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| 1 | Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions显示文摘Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated disease.This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology.Currently,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease control.This approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative measures.The optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain undefined.Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify patients.This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis.In the future,the molecular or microRNA profiles will likely improve the treatment selection process.The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and surgery.We also discuss areas of controversy and future directions. | Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro | 2019 | World Journal of Clinical Oncology2019，10，10： | 5 |
| 2 | Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum显示文摘In the new era of functional magnetic resonance imaging(MRI), the utility of chest MRI is increasing exponentially due to several advances, including absence of ionizing radiation, excellent tissue contrast and high capability for lesion characterization and treatment monitoring. The application of several of these diagnostic weapons in a multiparametric fashion enables to better characterize thymic epithelial tumors and other mediastinal tumoral lesions, accurate assessment of the invasion of adjacent structures and detection of pathologic lymph nodes and metastasis. Also, 'do not touch lesions' could be identified with the associated impact in the management of those patients. One of the hotspots of the multiparametric chest MR is its ability to detect with acuity early response to treatment in patients with mediastinal malignant neoplasms. This has been related with higher rates of overall survival and progression free survival.Therefore, in this review we will analyze the current functional imaging techniques available(18 F-Fluorodeoxiglucose positron emission tomography/computed tomography, diffusion-weighted imaging, dynamic contrast-enhanced MRI, diffusion tensor imaging and MR spectroscopy) for the evaluation of mediastinal lesions, with a focus in their correct acquisition and post-processing. Also, to review the clinical applications of these techniques in the diagnostic approach of benign and malignant conditions of the mediastinum. | Jordi Broncano Ana María Alvarado-Benavides Sanjeev Bhalla Antonio álvarez-Kindelan Constantine A Raptis Antonio Luna | 2019 | World Journal of Radiology2019，11，3： | 4 |
| 3 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 4 | GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma显示文摘Malignant pleural mesothelioma(MPM)is a rare tumor with poor prognosis and rising incidence.Palliative care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional involvement.Numerous therapeutic advances have been made in recent years,including the use of less aggressive surgical techniques associated with lower morbidity and mortality(e.g.,pleurectomy/decortication),technological advancements in the field of radiotherapy(intensity-modulated radiotherapy,image-guided radiotherapy,stereotactic body radiotherapy,proton therapy),and developments in systemic therapies(chemotherapy and immunotherapy).These improvements have had as yet only a modest effect on local control and survival.Advances in the management of MPM and standardization of care are hampered by the evidence to date,limited by high heterogeneity among studies and small sample sizes.In this clinical guideline prepared by the oncological group for the study of lung cancer of the Spanish Society of Radiation Oncology,we review clinical,histologic,and therapeutic aspects of MPM,with a particular focus on all aspects relating to radiotherapy,including the current evidence base,associations with chemotherapy and surgery,treatment volumes and planning,technological advances,and reradiation. | Javier Luna Andrea Bobo Joaquín José Cabrera-Rodriguez María Pagola Margarita Martín-Martín María Ángeles González Ruiz Miguel Montijano Aurora Rodríguez Lira Pelari-Mici Almudena Corbacho Marta Moreno Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，8： | 2 |
| 5 | Characterization of Four Toll Related Genes During Development and Immune Responses in Anopheles gambiae显示文摘 | Xuelan Wang b Yarning Huang | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 6 | Calibration of Line-Scan Cameras 显示文摘 | Luna C A Mazo M Lazaro J L | 2010 | IEEE Transactions on Instrumentation and Measurement(S0018-9456)2010，59，8： | 1 |
| 7 | Cheese-making capacity of goat's milk during lactation: influence of stage and number of lactations显示文摘 | M B Lopez A Luna J Laencina | 1999 | J Sci Food Agrie1999，79，： | 1 |
| 8 | Pre- diction of haematoma growth and outcome in patients with in- tracerebral haemorrhage using the CT-angiography spot sign (PREDICT) a prospective observational study显示文摘 | Demchuk A M Dowlatshahi D Rodriguez Luna D | 2012 | Lancet Neu- rol2012，11，4： | 1 |
| 9 | Proposal of a hae-morheological profile for early detection of hypertensive gesta-tional disorders显示文摘 | Bollini A Hernandez G? Bravo Luna M | 2003 | Clin Hemorheol Microcirc2003，28，2： | 1 |
| 10 | Effect of thermal treatment on the performance of CO-tolerant anodes for polymer electrolyte fuel cells 显示文摘 | LUNA A M C CAMARA G A PAGANIN V A | 2000 | Electrochemistry Communications2000，2，4： | 1 |
| 11 | Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases显示文摘 | Baycs de Luna A Coumel P Lcclerq J F | 1989 | Am Heart J1989，117，1： | 1 |
| 12 | Polymorphous low-grade adenocarcinoma: A study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas 显示文摘 | Evans H L Luna M A | 2000 | Am J Surg Pathol2000，24，10： | 1 |
| 13 | A variety of Gram-positive bacteria carry mobile mef genes显示文摘 | Luna V A Coates P Eady E A | 1999 | Antimicrob Chemother1999，44，： | 1 |
| 14 | Community-ac-quired pneumonia:etiology,epidemiology,and outcome at a teach-ing hospital in Argentina显示文摘 | Luna CM Famiglietti A Absi R | 2000 | Chest2000，118，5： | 1 |
| 15 | Adaptive droop control applied to voltage source inverters operating in grid-connected and islanded modes 显示文摘 | VASQUEZ J C GUERRERO J M LUNA A | 2009 | IEEE Trans on Industrial Electronics2009，56，10： | 1 |
| 16 | Community-acquired pneumonia: etiology', epidemiology, and outcome at a teaching hospital in Argentina显示文摘 | Luna CM Famiglietti A Absi R | 2000 | Chest2000，118，5： | 1 |
| 17 | Simplified modeling of a DFIG for transient studies in wind power applica- tions显示文摘 | LUNA A LIMA F K RODRIGUEZ D SANTOS P | 2011 | IEEE Transactions on Industrial Electronics2011，58，1： | 1 |
| 18 | Rotor voltage dynamics in the doubly fed induction generator during grid faults显示文摘 | Lima F K Luna A Rodriguez P A | 2010 | IEEE Transactions on Power Electronics2010，25，1： | 1 |
| 19 | A stationary reference frame grid synchronization system for three-phase grid-connected p6wer converters under adverse grid conditions 显示文摘 | Rodriguez P Luna A Munoz-Aguilar R S | 2012 | IEEE Transactions on Power Electronics2012，27，1： | 1 |
| 20 | Determination of mercury in gasoline by cold vapor atomic absorption spectrometry with direct reduction in microemulsion media显示文摘 | Brand G P De C R Luna A S | 2005 | Spectrochimica Acta: Part B2005，60，5： | 1 |
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