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| 1 | Elastic catenary cable element considering frictional slip effect显示文摘Conventional analysis methods of cable structures do not consider sliding of cables inside the joint,which may lead to inaccuracy of the theoretical behavior of the structure.In order to develop an effective method for cable sliding,a two-node cable element based on the analytical solution for an elastic catenary was studied.The cable sliding stiffness and the effect of friction were investigated.To validate the proposed numerical method,analyses of two examples given in the literature were conducted.The results demonstrated that the method given in this paper is accurate and effective,and can take into account cable sliding in cable structures.In addition,it was shown that the effect of cable sliding on the behavior of cable structures is significant.It was also shown that the friction at the support hampers the flow of the cable force,leading to unequal cable tensions on both sides of the support. | CAI JianGuo LIM James FENG Jian XU YiXiang WANG Kai | 2012 | Science China(Technological Sciences)2012，55，6： | 10 |
| 2 | Multicentre collaborative cohort study of the use of Kirschner wires for the management of supracondylar fractures in children显示文摘Purpose:Supracondylar fractures of the humerus cause significant morbidity in children.Nerve damage and loss of fracture reduction are common recognised complications in patients with this injury.Uncertainty surrounds the optimal Kirschner wire configuration and diameter for closed reduction and pinning of these fractures.This study describes current practice and examined the association between wire configuration or diameter and outcomes(clinical and radiological)in the operative management of paediatric supracondylar fractures.Methods:Children presenting w让h GartlandⅡorⅢsupracondylar fractures at five hospitals in southwest England were eligible for inclusion.Collaborators scrutinised paper and electronic case notes.Outcome measures were maintenance of reduction and iatrogenic nerve injury.Results:Altogether 209 patients were eligible for inclusion:15.7%had a documented neurological deficit at presentation;3.9%who were neurologically intact at presentation sustained a new deficit caused by treatment and 13.4%experienced a clinically significant loss of reduction following fixation.Maintenance of reduction was significantly better in patients treated specifically with crossed×3 Kirschner wire configuration compared to all other configurations.The incidence of iatrogenic nerve injury was not significantly different between groups treated with different wire configurations.Conclusion:We present a large multicentre cohort study showing that crossed×3 Kirschner wires are associated with better maintenance of reduction than crossed×2 or lateral entry wires.Greater numbers would be required to properly investigate nerve injury relating to operative management of supracondylar fractures.We found significant variations in practice and compliance w让h the British Orthopaedic Association Standard for Trauma(BOAST)11 guidelines. | Henry Claireaux Richard Goodall Joshua Hill Elizabeth Wilson Philippa Coull Sebastian Green James Schuster-Bruce Diana Lim Joanna Miles Payam Tarassoli | 2019 | Chinese Journal of Traumatology2019，22，5： | 7 |
| 3 | The Involvement of Lipids in Alzheimer's Disease显示文摘It has been estimated that Alzheimer's disease(AD), the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined.Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the ε4 variant of apolipoprotein E(APOE).Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD. | Wei Ling Florence Lim Ian James Martins Ralph Nigel Martins | 2014 | Journal of Genetics and Genomics2014，41，5： | 6 |
| 4 | Laparoscopic resection of gastrointestinal stromal tumors:Does laparoscopic surgery provide an adequate oncologic resection?显示文摘Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI tract.Surgical resection remains the mainstay of non-metastatic disease.However,the ability to provide an adequate oncologic resection using laparoscopic surgery is still an area of debate.This is a thorough review of the current literature,looking particularly at the use of laparoscopic surgery for larger GISTs and the long-term oncologic outcomes compared to the results of open surgery.Laparoscopic resections provide an adequate oncologic result for GISTs of all sizes,including those greater than 5 cm in size. | Joseph J Kim James Y Lim Scott Q Nguyen | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 5 | Non-invasive splenic parameters of portal hypertension:Assessment and utility显示文摘BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and mortality.The present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or esophagogastroduodenoscopy.However,these methods are invasive,carry a risk of complications and are associated with significant patient discomfort.Therefore,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal hypertension.However,diagnostic accuracy and reproducibility remains unvalidated.AIM To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal