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| 1 | Geographical characteristics of China’s wetlands derived from remotely sensed data显示文摘In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland maps developed at different times, a set of standard guidelines on the wetland categories to be mapped, and the mapping methods to be used must be well conceived, developed and effectively employed. We carried out some initial geographical analysis on the distribution of wetlands. | NIU ZhenGuo GONG Peng CHENG Xiao GUO JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG XiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong GUO ZiQi DAI YongJiu | 2009 | Science China Earth Sciences2009,52,6: | 15 |
| 2 | Absolute calibration of the Chang'E-1 IIM camera and its preliminary application显示文摘The interference imaging spectroradiometer (IIM) onboard the first lunar satellite of China 'Chang'E-1' can now provide approximately global high spectral and spatial resolution reflectance spectra of the Moon. It is the essential instrument with which to accomplish one of the four missions of the first lunar satellite of China. As the current data provided by the Lunar Exploration Program Center and National Astronomical Observatories (NAOC) are not reflectance and the sensor response is inhomogeneous in the line direction,users can not use the current data directly. Moreover,due to the narrow band range,IIM data cannot cover the absorption peak of the mafic minerals of the Moon completely,which limits its ability for identifying minerals. The main objective of this study is to describe the methods for absolute calibration,correction and acquiring the absorption center of minerals for IIM data. The results from our study show that in the space domain the sensor response decreases toward the left,and in the spectral domain the response of the longer bands is more inhomogeneous than that of the shorter bands. After the calibration and correction,the reflectance of IIM matches the earth-based telescopic spectra well,which suggests the possible use of the processed data in the geological research. A high correlation was found between the absorption center and the wavelength at which the first derivative equals 0,i.e.,the so-called Stagnation Point in the mathematical sense. In the end,we show a preliminary applied study of the two craters with diameter larger than 35 km using the calibrated data. The spectra of IIM data show that the lunar crust has compositional diversity within the km scale. Pure anorthosite may be found on the wall and floor of the Aristarchus crater with the map of absorption center,which indicates that anorthosite is ubiquitously present within the lunar crust. IIM,with its capacity to acquire lunar composition at the regional and global scale,will contribute to the research of lunar origin and evolution. | WU YunZhao XU XiSheng XIE ZhiDong TANG ZeSheng | 2009 | Science China(Physics,Mechanics & Astronomy)2009,52,12: | 11 |
| 3 | Global absorption center map of the mafic minerals on the Moon as viewed by CE-1 IIM data显示文摘Determining the global distribution of minerals on the Moon has been an important goal of lunar science. Hyperspectral remote sensing is an important approach to acquiring minerals on the Moon on the global scale. The wavelength of the absorption band center is the key parameter for identifying minerals with reflectance spectra as well as remote sensing data. The global absorption center map of the mafic minerals of the Moon was produced for the first time with the Chang’E-1 IIM data. This map shows the global distribution of mafic minerals such as orthopyroxenes, clinopyroxenes, and olivine and even plagioclase feldspar of the Moon. The validation for some representative areas indicates that the global map is reliable and even more detailed than the results derived from Clementine-data. Moreover, our method is insensitive to the topography and viewing and illumination geometries. The global absorption band center map not only contributes to the lunar science research, but also has other implications to be further studied. Moreover, the preprocessing methods such as calibration and correction introduced in this study can be useful in other research with IIM data. | WU YunZhao 1,4* , ZHANG Xia 2 , YAN BoKun 3 , GAN FuPing 3 , TANG ZeSheng 4 , XU AoAo 4 , ZHENG YongChun 5 & ZOU YongLiao 5 1 School of Geographic and Oceanographic Sciences, Nanjing University, Nanjing 210093, China 2 Institute of Remote Sensing Applications, Chinese Academy of Sciences, Beijing 100101, China 3 Institute for Remote Sensing Method, China Aero Geophysical Survey and Remote Sensing Center for Land and Resources, Beijing 100083, China 4 Collaborative Research Laboratory on Lunar and Planetary Exploration, Macao University of Science and Technology, Taipa, Macao, China 5 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010,53,12: | 11 |
