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| 1 | Plant ABC Transporters Enable Many Unique Aspects of a Terrestrial Plant's Lifestyle显示文摘陆上的植物有更多的 ATP 有约束力的盒子(ABC ) 二~四次 transporter 基因比另外的有机体,包括他们的祖先的 microalgae。最近的研究发现在这些 transporters 怀有变化的植物展出戏剧的显型,许多哪个与发展过程和为干燥土地上的生活必要的功能有关。这些结果建议在进化期间乘并且假定允许植物适应陆上的环境条件的新奇功能的那 ABC transporters。从这个观点在植物 ABC transporters 上检验文学导致了我们建议多样的 ABC transporters 启用了陆上的植物的生活方式的许多唯一、必要的方面,由搬运越过植物的特定的膜的各种各样的混合物。 | Jae-Ung Hwang Won-Yong Song Daewoong Hong Donghwi Ko Yasuyo Yamaoka Sunghoon Jang Sojeong Yim Eunjung Lee Deepa Khare Kyungyoon Kim Michael Palmgren Hwan Su Yoon Enrico Martinoia Youngsook Lee | 2016 | Molecular Plant2016，9，3： | 20 |
| 2 | Helicobacter pylori and interleukin-8 in gastric cancer显示文摘Helicobacter pylori(H.pylori)is a major etiological factor in the development of gastric cancer.Large-scale epidemiological studies have confirmed the strong association between H.pylori infection and both cancer development and progression.Interleukin-8(IL-8)is overexpressed in gastric mucosa exposed to H.pylori.The expression of IL-8 directly correlates with a poor prognosis in gastric cancer.IL-8 is multifunctional.In addition to its potent chemotactic activity,it can induce proliferation and migration of cancer cells.In this review,we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer.The relationship between IL-8 and H.pylori is discussed.We also summarize the current therapeutics against IL-8 in gastric cancer. | Ko Eun Lee Pham Ngoc Khoi Yong Xia Jung Sun Park Young Eun Joo Kyung Keun Kim Seok Yong Choi Young Do Jung | 2013 | World Journal of Gastroenterology2013，19，45： | 15 |
| 3 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 4 | 土壤和白菜中低分子量有机酸的气相色谱分析显示文摘利用甲醇-硫酸混合液(体积比10∶7)对土壤和白菜中低分子量有机酸同时进行提取和甲酯化衍生,然后利用二氯甲烷液-液萃取,气相色谱法分析。土壤中7种低分子量有机酸(草酸、丙二酸、反丁烯二酸、琥珀酸、马来酸、L-苹果酸、柠檬酸)的添加回收率为81.93%~95.58%,白菜中的添加回收率为84.78%~106.99%,方法的检出限为0.72~4.14 mg/kg。方法用于测定根际、非根际土壤和白菜根系、茎叶中的低分子量有机酸,结果准确可靠。 | 谢文明 KO Kwang-yong LEE Kyu-seung | 2009 | 岩矿测试2009，28，2： | 13 |
| 5 | Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease显示文摘AIM: To determine whether Helicobacter pylori(H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease(NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to 13 C urea breath tests. NAFLD was defined using the hepatic steatosis index(HSI) and NAFLD liver fat score(NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS >-0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for NAFLD.RESULTS: Three thousand six hundred and sixtythree people were analyzed and 1636(44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects(median 33.2, interquartile range(IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median-1.7, IQR-2.4--0.7 vs median-1.8, IQR-2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differbetween infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for NAFLD.CONCLUSION: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered. | Myong Ki Baeg Seung Kew Yoon Sun-Hye Ko Yong-Sun Noh In-Seok Lee Myung-Gyu Choi | 2016 | World Journal of Gastroenterology2016，22，8： | 12 |
| 6 | Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery显示文摘BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cH CC-CC) is a rare subtype of primary liver cancer consisting of both hepatocellular carcinoma (HCC)and cholangiocarcinoma (CC). Because of the rarity of this tumor its feature is poorly understood. The present study aimed to evaluate the clinicopathological features and long-term prognosis of patients with cH CC-CC after surgery and to compare with those of the patients with stage-matched HCC and CC.METHODS: The clinicopathological features of the patients who underwent surgery for cH CC-CC at our center during the period of 2001-2010 were retrospectively analyzed and compared with those of stage-matched HCC and CC patients Cancer staging was performed according to the AJCC Cancer Staging Manual (6th ed.). Overall survival and disease-free survival were compared among the groups and prognostic factors of cH CC-CC were evaluated.RESULTS: Significant differences were observed in