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| 1 | 小切口单髁置换和全膝关节置换配对比较临床早期结果显示文摘目的 通过配对比较 ,观察小切口单髁置换和全膝关节置换治疗单室膝关节骨性关节炎的早期临床结果。方法 2 0 0 1年 6~ 12月 ,新加坡中央医院采用小切口单髁置换连续治疗 5 0例内侧单室膝关节骨关节炎患者 ,同时对在年龄、临床症状、膝关节的X线分级上进行配对比较的 5 0例内侧单室膝关节骨关节炎患者进行全膝关节置换。小切口单髁置换组 ,男 9例 ,女 4 1例 ;年龄 5 2~ 85岁 ,平均 6 4岁。全膝关节置换组 ,男 8例 ,女 4 2例 ;年龄 5 5~ 80岁 ,平均 6 7岁。临床均表现为膝关节内侧间隙疼痛 ,AhlbackX线分级Ⅰ~Ⅲ级。结果 小切口单髁置换组与全膝关节置换组比较 ,具有出血量少、膝关节功能恢复快、住院时间短、并发症少、创伤小、康复快、费用少等优点。结论 对于单室膝关节骨关节炎 ,小切口单髁置换与全膝关节置换术比较 。 | 王铭春 Lo Ngai Nung Yeo Seng Jin Seow Kang Hong Yang Kuang Ying | 2002 | 上海医学2002，25，11： | 5 |
| 2 | Overview of the Shenzhen Emergency Medical Service Call Pattern显示文摘BACKGROUND:In Shenzhen,the Emergency Medical Service(EMS) system has been in service since 1997.This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling EMS.METHODS:In this retrospective quantitative descriptive study,the data from the Shenzhen 120 EMS registry in 2011 were analyzed.RESULTS:Shenzhen 120 EMS center is a communication command center.When the number of 120 are dialed,it is forwarded to the closest appropriate hospital for ambulance dispatch.In2011,the Shenzhen 120 EMS center received 153 160 ambulance calls,with an average of 420 calls per day.Calling emergency services was mainly due to traffic accidents.Trauma and other acute diseases constituted a majority of ambulance transports.The adult patients aged 15-60 years are the principal users of EMS.There are no recognized 'paramedic' doctors and nurses.The pre-hospital emergency service is under the operation of emergency departments of hospitals.Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management.Moreover,specialized pre-hospital training,financial support,and public health education on proper use of EMS should be emphasized.CONCLUSION:The Shenzhen 120 EMS center has its own epidemiology characteristics.Traumatic injury and traffic accident are the main reasons for calling ambulance service.In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS. | Shuk Man Lo Yi Min Yu Lap Yip Larry Lee Mi Ling Eliza Wong Sek Ying Chair Edward J Kalinowski Tak Shing Jimmy Chan | 2012 | World Journal of Emergency Medicine2012，3，4： | 4 |
| 3 | Health Emergency and Disaster Risk Management (Health-EDRM):Developing the Research Field within the Sendai Framework Paradigm显示文摘The intersection of health and disaster risk reduction(DRR) has emerged in recent years as a field of critical inquiry.Health is recognized as an outcome and a goal of DRR,and the integration of both fields is essential to ensure the implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030.Health Emergency and Disaster Risk Management(Health-EDRM) has emerged as an umbrella field that encompasses emergency and disaster medicine,DRR,humanitarian response,community health resilience,and health systems resilience.In September 2016,an international group of experts met in Hong Kong to assess the current status and potential of the Health-EDRM research field,a research area that these scholars characterized as underdeveloped and fragmented.Key challenges identified include research overlap,lack ofstrategic research agenda,absence of consensus regarding terminology,and limited coordination between stakeholders.The Sendai Framework provides a useful paradigm within which to shape the research field's strategic development.The WHO Thematic Platform for Health-EDRM Research Group was established to coordinate activities,promote information-sharing,develop partnerships,and provide technical advice to strengthen the Health-EDRM research field.This group will promote the generation of robust and scientific health research to support the meaningful implementation of the Sendai Framework. | Sharon Tsoon Ting Lo Emily Ying Yang Chan Gloria Kwong Wai Chan Virginia Murray Jonathan Abrahams Ali Ardalan Ryoma Kayano Johnny Chung Wai Yau | 2017 | International Journal of Disaster Risk Science2017，8，2： | 3 |
| 4 | Selective Aerobic Oxidation of Alcohols Catalyzed by Iron Chloride Hexahydrate/ TEMPO in the Presence of Silica Gel 显示文摘 | Wang Lianyue Li Jun LO Ying | 2012 | Appl Organomet Chem2012，26，1： | 1 |
