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| 1 | Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment显示文摘AIM: To investigate the association of hepatitis B virus (HBV) genotype and HBeAg seroconversion after nucleotide analogue treatment.METHODS: Chronic hepatitis B patients receiving lamivudine followed up for at least 6 months post-treatment were studied. Consecutive treatment-naive patients who were prospectively followed up in the clinic for at least 18 months were studied as controls. HBeAg seroconversion was defined as loss of HBeAg, appearance of anti-HBe and normalization of alanine aminotransferase for at least 6 months.RESULTS: Thirty-five patients on lamivudine and 96 control patients followed up for 39 (18-49) months were studied.Lamivudine was given for 12 (10-18) months, and patients were followed up for 15 (6-34) months after drug cessation.Genotype B and C HBV were found in 43 and 88 patients and HBeAg seroconversion occurred in 12 (28 %) and 16(18 %) patients, respectively (P=0.30). There was no difference in HBeAg seroconversion between patients infected by genotype B and C HBV in the control (35 % vs 21%, P=0.25) and lamivudine-treated (14 % vs 10 %,P=1.00) groups.CONCLUSION: HBeAg seroconversion after treatment by lamivudine was not influenced by the HBV genotype. | Henry Lik-Yuen Chan May-Ling Wong Alex Yui Hui Angel Mei-Ling Chim Ada Mei-Ling Tse Lawrence Cheung-Tsui Hung Francis Ka-Leung Chan Joseph Jao-Yiu Sung | 2003 | World Journal of Gastroenterology2003，9，12： | 21 |
| 2 | A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer显示文摘 | Edward J. Kim Edgar Ben‐Josef Joseph M. Herman Tanios Bekaii‐Saab Laura A. Dawson Kent A. Griffith Isaac R. Francis Joel K. Greenson Diane M. Simeone Theodore S. Lawrence Daniel Laheru Christopher L. Wolfgang Terence Williams Mark Bloomston Malcolm J. Moo | 2013 | Cancer2013，，15： | 3 |
| 3 | The Use of Negative-Pressure Wound Therapy (NPWT) in the Temporary Treatment of Soft-Tissue Injuries Associated With High-Energy Open Tibial Shaft Fractures显示文摘 | Barnaby T Dedmond Bill Kortesis Kathleen Punger Jordan Simpson Joseph Argenta Brenda Kulp Michael Morykwas Lawrence X Webb | 2007 | Journal of Orthopaedic Trauma2007，，1： | 2 |
| 4 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 5 | EMR for Barrett’s esophagus–related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy 显示文摘 | Mari Mino-Kenudson Mindy J. Hull Ian Brown Alona Muzikansky Amitabh Srivastava Jonathan Glickman Do-Youn Park Lawrence Zuckerberg Joseph Misdraji Robert D. Odze Gregory Y. Lauwers | 2007 | Gastrointestinal Endoscopy2007，，： | 2 |
| 6 | Split-dose administration of a dual-action, low-volume bowel cleanser for colonoscopy: the SEE CLEAR I study显示文摘 | Douglas K. Rex Philip O. Katz Gerald Bertiger Stephen Vanner Lawrence C. Hookey Vivian Alderfer Raymond E. Joseph | 2013 | Gastrointestinal Endoscopy2013，，1： | 2 |
| 7 | Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases显示文摘 | Aric J Hui Ronald M.Y Wong Jessica Y.L Ching Lawrence C.T Hung S.C Sydney Chung Joseph J.Y Sung | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 8 | AGA Institute Review of Endoscopic Sedation显示文摘 | Lawrence B. Cohen Mark H. DeLegge James Aisenberg Joel V. Brill John M. Inadomi Michael L. Kochman Joseph D. Piorkowski | 2007 | Gastroenterology2007，，2： | 2 |
| 9 | Follow up of serial urea breath test results in patients after consumption of antibiotics for non-gastric infections显示文摘AIM: The widespread use of antibacterial therapy hasbeen suggested to be the cause for the decline in theprevalence of Helicobacter pyloriinfection. This studyexamine the serial changes of urea breath test resultsin a group of hospitalized patients who were givenantibacterial therapy for non-gastric infections.METHODS: Thirty-five hospitalized patients who weregiven antibacterial therapy for clinical infections,predominantly chest and urinary infections, werestudied. Most (91%) patients were given singleantibiotic of either a penicillin or cephalosporin group.Serial 13C-urea breath tests were performed within 24hours of initiation of antibiotics, at one-week