clinico pathological features among 42 patients with cH CC-CC, 90patients with HCC and 45 patients with CC. Similar to HCC patients, cH CC-CC patients had frequent hepatitis B virus antigen positivity, microscopic vessel invasion, cirrhosis and high level of serum alpha-fetoprotein. Similar to CC patients, cH CC-CC patients showed increased bile duct invasion and decreased capsule. The 1-, 3-, and 5-year overall survival and disease free survival of patients with cH CC-CC were not significantly different from those with stage-matched patients with CC;but significantly poorer than those with HCC. In subanalysis of patients with stage II, the overall survival in patients with cH CC-CC or CC was significantly poorer than that in patients , with HCC. We did not find the difference in patients with other stages. Univariate analysis of overall and disease-free survival of patients with cH CC-CC showed that the vascular invasion and intrahepatic metastasis were the significant predictive factors.CONCLUSION: Patients with cH CC-CC showed similar clinico- pathological features as those with HCC or CC, and patients with cH CC-CC or CC had a poorer prognosis compared with those with HCC, especially at matched stage II.. | Seung Duk Lee Sang-Jae Park Sung-Sik Han Seong Hoon Kim Young-Kyu Kim Soon-Ae Lee Young Hwan Ko Eun Kyung Hong | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 11 |
| 7 | Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma显示文摘Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE alone.The present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall survival.Methods:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November 2017.Patients were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control groups.The baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were analyzed.Results:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well tolerated.The TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both P<0.001).Conclusions:Sequential TACE and PVE prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic resection.The active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression. | Gil Chun Park Sung Gyu Lee Young In Yoon Kyu Bo Sung Gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 9 |
| 8 | Wetting Characteristics of Insect Wing Surfaces显示文摘Biological tiny structures have been observed on many kinds of surfaces such as lotus leaves,which have an effect on thecoloration of Morpho butterflies and enhance the hydrophobicity of natural surfaces.We investigated the micro-scale andnano-scale structures on the wing surfaces of insects and found that the hierarchical multiple roughness structures help in enhancingthe hydrophobicity.After examining 10 orders and 24 species of flying Pterygotan insects,we found that micro-scaleand nano-scale structures typically exist on both the upper and lower wing surfaces of flying insects.The tiny structures such asdenticle or setae on the insect wings enhance the hydrophobicity,thereby enabling the wings to be cleaned more easily.And thehydrophobic insect wings undergo a transition from Cassie to Wenzel states at pitch/size ratio of about 20.In order to examinethe wetting characteristics on a rough surface,a biomimetic surface with micro-scale pillars is fabricated on a silicon wafer,which exhibits the same behavior as the insect wing,with the Cassie-Wenzel transition occurring consistently around apitch/width value of 20. | Doyoung Byun Jongin Hong Saputra Jin Hwan Ko Young Jong Lee Hoon Cheol Park Bong-Kyu Byun Jennifer R.Lukes | 2009 | Journal of Bionic Engineering2009，6，1： | 9 |
