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| 1 | Graphdiyne oxide enhances the stability of solid contact-based ionselective electrodes for excellent in vivo analysis显示文摘Quantitively and stably tracking ion dynamics in the living brain of animals is essential to understanding many physiological and pathological processes.Solid-state ion-selective electrodes(ISEs)are powerful tools for monitoring the dynamic change of ions at physiological concentration range;however,the unintentional accumulation of an aqueous layer at the ion selective membrane/solid contact interface compromises the electrode potential stability,limiting its in vivo application.Here,using manganese dioxide(MnO2)and potassium ISE(K-+ISE)as model solid contact and ISEs,we demonstrate for the first time that graphdiyne oxide(GDYO)can enhance the potential stability of solid contact-based ISEs.Our results suggest that the intrinsic structural and hydrophobic features of GDYO,plays a key role in impeding and stabilizing the formation of water layer.With GDYO-MnO2 acting as the solid contact,the K-+ISE displays an excellent short-term potential stability and maintains great selectivity,achieving reliable K+sensing at the animal level.The GDYO-based strategy is generalizable to different ISEs and does not require complicated processing steps,paving an exciting opportunity for in vivo ion recognition and sensing. | Lijun Zhao Ying Jiang Jie Hao Huan Wei Wei Zheng Lanqun Mao | 2019 | Science China Chemistry2019，62，10： | 4 |
| 2 | In vivo electrochemical recording of continuous change of magnesium in medial vestibular nucleus following vertigo induced by ice water vestibular stimulation显示文摘Vertigo is one of the most common clinical symptoms. However, the chemical processes involved in the pathological mechanism of vertigo remain to be fully understood. In this study, we investigate the dynamic changes in the magnesium (Mg 2+ ) concentration in medial vestibular nucleus (MVN) of guinea pigs following vertigo induced by vestibular ice water stimulation with an electrochemical detection method consisting of in vivo microdialysis and on-line selective electrochemical detection. Electrochemical detection of Mg 2+ was accomplished based on the current enhancement of Mg 2+ towards the electrocatalytic oxidation of NADH at the electrodes modified with the polymerized film of toluidine blue O (TBO). Selectivity for the on-line electrochemical detection against Ca 2+ was achieved by using ethyleneglcol-bis(2-aminoethylether) tetraacetic acid (EGTA) as the selective masking agent for Ca 2+ . The basal level of the extracellular Mg 2+ in the MVN of guinea pigs was determined to be 759.7 ± 176.2 M(n = 16). Upon ice water irrigation of the left external ear canal, the concentration of Mg 2+ in the MVN decreases significantly, reaches 72 ± 6% (n = 8) of the basal level, and maintains for at least 1000 s. Control experiments reveal that neither warm water irrigation of the external ear canal nor ice water irrigation of the auricle induces the decrease in the concentration of Mg 2+ in the MVN. These results demonstrate that the extracellular Mg 2+ in the MVN decreases significantly following vertigo induced by vestibular ice water stimulation. This demonstration suggests that Mg 2+ might play an important role in the pathological mechanism of vertigo. | XIN Ying ZHANG ZiPin YU Ping MA FuRong MAO LanQun | 2013 | Science China Chemistry2013，56，2： | 2 |
| 3 | Electrochemical sensing of ATP with synthetic cyclophane as recognition element显示文摘A new electrochemical sensor for ATP with synthetic cyclophane stably attached onto single-walled carbon nanotubes (SWNTs) as the recognition elements is described. UV-vis and cyclic voltammetric results demonstrate that ATP may interact with the synthetic cyclophane recognition elements to form a stable adduct mainly through electrostatic, π-π stacking and donor-acceptor interactions. Such interactions eventually lead to a decrease in the peak currents of the cyclophane recognition elements attached onto the SWNT electronic transducer, which could be used for electrochemical sensing of ATP. Under the conditions employed here, the ratio of the decrease in the anodic peak current is linear with ATP concentration within a concentration range from 10 to 120 μM with a linear coefficiency of 0.993. This study may offer a new and simple electrochemical approach for effective sensing of ATP. | MA YuRong ZHAO Hong YU Ping SU Lei ZHANG DeQing MAO LanQun | 2009 | Science China Chemistry2009，52，6： | 2 |
| 4 | Synthesis of PtRu/carbon nanotube composites in supercritical fluid and their application as an electrocatalyst for direct methanol fuel cells显示文摘 | An Guimin Yu Ping Mao Lanqun | | 0，，03： | 1 |
