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| 1 | Synthesis and characteristics of a novel artificial hapten using the copper mercaptide of penicillenic acid from penicillin G for immunoassay of heavy metal ions显示文摘In this paper, we describe the synthesis of a novel copper ion hapten using the copper mercaptide of penicillenic acid (CMPA) derived from penicillin. Results from tests with immune rabbits indicate that: (i) A new antigen synthesized with CMPA has good stability and is safe for immunizing animals with no toxic phenomena being found in animal experiments; (ii) the immunogenic antigen (CMPA-BSA) can stimulate the immune system to produce specific antibodies with high titrations, up to 150000; and (iii) antibodies in antisera showed higher affinity to OVA-GSH-CuCl than OVA-GSH, which indicates that the antibodies have specific affinity towards copper ions. These results confirm that the novel hapten and relevant antigen for copper ion have been successfully synthesized, giving progress towards an immunoassay for copper ions in environmental and food samples. | XU Wu XIE Peng FAN LiuYin CAO ChengXi XI Tao ZHOU Pei | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 2 | 显示文摘 | ZHANGMu Xin(张沐新) LIUYin Yan(刘银燕) SUNWei(孙薇) YANGXiao-Hong(杨晓虹) WANGGuang-Shu(王广树) | | 高等学校化学学报0，，： | 1 |
| 3 | Separation and determi-nation of abused drugs clenbuterol and salbutamol from complex extractants in swine feed by capillary zone electrophoresis with simple pretreatment显示文摘 | CHEN Qian FAN Liuyin ZHANG Wei | 2008 | Talanta2008，76，2： | 1 |
| 4 | Utilization of soluble starch as a depressant for the reverse flotation of diaspore from kaolinite显示文摘 | XIA Liuyin ZHONG Hong LIU Guangyi | 2009 | Minerals Engineering2009，22，6： | 1 |
| 5 | The role of cationic polyacrylamide in the reverse flotation of diasporic bauxite显示文摘 | Guangyi Liu Hong Zhong Yuehua Hu Shenggui Zhao Liuyin Xia | 2007 | Minerals Engineering2007，，： | 1 |
| 6 | Flotation separation of diaspore from kaolinite, pyrophyllite and illite using three cationic collectors显示文摘 | Hong Zhong Guangyi Liu Liuyin Xia Yiping Lu Yuehua Hu Shenggui Zhao Xinyang Yu | 2008 | Minerals Engineering2008，，： | 1 |
| 7 | Flotation separation of the aluminosilicates from diaspore by a Gemini cationic collector显示文摘 | Liuyin Xia Hong Zhong Guangyi Liu Zhiqiang Huang Qingwei Chang | 2009 | International Journal of Mineral Processing2009，，： | 1 |
| 8 | Antimalarial effect of agmatine on Plasmodium berghei K173 strain显示文摘AIM: To study the antimalarial effect of agmatine (Agm) on chloroquine-susceptible Plasmodium berghei K173strain (S strain) and the P berghei K173 resistant strain (R strain). METHODS: The antimalarial effects of Agm onP berghei K173 S strain and R strain were evaluated by Peters 4-d suppression test in mice. RESULTS: Agm(12.5-200 mg/kg,ig,daily) decreased the parasitemia for both P berghei K173 S strain (IC50=139 mg/kg) and Rstrain (IC50=126mg/kg) in mice. Subcutaneous injection (sc) of Agm (5-40mg/kg,tid) showed relatively strongerantimalarial effect than intragastric gavage (IC50=30 mg/kg) in P berghei K 173 S strain. Spermidine antagonized theantimalarial effect of Agm for P berghei K173 S strain and R strain. Agm did not reverse the chloroquine resistanceof P berghei K173 S strain, dl-α-Difluoromethylornithine (DFMO, sc) decreased the parasitemia of P BergheiK173 S strain and this effect was antagonized by spermidine. CONCLUSION: Agm has an antimalarial effect andthe mechanism is related to its inhibition of polyamine synthesis. | SURui-Bin WEIXiao-Li LIUYin LIJin | 2003 | Acta Pharmacologica Sinica2003，24，9： | 1 |
| 9 | Flotation separation of the aluminosilicates from diaspore by a Gemini cationic collector显示文摘 | Xia Liuyin Zhong Hong Liu Guangyi | | 0，，1： | 1 |
| 10 | 显示文摘 | FAN Liuyin LIU Lihong CHEN Hongli | 2005 | J Chromatogr: A2005，1062，： | 1 |
| 11 | The synthesis of novel organosilicon collector qAS222 and its flotation performance on aluminosilicate minerals显示文摘 | Yu Xinyang Xia Liuyin Wang Shuai | | 0，，： | 1 |
| 12 | On-line conversion and determination of artemisinin and its kinetic parameters using orthogonal design by coupling of flow injection with capillary electrophoresis 显示文摘 | CHENG Yuqiao CHEN Hongli FAN Liuyin | 2004 | Anal Chim Acta2004，525，： | 1 |
| 13 | Separation and determination of acrylamide in potato chips by micellar dectrokinetic capillary chromatography显示文摘 | ZHOU Xun FAN Liuyin ZHANG Wei | 2007 | Talanta2007，71，4： | 1 |
