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| 1 | Promoting remyelination for the treatment of multiple sclerosis:opportunities and challenges显示文摘Multiple sclerosis (MS) is a chronic and devastating autoimmune demyelinating disease of the central nervous system. With the increased understanding of the pathophysiology of this disease in the past two decades, many disease-modifying therapies that primarily target adaptive immunity have been shown to prevent exacerbations and new lesions in patients with relapsing-remitting MS. However, these therapies only have limited efficacy on the progression of disability. Increasing evidence has pointed to innate immunity, axonal damage and neuronal loss as important contributors to disease progression. Remyelination of denuded axons is considered an effective way to protect neurons from damage and to restore neuronal function. The identification of several key molecules and pathways controlling the differentiation of oligodendrocyte progenitor cells and myelination has yielded clues for the development of drug candidates that directly target remyelination and neuroprotection. The long-term efficacy of this strategy remains to be evaluated in clinical trials. Here, we provide an overview of current and emerging therapeutic concepts, with a focus on the opportunities and challenges for the remyelination approach to the treatment of MS. | Yueting Zhang Taylor B.Guo Hongtao Lu | 2013 | Neuroscience Bulletin2013，29，2： | 6 |
| 2 | D-Ocean: an unstructured data management system for data ocean environment显示文摘 | Yueting ZHUANG Yaoguang WANG Jian SHAO Ling CHEN Weiming LU Jianling SUN Baogang WEI Jiangqin WU | 2016 | Frontiers of Computer Science2016，10，2： | 2 |
| 3 | T - tree or B-tree:MainMemory Database Index Structure Reviewed Austl' alasian DatabaseConrcrence 显示文摘 | Lu Hongjun + Yuet Yeung Ng + Tian Zengping | 2000 | 65 : 73-752000，65，： | 1 |
| 4 | Eco-environmental changes in the Chinese Loess Plateau during low-eccentricity interglacial Marine Isotope Stage 19显示文摘Eco-environmental changes during interglacials with an astronomical background similar to that of the Holocene are potentially helpful for understanding the future climatic evolution.Marine oxygen isotope stage(MIS)19 is similar to the Holocene in astronomical background,both being characterized by a low eccentricity of the Earth’s orbit.However,MIS 19 has attracted research attention only recently and therefore less is known about eco-environmental changes during this interval,especially based on terrestrial records.In the Chinese Loess Plateau(CLP),the S7 paleosol can provide valuable terrestrial paleoclimatic and paleoenvironmental record for MIS 19.Here,high-resolution terrestrial snail records from the L8–L7 strata of the Huining,Xifeng and Luochuan sequences in the CLP were analyzed in order to characterize spatio-temporal changes in climate and eco-environment during MIS 20–18.The results show that in all three sections the late part of MIS 20 was dominated by abundant cold-aridiphilous mollusc species,indicating that cold and dry climatic conditions prevailed across the entire CLP,under the strong influence of the winter monsoon.The mollusc fauna of MIS 19 were dominated by warmth-loving and thermohumidiphilous species that enable the definition of two climatic stages.The early part of MIS 19(~790–778 ka)was marked by warm and humid conditions,as evidenced by high abundances of warmth-loving and thermo-humidiphilous species.This interval was slightly warmer than today and it lasted for^12 kyr.The climate of the later part of MIS 19(~778–761 ka)was more moderate,and increased proportions of cold-aridiphilous and warmth-loving species were recorded.The warmth of this period was similar to that of today,but the climatic fluctuations were stronger.During the early part of MIS 18(~761–745 ka),the Xifeng and Luochuan sections in the eastern CLP still maintained high abundances of warmth-loving and thermo-humidiphilous species,indicating that the moderate climatic conditions during late MIS 19 continued during early MIS 18,lasting for another^15 kyr,and that the influence of the summer monsoon remained strong in the eastern CLP during early MIS 18.However,in the western CLP,cold-aridiphilous species in the Huining section became dominant during early MIS 18,reflecting the prevalence of a cold and dry glacial climate,with the strong influence of the winter monsoon.These findings indicate that a steeper climatic gradient and a pronounced regional environmental difference existed between the eastern and western CLP during the early part of MIS 18.Comparison of our mollusc results with the variation of Earth orbital parameters suggested that climate changes in the CLP during MIS 20–18 were likely controlled mainly by insolation changes forced by the configuration of Earth orbital parameters.The unique orbital configuration during the low eccentricity interglacial-to-glacial transition could have strengthened the East Asian summer monsoon which favored the amelioration of the eco-environment in the CLP,especially in the eastern CLP where the summer monsoon exerted a strong influence.Thus we speculate that,under natural climatic conditions,the climate of the CLP may remain in a warm,humid state for another 30 kyr,although climatic instability and the seasonal differences between winter and summer could strengthen. | Yueting ZHANG Naiqin WU Fengjiang LI Qingzhen HAO Yajie DONG Dan ZHANG Houyuan LU | 2020 | Science China Earth Sciences2020，63，9： | 0 |
| 5 | Mechanism of Huashi Xingyu Qingre recipe(化湿行淤清热方)in treating oral lichen planus based on network pharmacology and clinical trial verification显示文摘OBJECTIVE:To identify the main active components and targets of Huashi Xingyu Qingre recipe(化湿行淤清热方,HXQR)and to investigate its mechanism in the treatment of oral lichen planus(OLP).METHODS:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was searched to identify the active ingredients and corresponding targets of HXQR.Disease genes were obtained from the Gene Cards database,and a“drugdisease regulatory network”was constructed using Cytoscape software and PERL programming language.The STRING database was used to build a protein-protein interaction network.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)terms were analyzed using R software with a Bioconducter plugin.Finally,the results and the efficacy of HXQR in treating OLP were validated in a clinical trial that included enzyme-linked immunosorbent assay(ELISA)testing and observations of the post-treatment changes in clinical symptoms.RESULTS:HXQR contained 167 active components and 261 targets,with 391 disease targets.The intersection of these two categories in a Venn diagram revealed 57 drugdisease common targets.A compound-target network was constructed and revealed that the six key pharmaceutical ingredients of HXQR were quercetin,luteolin,wogonin,kaempferol,beta-carotene,and baicalein.The protein-protein interaction network mainly involved core proteins such as ALB,interleukin-6,and AKT1.Drug-disease common targets were enriched in 1628 GO terms and 117 KEGG terms,mainly involving inflammatory responses,viral infections,and tumorrelated pathways.ELISA testing indicated that HXQR inhibited the tumor necrosis factor(TNF)signaling pathway by reducing the expression of interleukin-6,matrix metalloproteinase-9,and intercellular adhesion molecule-1.The clinical symptoms of the patients with OLP were significantly improved after 8 weeks of treatment with HXQR.CONCLUSION:HXQR treats OLP by regulating the TNF signaling pathway,resulting in a marked treatment effect with few adverse effects. | DENG Qianlan LU Yueting YAN Lijuan LU Hualin JIN Ruizhe XU Yanzhi SONG Jing LIU Tiejun | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 0 |
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