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您的检索式：作者名="Laura Finch"
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| 1 | Enhancing the dissolution of phenylbutazone using Syloid based mesoporous silicas for oral equine applications显示文摘Three mesoporous silica excipients(Syloid? silicass AL-1 FP, XDP 3050 and XDP 3150) were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been investigated in previous studies, the effect of inclusion with these specific Syloid? silicas based excipients and more interestingly, with phenylbutazone, is unknown. This work reports a significant enhancement for both the extent and rate of drug release for all three forms of Syloid? silicas at a 1:1 drug:silica ratio over a period of 30 min. An explanation for this increase was determined to be conversion to the amorphous form and an enhanced drug loading ability within the pores. Differences between the release profiles of the three silicas were concluded to be a consequence of the physicochemical differences between the three forms. Overall, this study confirms that Syloid? silicas based excipients can be used to enhance dissolution, and potentially therefore bioavailability, for compounds with poor aqueous solubility such as phenylbutazone. In addition, it has been confirmed that drug release can be carefully tailored based on the choice of Syloid? silicas and desired release profile. | Laura J. Waters John P. Hanrahan Joseph M. Tobin Catherine V. Finch Gareth M.B. Parkes Shamsuddeen A. Ahmad Faraj Mohammad Maria Saleem | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 1 |
| 2 | 大学篮球运动中精神韧性与表现之间的调节变量关系(英文)显示文摘目的:探讨心理坚韧性与大学篮球队员的表现之间的关系,特别关注可能的调节变量(性别与先发状况)。方法大学男女篮球运动员(n=197)完成心理表现问卷——修订版(PPI-A——测量符合心理坚韧性的特性和技能)和PERF(客观测量篮球表现)。结果:心理坚韧性与先发状况状态能部分预测篮球表现。男队员的心理坚韧性大于女队员。先发球员与非先发球员在心理坚韧性方面无差异。调节分层回归分析显示对男队员的表现而言,心理坚韧性既受先发状况影响,也与其相互作用。而女队员则相反,只有先发状况能显著预测队员的表现。应鼓励篮球教练在女队员和非先发队员中培养与心理坚韧性相关的心理学技能。结论:本文对PPI-A作为心理坚韧性测量方式进行了探讨并提出改进建议。由于提高运动员表现是心理坚韧性研究的一项巨大推动力,今后需要进一步研究心理坚韧性及其客观表现。 | Aubrey Newland Maria Newton Laura Finch Colin R.Harbke Leslie Podlog | 2013 | Journal of Sport and Health Science2013，2，3： | 0 |
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