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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | HIF-1α is required for solid tumor formation and embryonic vascularization显示文摘 | Ryan H E Lo J Johnson R S | 1998 | EMBO J1998，17，11： | 2 |
| 3 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 4 | 14 MeV neutron yields from D-T operation of the MIT Cockcroft-Walton accelerator显示文摘 | Borras M C Lo D H Petrasso R D | 1993 | Journal of Fusion Energy1993，12，3： | 2 |
| 5 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 6 | Novel baculovirus DNA elements strongly stimulate activities of exogenous and endogenous promoters 显示文摘 | LO H R CHOU C C WU T Y | 2002 | The Journal of Biological Chemistry2002，277，7： | 1 |
| 7 | Characteristics of the Tatun Volcanic Erupptions,North Taiwan:impplications for a cauldron formation and Volcanic evolution显示文摘 | SONF S R TSAO S LO H J | | 0，，： | 1 |
| 8 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 9 | Cytochrome P450 2E1 Expression Induces nepatocyte Resistance to Cell Death from Oxidative Stress显示文摘 | Jones B E Liu H Lo C R | 2002 | hntioxid Redox Signal2002，4，5： | 1 |
| 10 | 'Delayed securi- ty price adjustments to financial analysts' forecasts of annual earnings 显示文摘 | Elgers P T May H Lo Pfeiffer R J | 2001 | The Accounting Review2001，28，： | 1 |
| 11 | A decision support framework for strategic purchasing显示文摘 | V H Y Lo R T McIvor | 2000 | Journal of Materials Processing Technology2000，，107： | 1 |
| 12 | How to share a quantum secret显示文摘 | Cleve R Gottesman D Lo H K | 1999 | Physical Review Letters1999，83，3： | 1 |
| 13 | Modified clays for waste containment and pollutant attenuation 显示文摘 | Lo I M-C Mak R K M Lee S C H | 1997 | Journal of Environmental Engineering1997，123，1： | 1 |
| 14 | Two new self-adaptive projection methods for variational inequality problems显示文摘 | LO H K | 2002 | Computers and Mathematics with Application2002，43，： | 1 |
| 15 | Treatment of landfill leachate with reverse osmosis显示文摘 | Hung Y - T Jawaji R K Lo H H | 2003 | Ohio J of Sci2003，103，1： | 1 |
| 16 | Chondrocyte apoptosis following intraarticular fracture in humans 显示文摘 | Kim H Lo M Pillarisetty R | 2002 | Osteoarthritis Cartilage2002，10，9： | 1 |
| 17 | Optimal preventive-maintenance warranty policy for repairable products显示文摘 | Yeh R H Lo H C | 2001 | European Journal of Operational Research2001，134，1： | 1 |
| 18 | Solutions for Effective Shear Properties in Three Phase Sphere and Cylinder Models 显示文摘 | Christensen R M Lo K H | 1979 | Journal of Mechanical Physics Solids1979，27，3： | 1 |
| 19 | A higher-order theory of plate deformation--part 2: laminated plates显示文摘 | Lo K H Christensen R M Wu E M | 1977 | Journal of Applied Mechanics Transactians ASME1977，44，4： | 1 |
| 20 | How to share a quantum secret显示文摘 | CLEVE R GOTFESMAN D LO H K | 1999 | Physical Review Letters1999，83，： | 1 |
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