| 4 | Interaction of sleep quality and sleep duration on glycemic control in patients with type 2 diabetes mellitus显示文摘 | Tang Yunzhao Meng lingling Li Daiqing Yang Min Zhu Yanjuan Li Chenguang Jiang Zhenhuan Yu Ping Li Zhu Song Hongna Ni Changlin | 2014 | Chinese Medical Journal2014,,20: | 9 |
| 5 | Thermal decomposition mechanism of ammonium sulfate catalyzed by ferric oxide显示文摘 | Xingfu SONG Jingcai ZHAO Yunzhao LI Ze SUN Jianguo YU | 2013 | Frontiers of Chemical Science and Engineering2013,7,2: | 8 |
| 6 | Roadmap for single-molecule surface-enhanced Raman spectroscopy显示文摘In the near future,single-molecule surface-enhanced Raman spectroscopy(SERS)is expected to expand the family of popular analytical tools for single-molecule characterization.We provide a roadmap for achieving single molecule SERS through different enhancement strategies for diverse applications.We introduce some characteristic features related to single-molecule SERS,such as Raman enhancement factor,intensity fluctuation,and data analysis.We then review recent strategies for enhancing the Raman signal intensities of single molecules,including electromagnetic enhancement,chemical enhancement,and resonance enhancement strategies.To demonstrate the utility of single-molecule SERS in practical applications,we present several examples of its use in various fields,including catalysis,imaging,and nanoelectronics.Finally,we specify current challenges in the development of single-molecule SERS and propose corresponding solutions. | Yang Yu Ting-Hui Xiao Yunzhao Wu Wanjun Li Qing-Guang Zeng Li Long Zhi-Yuan Li | 2020 | Advanced Photonics2020,2,1: | 7 |
| 7 | Pore throat characteristics of tight sandstone of Yanchang Formation in eastern Gansu,Ordos Basin显示文摘An important factor to evaluate reservoir quality is the pore-throat size.However,the strong heterogeneity makes it difficult to characterize the pore-throat distribution in tight reservoirs.The field emission scanning electron microscope(FESEM),high pressure mercury injection and rate-controlled mercury injection are used to investigate the pore-throat size distribution in tight sandstone reservoirs of Member 7 of the Yanchang Formation in eastern Gansu,Ordos Basin,and studies of the pore throat size controlling on physical property of the tight sandstone reservoirs are also carried out.The result shows that the pore type is mainly dominated by the residual intergranular pore,dissolution pore,micropore and a few micro-fractures;the high-pressure mercury injection experiment indicates that the pore-throat size ranges from 0.0148 μm to 40mm,the pore throat more than 1 mm is less;the ratecontrolled mercury injection experiment reveals that for samples with different physical properties,the pore radius mainly varies from 80 μm to 350 μm;the throat radius exhibits the strong heterogeneity,and is from 0.12 μm to 30μm;the pore-throat size can be effectively characterized by combination of high-pressure and rate-controlled mercury injections,and it varies from 0.0148 μm to 350 μm.The permeability is mainly controlled by the large pore throat(>R_(50))which accounts for a small proportion;in the tight sandstone with the permeability greater than 0.1 mD,the permeability is mainly controlled by the micropore and mesopore;in the tight sandstone with the permeability smaller than 0.1 mD,the permeability is mainly controlled by the nanopore and micropore;the proportion of small pore throat increases with reduction of permeability,it is important that the small pore throat influences the reservoir storage property though its effect on permeability are small. | Hao Wu Chunlin Zhang Youliang Ji Rui'e Liu Shang Cao Sheng Chen Yunzhao Zhang Ye Wang Wei Du Gang Liu | 2018 | Petroleum Research2018,3,1: | 7 |
| 8 | Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis显示文摘 | ZhaoZhang XiangdongLv JinJiang LeiZhang YunZhao | 2013 | Cell Research2013,23,4: | 6 |
