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| 1 | I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life显示文摘AIM:To determine the dose-related effects of a novel probiotic combination,I.31,on irritable bowel syndrome(IBS)-related quality of life(IBS-QoL).METHODS:A multicenter,randomized,double-blind,placebo-controlled intervention clinical trial with three parallel arms was designed.A total of 84 patients(53female,31 male;age range 20-70 years)with IBS and diarrhea according to Rome-Ⅲcriteria were randomly allocated to receive one capsule a day for 6 wk containing:(1)I.31 high dose(n=28);(2)I.31 low dose(n=27);and(3)placebo(n=29).At baseline,and 3and 6 wk of treatment,patients filled the IBSQoL,Visceral Sensitivity Index(VSI),and global symptom relief questionnaires.RESULTS:During treatment,IBS-QoL increased in all groups,but this increment was significantly larger in patients treated with I.31 than in those receiving placebo(P=0.008).After 6 wk of treatment,IBS-QoL increased by 18±3 and 22±4 points in the high and the low dose groups,respectively(P=0.041 and P=0.023vs placebo),but only 9±3 in the placebo group.Gutspecific anxiety,as measured with VSI,also showed a significantly greater improvement after 6 wk of treatment in patients treated with probiotics(by 10±2 and14±2 points,high and low dose respectively,P<0.05for both vs 7±1 score increment in placebo).Symptom relief showed no significant changes between groups.No adverse drug reactions were reported following the consumption of probiotic or placebo capsules.CONCLUSION:A new combination of three different probiotic bacteria was superior to placebo in improving IBS-related quality of life in patients with IBS and diarrhea. | Vicente Lorenzo-Zú?iga Elba Llop Cristina Suárez Beatriz álvarez Luis Abreu Jordi Espadaler Jordi Serra | 2014 | World Journal of Gastroenterology2014，20，26： | 13 |
| 2 | Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?显示文摘AIM: To study the possible association between chronic pancreatitis (CP) and liver cirrhosis (LC) of alcoholic etiology,after excluding any other causes.METHODS: One hundred and forty consecutive alcoholic patients were subdivided into three groups: CP (n = 53),LC (n = 57),and asymptomatic alcoholic (n = 30).Clinical,biochemical and morphological characteristics,Child-Pugh index,indocyanine green test,and fecal pancreatic elastase-1 test were assessed.RESULTS: In patients with cirrhosis,major clinical manifestations of CP such as pancreatic pain and steatorrhea,as well as imaging alterations of CP such as calcifications,duct dilation and pseudocysts were absent; insulin-dependent diabetes was present in 5.3% of cases,and elastase-1 test was altered in only 7%,and severely altered in none.In patients with CP,clinical characteristics of cirrhosis such as ascites,encephalopathy and gastrointestinal hemorrhage were present in one case,Child-Pugh grade > A in 5.7%,and altered indocyanine green test in 1.9% cases.In asymptomatic alcoholism,there was only a non-coincident alteration of elastase-1 test and indocyanine test in 14.8% and 10%,respectively,but other characteristics of cirrhosis or CP were absent.An inverse correlation (r = -0.746) between elastase-1 test and indocyanine test was found in alcoholic patients.CONCLUSION: There is a scarce coincidence in clinical and morphological alterations among patients with CP or LC of alcoholic etiology,but an inverse correlation between pancreatic and liver function tests.These findings support that these alcoholic diseases evolve in a different manner and have different etiopathogenesis. | Luis Aparisi Luis Sabater Juan Del-Olmo Juan Sastre Miguel-Angel Serra Ricardo Campello Daniel Bautista Abdalla Wassel José-Manuel Rodrigo | 2008 | World Journal of Gastroenterology2008，14，40： | 4 |