| 9 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 10 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 11 | Survival analysis following early surgical success in intermittent exotropia surgery显示文摘AIM:To assess the consecutive recurrence following early success of intermittent exotropia surgery and to determine the clinical factors that affect the survival.METHODS:One hundred and thirty-five patients who underwent intermittent exotropia surgery and experienced early surgical success[≤5 prism diopters(PD)esophoria(E)to≤10 PD exophoria(X)on the postoperative sixth month]were enrolled in this study.Their consecutive survival on the postoperative first year,second year and third year and at the last visit of fourth year or more,and the factors that might affect their survival,were analyzed.The final surgical outcomes after the postoperative fourth year were also investigated by dividing the patients into the success group(≤5 PD E to≤10 PD X)and the failure group(>5 PD esodeviation or>10 PD exodeviation)RESULTS:The survival rates from the Kaplan-Meier analysis were 97.78%,92.89%,83.70%and 50.49%on the postoperative first,second and third years and fourth year or more,respectively.None of the clinical factors was determined to have affected the survival.The amount of the exodrift was largest(2.29 PD)between the first year and the second year,and smallest(1.47 PD)between the fourth year and the last visit.Sixty-three patients had their final visit after the postoperative fourth year,and 29 of them were in the failure group.Twentyfive patients in the failure group had an intermittent exotropia(IXT)of<20 PD with good to fair distant fusion;two had an IXT of<20 PD with poor distant fusion;one had an IXT of≥20 PD with fair distant fusion;and another had delayed-onset consecutive esotropia.The exodeviation on the postoperative sixth month was smaller in the success group than in the failure group(2.81 PD vs 5.86 PD,P=0.012).The reoperation rate for recurrent IXT was 3.7%.CONCLUSION:The survival rate steadily decreases with the exodrift,but the amount of the exodrift decreases with long-term follow-up.The final outcomes demonstrate favorable results via surgical success or small-angle IXT with good fusion in most of the patients.A smaller deviation on the postoperative sixth month is associated with long-term survival. | Joo Yeon Lee Sung Ju Ko Sung Uk Baek | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 8 |
| 12 | A novel synthetic compound MCAP suppresses LPS- induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways显示文摘目的:调查新奇合成混合物的 anti-neuroinflammatory 活动,对在 vitro.Methods 的 导致LPS 的 microglial 激活的 7-methylchroman-2-carboxylic 酸N-( 2-trifluoromethyl ) phenylamide ( MCAP ):主要老鼠 microglia 和 BV2 microglia 房间暴露于 LPS ( 50 或 100 ng/mL )。iNOS 和 COX-2 的表示, proinflammatory cytokines, NF-κ B 和 p38 MAPK 发信号分子被 RT-PCR,西方的污点和 ELISA 分析。microglia 的词法变化和 NF-ĸ 的原子 translocation; B 用阶段对比和荧光显微镜学被设想, respectively.Results : 有 MCAP 的预告的处理(0.1, 1, 10 μ mol/L ) 在 BV2 microglia 房间的 iNOS 和 COX-2 的 dose-dependently 禁止的导致 LPS 的表示。类似的结果与 MCAP 在主要 microglia pretreated 被获得(0.1, 0.5 μ mol/L ) 。MCAP dose-dependently 消除了 TNF-α 的导致 LPS 的版本;, IL-6 和 IL-1β,并且 NF-κ 的减轻的导致 LPS 的激活;由减少 Iκ 的 phosphorylation 的 B; Bα在 BV2 microglia 房间。而且, MCAP 稀释了 p38 MAPK 的 导致LPS 的 phosphorylation SB203580 ,一个 p38 MAPK 禁止者, MEF-2 ( p38 MAPK 下游的一个抄写因素)的表示上的显著地加强的 引起MCAP 的抑制 .Conclusion : MCAP 由禁止 p38 MAPK 和 NF-κ 在 vitro 在鼠科的 microglia 施加反煽动性的效果; B 发信号小径和 proinflammatory 回答。MCAP 可以为治疗包含激活的 microglial 房间的疾病作为一个新奇代理人被开发。 | Byung-Wook KIM Sandeep Vasant MORE Yo-Sep YUN Hyun-Myung KO Jae-Hwan KWAK Heesoon LEE Kyoungho SUK In-Su KIM Dong-Kug CHOI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 8 |
| 13 | Evaluation of anatomical considerations in the posterior maxillae for sinus augmentation显示文摘The edentulous posterior maxilla is considered a clinical challenge during dental implant treatment for many dental practitioners. This is because its insufficient bone quality, deficient alveolar ridge, spiny ridges, undercuts, and sinus pneumatization are often encountered after tooth loss. To overcome these problems, several approaches have been developed and are currently used, including sinus augmentation and bone augmentation. Today, two main procedures of sinus floor elevation for dental implant placement are in use: a two-stage technique using the lateral window approach, and a onestage technique using a lateral or a crestal approach. In this study, we deal with the anatomic relations ofthe structures of the maxillary sinus during sinus augmentation. These anatomical findings can help in complications and potential injuries of the maxillary sinus procedures. It can be suggested that pre-operative evaluation is helpful for diagnosis and treatment planning and minimizing complication during the surgery. | Ji-Eun Lee Seong-Ho Jin Youngkyung Ko Jun-Beom Park | 2014 | World Journal of Clinical Cases2014，2，11： | 7 |
