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| 1 | Dynamic model of vibrating-sliding-uplift rocking coupled motion and dynamic design method of caisson breakwaters显示文摘Vibrating, sliding and uplift rocking are three elementary motion types of caisson breakwaters. The dynamic model and the numerical simulation method of vibrating-sliding-uplift rocking coupled motion of caisson breakwaters are developed. The histories of displacement, rotation, sliding force and overturning moment of a caisson breakwater under the excitation of breaking wave impact are calculated for the motion models of vibrating, vibrating-sliding, vibrating-uplift rocking and vibrating-sliding-uplift rocking. The effects of various motion models on the stability of caisson breakwaters are investigated. The feasibility of the dynamic design idea that the sliding motion and the uplift rocking motion of caisson breakwaters are allowed under the excitation of breaking wave impact is discussed. | WANG Yuanzhan HUA Leina DONG Shaowei | 2004 | Science China(Technological Sciences)2004，47，3： | 6 |
| 2 | Cisplatin resistance in lung cancer is mediated by MACC1 expression through PI3K/AKT signaling pathway activation显示文摘 | Qiang Zhang Bin Zhang Leina Sun Qingna Yan Yu Zhang Zhenfa Zhang Yanjun Su Changli Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 3 |
| 3 | BWMK1 Responds to Multiple Environmental Stresses and Plant Hormones显示文摘许多种激活 mitogen 的蛋白质家族 ases (MAPK ) 在调整回答到不能生活、关於生命的压力起一个重要作用。首先报导的米饭 MAPK 基因 BWMK1is 由两个导致了稻瘟病(Magnaporthe grisea ) 感染并且机械伤害。为它对另外的环境暗示和植物激素的反应的进一步的分析,例如 jasmonic 酸(JA ) ,水杨酸(SA ) ,和 benzothiadiazole (BTH ) , BWMK1 的倡导者与贝它 -glucuronidase (GUS ) 的编码区域被熔化记者基因。分别地,有 1.0- and2.5-kb 倡导者碎片的二 promoter-GUS 构造被产生并且转变了成装饰用的梨树米饭栽培变种 TP309 和 Zhonghua 11。GUS 的表示被寒冷,干旱,黑暗,和 JA 在转基因的行导致。然而,光, SA,和 BTH 处理压制了 GUS 表示。Theseresults 证明 BWMK1 对多重不能生活的压力和植物激素应答并且可以在在不同发信号的小径之间的串音起一个作用…… | Wai-Foong Hong Chaozu He Lijun Wang Dong-Jiang Wang Leina M. Joseph Chatchawan Jantasuriyarat Liangying Dai Guo-Liang Wang | 2007 | Journal of Integrative Plant Biology2007，49，6： | 3 |
| 4 | A novel strategy for cancer treatment:Targeting cancer stem cells显示文摘Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule in-hibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a signifi-cant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment. | LIU Jia MA LeiNa WANG YiGang LIU XinYuan QIAN QiJun | 2008 | Chinese Science Bulletin2008，53，12： | 2 |
| 5 | Gene duplication drove the loss of awn in sorghum.显示文摘Loss of the awn in some cereals including sorghum is a key transition during cereal domestication or improvement that has facilitated grain harvest and storage.The genetic basis for the loss of awn in sorghum during domestication or improvement remains unknown.Here,we identified a transcription factor gene awn1 encoding an ALOG domain,which is responsible for awn loss during sorghum domestication or improvement.awn1 arose from a gene duplication from chromosome 10 that translocated to chromosome 3,recruiting a new promoter from the neighbouring intergenic region filled with'noncoding DNA',and recreating the first exon and intron.The awn1 acquires high expr`ession after duplication and represses the elongation of awns in domesticated sorghum.Comparative mapping revealed a high collinearity at awn1 paralog locus on chromosome 10 across cereals and awn growth and development was successfully reactivated on the rice spikelet by inactivating rice awn1 orthologue.Further RNA-seq and DAP-seq revealed that as a transcription repressor,AWN1 directly bound to the motif in the regulatory regions from three MADS genes related to flower development and two genes DL and LKS2 for the development of awn,downregulated the expressions of these genes,and then repressed the elongation of awn.The preexistence of regulatory elements in the neighbouring intergenic region of awn1 before domestication signified that noncoding DNA may serve as a treasure trove for evolution during adaptation to a changing world.Our results supported that gene duplication can promptly drive the evolution of gene regulatory network. | Leina Zhou Can Zhu Xiaojian Fang Hangqin Liu Shuyang Zhong Yan Li Jiacheng Liu Yang Song Xing Jian Zhongwei Lin | 2021 | Molecular Plant2021，14，11： | 2 |