| 9 | Extraction of hydrogen chloride by a coupled reaction-solvent extraction process显示文摘A coupled 反应溶剂抽取过程被用来把 HCl 从模仿的蒸馏器浪费移开。各种各样的提炼之物和 diluents 的抽取表演被比较,在各种各样的 diluents 的 N235 (第三级的胺的混合物) 的明显的盐基度是坚定的。最好的结果作为提炼之物用 N235 和 isoamyl 酒精被获得并且稀释分别地。从联合抽取的 HCl 的收益与这个抽取系统是 75% 。为在两个的 HCl 的移动的机制直接、联合的抽取被调查。为联合抽取, R 3 NHCl 离子对建筑群涉及 HCl 移动。为直接抽取,机制在 HCl 的高集中包含了氢契约的形成。 | Yunzhao Li Xingfu Song Guilan Chen Shuying Sun Yanxia Xu Jianguo Yu | 2015 | Frontiers of Chemical Science and Engineering2015,9,4: | 6 |
| 10 | Remote Sensing Retrieval of Surface Suspended Sediment Concentration in the Yellow River Estuary显示文摘Accurate assessment of surface suspended sediment concentration(SSSC) in estuary is essential to address several important issues: erosion, water pollution, human health risks, etc. In this study, an empirical cubic retrieval model was developed for the retrieval of SSSC from Yellow River Estuary. Based on sediments and seawater collected from the Yellow River and southeastern Laizhou Bay, SSSC conditions were reproduced in the laboratory at increasing concentrations within a range common to field observations. Continuous spectrum measurements of the various SSSCs ranging from 1 to 5700 mg/l were carried out using an Ava Field-3 spectrometer. The results indicated the good correlation between water SSSC and spectral reflectance(Rrs) was obtained in the spectral range of 726–900 nm. At SSSC greater than 2700 mg/L, the 740–900 nm spectral range was less susceptible to the effects of spectral reflectance saturation and more suitable for retrieval of high sediment concentrations. The best correlations were obtained for the reflectance ratio of 820 nm to 490 nm. Informed by the correlation between Rrs and SSSC, a retrieval model was developed(R2 = 0.992). The novel cubic model, which used the ratio of a near-infrared(NIR) band(740–900 nm) to a visible band(400–600 nm) as factors, provided robust quantification of high SSSC water samples. Two high SSSC centers, with an order of 103 mg/l, were found in the inversion results around the abandoned Diaokou River mouth, the present Yellow River mouth to the abandoned Qingshuigou River mouth. There was little sediment exchange between the two high SSSC centers due to the directions of the residual currents and vertical mixing. | ZHAN Chao YU Junbao WANG Qing LI Yunzhao ZHOU Di XING Qinghui CHU Xiaojing | 2017 | Chinese Geographical Science2017,27,6: | 5 |
| 11 | Plant Diversity Performance After Natural Restoration in Reclaimed Deyeuxia angustifolia Wetland显示文摘Deyeuxia angustifolia wetlands were widely distributed in the Sanjiang Plain in Northeast China. Due to strong demand for food production, large-area wetlands were reclaimed to farmlands, which threatened regional ecological security greatly. Since the 21 th century, returning farmlands to wetlands was widely adopted for natural restoration in the Sangjiang Plain. As the first reflection of wetland restoration, vegetation succession of restored D. angustifolia wetlands should be fully assessed. In this study, vegetation investigation was carried out in three restored D. angustifolia wetlands with 5, 8 and 12 yr restoration, respectively. Meanwhile, a natural D. angustifolia wetland was selected as reference wetland. Results showed that community composition changed greatly and there was visible community succession. Community dominant species changed from composite to gramineae as restoration time increasing.At first, weeds community appeared in the restored wetlands, especially the xerophytes developed to the pioneer species rapidly. And then, mesophytes and wetland species became the dominant species in the restored wetlands. Finally, wetland species, especially D. angustifolia, occupied the dominant position of restored community. Shannon-wiener index(H) and Simpson index(D) both decreased to close to natural D. angustifolia wetlands. Compared with natural D. angustifolia wetland, species composition and diversity in restored wetlands were more complex and higher. As restoration time increasing, there were not significant differences between community characteristics of restored wetlands and natural wetland. All these suggested that vegetation in reclaimed D. angustifolia wetland could be restored naturally, but its restored period is 10 yr at least. From another angle, it is important to protect current natural wetlands. | WANG Xuehong TONG Shouzheng LI Yunzhao Qi Qing ZHANG Dongjie LYU Xianguo GUO Yue LIU Yan | 2019 | Chinese Geographical Science2019,29,3: | 5 |