| 5 | A facile electrochemical method for simuhaneous and on-line measurements of glucose and lactate in brain microdialysate with prussian blue as the electrocatalyst for reduction of hydrogen peroxide 显示文摘 | LIN Yuqing LIU Kun MAO Lanqun | 2007 | Anal Chem2007，79，24： | 1 |
| 6 | Electrochemical characterization of catalytic activities of manganese oxides to oxygen reduction in alkaline aqueous solution显示文摘 | LANQUN M SOTOMURA T NAKATSU K | 2002 | J Electrochem Soc2002，149，4： | 1 |
| 7 | Mechanistic study of the reduction of oxygen in air electrode with manganese oxides as electrocatalysts 显示文摘 | MAO Lanqun ZHANG Dun SOTOMUR T | 2003 | Electrochimica Acta2003，48，8： | 1 |
| 8 | On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats显示文摘This study demonstrates an on-line method for continuous measurements of cerebral hypoxanthine in the freely moving rats with integration of selective electrochemical biosensing with in vivo microdialysis sampling. The selective electrochemical biosensing is achieved by using xanthine oxidase (XOD) as the specific sensing element and Prussian blue (PB) as the electrocatalyst for the reduction of H2O2 generated from the oxidase-catalyzed reaction. The method is virtually interference-free from the co-existing electroactive species in the brain and exhibits a good stability and reproducibility. Upon integrated with in vivo microdialysis, the on-line method is well suitable for continuous measurements of cerebral hypoxanthine of freely moving rats, which is illustrated by the measurements of the microdi-alysates after the hypoxanthine standard was externally infused into the rat brain. This study essentially offers a facile on-line electrochemical approach to continuous measurements of cerebral hypoxanthine and could find some interesting applications in physiological and pathological investigations associated with hypoxanthine. | ZHANG ZiPin LIN YuQing MAO LanQun | 2009 | Science China Chemistry2009，52，10： | 1 |
| 9 | Single-atom electrocatalysis: a new approach to in vivo electrochemical biosensing显示文摘Modulation of interfacial electron transfer has been proven to pave a new approach to in vivo electrochemical monitoring of brain chemistry;however,designing and establishing highly efficient electrocatalytic scheme towards neurochemicals remain a longstanding challenge.Here,we find that recently established single-atom catalyst(SAC)can be used for catalyzing the electrochemical process of physiologically relevant chemicals and thus offers a new avenue to in vivo electrochemical biosensing.To prove this new concept,we used Co single-atom catalyst(Co-SAC),in which the atomic active sites are dispersed in ordered porous N-doping carbon matrix at atomic level,as an example of SACs for analyzing glucose as the physiologically relevant model chemicals.We found that Co-SAC catalyzes the electrochemical oxidation of hydrogen peroxide(H2O2)at a low potential of ca.+0.05 V(vs.Ag/AgCl).This property was further used for developing an oxidase-based glucose biosensor that was used subsequently as a selective detector of an online electrochemical system(OECS)for continuous monitoring of microdialysate glucose in rat brain.The OECS with Co-SAC-based glucose biosensor as the online detector was well responsive to glucose without interference from other electroactive species in brain microdialysate.This study essentially offers a new approach to in vivo electrochemical analysis with SACs as electrocatalysts to modulate interfacial electron transfer. | Hanfeng Hou Junjie Mao Yunhu Han Fei Wu Meining Zhang Dingsheng Wang Lanqun Mao Yadong Li | 2019 | Science China Chemistry2019，62，12： | 1 |
| 10 | Mechanistic study of reduction of oxygen in air electrode with manganese oxides as electrocatalysts 显示文摘 | Mao Lanqun Zhang Dun Tadashi Sotomura | 2003 | Electrochimica Acta2003，48，： | 1 |
| 11 | Mechanistic study of the reduction of oxygen in air electrode with manganese oxides as electrocatalysts显示文摘 | Mao Lanqun Zhang Dun Tadashi Sotomura | 2003 | Electrochim Acta2003，48，8： | 1 |
| 12 | Mechanistic study of reduction of oxygen in air electrode with manganese oxides as electrocatalysts 显示文摘 | Mao Lanqun Zhang Dun Tadashi Sotomura | 2003 | Electrochimica Acta2003，48，： | 1 |
| 13 | Mechanis- tic study of the reducton of oxygen in air electrode with man- ganese oxides as electrocatalysts显示文摘 | Mao Lanqun Zhang Dun Tadashi Sotomura | 2003 | Electrochim Acta2003，48，8： | 1 |
