|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective analysis of extra-gastrointestinal stromal tumors显示文摘AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South Korea.METHODS:A total of 51 patients with an EGIST were identified.The clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were analyzed.RESULTS:The median age was 55 years(range:29-80years),and male:female ratio was 1:1.04.The most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon 11mutation.Among 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free survival.Of the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as'high risk'according to the risk criteria.However,the relapse-free survival was not different(P=0.157)between two groups.CONCLUSION:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features. | Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park Young-Woong Won Sung Hee Lim Se Hoon Park | 2015 | World Journal of Gastroenterology2015，21，6： | 9 |
| 2 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 3 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 2 |
| 4 | Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)显示文摘 | Tae Nyun Kim Man Sik Park Kang Il Lim Sae Jeong Yang Hye Jin Yoo Hyun Joo Kang Wook Song Ji A. Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Kyung Mook Choi | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 5 | Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer显示文摘Objective:The aim of this study is to develop a nomogram for prediction of pathologic complete remission(p CR)after preoperative chemoradiotherapy(CRT)for rectal cancer.Methods:m RNA expression levels of seven molecular markers[p53,p21,Ki-67,vascular endothelial growth factor(VEGF),CD133,CD24,CD44]were measured by reverse transcriptase polymerase chain reaction(RTPCR)in 120 rectal cancers.Endoscopic findings of clinical complete remission(c CR)and biologic variables were used to construct nomogram in the training group(n=80),which was validated in the validation group(n=40).Results:m RNA expression levels of four markers(p53,p21,Ki67,CD133)correlated with p CR(24/80,30.0%)in the training group.Low expression of p53 and/or high expression of p21,Ki67 and CD133 showed greater p CR rate.p CR was shown in 18(69.2%)of 26 cases showing endoscopic c CR in the training group.Higher p CR rate was demonstrated in lower tumor location than middle tumor(19/49,38.8%vs.5/31,16.1%).A nomogram for prediction of p CR was developed from the multivariate prediction model using these six variables,which showed good discrimination ability in the training group[area under the curve(AUC)=0.945]and validation group(AUC=0.922).The calibration plot showed good agreement between actual and predicted p CR in both patient groups.Conclusions:Nomogram for assessment of p CR can be useful for making treatment decisions after CRT according to predicted responses. | Hyuk Hur Min Soo Cho Woong Sub Koom Joon Seok Lim Tae Il Kim Joong Bae Ahn Hoguen Kim Nam Kyu Kim | 2020 | Chinese Journal of Cancer Research2020，32，2： | 2 |
| 6 | Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma显示文摘AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was designed.Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and 8.Treatment was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent withdrawal.The primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely excluded.Disease control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), respectively.CONCLUSION: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC. | Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 7 | Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non-small-cell lung cancer显示文摘 | Hong-Gyun Wu Yung-Jue Bang Eun Kyung Choi Yong Chan Ahn Young Whan Kim Tae-Hwan Lim Cheolwon Suh Keunchil Park Charn Il Park | 2002 | International Journal of Radiation Oncology Biology Physics2002，，1： | 1 |
| 8 | Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis显示文摘 | Sang In Park Jung Yeon Lim Chang Hyun Jeong Seong Muk Kim Jin Ae Jun Sin-Soo Jeun Won Il Oh Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 9 | A New Suggestion for the Radiation Target Volume After a Subtotal Gastrectomy in Patients With Stomach Cancer显示文摘 | Heerim Nam Do Hoon Lim Sung Kim Won Ki Kang Tae Sung Sohn Jae Hyung Noh Yong Il Kim Chan Hyung Park Chul Keun Park Yong Chan Ahn Seung Jae Huh | 2008 | International Journal of Radiation Oncology Biology Physics2008，，2： | 1 |
