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| 1 | New Classification of Herlyn-Werner-Wunderlich Syndrome显示文摘 | Lan Zhu Na Chen Jia-Li Tong Wei Wang LeiZhang Jing-He Lang | 2015 | Chinese Medical Journal2015，，2： | 30 |
| 2 | Montelukast modulates lung CysLT_1 receptor expression and eosinophilic inflammation in asthmatic mice显示文摘AIM: To determine the expressions of cysteinyl leukotriene receptors, CysLTt and CysLT2, in airway eosinophilic inflammation of OVA-induced asthmatic mice and the modulation by montelukast, a CysLT1 receptor antagonist. METHODS: Asthma model was induced by chronic exposure to ovalbumin (OVA) in C57BL/6 mice. The eosinophils in bronchoalveolar lavage (BAL) fluid and lung tissues were counted, IL-5 level in BAL fluid was measured, and CysLT1 and CysLT2 receptor mRNA expressions were detected by semi-quantitative RT-PCR. RESULTS: Montelukast (6 mg/kg, once per day for 20 d) significantly suppressed the increased eosinophils in BAL fluid and lung tissue, and increased IL-5 level in BAL fluid in OVA challenged mice. OVA challenge increased CysLT1 but decreased CysLT2 receptor mRNA expression. Montelukast inhibited the increased CysLT1 but not the reduced CysLT2 expression after OVA challenge. CONCLUSION: CysLT receptors are modulated immunologically, and montelukast inhibits up-regulation of CysLT1 receptor and airway eosinophilic inflammation in asthmatic mice. | Yan-junZHANG LeiZHANG Shao-binWANG Hua-haoSHEN Er-qingWEI | 2004 | Acta Pharmacologica Sinica2004，25，10： | 13 |
| 3 | Cloning and Characterization of a Differentially Expressed Phenylalanine Ammonialyase Gene (liPAL) After Genome Duplication from Tetraploid Isatis indigotica Fort.显示文摘 | Bei-Bei Lu Zhen Du Ru-Xian Ding LeiZhang Xiao-Jing Yu Cheng-Hong Liu Wan-Sheng Chen | 2006 | Journal of Integrative Plant Biology2006，48，12： | 13 |
| 4 | Raman spectra of single cell from gastrointestinal cancer patients显示文摘AIM: To explore the difference between cancer cells and normal cells, we investigated the Raman spectra of singlecells from gastrointestinal cancer patients. METHODS: All samples were obtained from 30 diagnosed as gastrointestinal cancer patients. The flesh tumor specimen is located in the center of tumor tissue, while the normal ones were 5 cm away from the outside tumor section. The imprint was put under the microscope and a single cell was chosen for Raman measurement. All spectra were collected at confocal Raman micro-spectroscopy (British Renishaw) with NIR 780 nm laser.RESULTS: We measured the Raman spectra of several cells from gastrointestinal cancer patients. The result shows that there exists the strong line at 1 002/cm with less half-width assigned to the phenylalanine in several cells. The Raman lines of white cell were lower and less, while those of red cell were not only higher in intensity and more abundant, but also had a parti cular C-N breathing stretching band of pyrrole ring at 1 620-1 540/cm. The line at 1 084/cm assigned to phosphate backbone of DNA became obviously weaker in cancer cell. The Raman spectra of stomach cancer cells were similar to those of normal cells, but the Raman intensity of cancer cells was much lower than that of normal cells, and even some lines disappear. The lines of enteric cancer cells became weaker than spectra above and many lines disappeared, and the cancer cells in different position had different fluorescence intensity.CONCLUSION: The Raman spectra of several cells from cancer patients show that the structural changes of cancer cells happen and many bonds rupture so that the biological function of cells are lost. The results indicate that Raman spectra can offer the experiment basis for the cancer diagnosis and treatment. | Xun-LingYan Rui-XinDong LeiZhang Xue-JunZhang Zong-WangZhang | 2005 | World Journal of Gastroenterology2005，11，21： | 10 |