| 5 | Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit显示文摘 | Lo C G Xu Ying Proia R L | 2005 | JEM2005，201，2： | 1 |
| 6 | Preparation of epoxy res- in/silica composites for epoxy molding compounds显示文摘 | Ying - Ling Liu Yu - Lo Lin Ru - Jong Jeng | 2003 | Journal of Applied Polymer Science2003，，90： | 1 |
| 7 | Functional characterization of Narc 1, a novel proteinase related to proteinase K显示文摘 | Saule Naureckiene Linh Ma Kodangattil Sreekumar Urmila Purandare C Frederick Lo Ying Huang Lillian W Chiang Jill M Grenier Bradley A Ozenberger J Steven Jacobsen Jeffrey D Kennedy Peter S DiStefano Andrew Wood Brendan Bingham | 2003 | Archives of Biochemistry and Biophysics2003，，1： | 1 |
| 8 | Replica Molding of Hig-Aspect-Ratio Polymeric Nanopillar Arrays with High Fidelity显示文摘 | Zhang Ying Lo Chi-Wei Taylor J Ashley | 2006 | Langmuir2006，22，： | 1 |
| 9 | Modelling root–soil interactions using three–dimensional models of root growth, architecture and function显示文摘 | Vanessa M. Dunbabin Johannes A. Postma Andrea Schnepf Lo?c Pagès Mathieu Javaux Lianhai Wu Daniel Leitner Ying L. Chen Zed Rengel Art J. Diggle | 2013 | Plant and Soil2013，，1： | 1 |
| 10 | High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia显示文摘 | Jianhua Qiu Jian Xu Yi Zheng Ying Wei Xiaoxia Zhu Eng H. Lo Michael A. Moskowitz John R. Sims | 2010 | Stroke2010，，9： | 1 |
| 11 | Geochemical and Sr-Nd isotopic characteristics of Late Paleagene ultrapotassic magmatism in southeastern Tibet 显示文摘 | Li Xian-hua Zhou Han-wen Chung Sun-lin Lo Ching-hua Wei Gang-jian Liu Ying Lee Chi-yu | 2002 | Int Geol Rev2002，44，6： | 1 |
| 12 | Performance analysis of high-speed spindle aerostatic bearings 显示文摘 | Cheng Ying Lo Cheng Chi Wang Yu Han Lee | 2005 | Tribology International2005，38，： | 1 |
| 13 | Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties显示文摘A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC 16872.Heterologous production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 VrcB.Intriguingly,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic window.Our study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities. | Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 14 | Endothelial DLC1 is dispensable for liver and kidney function in mice显示文摘DLC1 is a focal adhesion molecule that regulates cell polarity,proliferation,migration,and survival.DLC1 functions as a tumor suppressor and its expression is often down-regulated in.various malignant neoplasms of epithelial origin.Recent studies have suggested that lack of DLC1 in endothelial cells may contribute to the development of angiosarcoma,and that DLC1 mutations have been identified in patients with nephrotic syndrome,a disease mainly due to leaky glomerular filtration barriers.To demonstrate whether lack of endothelial DLC1 induces angiosarcoma and/or damages glomerular capillaries leading to nephrotic syndrome,we have extended our analyses on endothelial cell-specific DLC1 knockout mice with focuses on their liver and kidney function.Mice were monitored up to 24 months of age.However,no histological or clinical difference was found between DLC1 knockout and wild type mice,indicating that lack of endothelial DLC1 alone does not compromise kidney and liver function in mice. | Ying Tan Su Hao Lo | 2022 | Genes & Diseases2022，9，3： | 0 |
| 15 | C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice显示文摘Tensin-1(TNS1)is a 220 kD focal adhesion protein that binds to actin filaments,integrin receptors,small GTPases,tyrosine-phosphorylated proteins,and lipids.1 These binding activities enable TNS1 to link the actin cytoskeleton to integrins and transduce outside-in and inside-out signals at focal adhesion sites,thereby regulating cell attachment,migration,proliferation,and mechanical sensing.1 Lack of TNS1 in kidney epithelial cells results in multiple lumen,instead of single lumen,phenotypes in the three-dimensional(3D)culture. | Chun-Lung Chiu Shiao-Ya Hong Ying Tan Yuh-Ru Julie Lee Yi-Ping Shih Clifford GTepper Su Hao Lo | 2023 | Genes & Diseases2023，10，3： | 0 |