| 14 | Flotation separation of the aluminosilicates from diaspore by a Gemini cationic collector显示文摘 | Liuyin Xia Hong Zhong Guangyi Liu Zhiqiang Huang Qingwei Chang | 2009 | International Journal of Mineral Processing2009，，1： | 1 |
| 15 | Separation and determination of acrylamide in potato chips by micellar electrokinetic capillary chromatography 显示文摘 | Zhou Xun Fan Liuyin Zhang Wei | 2007 | Talanta2007，71，： | 1 |
| 16 | Improving copper flotation recovery from a refractory copper porphyry ore by using ethoxycarbonyl thiourea as a collector显示文摘 | LIU Guangyi ZHONG Hong XIA Liuyin | 2011 | Minerals Engineering2011，24，： | 1 |
| 17 | Biomarkers for early diagnosis of autism obtained through bioinformatics analysis of human blood sample显示文摘Objective:autism spectrum disorder(ASD),a serious disorder that begins early in life,con-tinues throughout the lifespan.Children with ASD who are diagnosed early are more responsive to therapeutic interventions and have less social and language impair-ment than children diagnosed later;however,current di-agnostic measures are mostly applied to children older than one year and lack the appropriate biological markers for early diagnosis of ASD.Using bioinformatic analy-sis,this study explores the molecular information mech-anism of ASD.Method:in this study,we used dataset GSE6575 from Gene Expression Omnibus(GEO)to an-alyze the mRNA expression profile of ASD,including 35 ASD samples and 12 normal control samples looking for different genes and we did enrichment analysis of those genes.We then used the STRING database to construct a protein-protein interaction(PPI)network of differential genes.Finally,Cytoscape plug-in cytoHubba was used to search for hub genes.The diagnostic value of the hub genes was verified by subject operating characteristic curves.Result:we looked for 50 different genes and did an enrichment analysis of those genes.The results of the enrichment analysis showed that these differential genes were mainly concentrated in the response to viruses,the immune regulation of inflammation and energy metabo-lism.Using Cytoscape plug-in cytoHubba,we found ten different genes.We drew ROC curves for all ten genes among which two genes,interleukin 2 receptor subunit beta(IL2Rβ)and perforin 1(PRF1),had good sensitivity and specificity for the early diagnosis of autism.The ar-eas under the ROC curves were 0.855,0.830 for IL2Rβ,PRF1.Conclusion:data analysis using the GEO data-base can provide new insights into the etiology of ASD as well as some possible biomarkers and therapeutic targets for early diagnosis and treatment of ASD. | Liuyin Jin Linman Wu Zhilan Yang Junyi Xiang Wenqian Xu Chang Shu Gaohua Wang | 2021 | Journal of Translational Neuroscience2021，6，4： | 0 |
| 18 | New development of drugs against opioid addiction显示文摘Opioid addiction has been a big trouble for human being for several centuries. In China, it also has become a main direct threat against national safety, society advancement, economic development and public health. Based on the national report in 2002, the number of addicts registered in due form is over 1 million, which are distributed in 2148 counties and cities in China. The real number of addicts, however, is much more than those as mentioned above. Money used for buying opioids each year in China might be over 10 billion except for other payment. Base on the statistics, 20 - 50% crimes are commited by addicts. On the other hand, drug abuse often induces contagion spread, such as tuberculosis, hepatitis and HIV disease. About 70% HIV positive subjects in China are related to drug abuse. We are very happy to see more andmore attention has been paid to the problem in our country. Recently, a program on neurobiological basis and medical biological measures of addiction has been supported by National Science and Technology Ministry as a 973 program. | LiJin SuRui-bin LuXin-qiang LiuYin | 2004 | 中国药理通讯2004，21，2： | 0 |
| 19 | An Optimized Culture Method of Rat Dorsal Root Ganglion Neurons显示文摘AIM: To establish a primary culture technique of acutely isolated dorsal root ganglion (DRG) neurons, and provide a simple & useful in vitro model for study of analgesia. Methods: Acutely isolated dorsal root ganglion (DRG) neurons were planted and cultured; the configuration and growth characters of DRG neurons were observed through inverted microscope. | LIUYin CHENJing-Hong GONGZe-Hui | 2004 | 中国药理通讯2004，21，2： | 0 |
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