| 5 | Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors显示文摘Aim: To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2),one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors. Methods: Brain specimens were obtained from patients who underwent brain surgery. CysLT2 in brain tissues was examined using immunohistochemical analysis. Results: CysLT2 was expressed in the smooth muscle cells (not in the endothelial cells) of arteries and veins. CysLT2 was also expressed in the granulocytes in both vessels and in the brain parenchyma. In addition, CysLT2 was detected in neuron- and glial-appearing cells in either the late stages of traumatic injury or in the area surrounding the tumors. Microvessels regenerated 8 d after trauma and CysLT2 expression was recorded in their endothelial cells.Conclusion: CysLT2 is distributed in vascular smooth muscle cells and granulocytes, and brain trauma and tumor can induce its expression in vascular endothelial cells and in a number of other cells. | HuaHU GaoCHEN Jian-minZHANG Wei-pingZHANG LeiZHANG Qiu-fuGE Hong-tianYAO WeiDING ZhongCHEN Er-qingWEI | 2005 | Acta Pharmacologica Sinica2005，26，6： | 9 |
| 6 | THE INVERSE PROBLEM OF CENTROSYMMETRICMATRICES WITH A SUBMATRIX CONSTRAINT显示文摘By using Moore-Penrose generalized inverse and the general singular value decomposition of matrices, this paper establishes the necessary and sufficient conditions for the existence of and the expressions for the centrosymmetric solutions with a submatrix constraint of matrix inverse problem AX = B. In addition, in the solution set of corresponding problem, the expression of the optimal approximation solution to a given matrix is derived. | Zhen-yunPeng Xi-yanHu LeiZhang | 2004 | Journal of Computational Mathematics2004，22，4： | 9 |
| 7 | From graphite to porous graphene-like nanosheets for high rate lithium-ion batteries显示文摘Graphene nanosheets possess a promising potential as electrodes in Li-ion batteries (LIBs); consequently, the development of low-cost and high-productivity synthetic approaches is crudal. Herein, porous grapheneqike nanosheets (PGSs) have been synthesized from expandable graphite (EG) by initially intercalating phosphoric acid, and then performing annealing to enlarge the interlayer distance of EG, thus fadlitating the successive intercalation of zinc chloride. Subsequently, the following pyrolysis of zinc chloride in the EG interlayer promoted the formation of the porous PGS structure; meanwhile, the gas produced during the formation of the porous structure could exfoliate the EG to graphene-like nanosheets. The synthetic PGS material used as LIB anode exhibited superior Li+ storage performance, showing a remarkable discharge capacity of 830.4 mAh.g-1 at 100 mA.g-1, excellent rate capadty of 211.6 mAh'g-1 at 20,000 mA-g-1, and excellent cycle performance (near 100% capacity retention after 10,000 cycles). The excellent rate performance is attributed to the Li+ ion rapid transport in porous structures and the high electrical conductivity of graphene-like nanosheets. It is expected that PGS may be widely used as anode material for high-rate LIBs via this facile and low-cost route by employing EG as the raw material. | Dongdong Zhao Lei Wang Peng Yu Lu Zhao Chungui Tian Wei Zhou LeiZhang Honggang Fu | 2015 | Nano Research2015，8，9： | 8 |
| 8 | The role of autophagy in Parkinson's disease显示文摘Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation. | LeiZhang Yaru Dong Xiaoheng Xu Zhong Xu | 2012 | Neural Regeneration Research2012，7，2： | 7 |
| 9 | Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis显示文摘 | ZhaoZhang XiangdongLv JinJiang LeiZhang YunZhao | 2013 | Cell Research2013，23，4： | 6 |
| 10 | LEAST-SQUARES SOLUTIONS OF X^TAX = B OVER POSITIVE SEMIDEFINITE MATRIXES A显示文摘This paper is mainly concerned with solving the following two problems:Problem I.Given X∈R^n×m,B∈R^m×m.Find A∈Pn such that ‖X^T AX-B‖F=min,where Pn={A∈R^n×n|x^T Ax≥0,A↓x∈R^n}.Problem Ⅱ.Given A^~∈R^n×n.Find A^~∈SE such that‖A^~A^^‖F=minA∈SE‖A^~A‖F,where‖-‖F is Frobenius norm,and SE denotes the solution set of Problem I.The general solution of Problem I has been given.It is proved that there exists a unique solution for Problem Ⅱ.The expression of this solution for corresponding Problem Ⅱ for some special case will be derived. | DongxiuXie LeiZhang | 2003 | Journal of Computational Mathematics2003，21，2： | 6 |
| 11 | Analysis of Serum Metabolic Profile by Ultra-performance Liquid Chromatography-mass Spectrometry for Biomarkers Discovery: Application in a Pilot Study to Discriminate Patients with Tuberculosis显示文摘 | Shuang Feng Yan-Qing Du Li Zhang LeiZhang Ran-Ran Feng Shu-Ye Liu | 2015 | Chinese Medical Journal2015，，2： | 6 |