| 6 | Fructose and fructose kinase in cancer and other pathologies显示文摘Fructose metabolism and fructose kinase KHKe C/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and cancer.Here,we summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHKe C and KHKe A in metabolic liver diseases and their relevant metabolic disorders and cancer,and we highlight the specific protein kinase activity of KHKe A in tumor development.In addition,different approaches that have been used to inhibit KHK and the exploration of KHK inhibitors in clinical treatment are introduced. | Hongfei Jiang Qian Lin Leina Ma Shudi Luo Xiaoming Jiang Jing Fang Zhimin Lu | 2021 | Journal of Genetics and Genomics2021，48，7： | 1 |
| 7 | Research on ranging optimization and twice-weighted centroid calculation in wireless sensor networkslocalization algorithm显示文摘 | Gao Leina Peng Jianshe | 2013 | The Open Automation and Control Sys- tems Journal2013，5，： | 1 |
| 8 | Molecular characterization of the Arabidopsis 9-cis-epoxycarotenoid dioxygenase gene family显示文摘 | Tan Bao-Cai Joseph Leina Deng Wen-Tao | 2003 | Plant J2003，35，1： | 1 |
| 9 | Molecular charzcterization Arabidopsis 9-cisepoxycaotenoid dioxygenase gene family显示文摘 | BAO-CAI TAN LEINA M J WEN-TAO D LIGUAN L KENNETH C DONALD R M | 2003 | The Plant Journal2003，35，： | 1 |
| 10 | The neurotensin re- ceptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer 显示文摘 | James M B Leina A R Kevin J | 2012 | Int J Cancer2012，130，8： | 1 |
| 11 | Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model显示文摘 | Wenjia Lou Qing Chen Leina Ma Jia Liu Zhi Yang Junjie Shen Youhong Cui Xiu-wu Bian Cheng Qian | 2013 | Journal of Molecular Medicine2013，，6： | 1 |
| 12 | 具有细支气管肺泡癌特征肺腺癌与其他类型腺癌的对比分析(英文)显示文摘Objective: The aim of this study was to investigate the clinicopathologic and prognostic factors of the partial subtypes of lung adenocarcinoma, including pure bronchioloalveolar carcinoma (BAC), adenocarcinoma (AC) with BAC component and AC without BAC component. Methods: One hundred and six adenocarcinoma specimens which were followed up completely for 3 years, were obtained from 106 patients (45 men and 61 women) who underwent surgical resection for pathologically confirmed pulmonary adenocarcinoma in the Cancer Hospital of Tianjin Medical University, from June 2004 to December 2005. According to the recent 2004 World Health Organization (WHO) pathological classification criteria of lung cancer, lung adenocarcinomas were divided into three subgroups: pure BAC, AC with BAC component and AC without BAC component. The clinical data were retrospectively analyzed based on statistical methods. All data were analyzed using SPSS statistics software and Kaplan-Meier survival curves were constructed, meanwhile, we conducted a Log-rank test. Results: The statistical analysis showed that no significant association was found among the three groups in gender and age; however, smoke index, tumor size, N stage, TNM stage, postoperative recurrence and metastasis had a statistically significant correlation among three groups (P < 0.01). The 3-year survival rates of the three groups were 96.4%, 61.0% and 40.5% respectively, which had a statistically significant difference. And the 3-year survival rate was significantly higher in the patients with pure BAC than in the patients with other types of lung adenocarcinomas (P < 0.01). In contrast to the other two groups (pure BAC and AC with BAC component), we found the evidence that the 3-year prognosis of lung adenocarcinoma without BAC component was worse than the two formers. Conclusion: The three groups (pure BAC, AC with BAC component and AC without BAC component) have their own distinct clinicopathologic features respectively and completely different clinical prognosis. The strict distinction of the subtypes of lung adenocarcinoma can provide more reliable basis for scientific and comprehensive clinical treatment and contribute to assess the clinical prognosis effectively. | Leina Sun,Yan Guo,Zhongli Zhan,Baocun Sun,Na Dong,Ankang Gu,Huanling Luan Department of Pathology,Tianjin Medical Universit Cancer Institute and Hoapital,Tianjin Key Laboratory of Cancer Prevention Tianjin Diagnosis and Therapy Cancer of Lung Cancer,Tianjin 300060,China | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，1： | 1 |
