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| 1 | Modern stalagmite oxygen isotopic composition and its implications of climatic change from a high-elevation cave in the eastern Qinghai-Tibet Plateau over the past 50 years显示文摘An oxygen isotope record of a stalagmite from Huanglong Cave in the eastern Qinghai-Tibet Plateau dated with 230Th and 210Pb methods provides variations of the Asian monsoon with an average resolu-tion of 1 year over the past 50 years. This study shows that the δ18O of dripwater in the cave represents the annual mean δ18O of local meteoric precipitation and the stalagmites were deposited in isotopic equilibrium. A comparison of the stalagmite δ18O record with instrumentally meteorological data indi-cates that shifts of the δ18O are largely controlled by the amount effect of meteoric precipitation con-veyed through the southwest monsoon(the Indian monsoon) and less affected by temperature. Therefore,the variations of δ18O record reflect the changes in monsoon precipitation on inter-annual time scales under the influence of the southwest monsoon. Like many other stalagmite δ18O records in the Asian monsoon regions,the δ18O record of the stalagmite from Huanglong Cave also reveals a gradually enriched trend during the past 50 years,i.e. relatively enriched in 18O. This trend may indicate the decline of the Asian monsoon intensity which is consistent with the decrease of monsoon indices. The weakening of the modern Asian monsoon well matched with the temperature changes in strato-sphere,which may illustrate that the weakening of the monsoon mainly results from the lowering of solar radiation. | YANG XunLin ZHANG PingZhong CHEN FaHu HUH Chih-an LI HongChun CHENG Hai Kathleen R. JOHNSON LIU JingHua AN ChunLei | 2007 | Chinese Science Bulletin2007，52，9： | 20 |
| 2 | A Scenario-Based Robust Transmission Network Expansion Planning Method for Consideration of Wind Power Uncertainties显示文摘This paper uses a novel scenario generation method for tackling the uncertainties of wind power in the transmission network expansion planning(TNEP)problem.A heuristic moment matching(HMM)method is first applied to generate the typical scenarios for capturing the stochastic features of wind power,including expectation,standard deviation,skewness,kurtosis,and correlation of multiple wind farms.Then,based on the typical scenarios,a robust TNEP problem is presented and formulated.The solution of the problem is robust against all the scenarios that represent the stochastic features of wind power.Three test systems are used to verify the HMM method and is compared against Taguchi’s Orthogonal Array(OA)method.The simulation results show that the HMM method has better performance than the OA method in terms of the trade-off between robustness and economy.Additionally,the main factors influencing the planning scheme are studied,including the number of scenarios,wind farm capacity,and penalty factors,which provide a reference for system operators choosing parameters. | Jinghua Li Liu Ye Yan Zeng Hua Wei | 2016 | CSEE Journal of Power and Energy Systems2016，2，1： | 15 |
| 3 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 4 | Asian summer monsoon precipitation recorded by stalagmite oxygen isotopic composition in the western Loess Plateau during AD1875―2003 and its linkage with ocean-atmosphere system显示文摘Based on 5 high-precision 230Th dates and 103 stable oxygen isotope ratios (δ18O) obtained from the top 16 mm of a stalagmite collected from Wanxiang Cave,Wudu,Gansu,variation of monsoonal precipita-tion in the modern Asian Monsoon (AM) marginal zone over the past 100 years was reconstructed. Comparison of the speleothem δ18O record with instrumental precipitation data at Wudu in the past 50 years indicates a high parallelism between the two curves,suggesting that the speleothem δ18O is a good proxy for the AM strength and associated