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| 1 | Monte-Carlo simulation of pinhole collimator of a small field of view gamma camera for small animal imaging显示文摘Needs in scintimammography applications,especially for small animal cardiac imaging,lead to develop a small field of view,high spatial resolution gamma camera with a pinhole collimator.However the ideal pinhole collimator must keep a compromise between spatial resolution and sensitivity.In order to design a pinhole collimator with an optimized sensitivity and spatial resolution,the spatial resolution and the geometric sensitivity response as a function of the source to collimator distance has been obtained by means of Monte-Carlo simulation for a small field of view gamma camera with a pinhole collimator of various-hole diameters.The results show that the camera with pinhole of 1 mm,1.5 mm and 2 mm diameter has respectively spatial resolution of 1.5 mm,2.25 mm and 3 mm and geometric sensitivity of 0.016%,0.022%and 0.036%,while the source to collimator distance is 3 cm.We chose the pinhole collimator with hole diameter size of 1.2 mm for our the gamma camera designed based on the trade-off between sensitivity and resolution. | ZHU Jie MA Wenyan ZHU Yufeng MA Hongguang WU Yuelei HU Huasi ZHANG Boping HUO Yonggang LIU Silu JIAN Bin WANG Zhaomin | 2009 | Nuclear Science and Techniques2009，20，1： | 4 |
| 2 | Microstructural softening induced adiabatic shear banding in Ti-23Nb-0.7Ta-2Zr-O gum metal显示文摘Ti-23Nb-0.7Ta-2Zr-O gum metal(GM)is an attractive candidate material for applications that require superior mechanical properties.In our earlier investigation of the GM[1],geometrical softening and the generation of adiabatic shear bands(ASBs)were proposed as primary reasons for the documented anisotropic impact response.In the present study,electron backscattered diffraction(EBSD)analysis reveals two different deformed microstructures,i.e.,deformed ultrafine grains(UFGs)and dynamically recrystallized UFGs,formed in the ASBs of GM samples processed by extrusion equal channel angular pressing(ECAP),respectively.Additional calculation of temperature rise during dynamic compression suggests that the above microstructure differences in the ASBs was originated from their different maximum ASB temperatures(608 K for extruded GM and 1159 K for ECAP-processed GM).Moreover,our calculation on the temperature at the onset of ASBs indicates that microstructural softening is the primary cause for the development of ASBs in both extruded GM(321 K)and ECAP-processed GM(331 K). | Silu Liu Y.Z.Guo Z.L.Pan X.Z.Liao E.J.Lavernia Y.T.Zhu Q,M,Wei Yonghao Zhao | 2020 | Journal of Materials Science & Technology2020，54，19： | 2 |
| 3 | Recent advances in nonlinear optics for bio‐imaging applications显示文摘Nonlinear optics,which is a subject for studying the interaction between intense light and materials,has great impact on various research fields.Since many structures in biological tissues exhibit strong nonlinear optical effects,nonlinear optics has been widely applied in biomedical studies.Especially in the aspect of bio-imaging,nonlinear optical techniques can provide rapid,label-free and chemically specific imaging of biological samples,which enable the investigation of biological processes and analysis of samples beyond other microscopy techniques.In this review,we focus on the introduction of nonlinear optical processes and their applications in bio-imaging as well as the recent advances in this filed.Our perspective of this field is also presented. | Silu Zhang Liwei Liu Sheng Ren Zilin Li Yihua Zhao Zhigang Yang Rui Hu Junle Qu | 2020 | Opto-Electronic Advances2020，3，10： | 2 |
| 4 | Discrete composite control of piezoelectric actuators for high-speed and precision scanning显示文摘 | LIU Lei TAN K K CHEN Silu | 2013 | IEEE Transactions on Industrial Informatics2013，9，2： | 1 |
