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您的检索式：作者名="Leslie Chang"
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| 1 | Three dimensional computerized tomograpgic analysis of the deformity of lateral growth disturbance of proximal femoral physis 显示文摘 | Sun YJ Chang WO Leslie G | 2009 | J Pediatric Orthop2009，29，： | 1 |
| 2 | Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues显示文摘Human osteogenic progenitors are not precisely defined,being primarily studied as heterogeneous multipotent cell populations and termed mesenchymal stem cells(MSCs).Notably,select human pericytes can develop into bone-forming osteoblasts.Here,we sought to define the differentiation potential of CD146 f human pericytes from skeletal and soft tissue sources,with the underlying goal of defining cell surface markers that typify an osteoblastogenic pericyte.CD146+CD31~CD45_pericytes were derived by fluorescence-activated cell sorting from human periosteum,adipose,or dermal tissue.Periosteal CD146+CD31—CD45 cells retained canonical features of pericytes/MSC.Periosteal pericytes demonstrated a striking tendency to undergo osteoblastogenesis in vitro and skeletogenesis in vivo,while soft tissue pericytes did not readily.Transcriptome analysis revealed higher CXCR4 signaling among periosteal pericytes in comparison to their soft tissue counterparts,and CXCR4 chemical inhibition abrogated ectopic ossification by periosteal pericytes.Conversely,enrichment of CXCR4+pericytes or stromal cells identified an osteoblastic/non-adipocytic precursor cell.In sum,human skeletal and soft tissue pericytes differ in their basal abilities to form bone.Diversity exists in soft tissue pericytes,however,and CXCR4+pericytes represent an osteoblastogenic,non-adipocytic cell precursor.Indeed,enrichment for CXCR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering. | Jiajia Xu Dongqing Li Ching-Yun Hsu Ye Tian Leititia Zhang Yiyun Wang Robert J.Tower Leslie Chang Carolyn A.Meyers Yongxing Gao Kristen Broderick Carol Morris Jody E.Hooper Sridhar Nimmagadda Bruno Peault Aaron W.James | 2020 | Bone Research2020，8，3： | 1 |
| 3 | Genome-wide association and genomic prediction identifies soybean cyst nematode resistance in common bean including a syntenic region to soybean Rhg1 locus显示文摘A genome-wide association study(GWAS)was applied to detect single nucleotide polymorphisms(SNPs)significantly associated with resistance to Heterodera glycines(HG)also known as the soybean cyst nematode(SCN)in the core collection of common bean,Phaseolus vulgaris.There were 84,416 SNPs identified in 363 common bean accessions.GWAS identified SNPs on chromosome(Chr)1 that were significantly associated with resistance to HG type 2.5.7.These SNPs were in linkage disequilibrium with a gene cluster orthologous to the three genes at the Rhg1 locus in soybean.A novel signal on Chr 7 was detected and associated with resistance to HG type 1.2.3.5.6.7.Genomic predictions(GPs)for resistance to these two SCN HG types in common bean achieved prediction accuracy of 0.52 and 0.41,respectively.Our study generated a high-quality SNP panel for 363 common bean accessions and demonstrated that both GWAS and GP were effective strategies to understand the genetic architecture of SCN resistance in common bean. | Liwei Wen Hao-Xun Chang Patrick J.Brown Leslie L.Domier Glen L.Hartman | 2019 | Horticulture Research2019，6，1： | 0 |
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