| 14 | Effects of ozonation and coagulation on effluent organic matter characteristics and ultrafiltration membrane fouling显示文摘Effluent organic matter(EfOM) is the major cause of fouling in the low pressure membranes process for wastewater reuse. Coagulation and oxidation of biological wastewater treatment effluent have been applied for the fouling control of microfiltration membranes. However, the change in EfOM structure by pre-treatments has not been clearly identified. The changes of EfOM characteristics induced by coagulation and ozonation were investigated through size exclusion chromatography,UV/Vis spectrophotometry, fluorescence spectrophotometry and titrimetric analysis to identify the mechanisms in the reduction of ultrafiltration(UF) membrane fouling. The results indicated that reduction of flux decline by coagulation was due to modified characteristics of dissolved organic carbon(DOC) content. Total concentration of DOC was not reduced by ozonation. However, the mass fraction of the molecules with molecular weight larger than 5 kDa, fluorescence intensity,aromaticity, highly condensed chromophores, average molecular weight and soluble microbial byproducts decreased greatly after ozonation. These results indicated that EfOM was partially oxidized by ozonation to low molecular weight, highly charged compounds with abundant electronwithdrawing functional groups, which are favourable for alleviating UF membrane flux decline. | Kwon Jeong Dae-Sung Lee Do-Gun Kim Seok-Oh Ko | 2014 | Journal of Environmental Sciences2014，26，6： | 7 |
| 15 | Intraluminal versus infiltrating gallbladder carcinoma:Clinical presentation,ultrasound and computed tomography显示文摘AIM: To compare clinical presentation and ultrasound (US) and computed tomography (CT) sensitivity between intraluminal and inf iltrating gallbladder carcinoma (GBCA). METHODS: This retrospective study evaluated 65 cases of GBCA that were categorized morphologically into the intraluminal-GBCA (n = 37) and infiltrating-GBCA(n = 28) groups. The clinical and laboratory fi ndings, presence of gallstones, gallbladder size, T-staging, nodal status, sensitivity of preoperative US and CT studies, and outcome were compared between the two groups.RESULTS: There were no signif icant differences between the two groups with respect to female predominance, presence of abdominal pain, serum aminotransferases level, T2-T4 staging, and regional metastatic nodes. Compared with the patients with intraluminal-GBCA, those with infiltrating-GBCA were significantly older (65.49 ± 1.51 years vs 73.07 ± 1.90 years), had a higher frequency of jaundice (3/37 patients vs 13/28 patients) and fever (3/37 patients vs 10/28 patients), higher alkaline phosphatase (119.36 ± 87.80 IU/L vs 220.68 ± 164.84 IU/L) and total bilirubin (1.74 ± 2.87 mg/L vs 3.50 ± 3.51 mg/L) levels, higher frequency of gallstones (12/37 patients vs 22/28 patients), smaller gallbladder size (length, 7.47 ± 1.70 cm vs 6.47 ± 1.83 cm; width, 4.21 ± 1.43 cm vs 2.67 ± 0.93 cm), and greater proportion of patients with < 12 mo survival (16/37 patients vs 18/28 patients). The sensitivity for diagnosing intraluminal-GBCA with and without gallstones was 63.6% and 91.3% by US, and 80% and 100% by CT, respectively. The sensitivity for diagnosing inf iltrating-GBCA with and without gallstones was 12.5% and 25% by US, and 71.4% and 75% by CT, respectively. CONCLUSION: In elderly women exhibiting small gallbladder and gallstones on US, especially those with jaundice, fever, high alkaline phosphatase and bilirubin levels, CT may reveal concurrent infi ltrating-GBCA. | Tze-Yu Lee Sheung-Fat Ko Chung-Cheng Huang Shu-Hang Ng Jiun-Lung Liang Hsuan-Ying Huang Min-Chi Chen Shyr-Ming Sheen-Chen | 2009 | World Journal of Gastroenterology2009，15，45： | 7 |