| 5 | Extraction Process and Quality Standard of Danshen Jianxin Capsules显示文摘[Objectives]This study was conducted to establish the quality standard of Danshen Jianxin Capsules.[Methods]Orthogonal design was adopted to optimize the water extraction process by taking the amount of water added,extraction time and extraction times as factors,and the content of tanshinone I as the index.Salviae Miltiorrhizae,Notoginseng Radix Et Rhizoma and Radix Astragali in the capsules were qualitatively identified by TLC,and the content of tanshinone I in the capsules was determined by HPLC.[Results]The best water extraction process included the steps of adding 12 times of water each time,extracting the materials twice,for 1 h each time.In TLC identification,the test samples showed spots of the same color at the positions corresponding to tanshinone II A,ginsenoside Rg1,notoginsenoside R1 and astragaloside IV reference samples.[Conclusions]Danshen Jianxin Capsules was prepared by the water extraction method,which is characterized by high efficiency and being suitable for mass production.The quality control method is reliable,fast and accurate,which can effectively control the quality of the product. | Chengtong LIU Xinying MO Silu HE Donglian CHEN Guilin YANG Hongsheng TAN Peng LIANG Haisheng ZENG | 2023 | Medicinal Plant2023，14，1： | 1 |
| 6 | Ultra-high general and special color rendering index white organic light-emitting device based on a deep red phosphorescent dye显示文摘 | Yang Li Wei Zhang Letian Zhang Xuemei Wen Yongming Yin Shihao Liu Wenfa Xie Hongyu Zhao Silu Tao | 2013 | Organic Electronics2013，，12： | 1 |
| 7 | Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS显示文摘The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is lacking.To address this gap,we conducted a study aiming to investigate this association and identify relevant biomarkers.We analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune microenvironment.Additionally,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)populations.We employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune cells.Our findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal tissues.Moreover,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA replication.In conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets. | Sumeng Wang Silu Chen Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu Lingxiang Liu | 2024 | The Journal of Biomedical Research2024，38，1： | 0 |
| 8 | Implementation and application of FRET-FLIM technology显示文摘With the development of the new detection methods and the function of fluorescent molecule,researchers hope to further explore the internal mechanisms of organisms,monitor changes in the intracellular microenvironment,and dynamic processes of molecular interactions in cells.Fluo-rescence resonance energy transfer(FRET)describes the energy transfer process between donor fluorescent molecules and acceptor fluorescent molecules.It is an important means to detect protein-protein interactions and protein conformation changes in cells.Fluorescence lifetime imaging microscopy(FLIM)enables noninvasive measurement of the fAuorescence lifetime of fluorescent particles in vivo.The FRET-FLIM technology,which is use FLIM to quantify and analyze FRET,enables real-time monitoring of dynamic changes of proteins in biological cells and analysis of protein interaction mechanisms.The distance between donor and acceptor and their respective fAuorescent lifetime,which are of great importance for studying the mechanism of intracellular activity can be obtained by data analysis and algorithm ftting. | Shiqi Wang Binglin Shen Sheng Ren Yihua Zhao Silu Zhang Junle Qu Liwei Liu | 2019 | Journal of Innovative Optical Health Sciences2019，，5： | 0 |
| 9 | Ratiometric fluorescence immunoassay of SARS-CoV-2 nucleocapsid protein via Si-FITC nanoprobe-based inner filter effect显示文摘The global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus has necessitated rapid,easy-to-use,and accurate diagnostic methods to monitor the virus infection.Herein,a ratiometric fluorescence enzyme-linked immunosorbent assay(ELISA)was developed using Si-fluorescein isothiocyanate nanoparticles(FITC NPs)for detecting SARSCoV-2 nucleocapsid(N)protein.Si-FITC NPs were prepared by a one-pot hydrothermal method using 3-aminopropyl triethoxysilane(APTES)-FITC as the Si source.This method did not need post-modification and avoided the reduction in quantum yield and stability.The p-nitrophenyl(pNP)produced by the alkaline phosphatase(ALP)-mediated hydrolysis of pnitrophenyl phosphate(pNPP)could quench Si fluorescence in Si-FITC NPs via the inner filter effect.In ELISA,an immunocomplex was formed by the recognition of capture antibody/N