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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 4 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 5 | Fast-track anesthesia with remifentanil and spinal analgesia for surgery: the effect on pain control and quality of reeovery显示文摘 | Lena P Balarac N Lena D | 2008 | J Cardiothorac Vasc Anesth2008，22，4： | 1 |
| 6 | Craniopharyngioma in children:marseille experience显示文摘 | Lena G Paz Paredes A Scavarda D | 2005 | Childs Nerv Syst2005，21，8： | 1 |
| 7 | Fast-track anesthesia with remifentanil and spinal analgesia for cardiac surgery:the effect on pain control and quality of recovery显示文摘 | Lena PBalarac N Lena D | 2008 | J Cardiothorac Vasc Anesth2008，22，4： | 1 |
| 8 | A study on the influence of fucosterol on thermal polymerization of purified high oleic sun-flower triacylglycerols显示文摘 | Anna M L Lena H D | 1999 | J Sci Food Agric1999，79，： | 1 |
| 9 | Determination of food constituents based on SFE:applications to vitamins A and E in meat and milk显示文摘 | HANS B CHARLOTTA T LENA D | 2000 | Journal of Biophysics Methods2000，43，： | 1 |
| 10 | Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats显示文摘 | Amanda Miller Vibhas Mujumdar Lena Palmer John D Bower Suresh C Tyagi | 2002 | American Journal of Hypertension2002，，2： | 1 |
| 11 | Leptin and mechanisms of endothelial dysfunction and cardiovascular disease 显示文摘 | JARROD D KNUDSON GREGORY A PAYNE LENA BORBOUSE et at | 2008 | Current Hypertension Re- ports2008，10，43： | 1 |
| 12 | Experimental investigation of the Zr comer of the ternary Zr-Nb-Fe phase diagram显示文摘 | GRANOVSKY M S CANAY M LENA E ARIAS D | 2002 | J Nucl Mater2002，302，： | 1 |
| 13 | Implementation of food safety management systems in the UK显示文摘 | Lena D M Denyse J | 2011 | Food Control2011，22，8： | 1 |
| 14 | Fast-track anesthe- sia with remifentani and spinal analgesia for cardiac surgery the effect on pain control and quality of re- covery显示文摘 | Lena P Balarac N Lena D | 2008 | J Cardiothorac Vasc Anesth2008，22，4： | 1 |
| 15 | Sub-scalar reactions during oxidation of Iw-phase SiAlON glass ceramics under a very low oxygen partial pressure显示文摘 | IAN MacLaren LENA K L FAIKA A D | 2001 | Journal of the European Ceramic Society2001，，21： | 1 |
| 16 | Craniopharyngioma in children marseille experience 显示文摘 | Lena G Paredes A Scavarda D | 2005 | Childs Nerv Syst2005，21，8： | 1 |
| 17 | Modeling and constraint optimisation of an aromatic nitration in liquid-liquid medium 显示文摘 | Flavio Augusto D'Angelo Lena Brunet Patrick Cognet | 2003 | Chemical Engineering Journal2003，91，1： | 1 |
| 18 | Transition metal catalysts for controlled radical polymerization显示文摘 | Lena F D Matyjaszewski K | 2010 | Prog Polym Sci2010，35，7： | 1 |
| 19 | Rat hippocampal neurons are critically involved in physiological improvement of memory processes induced by cholecystokinin-B receptor stimulation 显示文摘 | Sebret A Lena 1 Crete D | 1999 | Neuresci1999，19，16： | 1 |
| 20 | Soy sterol esters and 显示文摘 | Lena N Paresh D Agot L | 2000 | Am J Clin Nutr2000，71，4： | 1 |
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