019，，4： | 1 |
| 13 | Development of aquatic life criteria for nitrobenzene in China显示文摘 | YAN Zhenguang ZHANG Zhisheng WANG Hong | 2012 | Environ Pollut2012，162，： | 1 |
| 14 | Development of freshwater aquatic life criteria for tetrbromobisphenol A in China 显示文摘 | YANG Sunweu YAN Zhenguang XU Fanfan | 2012 | Environ Pollut2012，169，： | 1 |
| 15 | Failure detection, isolation, and recovery of multifunctional self- validating sensor显示文摘 | Shen Zhenguang Wang Qi | 2012 | IEEE Transactions an Instrumen- tation and Measurement2012，61，12： | 1 |
| 16 | A possible mechanism for the formation of annual growth lines in bivalve shells显示文摘We report a unique shell margin that differed from the usual shell structure of Pinctada fucata.We observed empty organic envelopes in the prismatic layer and the formation of the nacreous layer in the shell margin.All the characteristics of the growing margin indicated that the shell was growing rapidly.To explain this anomaly,we propose the concept of 'jumping development'.During jumping development,the center of growth in the bivalve shell jumps forward over a short time interval when the position of the mantle changes.Jumping development explains the unusual structure of the anomalous shell and the development of annual growth lines in typical shells.Annual growth lines are the result of a discontinuity in the shell microstructure induced by jumping development. | LIU XiaoJun YAN ZhenGuang ZHENG GuiLan ZHANG GuiYou WANG HongZhong XIE LiPing ZHANG RongQing | 2011 | Science China(Life Sciences)2011，54，2： | 1 |
| 17 | Developing a national water quality criteria system in China显示文摘 | YAN Zhenguang WANG Hong WANG Yizhe | 2013 | Water Policy2013，15，6： | 1 |
| 18 | Development of aquatic life criteria for nitrobenzene in China显示文摘 | YAN Zhenguang ZHANG Zhisheng WANG Hong | 2012 | E nvironmental Pollution2012，162，： | 1 |
| 19 | Corrosion behavior of single-and poly-crystalline dual-phase TiAl–Ti3Al alloy in NaCl solution显示文摘To clarify the correlation of single-crystalline structure with corrosion performance in high-strength TiAl alloys, electrochemical and surface characterization was performed by comparing Ti–45Al–8Nb dual-phase single crystals with their polycrystalline counterparts in NaCl solution. Polarization curves show a lower corrosion rate and a higher pitting potential of ~280 mV for the dual-phase single crystals. Electrochemical impedance spectroscopy and potentiostatic polarization plots revealed a higher impedance of the charge transfer through the compact passive film. Surface composition analysis indicated a compact film with more content of Nb, as twice as that in the film on the polycrystals.Our results reflect that the dual-phase Ti–45Al–8Nb single crystals possess a higher corrosion resistance in NaCl solution, compared with their polycrystalline counterpart, arising from a more homogeneous microstructure and composition distribution. | Dongpeng Wang Guang Chen Anding Wang Yuxin Wang Yanxin Qiao Zhenguang Liu Zhixiang Qi Chain Tsuan Liu | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 1 |
| 20 | Developmentof aquatic life criteria for nitrobenzene in China显示文摘 | YAN Zhenguang ZHANG Zhisheng WANG Hong | 2012 | Environ Pollut2012，162，： | 1 |
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