| 13 | 肺腺癌神经内分泌分化的临床意义(英文)显示文摘Objective:The aim of our study was to investigate the prevalence and clinical relevance of neuroendocrine(NE) differentiation in lung adenocarcinoma.Methods:Eighty-six adenocarcinoma paraffin-embedded specimens and cases which were followed up completely for 3 years,were obtained from 86 patients(35 men and 51 women) who underwent surgical resection for pathologically supported adenocarcinoma in the Cancer Hospital of Tianjin Medical University,from June 2005 to December 2006.Immunohistochemical EnVision two-step method was used to detect the expression of neuron-specific enolase(NSE),synaptophysin(SYN) and chromogranin A(CGA).All data were analyzed using SPSS statistics software and Kaplan-Meier survival curves were constructed,meanwhile,we conducted a Log-rank test.Results:All patients with lung adenocarcinoma,35 cases with NE differentiation(40.7%).The statistical analysis showed that the positive rate of NE differentiation in lung adenocarcinoma was significantly associated with cancer recurrence and histological differentiation.In addition,CGA,NSE and SYN positive rates were 27.9%,50.0%,43.0%,respectively.A statistically significant difference was found between positive expression of SYN and other clinicopathological parameters,such as pathological type,histological differentiation,lymph node metastasis,postoperative recurrence and 3-year survival rate(P = 0.001) and so on.Conclusion:NE differentiation can be used as a metastatic potentially indicator of biological behavior of lung adenocarcinoma,and combined detection of NSE and SYN markers may be recommended to examine NE differentiation of lung adenocarcinoma.Positive expression of SYN indicates poor prognosis. | Yuanhuan Dong Leina Sun Baocun Sun Dongxiang Yu Zhongli Zhan | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 1 |
| 14 | MicroRNA-122 sensitizes HCC canc- er ceils to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest显示文摘 | Yanmin Xu Feng Xia Leina Ma | 2011 | Cancer Letters2011，310，2： | 1 |
| 15 | Face off:a metabolic enzyme becomes a protein phosphatase显示文摘Metabolism and metabolic enzymes are differentially regulated in normal and tumor cells,resulting in specific metabolic features of cancer cells to support their rapid proliferation and migration,and counteract metabolic and genotoxic stress during cancer progression(Wang et al.,2018).These metabolic features include the Warburg effect,which is reflected by high rates of glycolysis with elevated levels of lactic acid regardless of oxygen levels,a substantial increase of anabolism,and reprogrammed catabolism and redox homeostasis(Li et al.,2018;Wang et al.,2018). | Gaoxiang Zhao Qian Lin Zhaoyuan Meng Xinlei Sheng Leina Ma Yingming Zhao | 2023 | Protein & Cell2023，14，7： | 0 |
| 16 | Antioxidant and anti-diabetic activities in commercial and homemade pomegranate molasses in Lebanon显示文摘Pomegranate fruit and its derived products are rich sources of bioactive compounds.They have many biological activities.Pomegranate molasses(PM)is a thick,traditional Middle Eastern syrup used in many recipes for Lebanese and international cuisines.It is a highly nutritious product which makes it of great interest.The purpose of this study was to assess the phytochemical composition,antioxidant and anti-diabetic properties of homemade and commercial PM consumed in Lebanon using samples collected from households in rural areas(n=4)and the market(n=28).The objectives of this study were to determine their total phenolic content using the Follin-Ciocalteu method,their total flavonoid content using aluminum chloride method,their antioxidant activity using DPPH radical scavenging as well as ferrous ion chelating assays and their anti-diabetic activity usingα-amylase andα-glucosidase inhibitory activities with acarbose,a known anti-diabetic drug,used as the standard reference.Homemade PM samples exhibited a higher antioxidant activity than commercial samples,with the most active homemade PM sample having IC_(50)values of 0.09 mg/mL(DPPH radical scavenging assay)and 46.78%ferrous ion chelating assay).Homemade PM samples also showed higher anti-diabetic activity than commercial samples,with the most active homemade PM sample having an IC_(50)values of 0.63 mg/mL(α-amylase inhibitory activity)and of 0.41 mg/mL(α-glucosidase inhibitory activity)and being almost as active as acarbose with both enzymes(1.5 times).Significant inverse strong/moderate correlations were observed between total phenolic content/total flavonoid content and the IC_(50)value of DPPH radical scavenging assay,indicating positive associations between total phenolic and flavonoid contents and antioxidant activity.In addition,significant negative moderate correlations were observed between total phenolic/flavonoid contents andα-amylase inhibitory activity,indicating positive associations between total phenolic and flavonoid contents and anti-diabetic activity. | Mira Bou Dargham Jocelyne Matar Boumosleh Antoine Farhat Salwa Abdelkhalek Elias Bou-Maroun Leina El Hosry | 2022 | Food Bioscience2022，46，2： | 0 |
