|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ELECTROACTIVE AND NANOSTRUCTURED POLYMERS AS SCAFFOLD MATERIALS FOR NEURONAL AND CARDIAC TISSUE ENGINEERING显示文摘Conducting polymer, polyaniline (PANI), has been studied as a novel electroactive and electrically conductive material for tissue engineering applications. The biocompatibility of the conductive polymer can be improved by (i) covalently grafting various adhesive peptides onto the surface of prefabricated conducting polymer films or into the polymer structures during the synthesis, (ii) co-electrospinning or blending with natural proteins to form conducting nanofibers or films, and (iii) preparing conducting polymers using biopolymers, such as collagen, as templates. In this paper, we mainly describe and review the approaches of covalently attaching oligopeptides to PANI and electrospinning PANI-gelatin blend nanofibers. The employment of such modified conducting polymers as substrates for enhanced cell attachment, proliferation and differentiation has been investigated with neuronal PC-12 cells and H9c2 cardiac myoblasts. For the electrospun PANI-gelatin fibers, depending on the concentrations of PANI, H9c2 cells initially displayed different morphologies on the fibrous substrates, but after one week all cultures reached confluence of similar densities and morphologies. Furthermore, we observed, that conductive PANI, when maintained in an aqueous physiologic environment, retained a significant level of electrical conductivity for at least 100 h, even though this conductivity was decreasing over time. Preliminary data show that the application of micro-current stimulates the differentiation of PC-12 cells. All the results demonstrate the potential for using PANI as an electroactive polymer in the culture of excitable cells and open the possibility of using this material as an electroactive scaffold for cardiac and/or neuronal tissue engineering applications that require biocompatibility of conductive polymers. | Paul Bidez Elizabeth Guterman-Tretter Alan G. MacDiarmid Peter I. Lelkes 危岩 | 2007 | Chinese Journal of Polymer Science2007，25，4： | 2 |
| 2 | Reactive oxygen species,apoptosis and altered NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose:an in vitro cellular model for diabetic neuropathy显示文摘 | Lelkes E Unsworth B R Lelkes P I | 2001 | Neurotox Res2001，3，： | 1 |
| 3 | Tasting Freedom : Happiness, Religion and Economic Transition 显示文摘 | Lelkes O | 2006 | Journal of Economic Behavior and Or- ganization2006，59，： | 1 |
| 4 | Growing tissues in microgravity显示文摘 | Unsworth B R Lelkes P I | 1998 | Nat Med1998，4，8： | 1 |
| 5 | Pulsatile flow and EC morphology in a VAD-like chamber显示文摘 | Lelkes PI Samet MM | 1991 | ASAIO tras-actions1991，37，： | 1 |
| 6 | Cross talk between thecardiovascular and nervous systems:Neurotrophic effects of vas-cular endothelial growth factor(VEGF)and angiogenic effects ofnerve growth factor(NGF)-implications in drug development显示文摘 | Lazarovici P Marcinkiewicz C Lelkes PI | 2006 | Curr Pharm Des2006，12，： | 1 |
| 7 | Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications显示文摘 | Mengyan Li Yi Guo Yen Wei Alan G. MacDiarmid Peter I. Lelkes | 2005 | Biomaterials2005，，13： | 1 |
| 8 | Reactive oxygen species, apoptosis and altered NGF-induced signaling in PC12 eochro- mocytoma cells cultured in elevated glucose:an in vitro cellu- lar model for diabetic neuropathy显示文摘 | Lelkes E Unsworth BR Lelkes PI | 2001 | Neurotox Res2001，3，2： | 1 |
| 9 | Tasting Freedom: Happiness, Religion and Economic Transition显示文摘 | Lelkes O | 2006 | Journal of Economic Behavior and Organization2006，59，4： | 1 |
| 10 | Reactive oxygen species,apoptosis and altered NGF-induced signaling in PC12 pheochromocytoma cells cultured in elevated glucose:an in vitro cellular model for diabetic neuropathy显示文摘 | LELKES E UNSWORTH B R LELKES P I | 2001 | Neurotox Res2001，3，2： | 1 |
| 11 | Growing tissues in microgravity显示文摘 | Unsworth BR Lelkes PI | 1998 | Nat Med1998，4，： | 1 |
| 12 | Tasting Freedom: Happiness, Reli- gion and Economic Transition 显示文摘 | Lelkes O | 2006 | Journal of Economic Behavior & Organization2006，59，2： | 1 |
| 13 | Gene expression profiling of human aortic endothelial cells exposed to disturbed flow and steady laminar flow显示文摘 | Brooks AR Lelkes PI Rubanyi GM | 2002 | Physiol Genomics2002，9，1： | 1 |
| 14 | Fluorescent PLLA-nanodiamond composites for bone tissue engineering显示文摘 | Qingwei Zhang Vadym N. Mochalin Ioannis Neitzel Isabel Y. Knoke Jingjia Han Christopher A. Klug Jack G. Zhou Peter I. Lelkes Yury Gogotsi | 2010 | Biomaterials2010，，1： | 1 |
| 15 | Batch extractive distillation: the process and the operational policies 显示文摘 | Lelkes Z Lang P Moszkowicz P | 1998 | Chemical Engineering Science1998，53，7： | 1 |
| 16 | A novel real-time system to mo nitor cell aggregation and trajectories in rotating wall vessel bioreactors显示文摘 | MANLEY P LELKES P I | 2006 | Journal of Biotechnology2006，125，3： | 1 |
| 17 | Different Operational Policies the Batch Extractive Distillation, Comput 显示文摘 | Lang P Lelkes Z Moszkowicz P | 1995 | Chem Eng1995，19，： | 1 |
| 18 | Cross talk between the cardi- ovascular and nervous systems: neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF) -implications in drug development 显示文摘 | Zarovici P Marcinkiewicz C Lelkes PL | 2006 | Curr Pharm Des2006，12，21： | 1 |
| 19 | Growing tissues in microgravity显示文摘 | Unsworth BR Lelkes PI | 1998 | Nat Med1998，4，： | 1 |
| 20 | Angiogenesis, angiogenic growth factors, and cell adhesion molecules are upregulated in chronic pancreatic diseases: angiogenesis in chronic pancreatitis and pancreatic cancer显示文摘 | Lelkes PI Bloechle C | 1999 | Pancreas1999，18，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员