| 12 | The improvement of cross-calibration of IIM data and band selection for FeO inversion显示文摘Chang’E-1(CE-1)Interference Imaging Spectrometer(IIM)dataset suffers from the weak response in the near infrared(NIR)bands,which are the important wavelength for retrieving the minerals and elements of the Moon.In this paper,the cross-calibration was implemented to the IIM hyperspectral data for improving the weak response in NIR bands.The results show that the cross-calibrated IIM spectra were consistent to the Earth-based telescopic spectra,which suggests that the cross-calibration yields acceptable results.For further validating the influence of the cross-calibration on the FeO inversion and searching the optimal bands to retrieve lunar FeO contents,four band selection schemes were designed to retrieve FeO using the original and cross-calibrated IIM spectra.By comparing the distribution patterns and histograms of the IIM derived FeO contents with the Clementine derived FeO,the IIM 891 nm band after cross-calibration showed a higher accuracy in the FeO inversion,hence most useful for lunar FeO inversion. | WANG Chao WU YunZhao SHI RunHe GAO Wei | 2013 | Science China(Physics,Mechanics & Astronomy)2013,56,11: | 4 |
| 13 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017,5,3: | 4 |
| 14 | Plasma Modified Polyaramid Fiber Surface and Fiber/Epoxy Interface显示文摘Kevlar-49 fiber was surface-modified through cold air plasma treatment and plasma grafting ofacrylic acid (AA).Fiber surface properties were studied with ESCA,while interface properties with asingle fiber pull-out (SFPO) test.The stated surface modifications evidently improved the interfacialadhesion and increased the interfacial fracture energy of the aramid/epoxy composite system. | Chunxin ZHANG Shijiu JIN Yunzhao YU Institute of Chemistry,Academia Sinica,Beijing 100080,China | 1993 | Journal of Materials Science & Technology1993,9,6: | 4 |
| 15 | Erratum:Global absorption center map of the mafic minerals on the Moon as viewed by CE-1 IIM data [Sci China-Phys Mech Astron,2010,53(12):2160-2171]显示文摘The boxes of 'Badline Repair', 'Bad pixel Repair' and'Destriping' shown in Figure 3 of the original paper shouldbe in dashed line (see Figure 1) in ref. [1]. They are the ten-tative work for the following work for producing the globalmap of the absorption center of the mafic minerals. | WU YunZhao | 2012 | Science China(Physics,Mechanics & Astronomy)2012,55,3: | 4 |
| 16 | Novel derivative of Danshensu acts as anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57显示文摘OBJECTIVE To identify the specific targets of a novel derivative of Danshensu ADTM as the protein disulfide isomerase(PDI)family proteins including ERp57.To further investigate the underlying mechanism of ADTM to modulate ERp57 to regulate platelet function with direct interaction withαⅡbβ3 integrin.METHODS To isolate the protein targets that bound to ADTM,a biotin-conjugated ADTM analogue(BAA)was designed and synthesized.BAA(300μmol·L-1)was incubated with rat blood platelet lysates and the BAA-protein complexes were pulled down with NeutrAvidin-agarose followed by protein profiling using LC-MS/MS.To determine platelet aggregation in vitro,rabbit platelets were incubated with the indicated concentrations of compounds and aggregation was induced by ADP(10μmol·L-1)or AA(200μmol·L-1)and measured using a platelet aggregometer.To determine platelet aggregation-induced by ADP in rat in vivo,ADTM(5-20mg·kg-1)in comparison with DSS(10mg·kg-1)and clopidogrel(18mg·kg-1)were administered daily by i.v.injection for 5d,respectively.To determine the action of ADTM on the ERp57/αⅡbβ3 interaction,it was examined by immunoprecipitation with anti-αⅡbβ3antibody,followed by detection of ERp57 immunoreactivity using immunoblotting.RESULTS BAA could bind to various proteins involved in platelet function.In particular,platelet aggregation-associated proteins were identified with>95% protein identification probability including ERp72,ERp57ERp5 and PDI,which are members of the protein disulfide isomerase(PDI)family related to platelet function and redox homeostasis.ADTM exhibited potent inhibition on the redox activity of ERp57 in a concentration-dependent manner(IC50=100 300μmol·L-1).In in vitro studies,ADTM exhibited concentration-dependent inhibition on ADP-induced and AA-induced platelet aggregation with comparable effects to aspirin and clopidogrel.In vivo study showed that ADP-induced platelet aggregation was significantly