| 17 | A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma显示文摘Objective:The immunoscore,which is used to quantify immune infiltrates,has greater relative prognostic value than tumor,node,and metastasis(TNM)stage and might serve as a new system for classification of colorectal cancer.However,a comparable immunoscore for predicting lung adenocarcinoma(LUAD)prognosis is currently lacking.Methods:We analyzed the expression of 18 immune features by immunohistochemistry in 171 specimens.The relationship of immune marker expression and clinicopathologic factors to the overall survival(OS)was analyzed with the Kaplan-Meier method.A nomogram was developed by using the optimal features selected by least absolute shrinkage and selection operator(LASSO)regression in the training cohort(n=111)and evaluated in the validation cohort(n=60).Results:The indicators integrated in the nomogram were TNM stage,neuron-specific enolase,carcino-embryonic antigen,CD8 center of tumor(CT),CD8 invasive margin(IM),Fox P3 CT,and CD45 ROCT.The calibration curve showed prominent agreement between the observed 2-and 5-year OS and that predicted by the nomogram.To simplify the nomogram,we developed a new immune-serum scoring system(I-SSS)based on the points awarded for each factor in the nomogram.Our I-SSS was able to stratify same-stage patients into different risk subgroups.The combination of I-SSS and TNM stage had better prognostic value than the TNM stage alone.Conclusions:Our new I-SSS can accurately and individually predict LUAD prognosis and may be used to supplement prognostication based on the TNM stage. | Qiujuan Huang Tongyuan Qu Lisha Qi Changxu Liu Yuhong Guo Qianru Guo Guangning Li Yalei Wang Wenshuai Zhang Wei Zhao Danyang Ren Leina Sun Shengguang Wang Bin Meng Baocun Sun Bin Zhang Wenjuan Ma Wenfeng Cao | 2021 | Cancer Biology & Medicine2021，18，2： | 0 |
| 18 | Kaposiform Hemangioendothelioma:a Case Report显示文摘Case Report A 36-year-old man with a neoplasm in his right-leg had undergone surgical removal of this neoplasm at an out-patient clinic (OPD). The tumor size was about 1 cm×1 cm×0.5 cm. It was knotty and nonencapsulated. Its cross-section was kermesinus and its texture was moderate. The pathological examination confirmed a diagnosis of Kaposiform hemangioendothelioma. | Leina Sun Zhongli Zhan | 2006 | Chinese Journal of Clinical Oncology2006，3，4： | 0 |
| 19 | Governing glutaminolysis by regulation of glutaminase succinylation显示文摘Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA). | Qingxia Ma Hongfei Jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu | 2022 | Protein & Cell2022，13，3： | 0 |
| 20 | Changes in Meteorological Information Transmission in the All-media Era显示文摘In the all-media era,in order to adapt to the transmission of different channels,the requirements for meteorological information have become increasingly high,and the display format has also undergone a huge change.To expand the effect of communication,create public opinion and hot spots,popularize meteorological knowledge,and spread meteorological disaster prevention and mitigation knowledge,it is necessary to transform original meteorological information into video pictures or recently popular short videos,small moving pictures,etc.Transforming meteorological information into graphics,video,dynamic graphics,micro-video,etc.is collectively called the visualization process of meteorological information.Therefore,meteorological information visualization is extremely urgent,and the natural visual communication production advantages of meteorological film and television will play a huge role.In this paper,some methods of visualizing meteorological information,expanding the spread of visualized meteorological information,and enhancing the transmission rate were proposed. | Yeting GU Lu HUANG Leina CHEN | 2020 | Meteorological and Environmental Research2020，11，1： | 0 |
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