| 12 | Gene Transcription Profile in Mice Vaccinated with Ultraviolet-attenuated Cercariae of Schistosoma japonicum Reveals Molecules Contributing to Elevated IFN-γ Levels显示文摘AVaccination with ultraviolet-attenuated cercariae of Schistosoma japonicum induced protective immunity against challenge infection in experimental animal models. Our preliminary study on .he transcription levels of IFN-γ and IL-4 in splenic CD4~ T cells revealed that attenuated cercariae elicited predominantly a Thl response in mice at the early stage, whereas normal cercariae stimulated primarily Th2-dependent responses. Further analysis on the gene profile of the skin-draining lymph nodes demonstrated that the levels of IFN-γ were significantly higher in vaccinated mice than those in infected mice at day 4, 7 and 14 post-vaccination or post-infection. However, for IL-12 and IL-4, the potent inducers of Th1 and Th2 responses, respectively, as well as IL-10, there were no differences over the course of the experiment between the infected and vaccinated mice. To explore the underlying factors that may potentially contribute to elevated IFN-y in vaccinated mice, the mRNA profiles of the skin-draining lymph nodes at day 4 postexposure were compared using oligonucleotide microarrays. Within the 847 probe sets with increased signal values, we focused on chemokines, cytokines and relevant receptors, which were validated by semi-quantitative RT-PCR. A comprehensive understanding of the immune mechanisms of attenuated cercariae-induced protection may contribute to developing efficient vaccination strategies against S. japonicum, especially during the early stage of infection. | XiangZHU Zhao-SongZHANG Min-JunJI Hai-WeiWU YongWANG Xiao-PingCAI LeiZHANG Shu-YingHU Lin-LinFU FengLIU ChuanSU Guan-LingWU | 2005 | Acta Biochimica et Biophysica Sinica2005，37，4： | 5 |
| 13 | Aluminum-activated Oxalate Secretion does not Associate with Internal Content among Some Oxalate Accumulators显示文摘Although aluminum (Al)-activated secretion of oxalate has been considered to be an important Al-exclusion mechanism, whether it is a general response in oxalate accumulators and related to oxalate content in roots are still not clear. Here, we examined the oxalate secretion and oxalate content in some oxalate accumulators, and investigated the role of oxalate secretion in Al resistance. When oxalate content in amaranth roots was decreased by about 50% with the increased ratio of NH4+-N to NO3--N in nutrient solution, the amount of Al-activated oxalate secretion still remained constant. There was no relationship between the content of the water soluble oxalate in four species of oxalate accumulators and the amount of the Al-activated oxalate secretion in roots. Furthermore, oxalate secretion is poorly associated with Al resistance among these species. Based on the above results, we concluded that although all of the oxalate accumulators tested could secrete oxalate rapidly, the density of anion channels in plasma membrane may play a more important role in Al-activated oxalate secretion. | Jian Li Yang LeiZhang Shao Jian Zheng | 2008 | Journal of Integrative Plant Biology2008，50，9： | 4 |
| 14 | Co-expression and Immunity of Legionella pneumophila mip Gene and Immunoadjuvant ctxB Gene显示文摘The mip gene of Legionella pneumophila and the ctxB gene of Vibrio cholerae were amplified by PCR respectively. The amplified cDNA was ligated to the pcDNA3.1(+) vector. The recombinant plasmids pcDNA3.1-mip and pcDNA3.1-ctxB were identified by restriction analysis and PCR, and further confirmed by sequencing analysis. NIH3T3 cells were transfected with pcDNA3.1-mip and pcDNA3.1-ctxB according to the Lipofection method. Transient and stable products of the co-expression of the mip gene and ctxB gene were detected by immunofluorescence and Western blotting. The results showed that NIH3T3 cells were successfully transfected, and that the transiently and stably co-expressed products can be detected in the transfected cells. To detect the humoral and cellular immune response in immunized mice induced by the coimmunization of the mip and ctxB genes, female BALB/c mice were immunized intramuscularly with pcDNA3.1-mip and pcDNA3.1-ctxB. The results showed that the specific