hypertension.METHODS Of 50 patients with varying liver disease pathologies were prospectively recruited from the St.Mary’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal hypertension.Liver stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography system.The aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also calculated.Performance measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography variables.Interclass correlation coefficient was used to determine the reproducibility of splenic area and diameter.RESULTS On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P value<0.001],spleen area(AUROC 0.828,P value=0.002)and APRI score(AUROC 0.827,P value<0.001)were the most accurate variables in identifying the presence of portal hypertension.On multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity,100%positive predictive value and 100%negative predictive value.An alternative combination of spleen stiffness greater than 29.99 kPa and platelet count less than 126×10^9 had 88%sensitivity,75%specificity,78.6%positive predictive value and 85.7%negative predictive value.An interclass correlation coefficient value of 0.98(95%CI:0.94-0.99,P value<0.001)and 0.96(95%CI:0.91-0.99,P value<0.001)were determined for inter-operator variability for spleen area and diameter respectively.CONCLUSION Spleen area,spleen stiffness and platelet count may be useful markers to assess the presence of portal hypertension in patients of various etiologies. | Ayesha Karim Ahmad Sebastiana Atzori James Maurice Simon D Taylor-Robinson Adrian KP Lim | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 6 | Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes显示文摘 | Xin Yuan Dawn Waterworth John R.B. Perry Noha Lim Kijoung Song John C. Chambers Weihua Zhang Peter Vollenweider Heide Stirnadel Toby Johnson Sven Bergmann Noam D. Beckmann Yun Li Luigi Ferrucci David Melzer Dena Hernandez Andrew Singleton James Scott Paul | 2008 | The American Journal of Human Genetics2008，，4： | 1 |
| 7 | Finite Element Idealization of a Cold-Formed Steel Portal Frame显示文摘 | James B P Lim and David A Nethercot | 2004 | Journal of Structural Engineering2004，130，1： | 1 |
| 8 | Directed tagging of the Arabidopsis fatty acid elongation 1 (FAE1) gene with the maize transposon activator显示文摘 | James DW Jr Lim E Keller J | | 0，，3： | 1 |
| 9 | The Acute Hemodynamic Effects of MitraClip Therapy显示文摘 | Robert J. Siegel Simon Biner Asim M. Rafique Michael Rinaldi Scott Lim Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow Howard C. Herrmann Elyse Foster Ted Feldman Donald Glower Saibal Kar | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 10 | A phase I study of oxaliplatin in combination with gemcitabine: correlation of clinical outcome with gene expression显示文摘 | Stephen Shibata Warren Chow Paul Frankel Agnes Juhasz Lucille Leong Dean Lim Kim Margolin Robert Morgan Edward Newman George Somlo Yun Yen Timothy Synold David Gandara Heinz-Josef Lenz James Doroshow | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 11 | Longitudinal Strain Delay Index by Speckle Tracking Imaging: A New Marker of Response to Cardiac Resynchronization Therapy显示文摘 | Pascal Lim Adisai Buakhamsri Zoran B. Popovic Neil L. Greenberg Dimpi Patel James D. Thomas Richard A. Grimm | 2008 | Circulation2008，，11： | 1 |
| 12 | Lobe-specific mediastinal nodal dissection is sufficient during lobectomy by VATS or thoracotomy for early stage lung cancer显示文摘 | Mark Shapiro Sagar Kadakia James Lim | 2013 | Chest2013，144，5： | 1 |
| 13 | Cardiovascular effects of angiotensin converting enzyme inhibition or angiotensin receptor blockade in hemodialysis:a meta-analysis显示文摘 | Tai DJ Lim TW James MT | | 0，，： | 1 |
| 14 | Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia 显示文摘 | Jose FV Lim FY James C | 2010 | Joumal of Pediatric Surgery2010，45，4： | 1 |
| 15 | Coarctation of the Aorta - The Current State of Surgical and Transcatheter Therapies显示文摘 | Jeffrey E. Vergales James J. Gangemi Karen S. Rhueban D. Scott Lim | 2013 | Current Cardiology Reviews2013，，3： | 1 |
| 16 | Directed tagging of the Arabidopsis FATTY ACID ELONGATION 1 (FAE1) gene with the maize transposon activator显示文摘 | James DW Lim E Keller J | 1995 | Plant Cell1995，7，3： | 1 |
| 17 | Directed tagging of the arabidopsis fatty acid elongation( FAEI ) gene with the maize trans- poson activator K 显示文摘 | James Jr D W Lim E Keller J | 1995 | Plant Cell1995，7，3： | 1 |
| 18 | Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion显示文摘 | Ghassan Mouneimne Scott D. Hansen Laura M. Selfors Lara Petrak Michele M. Hickey Lisa L. Gallegos Kaylene J. Simpson James Lim Frank B. Gertler John H. Hartwig R. Dyche Mullins Joan S. Brugge | 2012 | Cancer Cell2012，，5： | 1 |
| 19 | Direcled tagging of the Arabi-dopsis FATTY ACID ELONGA TIONI ( EAE1) gene with maizetransposoa aclivator显示文摘 | James D W Lim E Keller J | 1995 | Plant Cell1995，7，： | 1 |
| 20 | Cardiovascular effects of angiotension converting enzyme inhibition or angiotension receptor blockade in hemodialysis:a meta-analysis显示文摘 | Tai DJ Lim TW James MT | | 0，，： | 1 |
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