precipitation,controlled by 'amount effect' of the pre-cipitation. Variation of the monsoonal precipitation during the past 100 years can be divided into three stages,increasing from AD 1875 to 1900,then decreasing from AD 1901 to 1946,and increasing again thereafter. This variation is quite similar to that of the Drought/Flooding index archived from Chinese historical documents. This speleothem-derived AM record shows a close association with the Pacific Decadal Oscillation (PDO) between AD 1875 and 1977,with higher monsoonal precipitation corre-sponding to cold PDO phase and vice versa at decadal timescale. The monsoonal precipitation varia-tion is out of phase with the PDO after AD 1977,probably resulting from the decadal climate jump in the north Pacific occurring at around AD 1976/77. These results demonstrate a strong linkage between the AM and associated precipitation and the Pacific Ocean via ocean/atmosphere interaction. This rela-tionship will aid to forecast future hydrological cycle for the AM monsoon region,and to improve forecasting potential of climatic model with observation data from cave. | LIU JingHua ZHANG PingZhong CHENG Hai CHEN FaHu YANG XunLin ZHANG DeZhong ZHOU Jing JIA JiHong AN ChunLei SANG WenCui Kathleen R. JOHNSON | 2008 | Chinese Science Bulletin2008，53，13： | 13 |
| 5 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 6 | Microstructure characterization and corrosion behavior of Mg-Y-Zn alloys with different long period stacking ordered structures显示文摘Mg-Y-Zn alloys with long period stacking ordered(LPSO)structure have received much attention recently and exhibit great potential in applications such as automotive,aerospace and in bio-medical fields.This paper aimed to investigate the effect of different phase constitution of LPSO structures on corrosion rate of bio-medical Mg-Y-Zn alloys.The results showed that as-cast Mg98.5Y1Zn0.5 alloys containing only 18R structure exhibited the highest corrosion resistance with the corrosion rate of 2.78 mm/year.The precipitation of 14H lamellas within a-Mg grains during solid solution treatment introduced the crystallographic orientation corrosion by accelerating micro-galvanic corrosion.The increase of 18R/14H interfaces deteriorated the corrosion resistance,and the grain boundaries also suffered from severe electrochemical dissolution.This work suggested that Mg-Y-Zn alloys with single LPSO structure(either 18R or 14H)exhibited better corrosion resistance than alloys with co-existence 18R and I4H LPSO structures. | Lisha Wang Jinghua Jiang Huan Liu Bassiouny Saleh Aibin Ma | 2020 | Journal of Magnesium and Alloys2020，8，4： | 11 |
| 7 | Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway显示文摘Influenza virus contains three integral membrane proteins:haemagglutinin,neuraminidase,and matrix protein(M1 and M2).Among them,M2 protein functions as an ion channel,important for virus uncoating in endosomes of virus-infected cells and essential for virus replication.In an effort to explore potential new functions of M2 in the virus life cycle,we used yeast two-hybrid system to search for M2-associated cellular proteins.One of the positive clones was identified as human Hsp40/Hdj1,a DnaJ/Hsp40 family protein.Here,we report that both BM2(M2 of influenza B virus)and A/M2(M2 of influenza A virus)interacted with Hsp40 in vitro and in vivo.The region of M2-Hsp40 interaction has been mapped to the CTD1 domain of Hsp40.Hsp40 has been reported to be a regulator of PKR signaling pathway by interacting with p58^(IPK) that is a cellular inhibitor of PKR.PKR is a crucial component of the host defense response against virus infection.We therefore attempted to understand the relationship among M2,Hsp40 and p58^(IPK) by further experimentation.The results demonstrated that both A/M2 and BM2 are able to bind to p58^(IPK)in vitro and in vivo and enhance PKR autophosphorylation probably via forming a stable complex with Hsp40 and P58^(IPK),and consequently induce cell death.These results suggest that influenza virus M2 protein is involved in p58^(IPK)mediated PKR regulation during influenza virus infection,therefore affecting infected-cell life cycle and virus replication. | Zhenhong Guan Di Liu Shuofu Mi Jie Zhang Qinong Ye Ming Wang George F.Gao Jinghua Yan | 2010 | Protein & Cell2010，1，10： | 11 |
