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| 1 | Endoscopic innovations to increase the adenoma detection rate during colonoscopy显示文摘Up to a quarter of polyps and adenomas are missed during colonoscopy due to poor visualization behind folds and the inner curves of flexures,and the presence of flat lesions that are difficult to detect.These numbers may however be conservative because they mainly come from back-to-back studies performed with standard colonoscopes,which are unable to visualize the entire mucosal surface.In the past several years,new endoscopic techniques have been introduced to improve the detection of polyps and adenomas.The introduction of high definition colonoscopes and visual image enhancement technologies have been suggested to lead to better recognition of flat and small lesions,but the absolute increase in diagnostic yield seems limited.Cap assisted colonoscopy and water-exchange colonoscopy are methods to facilitate cecal intubation and increase patients comfort,but show only a marginal or no benefit on polyp and adenoma detection.Retroflexion is routinely used in the rectum for the inspection of the dentate line,but withdrawal in retroflexion in the colon is in general not recommended due to the risk of perforation.In contrast,colonoscopy with the Third-Eye Retroscope?may result in considerable lower miss rates compared to standard colonoscopy,but this technique is not practical in case of polypectomy and is more time consuming.The recently introduced Full Spectrum Endoscopy?colonoscopes maintains the technical capabilities of standard colonoscopes and provides a much wider view of 330 degrees compared to the 170 degrees with standard colonoscopes.Remarkable lower adenoma miss rates with this new technique were recently demonstrated in the first randomized study.Nonetheless,more studies are required to determine the exact additional diagnostic yield in clinical practice.Optimizing the efficacy of colorectal cancer screening and surveillance requires high definition colonoscopes with improved virtual chromoendoscopy technology that visualize the whole colon mucosa while maintaining optimal washing,suction and therapeutic capabilities,and keeping the procedural time as low and patient discomfort as optimal as possible. | Vincent K Dik Leon MG Moons Peter D Siersema | 2014 | World Journal of Gastroenterology2014,20,9: | 6 |
| 2 | Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain显示文摘 | Leone P Samulski RJ | 1994 | Nat Genet1994,8,: | 1 |
| 3 | Endogenous nitricoxid is present in the exhaled air of rab- bits, guinea pig and humans 显示文摘 | GUSTAFSSON LE LEONE AM PERSSON MG | 1991 | Biochem Biophys Res Commun1991,181,: | 1 |
| 4 | Laparoscopic management of small bowel obstraction:indication and outcome 显示文摘 | LEON EL SARR MG VANEK VW | 1998 | J Gastrointrst Surg1998,2,2: | 1 |
| 5 | Laparoscopic management of small bowel obstruction:indicatl on and outcome显示文摘 | LEON EL SARR MG VANCK VW | 1998 | J Gastrointrst Surg1998,2,2: | 1 |
| 6 | Changes of lipocalin type prostaglandin D-synthase in the seminal plasma of subfertile man显示文摘 | Leone MG Abdel HH Gennaro G | 2001 | Res Commun Mol Pathol Pharmacol2001,110,12: | 1 |
| 7 | Endogenous present in the Persson nitric exhaled rabbits, guinea pigs 显示文摘 | Gustafsson LE Leone AM MG et oxide air of humans a is 1 | 1991 | Biochem Biophys Commun1991,181,: | 1 |
| 8 | Randomized controlled trial comparing simultaneous versus optimized sequential interventricular stimulation during cardiac resynchronization therapy显示文摘 | Abraham WT Leon AR St John Sutton MG | 2012 | Am Heart J2012,164,: | 1 |
| 9 | Laparoscopic nlanagement of small bowel obstruction: indication and outcome 显示文摘 | Leon EL Sarr Mg Vanck VW | 1998 | J Gastroin -trstSurg1998,2,2: | 1 |
| 10 | Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain显示文摘 | Kaplitt MG Leone P Samulski RJ | 1994 | Nat Genet1994,8,2: | 1 |
| 11 | Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans 显示文摘 | Gustafsson LE Leone AM Persson MG | 1991 | Biochem Biophys Res Commun1991,181,2: | 1 |
| 12 | Myxoid calcified hamartoma and natal teeth: a case report 显示文摘 | Agostini M Leon JE Kellermann MG | 2008 | Int J Pediatr Otorhinolaryngol2008,72,12: | 1 |
| 13 | Changes of Lipocalin type prostaglandin D-synthase in the seminal plasma of subfertile man显示文摘 | Leone MG Abdel HH Gennaro G | 2001 | Res Commun Mol Pathol Pharmacol2001,110,: | 1 |
| 14 | Lipocalin-type prostaglandin D synthase:Which role in male fertility显示文摘 | Leone MG Haq HA Saso L | 2002 | Contaception2002,65,4: | 1 |
| 15 | The clinical significance of mitral insufficiency detected by Doppler echocardiography in acute myocardial infarct显示文摘 | Bordalo e Sa AL Gonzalez DS Leon MG | 1993 | Rev Port Cardiol1993,12,1: | 1 |
| 16 | Endogenous nitric oxide is present in the eaha|ed air of rabbits,guinea pigs and humans显示文摘 | Gustafsso LE Leone AM Persson MG | 1991 | Biochem Biophys Respir Commun1991,181,2: | 1 |
| 17 | Endogenous nitric ox- ide is present in the exhaled air of rabbits, guinea pigs and humans显示文摘 | Gustafsson LE Leone AM Persson MG et 81 | 1991 | Bioehem Biophys Res Commun1991,181,2: | 1 |
| 18 | Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans 显示文摘 | Gustafsson LE Leone AM Persson MG | 1991 | Biochem Biophys Respir Commun1991,181,2: | 1 |
| 19 | Changes of Lipocalin type prostaglandin D-synthase in the seminal plasma of subfertile man显示文摘 | Leone MG Abdel HH Gennaro G | 2001 | Res Commun Mol Pathol Pharmacol2001,110,12: | 1 |
| 20 | Safe and cost effective use of alteplase for the clearance of occluded central venous access devices 显示文摘 | Timoney JP Malkin MG Leone DM | 2002 | JClin Oncol2002,20,7: | 1 |