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| 1 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 2 | Organic frameworks confined Cu single atoms and nanoclusters for tandem electrocatalytic CO_(2) reduction to methane显示文摘The electrochemical reduction reaction of carbon dioxide(CO_(2)RR)is considered to be an effective way to realize carbon neutrality.As a type of intensively studied materials,covalent organic frameworks(COFs)with a tunable pore structure and various functional groups are promising catalysts for CO_(2)RR.Herein,COF synthesized by 2,6‐diaminoanthraquinone and 2,4,6‐triformylphloroglucinol is employed to assist the synthesis of electrocatalysts from Cu single atoms(SAs)to nanoclusters by controlling the electrodeposition.A tandem catalyst for CO_(2)‐to‐CH4 conversion is thus achieved by the Cu nanoclusters dispersed among the isolated Cu SAs in the COF network.It is proposed that CO_(2) is first reduced to CO over the atomically isolated Cu SAs,followed by diffusion onto the neighboring Cu nanoclusters for further reduction into CH4.In addition,mechanistic analysis suggests that the coordinated K^(+)ions on the COF network promote the activation of CO_(2) and the adsorption of reaction intermediates,thus realizing the suppressed hydrogen evolution reaction and selective production of CH4.This study presents a new insight of COFs for the confined synthesis of a tunable SA to nanocluster electrocatalysts,disclosing the great potential of COFs in electrocatalysis. | Qinglan Zhao Yian Wang Meng Li Shangqian Zhu Tiehuai Li Jixiang Yang Ting Lin Ernest PDelmo Yinuo Wang Juhee Jang Meng Gu Minhua Shao | 2022 | SmartMat2022，3，1： | 1 |
| 3 | Pore-water distribution and quantification of diffusive benthic fluxes of nutrients in the Huanghai and East China Seas sediments显示文摘The distribution of nitrate, nitrite, ammonia, phosphate and silicate in pore-water and their exchange between sediments and overlying waters (benthic flux) were determined at nine locations on the shelve of Huanghai and East China Seas. On the basis of the redox po- tential of sediments and nutrients distributions in the pore-waters, it is found that the benthic sediments are being in a suboxic to anoxic environment in the Huanghai and East China Seas. The nutrients distribution in the pore-waters is mainly controlled by the sediment environment, and ammonia is the major inorganic nitrogen in the pore-waters. On the basis of benthic fluxes of nutrients calculated us- ing Fick’s first law, there is remarkable efflux of ammonia, dissolved inorganic nitrogen(DIN), phosphate and silicate from the sedi- ments to the overlying waters in the study area, and their benthic fluxes are 299.3￣2 214.8, 404.4￣2 159.5 , 5.5￣18.8 and 541.3￣1 781.6 μmol/(m2·d) respectively, and perhaps they are the major source of dissolved inorganic nitrogen, phosphate and sili- cate for the overlying water. At most stations, the nitrate flux was from the overlying waters to the sediments, which suggests that sub- oxic organic matter decomposition via denitrification is dominated in the most area of Huanghai and East China Seas. High benthic fluxes appearing in the coastal area and relatively low benthic fluxes occurring in the shelf area are found and are consistent with pri- mary productivity zoning in the study area. On the other hand, the ammonia flux displays an exponential decrease with water depth in- crease and an exponential increase with the bottom water temperature. However, others do not display this trend. | NI Jianyu LIU Xiaoya CHEN Qijiang LIN Yian | 2006 | Acta Oceanologica Sinica2006，25，1： | 1 |
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