| 8 | A study of phosphate adsorption by different temperature treated hydrous cerium oxides显示文摘An alkaline precipitation method was introduced to produce hydrous cerium oxides.The prepared powder was characterized by Brunauer-Emmett-Teller(BET) nitrogen adsorption-desorption,X-ray diffraction(XRD),Fourier transform infrared(FTIR) spectrometry,and thermal gravimetry(TG) approaches.The adsorbent has a chemical formula of CeO2·nH2O(n < 2) and a cubic fluorite-type structure after high temperature treatment.Adsorption capacity of different temperature treated hydrous cerium oxides does not directly correlate with BET specific surface area.Phosphate adsorption isotherms follow the Langmuir equation below the treatment temperature of 800°C.Phosphate adsorption causes no change on the structure of a hydrous cerium oxides,and no signs of CePO4 precipitates are found.The ion-exchanging structure of hydrous cerium oxide plays a fundamental role in phosphate adsorption.The structure is highly temperature resistant and forms adsorption sites which adsorb both water and some anions.Complete loss of adsorption ability cannot be achieved unless the treatment temperature is higher than 1200°C.Mechanism study shows that the adsorption of phosphates is mainly an anion-exchange process. | GUO Huichao LI Wenjun WANG Huanying ZHANG Jinghua LIU Yang ZHOU Yue | 2011 | Rare Metals2011，30，1： | 10 |
| 9 | Microstructure and mechanical property of a high-strength Mg-10Gd-6Y-1.5Zn-0.5Zr alloy prepared by multi-pass equal channel angular pressing显示文摘In this work,a high-strength Mg–10Gd–6Y–1.5Zn–0.5Zr(wt.%)alloy was fabricated by successive multi-pass equal channel angular pressing(ECAP).The microstructure and mechanical property of as-cast and ECAP alloys were systematically researched by X-ray diffractometer,scanning electron microscopy,transmission electron microscopy and compression test.The results show that the microstructure of as-cast alloy consists ofα-Mg grains,Mg24Y5 networks,18R blocks,fine 14H lamellas,and fewY-rich particles.After 8 passes ECAP,dynamic recrystallization ofα-Mg is developed and their average grain size decreases to about 1μm.The network Mg_(24)Y_(5) phase at grain boundaries is broken into small particles with average diameter lower than 0.5μm.Moreover,18R blocks are kinked and delaminated,or broken into small particles and blended with Mg24Y5 particles.14H lamellas grow gradually or are dynamically precipitated within certainα-Mg grains.Compression tests indicate that 8p ECAP alloy exhibits excellent mechanical property with compressive strength of 537 MPa and fracture strain of 17.0%.The significant improvement for both strength and ductility of deformed alloy could be ascribed to DRX grains,refined Mg24Y5 particles,18R kinking and dynamical precipitation of 14H. | Huan Liu He Huang Xiaowei Yang Cheng Li Jingli Yan Jinghua Jiang Aibin Ma | 2017 | Journal of Magnesium and Alloys2017，5，2： | 10 |