| 16 | Identifying Pb-free perovskites for solar cells by machine learning显示文摘Recent advances in computing power have enabled the generation of large datasets for materials,enabling data-driven approaches to problem-solving in materials science,including materials discovery.Machine learning is a primary tool for manipulating such large datasets,predicting unknown material properties and uncovering relationships between structure and property.Among state-of-the-art machine learning algorithms,gradient-boosted regression trees(GBRT)are known to provide highly accurate predictions,as well as interpretable analysis based on the importance of features.Here,in a search for lead-free perovskites for use in solar cells,we applied the GBRT algorithm to a dataset of electronic structures for candidate halide double perovskites to predict heat of formation and bandgap.Statistical analysis of the selected features identifies design guidelines for the discovery of new lead-free perovskites. | Jino Im Seongwon Lee Tae-Wook Ko Hyun Woo Kim YunKyong Hyon Hyunju Chang | 2019 | npj Computational Materials2019，，1： | 6 |
| 17 | Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells显示文摘AIM:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells.METHODS:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC function.The mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow cytometry.In addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,respectively.To confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic acid.The protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed tissue.RESULTS:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-L),MHCII and cyclooxygenase(COX)-2.Cinnamon extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(IL)-1β,IL-6,IL-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(IL-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into IL-10high CD4+ T cells.Furthermore,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokines(IL-1β,IFN-γ and TNF-α),while enhancing IL-10 levels.CONCLUSION:Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells. | Ho-Keun Kwon Ji-Sun Hwang Choong-Gu Lee Jae-Seon So Anupama Sahoo Chang-Rok Im Won Kyung Jeon Byoung Seob Ko Sung Haeng Lee Zee Yong Park Sin-Hyeog Im | 2011 | World Journal of Gastroenterology2011，17，8： | 6 |
| 18 | Impact of body mass index and gender on quality of life in patients with gastroesophageal reflux disease显示文摘AIM:To investigate the symptom presentation and quality of life in obese Chinese patients with gastroesophageal reflux disease(GERD).METHODS:Data from patients diagnosed with GERD according to the Montreal definition,were collected between January 2009 to March 2010.The enrolled patients were assigned to the normal [body mass index(BMI) < 25 kg/m 2 ],overweight(25-30 kg/m 2),and obese(BMI > 30 kg/m 2) groups.General demographic data,endoscopic findings,and quality of life of the three groups of patients were analyzed and compared.RESULTS:Among the 173 enrolled patients,102,56 and 15 patients were classified in the normal,overweight,and obese,respectively.There was significantly more erosive esophagitis(73.3% vs 64.3% vs 39.2%,P = 0.002),hiatal hernia(60% vs 33.9% vs 16.7%,P = 0.001),and males(73.3% vs 73.2% vs 32.4%,P = 0.001) in the obese cases.The severity and frequency of heartburn,not acid regurgitation,was positively correlated with BMI,with a significant association in men,but not in women.Obese patients were prone to have low quality of life scores,with obese women having the lowest scores for mental health.CONCLUSION:In patients with GERD,obese men had the most severe endoscopic and clinical presentation.Obese women had the poorest mental health. | Shou-Wu Lee Han-Chung Lien Chi-Sen Chang Yen-Chun Peng Chung-Wang Ko Ming-Chih Chou | 2012 | World Journal of Gastroenterology2012，18，36： | 5 |