and atsix-week post-therapy. H. pylori infection wasdiagnosed when one or more urea breath tests waspositive.RESULTS: All 35 patients completed three serial ureabreath tests and 26 (74 %) were H. pylori-positive. Ten(38 %) H. pylori-infected patients had at least onenegative breath test results during the study period.The medium delta 13C values were significantly lowerat baseline (8.8) than at one-week (20.3) and six-week(24.5) post-treatment in H. pylori-positive individuals(P=0.022). Clearance of H. pyloriat six-week was onlyseen in one patient who had received anti-helicobactertherapy from another source.CONCLUSION: Our results suggested that one-third ofH. pylori-infected individuals had transient false-negative urea breath test results during treatment withantibacterial agent. However, clearance of H. pyloriinfection by regular antibiotic consumption is rare. | Wai-Keung Leung Lawrence Cheung-Tsui Hung Carrie Ka-Li Kwok Rupert Wing-Loong Leong Daniel Kwok-Keung Ng Joseph Jao-Yiu Sung | 2002 | World Journal of Gastroenterology2002，8，4： | 2 |
| 10 | Aluminm alloy 2519 in military vehicles显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
| 11 | Aluminum alloy 2519 in military vehicles显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
| 12 | Use of Normal Tissue Complication Probability Models in the Clinic显示文摘 | Lawrence B. Marks Ellen D. Yorke Andrew Jackson Randall K. Ten Haken Louis S. Constine Avraham Eisbruch S?ren M. Bentzen Jiho Nam Joseph O. Deasy | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 13 | Posttraumatic Osteoarthritis: A First Estimate of Incidence, Prevalence, and Burden of Disease显示文摘 | Thomas D Brown Richard C Johnston Charles L Saltzman J Lawrence Marsh Joseph A Buckwalter | 2006 | Journal of Orthopaedic Trauma2006，，10： | 1 |
| 14 | Fatigue in Parkinson’s disease显示文摘 | Joseph H Friedman Ana Abrantes Lawrence H Sweet | 2011 | Expert Opinion on Pharmacotherapy2011，，13： | 1 |
| 15 | 玫瑰茄提取物对Wistar大鼠肾Na^+-K^+-ATP酶及Ca^(2+)-Mg^(2+)-ATP酶活性的影响(英文)显示文摘目的:研究口服玫瑰茄水提取物对大鼠肾 Na+-K+-ATP酶和Ca2+ -Mg2+-ATP酶活性的影响。方法:连续28d分别给予实验大鼠口服25和50mg/kg的玫瑰茄水提物,同时给予对照组大鼠灌胃适当剂量的蒸馏水。用光谱测定法分析大鼠肾脏中 Na+-K+-ATP酶和Ca2+-Mg2+-ATP酶的活性。结果:口服25和50mg/kg的玫瑰茄提取物后,实验组大鼠肾Ca2+-Mg2+-ATP酶活性显著降低(P<0.05),然而肾 Na+-K+-ATP酶的活性却未受到任何影响。实验组大鼠体质量、肾脏质量,血浆白蛋白和总蛋白浓度,碱性磷酸酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶活性以及血浆钠、钾、钙离子的浓度与对照组大鼠相比无明显变化;但大鼠的肌酐以及尿素水平均在服用50mg/kg的玫瑰茄提取物后明显降低(P<0.05)。结论:尽管口服玫瑰茄提取物会引起肾 Ca2+-Mg2+-ATP酶活性的减弱,但同时可以起到保护肾脏功能的作用。 | Lawrence A.Olatunji Taofeek O.Usman Joseph O.Adebayo Victoria A.Olatunji | 2012 | 中西医结合学报2012，10，9： | 1 |
| 16 | The Usefulness of Routine Small Bowel Biopsies in Evaluation of Iron Deficiency Anemia显示文摘 | Scott W Grisolano Amy S Oxentenko Joseph A Murray Lawrence J Burgart Ross A Dierkhising Jeffrey A Alexander | 2004 | Journal of Clinical Gastroenterology2004，，9： | 1 |
| 17 | Aluminum alloy 2519 in military vehicles显示文摘 | James J F Jr Lawrence S K Joseph R P | 2002 | Advanced Materials and Processing2002，160，9： | 1 |
| 18 | 农业健康研究中阳光暴露、维生素D受体基因变异与乳腺癌风险显示文摘[背景]流行病学证据表明,阳光暴露与乳腺癌风险之间存在负性相关。假设其机制是阳光诱导皮肤合成维生素D。[目的]探讨阳光暴露及其与维生素D受体(VDR)基因变异的交互作用对乳腺癌风险的影响。[方法]在前瞻性农业健康研究队列的入组人群中,研究31 021位持有私人执照的杀虫剂从业人员的妻子受到的阳光暴露与乳腺癌发病率,其中包括578个病例,平均随访8.6年。在一项由293名病例和586名匹配对照组成的巢式病例-对照研究中,评估阳光暴露、VDR变异体与乳腺癌之间的交互作用。有关阳光暴露的信息来自于队列入组时的问卷调查。对队列数据采用Cox比例风险回归估计相对风险,对巢式病例-对照数据采用条件logistic回归估计相对风险。[结果]在所有参与者中,患乳腺癌风险的小幅度下降与随访前10年中平时阳光暴露≥1 h/d相关(与<1 h/d相比)[风险比(HR)=0.8;95%CI:0.6~1.0]。这一相关性在雌激素受体阳性肿瘤(HR=0.7;95%CI:0.5~0.9)中比雌激素受体阴性肿瘤(HR=1.1;95%CI:0.6~2.1)中稍强。阳光暴露≥1 h/d和一个VDR单倍型的联合HR低于预期,因为单一暴露的HR为负值(交互作用,P=0.07)。[结论]上述研究结果提示,阳光暴露可能与乳腺癌风险降低相关,但是研究中并没有发现通过VDR变异体修饰的明确证据。需要进行更大规模的研究,特别是平时阳光暴露水平低的人群中可能能够更精确描述。 | Lawrence S.Engel Jaya Satagopan Camelia S.Sima Irene Orlow Urvi Mujumdar Joseph Coble Pampa Roy Sarah Yoo Dale P.Sandler Michael C.Alavanja | 2014 | 环境与职业医学2014，31，5： | 1 |
| 19 | Aluminum alloy 2519 in military vehicles显示文摘 | JAMES J F LAWRENCE S K JOSEPH R P | 2002 | Advanced Materials and Processing2002，160，9： | 1 |
| 20 | Aluminum alloy 2519 in military vehicles 显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
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