| 10 | Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus显示文摘Influenza virus is the causative agent of the seasonal and occasional pandemic flu.The current H1N1 influenza pandemic,announced by the WHO in June 2009,is highly contagious and responsible for global economic losses and fatalities.Although the H1N1 gene segments have three origins in terms of host species,the virus has been named swine-origin influenza virus(S-OIV)due to a predominant swine origin.2009 S-OIV has been shown to highly resemble the 1918 pandemic virus in many aspects.Hemagglutinin is responsible for the host range and receptor binding of the virus and is therefore a primary indicator for the potential of infection.Primary sequence analysis of the 2009 S-OIV hemagglutinin(HA)reveals its closest relationship to that of the 1918 pandemic influenza virus,however,analysis at the structural level is necessary to critically assess the functional significance.In this report,we report the crystal structure of soluble hemagglutinin H1(09H1)at 2.9Å,illustrating that the 09H1 is very similar to the 1918 pandemic HA(18H1)in overall structure and the structural modules,including the five defined antiboby(Ab)-binding epitopes.Our results provide an explanation as to why sera from the survivors of the 1918 pandemics can neutralize the 2009 S-OIV,and people born around the 1918 are resistant to the current pandemic,yet younger generations are more susceptible to the 2009 pandemic. | Wei Zhang Jianxun Qi Yi Shi Qing Li Feng Gao Yeping Sun Xishan Lu Qiong Lu Christopher J.Vavricka Di Liu Jinghua Yan George F.Gao | 2010 | Protein & Cell2010，1，5： | 10 |
| 11 | Potential of multi-pass ECAP on improving the mechanical properties of a high-calcium-content Mg-Al-Ca-Mn alloy显示文摘In this study,the multi-pass equal channel angular pressing(ECAP)was employed on a high-calcium-content Mg-Al-Ca-Mn alloy to tailor its microstructure and mechanical properties.The obtained results showed that the network-shaped Mg2Ca and(Mg,Al)2Ca eutectic compounds in as-cast alloy were gradually crushed into ultra-fine particles after ECAP,which exhibited a bimodal particle size distribution and most aggregated at original grain boundaries.Dynamic recrystallization(DRX)of α-Mg occurred during hot deformation via a particle stimulated mechanism,and the almost complete DRX with an average grain size around 1.5μm was obtained after 12p-ECAP.Moreover,abundant nano-sized acicular and spherical precipitates were dynamically precipitated withinα-Mg grains during ECAP.Tensile test results indicated that the maximum strength and ductility were acquired for 12p-ECAP alloy with ultimate tensile strength of 372 MPa and fracture elongation of 8%.The enhanced strength of the alloy could be ascribed to fine DRX grains,ultra-fine Ca-containing particles and dynamically precipitated nano-precipitates,while the improved ductility was mainly due to the refined and homogeneous microstructure,and weak texture with high average Schmid factors. | He Huang Huan Liu Ce Wang Jiapeng Sun Jing Bai Feng Xue Jinghua Jiang Aibin Ma | 2019 | Journal of Magnesium and Alloys2019，7，4： | 10 |
| 12 | Associations between Mycobacterium tuberculosis Beijing geno- type and drug resistance to four first-line drugs: a survey in China显示文摘在中国的 Mycobacterium 肺结核的基因差异上的调查证明了北京遗传型紧张起一个主导的作用。学习在 M. 之间的协会 ? 肺结核北京遗传型和药抵抗显型, 1286 M。肺结核临床和病人的流行病学、临床的信息孤立从肺结核(TB ) 的中心被收集在在中国的北京自治市和九个省或自治区域的预防和控制或 TB 医院。测试的药抵抗在所有 isolates 上被进行到四首要的 anti-TB 药(异菸肼, rifampicin,链球菌,和 ethambutol ) 。585 紧张的一个总数被发现对四 anti-TB 药中的至少一个抵抗。北京家庭紧张由 499 组成了(53.20%) 药敏感的紧张并且 439 (46.80%) 药抵抗的紧张,而非北京家庭紧张包括了 202 (58.05%) 药敏感的紧张并且 146 (41.95%) 药抵抗的紧张。没有重要差别在流行被观察(c 2=2.41, P > 0.05 ) 在在北京家庭紧张之中的药抵抗、药敏感的紧张之间。药抵抗的 monoresistance, multidrug 抵抗的 TB,和地理分发的分析没发现在 M. 之间的任何关系 ? 在中国的肺结核北京遗传型和药抵抗显型。结果证实了北京遗传型,占优势的 M。在中国的肺结核遗传型,没与药抵抗被联系。 | Haican Liu Yuanyuan Zhang Zhiguang Liu Jinghua Liu Yolande Hauck Jiao Liu Haiyan Dong Jie Liu Xiuqin Zhao Bing Lu Yi Jiang Gilles Vergnaud Christine Pource Kanglin Wan | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 13 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 14 | Screening and degrading characteristics and community structure of a high molecular weight polycyclic aromatic hydrocarbon-degrading bacterial consortium from contaminated soil显示文摘Inoculation with effcient microbes had been proved to be the most important way for the bioremediation of polluted