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19篇 您的检索式:作者名="Lanz G"
    题名 作者 年代 出处 被引量
1An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley 2014Cell Research2014,24,7:10
2Photocatalytic oxidation of water to O2 on AgCl-coated electrodes显示文摘Lanz M Schürch D Calzaferri G 1999Journal of Photochemistry and Photobiology A:Chemistry1999,120,2:1
3The γ-secretase inhibitor N--S-pbenylglycine t-butyl ester reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young ( plaque-free ) and aged ( plaque-bearing ) Tg2576 mice 显示文摘LANZ T A HIMES C S PALLANTE G 2003J Pharmacol Exp Ther2003,305,3:1
4Photocatalytic oxidation of water to O2 on AgCl-coated electrodes显示文摘 Calzaferri G 1997Journal of Photochemistry and Photobiology (A:Chemistry)1997,109,:1
5Epidural buprenorphine-a double-blind study of postoperative analgesia and side effects显示文摘Lanz E Simko G Theiss D 1984Anesth Analg1984,63,6:1
6Cooperative interaction of hypoxia inducible factor-2ct (hif-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 ( Flk-1 )显示文摘Elvert G Kappel A Heidenreieh R Englmeier U Lanz S Acker T 2003J Biol Chem2003,278,9:1
7An ultra-high speed emulator dedicated to power system dynamics computa- tion based on a mixed-signal hardware plafform显示文摘Fabre L Lanz G Kyriakidis T 2013IEEE Transactions on Power Systems2013,28,4:1
8Epidural buprenorphine-a double-blind study of postoperative analgesia and side effects显示文摘LANZ E SIMKO G THEISS D 1984Anesth Analg1984,63,6:1
9Differential regulation of genes for resveratrel synthase in cell -cultures of Arachis hypogaea 显示文摘Lanz T Sehroder G Schroder J 1990Planta1990,181,2:1
10mRNA cloning and expression studies of the quail homologue of HIF- 2α 显示文摘ELVERT G LANZ S KAPPEL A 1999Mechanisms of Development1999,87,:1
11A Comparisonof Methods Used for the Identification of Flutter from Experimental Data显示文摘Ghiringhell L G Lanz M Mantegazza P 1987J of Sound and Vibration1987,119,1:1
12Epidural buprenorphine-a double-blind study of postoperative analgesia and side effects显示文摘Lanz E Simko G Theiss D 1984Anesth Analg1984,63,6:1
13mRNA cloning and expression studies of the quail homologue of HIF-2 alpha显示文摘Elert G Lanz S Kappel A 1999Mech Dev1999,87,:1
14mRNA cloning and expression studies of the quail homologue of HIF-2α显示文摘ELVERT G LANZ S KAPPEL A 1999Mechanisms of Development1999,87,12:1
15Differential regulation of genes for resveratrol synthase in cell cultures of Arachis hypogaea L显示文摘Lanz T Schroder G Schroder J 1990Planta1990,181,:1
16A super early my- ocardial infarction marker Human heart-type fatty acid- binding protein显示文摘Chan CP Sanderson JE G lanz JF 2004Z Karcliol2004,93,5:1
17A comparison of methods used for the identification of flutter from experimental data显示文摘Ghiringhell L G Lanz M Mantegazza P 1987Journal of Sound and Vibration1987,119,1:1
18Differential regulation of genes for resveratrol synthase in cell cultures of Arachis hypogaea L显示文摘Lanz T Schroder G Schroder J 1990Planta1990,181,:1
19A study on carbon dioxide emission in developing countries显示文摘GALEOTTI M LANZE A RICHER G 1999Energy Policy1999,,10:1
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