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| 1 | Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease显示文摘 | Sunder Mudaliar Robert R. Henry Arun J. Sanyal Linda Morrow Hanns-Ulrich Marschall Mark Kipnes Luciano Adorini Cathi I. Sciacca Paul Clopton Erin Castelloe Paul Dillon Mark Pruzanski David Shapiro | 2013 | Gastroenterology2013，，： | 7 |
| 2 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 3 | Thoracoscopic segmentectomy compares favorably with thoracoscopic lobectomy for patients with small stage I lung cancer显示文摘 | Mark Shapiro Todd S. Weiser Juan P. Wisnivesky Cynthia Chin Michael Arustamyan Scott J. Swanson | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，6： | 3 |
| 4 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 5 | Hepatitis B vaccination in patients with inflammatory bowel disease显示文摘AIM:To determine the prevalence for hepatitis B virus(HBV) and HBV screening and vaccination practices for inflammatory bowel disease(IBD).METHODS:This study is a retrospective,cross-sectional observational study.A retrospective chart review was performed in 500 patients who have been consecutively treated for IBD between September 2008 and January 2013 at the Rush University Medical Center Gastroenterology section.The patients were identified through the electronic medical record with the criteria that they attended the gastroenterology clinic,and that they had a diagnosis of IBD at the time of visit discharge.Once identified,each record was analyzed to determine whether the subject had been infected with HBV in the past,already been vaccinated against HBV,or advised to get vaccinated and followed through with the recommended vaccination.RESULTS:About 254 out of 500 patients(51%) had HBV screening ordered.Among those ordered to have screening tests,86% followed through with HBV serology.Gastroenterology physicians had significantly different screening ratios from each other(P < 0.001).There were no significant differences in the ratios of HBV screening when IBD specialists were compared to other gastroenterology physicians(0.505 ± 0.023 vs 0.536 ± 0.066,P = 0.66).Of those 220 patients screened,51% of IBD patients were found not to be immune against HBV.Approximately 50% of gastroenterology physicians recommended HBV vaccinations to their patients in whom serology was negative for antibodies against HBV.IBD specialists recommended vaccinations to a higher percentage of their patients compared to other gastroenterology physicians(0.168 ± 0.019 vs 0.038 ± 0.026,P = 0.015).Present and/or past HBV infection was found in 3.6% of the patients who had serology checked.There was no statistically significant difference in the prevalence of hepatitis B surface antigen(HBsAg) between our study and that reported in previous studies done in Spain(4/220 vs 14/2076 respectively,P = 0.070); and in France(4/220 vs 3/315 respectively,P = 0.159).But,the prevalence of anti-HBcAb in this study was less than that reported in the study in Spain(7/220 vs 155/2076 respectively,P = 0.006); and was not sig-nificantly different from that reported in the study in France(7/220 vs 8/315 respectively,P = 0.313).CONCLUSION:The prevalence of HBsAg in our IBD patients was not higher than previously reported European studies.Most IBD patients are not routinely screened or vaccinated against HBV at a tertiary referral center in the United States. | Ruwaida Ben Musa Anuhya Gampa Sanjib Basu Ali Keshavarzian Garth Swanson Michael Brown Rana Abraham Keith Bruninga John Losurdo Mark DeMeo Sohrab Mobarhan David Shapiro Ece Mutlu | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 6 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 7 | Current Status of Gastrointestinal Carcinoids显示文摘 | Irvin M. Modlin Mark Kidd Igor Latich Michelle N. Zikusoka Michael D. Shapiro | 2005 | Gastroenterology2005，，6： | 2 |
| 8 | Non-line-of -sight singlescatter propagation model显示文摘 | Mark R Luettgen Jeffrey H Shapiro | 1991 | J Optical Society of America1991，8，： | 1 |
| 9 | A Dose–Volume Analysis of Radiation Pneumonitis in Non–Small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy显示文摘 | R. Bryan Barriger Jeffrey A. Forquer Jeffrey G. Brabham David L. Andolino Ronald H. Shapiro Mark A. Henderson Peter A.S. Johnstone Achilles J. Fakiris | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 10 | Lobe-specific mediastinal nodal dissection is sufficient during lobectomy by VATS or thoracotomy for early stage lung cancer显示文摘 | Mark Shapiro Sagar Kadakia James Lim | 2013 | Chest2013，144，5： | 1 |
| 11 | Patent Holdup and Royalty Stacking显示文摘 | LEMLEY MARK A SHAPIRO CARL | 2007 | Texas Law Review2007，58，： | 1 |
| 12 | Patent Holdup and Royalty Stacking显示文摘 | LEMLEY MARK A SHAPIRO CARL | 2007 | Texas Law Review2007，，58： | 1 |
| 13 | Patent Holdup and Royalty Stacking显示文摘 | Mark A. Lemley Carl Shapiro | | 0，，： | 1 |
| 14 | The Implications of the New Capital Adequacy Rules for Portfolio Management of Credit Assets显示文摘 | Wolfgang Hammes Mark Shapiro | 2001 | Journal of Banking and Finance2001，，25： | 1 |
| 15 | A Dose–Volume Analysis of Radiation Pneumonitis in Non–Small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy显示文摘 | R. Bryan Barriger Jeffrey A. Forquer Jeffrey G. Brabham David L. Andolino Ronald H. Shapiro Mark A. Henderson Peter A.S. Johnstone Achilles J. Fakiris | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 16 | Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis显示文摘 | Luciano Adorini Mark Pruzanski David Shapiro | 2012 | Drug Discovery Today (-)2012，，17： | 1 |
| 17 | A Comprehensive Review of Topical Hemostatic Agents: Efficacy and Recommendations for Use显示文摘 | Hardean E. Achneck Bantayehu Sileshi Ryan M. Jamiolkowski David M. Albala Mark L. Shapiro Jeffrey H. Lawson | 2010 | Annals of Surgery2010，，2： | 1 |
| 18 | Smoked cannabis for chronic neuropathic pain: a randomized controlled trial显示文摘 | Ware Mark A Wang Tongtong Shapiro Stan Robinson Ann Ducruet Thierry Huynh Thao Gamsa Ann Bennett Gary J Collet Jean-Paul | 2010 | Canadian Medical Association. Journal2010，，： | 1 |
| 19 | Chest Wall Toxicity After Stereotactic Body Radiotherapy for Malignant Lesions of the Lung and Liver显示文摘 | David L. Andolino Jeffrey A. Forquer Mark A. Henderson Robert B. Barriger Ronald H. Shapiro Jeffrey G. Brabham Peter A.S. Johnstone Higinia R. Cardenes Achilles J. Fakiris | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 20 | Patent Holdup and Roalty Stacking显示文摘 | Mark Lemley Carl Shapiro | 2007 | Texas Law Review2007，，85： | 1 |
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