environments. For the treatment of abandoned site of Beijing Coking Chemical Plant contaminated with high level of high-molecular-weight polycyclic aromatic hydrocarbons(HMW-PAHs) ,a bacterial consortium capable of degrading HMW-PAHs,designated 1-18-1,was enriched and screened from HMW-PAHs contaminated soil.Its degrading ability was analyzed by high performance liquid chromatography(HPLC) ,and the community structure was investigated by construction and analyses of the 16S rRNA gene clone libraries(A,B and F) at different transfers.The results indicated that 1-18-1 was able to utilize pyrene,fluoranthene and benzoapyrene as sole carbon and energy source for growth.The degradation rate of pyrene and fluoranthene reached 82.8%and 96.2%after incubation for 8 days at 30°C,respectively;while the degradation rate of benzoapyrene was only 65.1%after incubation for 28 days at 30°C. Totally,108,100 and 100 valid clones were randomly selected and sequenced from the libraries A,B,and F.Phylogenetic analyses showed that all the clones could be divided into 5 groups,Bacteroidetes,α-Proteobacteria,Actinobacteria,β-Proteobacteria andγ-Proteobacteria.Sequence similarity analyses showed total 39 operational taxonomic units(OTUs) in the libraries.The predominant bacterial groups wereα-Proteobacteria(19 OTUs,48.7%) ,γ-Proteobacteria(9 OTUs,23.1%) andβ-Proteobacteria(8 OTUs,20.5%) . During the transfer process,the proportions ofα-Proteobacteria andβ-Proteobacteria increased greatly(from 47%to 93%) ,while γ-Proteobacteria decreased from 32%(library A) to 6%(library F) ;and Bacteroidetes group disappeared in libraries B and F. | Run Sun Jinghua Jin Guangdong Sun Ying Liu Zhipei Liu | 2010 | Journal of Environmental Sciences2010，22，10： | 8 |
| 15 | Improving toughness of a Mg_(2)Ca-containing Mg-Al-Ca-Mn alloy via refinement and uniform dispersion of Mg_(2)Ca particles显示文摘In this work,two wrought Mg-3.66Al-4.25Ca-0.43 Mn(wt%)alloys with different morphology and distribution of Mg_(2)Ca particles were fabricated by hot extrusion and multi-pass(32)equal channel angular pressing(ECAP).The as-extruded alloy exhibits a banded microstructure with alternately arranged Mg_(2)Ca particle bands,fine α-Mg dynamically recrystallized(DRX)grain bands,and coarse α-Mg deformed grain bands.The Mg_(2)Ca bands are composed of broken Mg_(2)Ca particles which are aggregated and aligned along extrusion direction.The microstructure of ECAP alloy contains complete α-Mg DRX grains and refined Mg_(2)Ca particles which are dispersedly distributed at grain boundaries.Tensile test results show that the as-extruded alloy possesses high ultimate tensile strength(UTS)of 420 MPa and poor fracture elongation of 7%,while the ECAP alloy exhibits improved toughness with UTS of 347 MPa and fraction elongation of 16%.The higher strength of as-extruded alloy is mainly ascribed to the contribution of coarse deformed grains with strong texture,and its poor toughness is resulted from the formation of Mg_(2)Ca bands within which microcracks could form and extend rapidly.On the contrary,the refined and dispersedly distributed Mg_(2)Ca particles are effective to retard crack initiation and impede crack propagation,thereby enhancing the toughness of ECAP alloy significantly. | Huan Liu Chao Sun Ce Wang Yuhua Li Jing Bai Feng Xue Aibin Ma Jinghua Jiang | 2020 | Journal of Materials Science & Technology2020，59，24： | 7 |