protein/reporter antibody.ALP-linked secondary antibody bound to the reporter antibody and induced pNPP hydrolysis to specifically quench Si fluorescence in Si-FITC NPs.The change in fluorescence intensity ratio could be used for detecting N protein,with a wide linearity range(0.01-10.0 and 50-300 ng/mL)and low detection limit(0.002 ng/mL).The concentration of spiked SARS-CoV-2 N protein could be determined accurately in human serum.Moreover,this proposed method can accurately distinguish coronavirus disease 2019(COVID-19)and non-COVID-19 patient samples.Therefore,this simple,sensitive,and accurate method can be applied for the early diagnosis of SARS-CoV-2 virus infection. | Guobin Mao Yang Yang Shijie Cao Silu Ye Yifang Li Wei Zhao Hongwei An Yingxia Liu Junbiao Dai Yingxin Ma | 2023 | Nano Research2023，16，4： | 0 |
| 10 | Effects of Different Drying Methods on Content of Paederosidic Acid in Paederia scandens显示文摘[Objectives]To establish a method to simultaneously determine the content of paederosidic acid in Paederia scandens dried by four different methods.[Methods]Reversed-phase high performance liquid chromatography(RP-HPLC)was adopted.The chromatographic column:Thermo SCIENTIFIC Hypersil GOLD Dim.(mm);mobile phase:acetonitrile-0.1%phosphoric acid aqueous solution;gradient elution;column temperature:30℃;flow rate:1 mL/min;detection wavelength:236 nm;injection volume:10μL.[Results]The linear range of the detection injection volume of paederosidic acid was 0.64-9.60μg(R=0.9992);the limit of quantity(LOQ)was 5.10 ng,and the limit of detection(LOD)was 1.36 ng;the RSD of the precision,stability and reproducibility test was all less than 3%;the sample recovery rate was 98.87%,RSD<3.00,n=6.The results show that the content of paederosidic acid in the shade-dried P.scandens is the highest,and the order of the content is P.scandens(dry in shade)>P.scandens(dried at 50℃)>P.scandens(dried at 60℃)>P.scandens(dried at 70℃).[Conclusions]This method is sensitive,reliable and reproducible,and can be used to simultaneously determine the content of paederosidic acid in P.scandens dried by four different methods. | Jingrong LU Haisheng ZENG Silu HE Xiumei MA Dongmei HUANG Guilin YANG Chengtong LIU Qiji ZHOU | 2020 | Medicinal Plant2020，11，6： | 0 |
| 11 | Vinous-throated parrotbills breed in invasive smooth cordgrass habitat:Can native birds avoid the potential ecological trap?显示文摘Native animals are facing long-term coexistence with invasive plants worldwide,the impacts of which on animal behavior remain poorly known.Potential ecological traps could threaten native birds breeding in invasive plant habitats,but behavioral strategies for birds to avoid such risks are few concerned.The invasion of Smooth Cordgrass(Spartina alterniflra) has seriously varied the vegetation landscape in the coastal wetlands of eastern China,and affected the habitat selection of native birds.Here,we investigated the nesting and breeding characteristics of a common native passerine,the Vinous-throated Parrotbill(Sinosuthora webbiana),in habitats dominated by native Common Reed(Phragmites australis) and exotic cordgrass.We found that parrotbills could complete their breeding cycle in cordgrass habitat.Most nest failure was attributed to predation in native habitat but tide inundation in cordgrass habitat.However,the nest success rate and daily survival rate(DSR) in cordgrass habitat were higher.Moreover,nest height was markedly higher in cordgrass habitat and was the most important influencing variable(positively correlated with the DSR).These results suggest that cordgrass habitat is a potential ecological trap due to the tide inundation,but some parrotbills seem to effectively avoid this risk by increasing nest height.Our study reveals that a native passerine changes its nesting behavior to accommodate invasive plant habitat and highlights that habitat changes caused by invasive plants may drive the adaptive evolution of native animal behavior.The limitation of these results must be acknowledged for the small sample size,and there is a need for a larger sample and long-term data for further verification. | Pan Chen Yanhong Chen Huimin Chen Taiyu Chen Bin Liu Manyu Zhang Silu Wang Changhu Lu | 2023 | Avian Research2023，14，3： | 0 |