compromised(>40%reduction)in rats treated with ADTM(20mg·kg-1).Similarly,ADTM also exhibited significant anti-thrombotic effect in vivo as shown in the ferric chloride(FeCl3)-induced venous thrombosis.Immunoprecipitation with anti-αⅡbβ3antibody,followed by detection of ERp57 immunoreactivity using immunoblotting showed that ADTM disrupted the interaction of ERp57 with αⅡ bβ3.CONCLUSION These results demonstrated that ADTM exhibited broad-spectrum anti-platelet activities and ERp57 is a potential therapeutic target for anti-platelet therapy. | Guo-zhenCUI Lu-chenSHAN LinGUO IvanKeungCHU Guo-huiLI QuanQUAN YunZHAO Chenong-mengCHONG ZaijunZHANG PeiYU Pui-manHOI Ye-weiSUN Yu-qiangWANG Simonming-yuenLEE | 2015 | 中国药理学与毒理学杂志2015,29,S1: | 3 |
| 17 | Inversion of the asymmetry factor for desert areas of China显示文摘Deserts,which have high surface albedo and wide area,are important components of the earth system.It is very important for the research of surface radiation and energy balance to understand the anisotropic scattering of desert areas.The emergence and development of multi-angle remote sensing made possible the inversion of the anisotropic scattering of desert areas at the regional or global scale.Firstly,this paper explored the accuracy of the inversion of asymmetry factor using the Hapke model and the simulated single-and multi-phase MISR data.Based on the results,the asymmetry factor of representative surface of desert areas in northwestern China was retrieved.The values of the asymmetry factor retrieved from MISR data were compared with the values retrieved from the laboratory data.The results showed that the single-phase MISR data could be used for the inversion of asymmetry parameter of desert areas.The sign of the asymmetry parameter for the laboratory measurements was positive,which suggests that the surface of laboratory samples is forward scattering.The sign of the asymmetry parameter for MISR data was negative;that is,it is backscattering.The values of the asymmetry parameters retrieved from MISR data were related to the character of the land surface.At Loulan,where the surface was smoother than other sites,retrieved values exhibited the largest negative values of asymmetry factor,suggesting the strongest backscattering.The sand dune area of the Kumtag Desert,which has the greatest roughness,had only slightly negative asymmetry factor values.These findings indicated that at the sensor scale,a rough surface(e.g.,dunes) does not necessarily mean more backscattering than a smooth surface.This finding has significant implications for empirical methods(e.g.,using the normalized index of backward-scattered radiance minus forward-scattered radiance as an indicator of surface roughness),which should be used carefully for analyzing surface roughness from the remote sensing data. | WU YunZhao LU HuaYu LIU Qiang | 2010 | Science China Earth Sciences2010,53,4: | 2 |
| 18 | Visible and near infrared reflectance spectroscopy for measuring soil heavy metal content as a quick method显示文摘 | Yunzhao WU Jun CHEN Junfeng JI Peng GONG Qilin LIAO Hongrui MA | 2006 | Chinese Journal Of Geochemistry2006,25,B08: | 2 |
| 19 | Nuclear apoptosis induced by isolated mitochondria显示文摘We isolated and purified mitochondria from mouse livers and spinach leaves. When added into egg extracts of Xenopus laevis, they caused nuclei of mouse liver to undergo apoptotic changes. Chromatin condensation, margination and DNA ladder were observed. After incubating isolated mitochondria in some hypotonic solutions, and centrifuging these mixtures at high speed, we got mitochondrial supernatants. It was found that in the absence of cytosolic factor, the supernatant alone was able to induce apoptotic changes in nuclei. The effective components were partly of protein. DNA fragmentation was partly inhibited by caspase inhibitors AC-DEVD-CHO and AC- YVADCHO. Meanwhile, caspase inhibitors fully blocked chromatin condensation. Primary characterization of the nuclear endonuclease(s) induced by mitochondrial supernatants was also conducted. It was found that this endonuclease is different from endonuclease G, cytochrome c-induced nuclease, or Ca2+-activated endonuclease. | JIANGZHENGFAN YUNZHAO 等 | 2000 | Cell Research2000,10,3: | 2 |
| 20 | Novel thermosetting resin with a very high glass transition temperature based on bismaleimide and allylated novolac显示文摘 | Yuan Yao Tong Zhao Yunzhao Yu | 2005 | Journal of Applied Polymer Science2005,97,2: | 1 |