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| 1 | Does social capital determine innovation? To what extent?显示文摘 | Réjean Landry Nabil Amara Moktar Lamari | 2002 | Technological Forecasting & Social Change2002，，7： | 3 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | Why are some university researchers more likely to create spin-offs than others? Evidence from Canadian universities显示文摘 | Réjean Landry Nabil Amara Imad Rherrad | 2006 | Research Policy2006，，10： | 2 |
| 4 | Estimating the grazing impact of marine microzooplankton显示文摘 | LANDRY M R HASSET R P | 1982 | Marine biology1982，67，： | 1 |
| 5 | Tissue-specific posttranslational modification of the small heat shock protein HSP27 in Drosophila显示文摘 | Marin R Landry J Tanguay R M | | 0，，01： | 1 |
| 6 | A genetic map for Brassica oleracea based on RFLP markers detected with expressed DNA sequences and mapping of resistance genes to race 2 of Plasmodiophora brassicae (Woronin)显示文摘 | Landry B S Hubert N Crete R | 1992 | Genome1992，35，3： | 1 |
| 7 | Estimating the grazing impact of marine microzooplankton显示文摘 | Landry M R Hassett R P | 1982 | Mar Biol1982，67，： | 1 |
| 8 | The effects of biogenic silica detritus,zooplankton grazing,and diatom size structure on silicon cycling in the euphotic zone of the eastern equatorial Pacific显示文摘 | Krause J W Brzezinski M A Landry M R | | 0，，06： | 1 |
| 9 | Linguistic Landscape and Ethnolin- guistie Vitality: An Empirical Study 显示文摘 | Landry R R Bourhis | 1997 | Journal of Lan- guage and Social Psychology1997，，16： | 1 |
| 10 | Vasopressin pressorhypersensitivity in vasodilatory septic shock显示文摘 | Landry D W Levin D R Gallant E M | 1997 | Crit Care Med1997，25，8： | 1 |
| 11 | Lessons from In-novation Empirical Studies in the Manufacturing Sector:A Systematic Review of the Literature from 1993-2003显示文摘 | Beeheikh N Landry R Alnara N | | 0，，5： | 1 |
| 12 | Technology Transfer Organiza- tions : Services and Business Models显示文摘 | Landry R Amara N | 2013 | Teehnovation2013，，5： | 1 |
| 13 | Silent information regulator 2 family of NAD+-dependent histone/protein deacetylases generates a unique product, l-O-acetyl-ADP-ribose 显示文摘 | Tanner K G Landry J Sternglanz R | 2000 | Proc Natl Acad Sci USA2000，97，14： | 1 |
| 14 | Oxidation of octane and cyclohexane using a new porous substrate, Ti-MMM-1显示文摘 | Landry C C | 2002 | Micropor Mesopor Mat2002，52，： | 1 |
| 15 | Iron and grazing constraints on primary production in the central equatorial Pacific:An EqPac synthesis显示文摘 | Landry M R Barber R T Bidigare R R | 1997 | Limnol Oceanogr1997，，42： | 1 |
| 16 | Predicting excretion rates of microzooplankton from carbon metabolism and elemental ratios显示文摘 | Landry M R | 1993 | Limnol Oceanogr1993，38，： | 1 |
| 17 | The mechanisms leading to the useful electrical properties of polymer nanodielectrics显示文摘 | Smith R C Liang C Landry M | 2008 | IEEE Transactions on Dielec- trics and Electrical Insulation2008，15，1： | 1 |
| 18 | Technology trans- fer organizations : services and business models 显示文摘 | LANDRY R AMARA N CLOUTIER J S | 2013 | Technovation2013，33，12： | 1 |
| 19 | A genetic map for Brassica oleracea based on RFLP markers detected with expressed DNA sequences and mapping of resisance genes to race 2 of Plasmodiophora brassicae (Woronin)显示文摘 | Landry B S Hubert N Crete R | 1992 | Genome1992，35，： | 1 |
| 20 | Sources of Information as Determinants of Novelty of Innovation in Manufacturing Firms; Evidence from the 1999 Statistics Canada Innovation Survey 显示文摘 | AMARA N LANDRY R J | 2005 | Technovation2005，25，3： | 1 |
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