| 16 | The LEAFY floral regulator displays pioneer transcription factor properties显示文摘Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chromatin regions in which DNA is wrapped around histones and may be highly methylated.Subsequently,pioneer TFs are able to modify the chromatin state to initiate gene expression.In plants,LEAFY(LFY)is a master floral regulator and has been suggested to act as a pioneer TF in Arabidopsis.Here,we demonstrate that LFY is able to bind both methylated and non-methylated DNA using a combination of in vitro genomewide binding experiments and structural modeling.Comparisons between regions bound by LFY in vivo and chromatin accessibility data suggest that a subset of LFY bound regions is occupied by nucleosomes.We confirm that LFY is able to bind nucleosomal DNA in vitro using reconstituted nucleosomes.Finally,we show that constitutive LFY expression in seedling tissues is sufficient to induce chromatin accessibility in the LFY direct target genes APETALA1 and AGAMOUS.Taken together,our study suggests that LFY possesses key pioneer TF features that contribute to launching the floral gene expression program. | Xuelei Lai Romain Blanc-Mathieu Loïc GrandVuillemin Ying Huang Arnaud Stigliani Jeremy Lucas Emmanuel Thevenon Jeanne Loue-Manifel Laura Turchi Hussein Daher Eugenia Brun-Hernandez Gilles Vachon David Latrasse Moussa Benhamed Renaud Dumas Chloe Zubieta François Parcy | 2021 | Molecular Plant2021，14，5： | 0 |
| 17 | Differentiating structure of in situ and ex situ formation of laser-induced graphene hybrids显示文摘Laser-induced graphene(LIG)has been exploited in various fields,such as batteries,water treatment,and flexible actuators and sensors,with the advantages of ease in patternable fabrication and graphene/metal hybrid preparation.The in situ method which includes a single lase step and the ex situ method which uses two lase steps are both widely implemented to synthesize graphene/metal hybrids.However,the differences in the structures and properties of the resulting hybrids are not fully understood.Here,we investigate the advantages of ex situ and in situ methods for preparing LIG hybrids using NiFe/LIG as an example.The morphology,elemental composition,resistance to strong acid,and application in electrocatalysis and dye adsorption of ex situ and in situ NiFe/LIG hybrids were systematically studied and compared.Energy-dispersive X-ray spectrometry(EDS)and vibrating sample magnetometry(VSM)results confirmed the structural differences between the NiFe/LIG hybrids.Metal nanoparticles are mostly wrapped by carbon layers in the in situ NiFe/LIG hybrid,while the ex situ NiFe/LIG hybrid largely exposes the metal nanoparticles.These structural differences are significant for tailoring performance in applications,such as wastewater treatment and electrocatalysis.This work provides insights into the synthesis and properties of LIGs and has important implications for future applications. | Li-Bei Huang Wei-Hua Guo Le Cheng Jian-Jun Su Yun Song Fei-Jun Hu Ying Lo Law Zheng Yan Jian Lin Ru-Quan Ye | 2022 | Rare Metals2022，41，9： | 0 |
| 18 | In-Home Drug Storage by Older Adults显示文摘Globally,in-home drug-storage compliance is often unsatisfactory,especially among older adults,and can lead to negative health outcomes.This study used a cross-sectional and descriptive design to examine inhome drug-storage compliance among older adults.Convenience sampling was used to recruit 117 older adults in Hong Kong.An in-home drugstorage checklist was used to assess the in-home drug-storage environments(light,temperature,and humidity)and drug-storage methods(drug safety,packaging,information,and expiration)of each older adult.The findings showed that Hong Kong older adults’overall compliance rate in drug storage was 87.25%,and their compliance rate for drug-storage methods(84.59%)was lower than that for drug-storage environments(97.02%).Older