antibody titer and the cytotoxic T-lymphocyte response for pcDNA3.1-mip immunization and co-immunization were increased compared with that of pcDNA3.1(+) immunization. Furthermore, the specific antibody titer and cytotoxic T-lymphocyte response for co-immunization were increased compared with that of pcDNA3.1-mip immunization. Statistical analysis using one-way analysis of variance (ANOVA) showed that there was a significant difference between the groups (P<0.01). The results indicated that the ctxB gene enhanced the humoral and cellular immune response to the mip gene immunization. These findings provide experimental evidence to support the development of the L. pneumophila DNA vaccine. | TaoWANG Jian-PingCHEN HongLI Ke-QianZHI LeiZHANG Chun-LeiYANG Da-ChangTAO | 2005 | Acta Biochimica et Biophysica Sinica2005，37，3： | 4 |
| 15 | THE NEAREST BISYMMETRIC SOLUTIONS OF LINEAR MATRIX EQUATIONS显示文摘The necessary and sufficient conditions for the existence of and the expressions for the bisymmetric solutions of the matrix equations (Ⅰ)A1X1B1+A2X2B2+^…+AkXkBk=D,(Ⅱ)A1XB1+A2XB2+…+AkXBk=D and (Ⅲ) (A1XB1,A2XB2,…,AkXBk)=(D1,D2,…,Dk) are derived by using Kronecker product and Moore-Penrose generalized inverse of matrices. In addition, in corresponding solution set of the matrix equations, the explicit expression of the nearest matrix to a given matrix in the Frobenius norm is given. Numerical methods and numerical experiments of finding the neaxest solutions axe also provided. | Zhen-yunPeng Xi-yanHu LeiZhang | 2004 | Journal of Computational Mathematics2004，22，6： | 3 |
| 16 | THE INVERSE PROBLEM FOR PART SYMMETRIC MATRICES ON A SUBSPACE显示文摘In this paper, the following two problems are considered: Problem I. Given S∈R^n×p,X,B∈R^n×m, find A∈SRs,n such that AX=B, where SRs,n = {A∈R^n×n|x^T(A-A^T) = 0, for all x∈R(S)}.Problem Ⅱ. Given A^* ∈ R^n×n, find A^^∈SE such that ‖A^^-A^*‖=minA∈SE‖A-A^*‖,where SE is the solution set of Problem I.The necessary and sufficient conditions for the solvability of and the general form of the solutions of problem I are given. For problem Ⅱ, the expression for the solution, a numerical algorithm and a numerical example are provided. | Zhen-yunPeng Xi-yanHu LeiZhang | 2003 | Journal of Computational Mathematics2003，21，4： | 2 |
| 17 | Metabolic Engineering of Tropane Alkaloid Biosynthesis in Plants显示文摘Over the past decade, the evolving commercial importance of so-called plant secondary metabolites has resulted in a great interest in secondary metabolism and, particularly, in the possibilities to enhance the yield of fine metabolites by means of genetic engineering. Plant alkaloids, which constitute one of the largest groups of natural products, provide many pharmacologically active compounds. Several genes in the tropane alkaloids biosynthesis pathways have been cloned, making the metabolic engineering of these alkaloids possible. The content of the target chemical scopolamine could be significantly increased by various approaches, such as introducing genes encoding the key biosynthetic enzymes or genes encoding regulatory proteins to overcome the specific rate-limiting steps. In addition, antisense genes have been used to block competitive pathways. These investigations have opened up new, promising perspectives for increased production in plants or plant cell culture. Recent achievements have been made in the metabolic engineering of plant tropane alkaloids and some new powerful strategies are reviewed in the present paper. | LeiZHANG Guo-YinKAI Bei-BeiLU Han-MingZHANG Ke-XuanTANG Ji-HongJIANG Wan-ShengCHEN | 2005 | Journal of Integrative Plant Biology2005，47，2： | 2 |
| 18 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 19 | Utility of a physiologically–based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug–drug–disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice显示文摘 | Joseph A.Grillo PingZhao JulieBullock Brian P.Booth MinLu KathyRobie‐Suh Eva GilBerglund K. SandyPang AtiqurRahman LeiZhang Lawrence J.Lesko Shiew‐MeiHuang | 2012 | Drug Dispos2012，，2： | 1 |
| 20 | Survey on Japan-Oriented Offshore Software Developmentin China显示文摘 | LeiZHANG Meiping CHAI Xuan ZHANG et a 1 | 2007 | Computer Science2007，4716，： | 1 |
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