| 19 | Anxiety and depression propensities in patients with acute toxic liver injury显示文摘AIM:To investigate anxiety and depression propensities in patients with toxic liver injury.METHODS:The subjects were divided into three groups:a healthy control group(Group 1,n=125),an acute non-toxic liver injury group(Group 2,n=124),and a group with acute toxic liver injury group caused by noncommercial herbal preparations(Group 3,n=126).These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale(HADS),Beck Anxiety Inventory(BAI),Beck Depression Inventory(BDI),and the hypochondriasis scale.RESULTS:The HADS anxiety subscale was 4.9±2.7,5.0±3.0 and 5.6±3.4,in Groups 1,2,and 3,respectively.The HADS depression subscale in Group 3 showed the most significant score(5.2±3.2,6.4±3.4 and 7.2±3.4in Groups 1,2,and 3,respectively)(P<0.01 vs Group 1,P<0.05 vs Group 2).The BAI and BDI in Group 3showed the most significant score(7.0±6.3 and 6.9±6.9,9.5±8.6 and 8.8±7.3,10.7±7.2 and 11.6±8.5in Groups 1,2,and 3,respectively)(BAI:P<0.01 vs Group 1,P<0.05 vs Group 2)(BDI:P<0.01 vs Group1 and 2).Group 3 showed a significantly higher hypochondriasis score(8.2±6.0,11.6±7.5 and 13.1±6.5in Groups 1,2,and 3,respectively)(P<0.01 vs Group 1,P<0.05 vs Group 2).CONCLUSION:Psychological factors that present vulnerability to the temptation to use alternative medicines,such as herbs and plant preparations,are important for understanding toxic liver injury. | Jeong Ill Suh Jeong Kyu Sakong Kwan Lee Yong Kook Lee Jeong Bae Park Dong Joon Kim Yeon Seok SeoDepartment of Internal Medicine Korea University Anam Hospital Korea University College of Medicine Seoul 136-705 South Korea Jae Dong Lee Soon Young Ko Byung Seok Lee Seok Hyun Kim Byung Seok Kim Young Seok Kim Heon Ju Lee In Hee Kim Joo Hyun Sohn Tae Yeob Kim Byung Min Ahn | 2013 | World Journal of Gastroenterology2013，19，47： | 5 |
| 20 | Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature显示文摘Despite enthusiastic efforts directed at elucidating critical underlying mechanisms towards the identification of novel therapeutic targets for severe acute pancreatitis(SAP), the disease remains without a specific therapy to be executed within the first hours to days after onset of symptoms. Although earlier management for SAP should aim to either treat organ failure or reduce infectious complications, the current standard of care for the general management of AP in the first hours to days after onset of symptoms include intravenous fluid replacement, nutritional changes, and the use of analgesics with a close monitoring of vital signs. Furthermore, repeated evaluation of severity is very important, as the condition is particularly unstable in the early stages. In cases where biliary pancreatitis is accompanied by acute cholangitis or in cases where biliary stasis is suspected,an early endoscopic retrograde cholangiopancreatography is recommended.However,practice guidelines regarding the treatment of pancreatitis are suboptimal.In chronic pancreatitis,conservative management strategies include lifestyle modifications and dietary changes followed by analgesics and pancreatic enzyme supplementation.Recently,attention has been focused on phytoceuticals or antioxidants as agents that could surpass the limitations associated with currently available therapies.Because oxidative stress has been shown to play an important role in the pathogenesis of pancreatitis,antioxidants alone or combined with conventional therapy may improve oxidativestress-induced organ damage.Interest in phytoceuticals stems from their potential use as simple,accurate tools for pancreatitis prognostication that could replace older and more tedious methods.Therefore,the use of antioxidative nutrition or phytoceuticals may represent a new direction for clinical research in pancreatitis.In this review article,recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced.Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis,translation to the clinic has thus far been disappointing.However,it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. | Jong-Min Park Sooyeon Lee Mi Kyung Chung Sung-Hun Kwon Eun-Hee Kim Kwang Hyun Ko Chang Il Kwon Ki Baik Hahm | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
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