adults who were of advanced age,who were less educated or who lived alone demonstrated lower in-home drug-storage compliance.This indicates the need to revise existing health-education strategies to encourage in-home drug-storage compliance.Healthcare professionals should assess older adults’drug-storage compliance to identify less compliant subgroups and deliver specific drug-storage support as required.Family members should also be involved in this process. | Lori Suet Hang Lo Linda Yin King Lee Irene Yuen Fung Wong Yuen Yan Lai Hoi Tong Au Tsz Ying Wong Chui Ping Chueng Wai Lam Shek Choi Yi Wong Hoi Lam Chan Hon Sze Cheuk Nga Hing Mark Shu Ching Wong Wing Yan Cheung | 2020 | Journal of Geriatric Medicine2020，2，3： | 0 |
| 19 | Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude显示文摘AIM:To investigate the impact of primary glaucoma on sleep quality and daytime sleepiness of patients.METHODS:Prospective cross-sectional study with consecutive sampling in South-East Asian population was performed.Validated questionnaires:the Pittsburg Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were administered prospectively.Subjects with nonglaucomatous optic neuropathy or concomitant retinal pathology were excluded.Glaucoma severity was based on HVF 24-2 perimetry.Binocular single vision was represented based on the better eye.Frequency of and predictive factors for poor sleep quality and excessive daytime sleepiness were compared.RESULTS:A total of 79 primary open angle glaucoma(POAG),27 primary angle-closure glaucoma(PACG)patients,and 89 controls were recruited.PACG patients had higher median PSQI scores(P=0.004)and poorer sleep quality(P<0.001).Compared to controls,PACG patients were 3.34 times more likely to have poor sleep quality(P=0.008),which remained significant after adjustment for demographics(P=0.016)and predictive variables(P=0.013).PACG patients have poorer sleep quality when visual acuity(VA)was 6/15 or worse(P=0.009).Univariate and multivariate analysis of predictive variables for poor sleep quality and daytime sleepiness did not find statistical significance.CONCLUSION:PACG patients have poorer sleep quality but not daytime sleepiness.This is important in South-East Asian population with heavy disease burden.Evaluations on sleep disturbances can be considered to provide more ho istic care. | Jacob YH Chin Zhi Hong Toh Ying Tai Lo Hannah TY Wang Elizabeth YW Poh Chun Hau Chua Owen Kim Hee Boon Ang Lim Vernon KY Yong Augustinus Laude Hon Tym Wong Leonard WL Yip | 2020 | International Journal of Ophthalmology(English edition)2020，13，9： | 0 |
| 20 | Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells显示文摘Chromatin modification contributes to pluripotency maintenance in embryonic stem cells(ESCs).However,the related mechanisms remain obscure.Here,we show that Npac,a'reader'of histone H3 lysine 36 trimethylation(H3K36me3),is required to maintain mouse ESC(mESC)pluripotency since knockdown of Npac causes mESC differentiation.Depletion of Npac in mouse embryonic fibroblasts(MEFs)inhibits reprogramming efficiency.Furthermore,our chromatin immunoprecipitation followed by sequencing(ChIP-seq)results of Npac reveal that Npac co-localizes with histone H3K36me3 in gene bodies of actively transcribed genes in mESCs.Interestingly,we find that Npac interacts with positive transcription elongation factor b(p-TEFb),Ser2-phosphorylated RNA PolⅡ(RNA PolⅡSer2P),and Ser5-phosphorylated RNA PolⅡ(RNA PolⅡSer5 P).Furthermore,depletion of Npac disrupts transcriptional elongation of the pluripotency genes Nanog and Rif1.Taken together,we propose that Npac is essential for the transcriptional elongation of pluripotency genes by recruiting p-TEFb and interacting with RNA PolⅡSer2P and Ser5P. | Sue Yu Jia Li Guanxu Ji Zhen Long Ng Jiamin Siew Wan Ning Lo Ying Ye Yuan Yuan Chew Yun Chau Long Wensheng Zhang Ernesto Guccione Yuin Han Loh Zhi-Hong Jiang Henry Yang Qiang Wu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
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