| 14 | Enzyme-Catalyzed Activation of Pro-PROTAC for Cell-Selective Protein Degradation显示文摘Proteolysis targeting chimera(PROTAC)technology is a chemical protein knockdown approach that degrades protein by hijacking the cellular ubiquitinproteasome system to impede tumor growth.Its therapeutic potential,however,isdifficult to define due to the lack of control over the cell selectivity of PROTACs,in particular,if the therapeutic purpose is to be executedin a specific cell type.Herein,we report the design of a Pro-PROTAC and its catalytic activation of the endogenous overexpressed enzyme in cancer cells for cellselective protein degradation.We demonstrate that the chemical modification of the binding site between PROTAC and E3 ligase with trimethyl-locked quinone efficiently blocks the protein degradation capability of PROTAC.However,NAD(P)H quinone dehydrogenase 1(NQO1),an enzyme overexpressed in cancer cells,could reduce the trimethyl-locked quinone to remove the chemical modification and activate NQO1-PROTAC for cancer cell-selective protein degradation.Further,we show that NQO1-catalyzedβ-Lapachone reduction potentiated cellular oxidative stress to activate aryl boronic acid-caged ROS-PROTAC in living cells for bromodomain-containing protein 4 degradation with enhanced cell selectivity.Collectively,our strategy of designing Pro-PROTAC in response to endogenous species of diseased cells expands the chemical biology toolbox for cell-selective protein degradation and would be of great interest in targeted therapeutics discovery. | Chunjing Liang Qizhen Zheng Tianli Luo Weiqi Cai Lanqun Mao Ming Wang | 2022 | CCS Chemistry2022，4，12： | 1 |
| 15 | Electrocatalytic four-electron reduction of oxygen with Copper (II)-based metal-organic frameworks显示文摘 | Junjie Mao Lifen Yang Ping Yu Xianwen Wei Lanqun Mao | 2012 | Electrochemistry Communications2012，，： | 1 |
| 16 | Superoxide dismutase-based third-generation biosensor for superoxide anion显示文摘 | Yang T Lanqun M Takeyoshi O | 2002 | Anal Chem2002，74，10： | 1 |
| 17 | Mechanistic study of the reduction of oxygen in air electrode with manganese oxides as electrocatalysts显示文摘 | Mao Lanqun Zhang Dun Tadashi Sotomura | 2003 | Electrochimica Acta2003，48，8： | 1 |
| 18 | Surfactant functionlization of carbon nanotubes (CNTs) for layer - by - layer assembling of CNT multi - layer films and fabrication of gold nanoparticle/CNT nanohybrid显示文摘 | Zhang Meining Su Lei Mao Lanqun | 2006 | Carbon2006，44，： | 1 |
| 19 | Single-entity electrochemistry at confined sensing interfaces显示文摘Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes.Recent advances in the chemical measurement provide a means for ultra-sensitive analysis.Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity.In this review,we summarize the recent progress in single-entity electrochemistry of single molecules,single particles,single cells and even brain analysis.The benefits of confining these entities to a compatible size sensing interface are exemplified.Finally,the opportunities and challenges of single entity electrochemistry are addressed. | Yi-Lun Ying Jiajun Wang Anna Rose Leach Ying Jiang Rui Gao Cong Xu Martin A.Edwards Andrew D.Pendergast Hang Ren Connor K.Terry Weatherly Wei Wang Paolo Actis Lanqun Mao Henry S.White Yi-Tao Long | 2020 | Science China Chemistry2020，63，5： | 0 |
| 20 | Fluidic memristor:Bringing chemistry to neuromorphic devices显示文摘Neuromorphic devices,devices with resistance switch dynamic emulating the behavior of neurons,are experiencing a surge in development due to the demand for artificial intelligence and therapeutic devices such as neuroprosthetics.1 Toward reproducing the behaviors of neurons with artificial devices,neuromorphic devices based on two-terminalmemristors(devices with a single-valued relationship between charge Q and magnetic flux 4,i.e.,d4=MdQ)with various mechanisms(e.g.,redox,phase change,magnetic tunnelling,and ferroelectricity)have been developed for various applications,like in-memory computing or intelligent sensing.2 However,the performances and functions of these devices still lag behind those of real neurons.For example,biological neurons are strongly responsible for chemical changes in electrolyte solutions induced by transmitters and regulators,while most neuromorphic devices only show responses to the stimulations of electrical signals.Detecting and responding to these chemical signals could not only improve the performances of neuromorphic computing but also offer brand-new functions in brain-computer interfaces.However,the fabrication of neuromorphic devices responsible for chemical information remains a great problem since the founding of the memristor. | Tianyi Xiong Weiqi Li Ping Yu Lanqun Mao | 2023 | The Innovation2023，4，3： | 0 |
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