| 12 | Characteristics of parallel-hole and pinhole collimators for nuclear medicine imaging显示文摘In this paper,the spatial resolution and geometry sensitivity of parallel- and pin-hole collimators in compact gamma camera are presented,and quantitatively compared by GEANT4 code in Monte-Carlo library.The results show that the geometry sensitivity for pinhole collimator rapidly drops with increasing the gamma source-to- collimator distance(SCD);and for parallel-hole collimator,mildly.Meanwhile,the spatial resolution for pin-hole collimator mildly deteriorates;and for parallel-hole collimator,severely.The pin-hole collimator for close imaging objects has higher geometry sensitivity than parallel-hole collimator.Our findings are helpful for setting compact gamma camera collimators in nuclear medicine imaging. | LIU Silu ZHU Jie | 2012 | Nuclear Science and Techniques2012，23，4： | 0 |
| 13 | Route maintenance of on-demand routing protocol in mobile ad hoc networks显示文摘In mobile ad hoc networks(MANETs),if a muhihop route breaks,route maintenance is typicallyperformed to establish a new route which causes high control overhead and long packet delay.To decreasethe time of recovery and the overhead of maintenance,a new route maintenance mechanism in which themaintenance is confined to the vicinity of the broken link is proposed.This mechanism patches brokenroute through some other nodes in which only nodes near the broken link(s)may need to be substitutedand the rest of nodes can be retained on the route.The broken link can be repaired without consideringits relative position in the whole path,so the ability of dealing with link failure is improved obviously.Simulation results show that the proposed strategy improves network performance significantly,such as inmerits of control overhead and packet delay. | 肖百龙 Guo Wei Liu Jun Zhu Silu | 2008 | High Technology Letters2008，14，2： | 0 |
| 14 | Ratiometric fluorescent Si-FITC nanoprobe for immunoassay of SARS-CoV-2 nucleocapsid protein显示文摘Coronavirus disease 2019(COVID-19)highlights the importance of rapid and reliable diagnostic assays for the management of virus transmission.Here,we developed a one-pot hydrothermal method to prepare Si-FITC nanoparticles(NPs)for the fluorescent immunoassay of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleocapsid protein(N protein).The synthesis of Si-FITC NPs did not need post-modification,which addressed the issue of quantum yield reduction during the coupling reaction.Si-FITC NPs showed two distinct peaks,Si fluorescence atλem=385 nm and FITC fluorescence atλem=490 nm.In the presence of KMnO_(4),Si fluorescence was decreased and FITC fluorescence was enhanced.Briefly,in the presence of N protein,catalase(CAT)-linked secondary antibody/reporter antibody/N protein/capture antibody immunocomplexes were formed on microplates.Subsequently,hydrogen peroxide(H_(2)O_(2))and Si-FITC NPs/KMnO_(4)were injected into the microplate together.The decomposition of H_(2)O_(2)by CAT resulted in remaining of KMnO_(4),which changed the fluorescence intensity ratio of Si-FITC NPs.The fluorescence intensity ratio correlated significantly with the N protein concentration ranging from 0.02 to 50.00 ng/mL,and the detection limit was 0.003 ng/mL,which was more sensitive than the commercial ELISA kit with a detection limit of 0.057 ng/mL.The N protein concentration can be accurately determined in human serum.Furthermore,the COVID-19 and non-COVID-19 patients were distinguishable by this method.Therefore,the ratiometric fluorescent immunoassay can be used for SARS-CoV-2 infection diagnosis with a high sensitivity and selectivity. | Guobin Mao Silu Ye Wen Yin Yang Yang Xinghu Ji Jin He Yingxia Liu Junbiao Dai Zhike He Yingxin Ma | 2023 | Nano Research2023，16，2： | 0 |