| 3 | Structural theory and thermoeconomic diagnosis:Part I on malfunction and dysfunction analysis显示文摘 | CESAR Torres ANTONIO Valero LUIS Serra | 2002 | Energy Conversion and Mana-gement2002，43，912： | 1 |
| 4 | Structural theory and thermoeconomic diagnosis显示文摘 | Cesar Tones Antonio Valero Luis Serra Javier Royo | 2002 | Energy Conversion and management2002，，： | 1 |
| 5 | Optimal synthesis of regeneration systems subject to environmental constraints显示文摘 | Monica Carvalho Luis Maria Serra Miguel Angel | 2011 | Energy2011，36，6： | 1 |
| 6 | The effects of the control system on the thermoeconomic diagnosis of a power plant显示文摘 | VITTORIO Verda LUIS Serra ANTONIO Valero | 2004 | Energy2004，29，3： | 1 |
| 7 | Thermoeconomic optimization of a dual purpose power and desalination plant显示文摘 | Javier Uche Luis Serra Antonio Valero | 2001 | Desalination2001，136，： | 1 |
| 8 | Simulation and thermoeconomic analysis of different configuration of gas turbine(GT)-based dual-purpose power and desalination plants(DPPDP)and hybrid plants(HP)显示文摘 | Thibaut Rensonnet Javier Uche Luis Serra | 2007 | Energy2007，32，： | 1 |
| 9 | Structural Theory and Thermoeconomic Diagnosis显示文摘 | Antonio Valero Luis Serra Javier Royo | 2002 | Energy Conversion and Management2002，，43： | 1 |
| 10 | Comparison of heat transfer coefficient correlations for thermal desalination units显示文摘 | Javier Uche Javier Artal Luis Serra | 2002 | Desalination2002，152，： | 1 |
| 11 | Sturctural Theory as Standard for Thermoeconomics显示文摘 | BERIT ERLACH LUIS SERRA ANTONIO VLAERO | 1999 | Energy Conservation and Management1999，40，： | 1 |
| 12 | Evaluation of the Potential of Large Solar Heating Plants in Spain显示文摘 | Mateo de Guadalfajara Miguel A. Lozano Luis M. Serra | 2012 | Energy Procedia2012，，： | 1 |
| 13 | Life cycle assess- ment of water production technologies - Part 2: reverse osmosis de- salination versus the Ebro river water transfer (9 pp) 显示文摘 | R Gemma Raluy Luis Serra Javier Uche | 2004 | The Inter- national Journal of Life Cycle Assessment2004，，5： | 1 |
| 14 | Life cycle assessment of MSF, MED and RO desalination technologies显示文摘 | Gemma Raluy Luis Serra Javier Uche | 2006 | Energy2006，31，13： | 1 |
| 15 | Treatment of Gastric Leaks with Coated Self-Expanding Stents after Sleeve Gastrectomy显示文摘 | Carlos Serra Aniceto Baltasar Luis Andreo Nieves Pérez Rafael Bou Marcelo Bengochea Juan José Chisbert | 2007 | Obesity Surgery2007，，7： | 1 |
| 16 | Multicriteria synthesis of trigeneration systems considering economic and envi-ronment alaspects 显示文摘 | Carvalho Monica Lozano Miguel A Serra Luis M | 2012 | Applied Energy2012，，91： | 1 |
| 17 | Control and optimization of the divided wall column显示文摘 | Maria Serra Antonio Espuna Luis Puigjaner | 1999 | Chemical Engineering and Processing1999，38，： | 1 |
| 18 | Determination of ochratoxin A in wine grapes: comparison of extraction procedures and method validation显示文摘 | Rita Serra Carla Mendonca Luis Abrunhosa Amedeo Pietri Armando Venancio | 2004 | Analytica Chimica Acta2004，513，： | 1 |
| 19 | Thermoeconomic optimization of a dual-purpose power and desalination plant 显示文摘 | Uche Javier Serra Luis Valero Antonio | 2001 | De- salination2001，136，13： | 1 |
| 20 | Structural theory and thermoeconomic diagnosis : Part II : Application to an actual power plant显示文摘 | Valero Antonio Lerch Felix Serra Luis | 2002 | Energy Conversion and Management2002，43，912： | 1 |
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