| 10 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 11 | SLIPA? may be more useful than other LMADs for difficult airway management显示文摘 | Byung Gun Lim Kyung Jong Kim Myoung Hoon Kong Nan Suk Kim Sang Ho Lim Mi Kyoung Lee Il Ok Lee | 2012 | Canadian Journal of Anesthesia/Journal canadien d’anesthésie2012，，1： | 1 |
| 12 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 1 |
| 13 | Stress intensity factors for semi-circular specimens under three-point bending显示文摘 | LIM IL JOHNSTON IW CHOI SK | 1993 | Engineering Fracture Mechanics1993，44，3： | 1 |
| 14 | High performance α-Si TFT with ITO/n+ ohmic layer using a Ni-silicide显示文摘 | IL R J JIN C Y KEUN W I RYU J I CHOI Y J WOO I K LIM B C JANG J | 2000 | Journal of Non-Crystalline Solids Part B2000，，： | 1 |
| 15 | Short health scale: A valid measure of health-related quality of life in Korean-speaking patients with inflammatory bowel disease显示文摘AIM To evaluate the short health scale(SHS),a new,simple,four-part visual analogue scale questionnaire that is designed to assess the impact of inflammatory bowel disease(IBD)on health-related quality of life(HRQOL),in Korean-speaking patients with IBD.METHODS The SHS was completed by 256 patients with Crohn’s disease(CD)and ulcerative colitis(UC).Individual SHS items were correlated with inflammatory bowel disease questionnaire(IBDQ)dimensions and with disease activity to assess validity.Test-retest reliability,responsiveness and patient or disease characteristics with probable association with high SHS scores were analyzed.RESULTS Of 256 patients with IBD,139(54.3%)had UC and 117(45.7%)had CD.The correlation coefficients between SHS questions about'symptom burden','activities of daily living',and'disease-related worry'and their corresponding dimensions in the IBDQ ranged from0.62 to 0.71,compared with correlation coefficients ranging from-0.45 to-0.61 for their non-corresponding dimensions.There was a stepwise increase in SHS scores,with increasing disease activity in both CD and UC(all P values<0.001).Reliability was confirmed with test-retest correlations ranging from 0.68 to 0.90(all P values<0.001).Responsiveness was confirmed with the patients who remained in remission.Their SHS scores remained unchanged,except for the SHS dimension'disease-related worry'.In the multivariate analysis,female sex was associated with worse'general well-being'(OR=2.28,95%CI:1.02-5.08)along with worse disease activity.CONCLUSION The SHS is a valid and reliable measure of HRQOL in Korean-speaking patients with IBD. | Soo-Kyung Park Bong Min Ko Hyeon Jeong Goong Jeong Yeon Seo Sang Hyuk Lee Hae Lim Baek Moon Sung Lee Dong Il Park | 2017 | World Journal of Gastroenterology2017，23，19： | 1 |
| 16 | Remoral of CO2 by calcium-based sorbents in thepresence of SO2显示文摘 | SUN P GRACE J IL LIM C J | 2007 | Energy & Fuels2007，21，1： | 1 |
| 17 | Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: Matched case–control study显示文摘 | Jeong Il Yu Doo Ho Choi Won Park Seung Jae Huh Eun Yoon Cho Young Hyuk Lim Jin Suk Ahn Jung Hyun Yang Suk Jin Nam | 2010 | The Breast2010，，3： | 1 |
| 18 | Effect of chitosan on morphology and conformation of electrospun silk fibroin nanofibers显示文摘 | Won Ho Park Lim Jeong Dong Il Yoo | 2004 | Polymer2004，45，： | 1 |
| 19 | Phase II study of docetaxel and cisplatin combination chemotherapy in metastatic gastric cancer显示文摘 | Keon Woo Park Jin Seok Ahn Young Suk Park Jeeyun Lee Jung Hoon Kang Joon Oh Park Ho Yeong Lim Young-Hyuck Im Won Ki Kang Keunchil Park Soon Il Lee | 2007 | Cancer Chemotherapy and Pharmacology2007，，1： | 1 |
| 20 | Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with 11 C-methionine positron emission tomography显示文摘 | Jeehun Lee Bo Lyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Su Jin Lee Joon Young Choi Kyung-Han Lee Jung Il Lee Hyung-Jin Shin Ji Hye Kim Yeon Lim Suh Ke Hyang Lee Munhyang Lee | 2009 | Child’s Nervous System2009，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员