| 15 | Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve system injuries显示文摘Neuroinflammation,commonly associated with various central nervous system(CNS)diseases such as postoperative cognitive dysfunction(POCD),is primarily mediated by the disruption of biological signals in microglia.However,the effective treatment of CNS diseases remains an ongoing challenge as biological signals show limited microglia-targeting effect.In this study,taking advantage of the highly expressed lipoprotein receptor-related protein-1(LRP1)on the microglia,a nanobiosignal delivery system modified by LRP1 high-affinity peptide ligand RAP12(RAP:receptor-associated protein)was constructed to specifically regulate neuroinflammation via targeting microglia.The uptake of the RAP12 modified-nanobiosignaler by microglia increased significantly,indicating its microglia-targeting ability.Both in vitro/vivo studies proved that the“nanobiosignaler”significantly reduced the secretion of pro-inflammatory cytokines,induced specific M2(anti-inflammatory type)microglia differentiation,and remarkably alleviated cognitive function impairment in the mice model when compared with unmodified groups.It was indicated that the“nanobiosignaler”could target microglia to deliver the biological signal and inhibit the excessive activation of microglia.Overall,the cell-targeted biological signal transmission system inspired by“nanobiosignaler”has broad application prospects in the future. | Xiaoru Sun Huitong Ruan Qidong Liu Silu Cao Qi Jing Yaru Xu Lize Xiong Wenguo Cui Cheng Li | 2023 | Nano Research2023，16，2： | 0 |
| 16 | Preliminary Study on Quality Analysis of Root of Griffith Streptocaulon显示文摘[Objectives]To make a preliminary study on quality analysis of Root of Griffith Streptocaulon.[Methods]The moisture,ash and extract of Root of Griffith Streptocaulon were tested in accordance with the requirements of 2015 Chinese Pharmacopoeia(Volume 4).[Results]The moisture content of Root of Griffith Streptocaulon was not higher than 12.74%,not lower than 6.26%,total ash content was not higher than 15.36%,not lower than 6.17%,acid-insoluble ash content was not higher than 0.55%,not lower than 0.17%,and extract was not higher than 11.83%,not lower than 5.23%.[Conclusions]This experiment made a preliminary study on the quality analysis of the Root of Griffith Streptocaulon,in the hope of providing a scientific basis for its quality control and formulation of the quality standard. | Haisheng ZENG Chengtong LIU Silu HE Hongming CHEN Xinying MO Yudan LU Xiaobao GUO | 2020 | Medicinal Plant2020，11，5： | 0 |
| 17 | Disease and Economic Burden of Kashin-Beck Disease—China,2021显示文摘Summary What is already known about this topic?Kashin-Beck disease(KBD)is a chronic and degenerative osteoarthropathy characterized by cartilage degeneration.It is an endemic disease that is highly prevalent among the Chinese population and poses a significant health risk.What is added by this report?This is the first national report on the economic burden of KBD in China.According to the data from 2021,KBD has caused significant disease and economic burdens.The most substantial reduction in healthy life expectancy was observed among patients with degree II severity and those aged 60 years and older,resulting in a total indirect economic burden of 112.74 million Chinese Yuan(CNY).What are the implications for public health practice?The results of this study will contribute to informing the development of tailored prevention and control strategies by the government.These strategies will include targeted policies and recommendations for appropriate healthcare and financial subsidies,which will be based on the demographic characteristics of the endemic areas. | Silu Cui Wenjun Que Zhe Jiao Qing Deng Xufeng Zhang Yanhong Cao Ning Liu Ailin Li Alphonse Sowanou Zhe Li Tuo Wang Yang Li Jun Yu Junrui Pei | 2024 | China CDC weekly2024，6，2： | 0 |
| 18 | RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury显示文摘Dear Editor,Acute lung injury(ALI)is a significant contributor to the development of acute respiratory distress syndrome(ARDS),which is a severe clinical condition associated with high morbidity and mortality.1 It is increasingly evident that preserving mitochondrial health in alveolar epithelial cells holds great therapeutic potential for ARDS.2 Mitophagy,a cellular process aimed at maintaining mitochondrial health,plays a critical role in this regard.3 Therefore,gaining a comprehensive understanding of the factors that regulate mitophagy in alveolar epithelial cells during ALI could greatly inform the development of future therapeutic approaches for ARDS. | Xiaoju Tang Lichun Zhong Xin Tian Ying Zou Silu Hu Jia Liu Ping Li Min Zhu Fengming Luo Huajing Wan | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
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