| 16 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 17 | Identification of Flowering Regulatory Genes in Allopolyploid Brassica juncea显示文摘Brassica juncea is an allopolyploid originating from the interspecific hybridization between Brassica rapa and Brassica nigra, which is of multiple usage as a vegetable, oilseed and condiment worldwide. Both vernalization and non-vernalization under long-day photoperiod can promote floral transition in B. juncea suggesting merged flowering pathways of its ancestors and better environmental adaptability. We identified genomewide flowering regulatory genes in B. juncea, which include 84 and 79 genes from A and B sub-genomes, respectively. Ka/Ks analysis revealed a purification effect on both photoperiod and vernalization flowering regulation pathways during evolution. Expression profile of those genes during long-day and vernalization treatments suggested Bju ACO4, Bju AFT1, Bju BFT4, Bju ASOC1 and Bju ASOC4 may be the major functional copies of B. juncea flowering regulation. Further functional studies about Bju COs showed three days delayed flowering time in Bju ACO4 or Bju BCO3 silenced plants. Increased transcription of all BjuFLCs in Bju ACO4 or Bju BCO3 silenced plants suggested interactions between photoperiod and vernalization pathways governing flowering time. Our findings provided flowering regulating networks in allopolyploid B. juncea. | Ning Zhao Chang Liu Yiqing Meng Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2019 | Horticultural Plant Journal2019，5，3： | 6 |
| 18 | Giant magnetostrictive materials显示文摘Giant magnetostrictive materials are a kind of functional materials developed since 1970s, known as their large magnetostrain and high energy density. In this paper, an introduction of magnetostriction and the history of magnetostrictive materials are described firstly. Then we review the recent developments of both rare earth and non-rare earth magnetostrictive materials. Finally, the tendency of developing new giant magnetostrictive materials is presented. | LIU JingHua JIANG ChengBao XU HuiBin | 2012 | Science China(Technological Sciences)2012，55，5： | 6 |
| 19 | Presenting features and clinical course of 34 patients with septic pulmonary embolism caused by right-sided infective endocarditis显示文摘 | Liu Shuang Xie Jiang Chen Yong Yang Jinghua Zhang Jianqun Meng Xu Liu Yinglong | 2014 | Chinese Medical Journal2014，，15： | 6 |
| 20 | Characteristics and Outcome of Exertional Heatstroke Patients Complicated by Acute Hepatic Injury:A Cohort Study显示文摘Background and Aims:Exertional heatstroke(EHS)is associated with strenuous physical activity in hot environments.The present study aimed to investigate dynamic changes of hepatic function indices in EHS patients and determine risk factors for death.Methods:This single-center retrospective cohort study considered all patients with EHS admitted to the intensive care unit at the General Hospital of Southern Theater Command of PLA from October 2008 to May 2019.Data on general characteristics,organ function parameters,and the 90-day outcome of enrolled patients were collected.Hepatic indices were collected dynamically,and patients with acute hepatic injury(AHI)were identified by plasma total bilirubin(TBIL)≥34.2μmol/L and an international normalized ratio≥1.5,or with any grade of hepatic encephalopathy.Results:In patients who survived,TBIL,alanine aminotransferase and aspartate aminotransferase were increased at 24 h,peaked at 2–3 days,and began to decrease at 5 days.In non-survivors,TBIL continuously increased post-admission.The area under the receiver operating characteristic curve for the prediction of mortality based on sequential organ failure assessment(SOFA)scores was 89.8%,and the optimal cutoff value was 7.5.Myocardial injury and infection were identified as independent risk factors for death in EHS patients with AHI.Conclusions:In EHS patients,hepatic dysfunction usually occurred within 24 h.Patients with AHI had more severe clinical conditions,and significantly increased 90-day mortality rates.SOFA scores over 7.5,complicated with myocardial injury or infection,were found to be risk factors for death in EHS patients with AHI. | Jingjing Ji Jinghua Gao Conglin Wang Leifang Ouyang Zheying Liu Zhifeng Liu | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 6 |
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