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| 1 | Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy显示文摘AIM: To characterize the effects of iodinated contrast material(ICM) on magnetic resonance imaging(MRI) comparing different sequences and magnetic fields, with emphasis to similarities/differences with well-known signal characteristics of hemorrhage in the brain. METHODS: Aliquots of iopamidol and iodixanol mixed with normal saline were scanned at 1.5T and 3T. Signal intensity(SI) was measured using similar spin-echo(SE)-T1, SE-T2, gradient-echo(GRE) and fluid-attenuationinversion-recovery(FLAIR) sequences at both magnets. Contrast to noise ratio(CNR)(SI contrast-SI saline/SD noise) for each aliquot were calculated and Kruskall-wallis test and graphic analysis was used to compare different pulse sequences and ICMs. RESULTS: Both ICM showed increased SI on SE-T1 and decreased SI on SE-T2, GRE and FLAIR at both 1.5T and 3T, as the concentration was increased. By CNR measurements, SE-T2 had the greatest conspicuity at 3T with undiluted iopamidol(92.6 ± 0.3, P < 0.00) followed by iodixanol(77.5 ± 0.9, P < 0.00) as compared with other sequences(CNR range: 15-40). While SE-T2 had greatest conspicuity at 1.5T with iopamidol(49.3 ± 1, P < 0.01), SE-T1 showed similar or slightly better conspicuity(20.8 ± 4) than SE-T2 with iodixanol(23 ± 1.7). In all cases, hypo-intensity on GRE was less conspicuous than on SE-T2.CONCLUSION: Iodixanol and iopamidol shorten T1 and T2 relaxation times at both 1.5T and 3T. Hypo-intensity due to shortened T2 relaxation time is significantly more conspicuous than signal changes on T1-WI, FLAIR or GRE. Variations in signal conspicuity according to pulse sequence and to type of ICM are exaggerated at 3T. We postulate T2 hypointensity with less GRE conspicuity differentiates ICM from hemorrhage; given the wellknown GRE hypointensity of hemorrhage. Described signal changes may be relevant in the setting of recent intra-arterial or intravenous ICM administration in translational research and/or human stroke therapy. | Humberto Morales Lisa Lemen Ranasinghage Samaratunga Peter Nguyen Thomas Tomsick | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 2 | Relevance of Subcortical Stroke in Dysphagia显示文摘 | Monique G. Cola Stephanie K. Daniels David M. Corey Lisa C. Lemen Maryellen Romero Anne L. Foundas | 2010 | Stroke2010，，3： | 2 |
| 3 | The solar X-ray imaget for GOES显示文摘 | Lemen J R Duncan D Edwards C | 2004 | SPIE2004，5171，： | 1 |
| 4 | Shape and moment analysis of tidal expiration in normal and bronchopulmonary dysplasia infants显示文摘 | Morgen W J Lemen RJ | 1982 | Pediatr Res1982，16，： | 1 |
| 5 | Results of a 90-daysafety assurance study with rats fed grain from corn borer-protectedcorn显示文摘 | Hammond B G Dudek R Lemen J K | 2006 | Food and Chemical Toxicology2006，44，7： | 1 |
| 6 | CHRysotile asbestos as a cause of mesothelioma: application of the Hill causation model显示文摘 | LEMEN R A | 2004 | IntJ Occup Environ Health2004，10，2： | 1 |
| 7 | Occupational exposure to cHRysotile asbestos and cancer risk: a review of the amphibole hypothesis显示文摘 | STAYNER L T DANKOVlC D A LEMEN R A | | Am J Public Health0，86，2： | 1 |
| 8 | Results of 13- week safety assurance study with rats fed grain from glyphosate tolerant corn 显示文摘 | Hammond B Dudek R Lemen J | 2004 | Food and Chemical Toxicology2004，42，6： | 1 |
| 9 | Results of 90-day safety assurance study with rats fed grain from corn rootworm-protected corn 显示文摘 | Hammond B Lemen J Dudek R | 2006 | Food and Chemical Toxicology2006，44，2： | 1 |
| 10 | Sun Earth Connection Coronal and Heliospheric Investigation (SECCHI)显示文摘 | R. A. Howard J. D. Moses A. Vourlidas J. S. Newmark D. G. Socker S. P. Plunkett C. M. Korendyke J. W. Cook A. Hurley J. M. Davila W. T. Thompson O. C. St Cyr E. Mentzell K. Mehalick J. R. Lemen J. P. Wuelser D. W. Duncan T. D. Tarbell C. J. Wolfson A. Moo | 2008 | Space Science Reviews (-)2008，，1： | 1 |
| 11 | Results of 90 - day safety assurance study with rats fed grain from corn rootworm - protected corn 显示文摘 | Hammond B Lemen J Dudek R | 2006 | Food and Chemical Toxicology2006，44，： | 1 |
| 12 | Consequence of use of lower dose flat plate fluoroscopy in pediatric patients undergoing ablation for supraventricular tachycardia 显示文摘 | Spar DS Anderson JB Lemen L | 2013 | Am J Cardiol2013，112，1： | 1 |
| 13 | Results of a 13 week safety assurance study with rats fed grain from glyphosate tolerant corn 显示文摘 | Hammond B Dudek R Lemen J | 2004 | Food and Chemical Toxicology2004，42，6： | 1 |
| 14 | Cancer mortali- ty among cadmium production workers 显示文摘 | Lemen R A Lee J S Wagoner J K | 1976 | Annals of the New York Academy of Sciences1976，271，： | 1 |
| 15 | Solar x- ray imager for GOES显示文摘 | LEMEN J R DUNCAN D EDWARDS C | 2003 | SPIE2003，5171，1： | 1 |
| 16 | PET/CT and SPECT/CT Dosimetry in Children: The Challenge to the Pediatric Imager显示文摘 | Michael J. Gelfand Lisa C. Lemen | 2007 | Seminars in Nuclear Medicine2007，，5： | 1 |
| 17 | Post-flare loops of 26 June 1992显示文摘 | B. Schmieder P. Heinzel L. Driel-Gesztelyi J. R. Lemen | 1996 | Solar Physics1996，，2： | 1 |
| 18 | Consequence of use of lower dose flat plate fluoroscopy in pediatric patients undergoing ablation for supraventricular tachycardia显示文摘 | Spar DS Anderson JB Lemen L | 2013 | Am J Cardiol2013，，： | 1 |
| 19 | Relation between cool and hot post-flare loops of 26 June 1992 derived from optical and X-ray (SXT-Yohkoh) observations显示文摘 | B. Schmieder P. Heinzel J. E. Wiik J. Lemen B. Anwar P. Kotr? E. Hiei | 1995 | Solar Physics1995，，2： | 1 |
| 20 | EIT: Extreme-ultraviolet Imaging Telescope for the SOHO mission显示文摘 | J. -P. Delaboudinière G. E. Artzner J. Brunaud A. H. Gabriel J. F. Hochedez F. Millier X. Y. Song B. Au K. P. Dere R. A. Howard R. Kreplin D. J. Michels J. D. Moses J. M. Defise C. Jamar P. Rochus J. P. Chauvineau J. P. Marioge R. C. Catura J. R. Lemen L. | 1995 | Solar Physics (-)1995，，1： | 1 |
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