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| 1 | Effects of Y on the Microstructure, Mechanical and Bio-corrosion Properties of Mg-Zn-Ca Bulk Metallic Glass显示文摘The micro-alloying effects of Y on the microstructure, mechanical properties, and bio-corrosion behavior of Mg69-xZn27Ca4Yx(x= 0, 1, 2 at.%) alloys were investigated through X-ray diffraction, compressive tests,electrochemical treatments, and immersion tests. The Mg69Zn27Ca4 alloy was found to be absolutely amorphous, and its glass-forming ability decreased with the addition of Y. The Mg68Zn27Ca4Y1 alloy exhibited an ultrahigh compressive strength above 1010 MPa as well as high capacity for plastic strain above 3.1%.Electrochemical and immersion tests revealed that these Y-doped MgeZ neC a alloys had good bio-corrosion resistance in simulated body fluid(SBF) at 37℃. The results of the cytotoxicity test showed high cell viabilities for these alloys, which means good bio-compatibility. | Jingfeng Wang Yang Li Song Huang Yiyun Wei Xingfeng Xi Kaiyong Cai Fusheng Pan | 2014 | Journal of Materials Science & Technology2014，30，12： | 8 |
| 2 | All-small-molecule dynamic covalent gels with antibacterial activity by boronate-tannic acid gelation显示文摘Reversible boronate-catechol linkage was widely used to construct two-dimensional coatings and threedimensional nanostructures or hydrogels.The construction of these functional materials usually requires the pre-synthesis of macro molecular building blocks,and direct gelation between natural polyphenols and small molecule boranic acids is yet to be investigated.In this study,we fabricated a family of allsmall-molecule dynamic covalent gels consisting of tannic acid and boronic acids.Transparent and thixotropic gels were formed by boronate affinity towards catechol groups abundant on natural polyphenols.The gels showed multi-responsiveness,such as acid-,base-,reduction-and oxidantsensitive depending on the used boronic acid building blocks.The chemistry for gel formation and stimuli-responsiveness was characterized by11B NMR spectroscopy.The multi-stimuli responsiveness,green processing and facile modular design make the boronic acid-tannic acid gels promising candidates for the development of smart soft materials. | Xuejing Cheng Mengyu Li Hui Wang Yiyun Cheng | 2020 | Chinese Chemical Letters2020，31，3： | 6 |
| 3 | Common-Ion Effect Triggered Highly Sustained Seawater Electrolysis with Additional NaCl Production显示文摘Developing efficient seawater-electrolysis system for mass production of hydrogen is highly desirable due to the abundance of seawater.However,continuous electrolysis with seawater feeding boosts the concentration of sodium chloride in the electrolyzer,leading to severe electrode corrosion and chlorine evolution.Herein,the common-ion effect was utilized into the electrolyzer to depress the solubility of NaCl.Specifically,utilization of 6M NaOH halved the solubility of NaCl in the electrolyte,affording efficient,durable,and sustained seawater electrolysis in NaCl-saturated electrolytes with triple production of H_(2),O_(2),and crystalline NaCl.Ternary NiCoFe phosphide was employed as a bifunctional anode and cathode in simulative and Ca/Mg-free seawater-electrolysis systems,which could stably work under 500 mA/cm^(2) for over 100 h.We attribute the high stability to the increased Na^(+)concentration,which reduces the concentration of dissolved Cl-in the electrolyte according to the common-ion effect,resulting in crystallization of NaCl,eliminated anode corrosion,and chlorine oxidation during continuous supplementation of Ca/Mg-free seawater to the electrolysis system. | Pengsong Li Shiyuan Wang Imran Ahmed Samo Xingheng Zhang Zhaolei Wang Cheng Wang Yang Li Yiyun Du Yang Zhong Congtian Cheng Wenwen Xu Xijun Liu Yun Kuang Zhiyi Lu Xiaoming Sun | 2020 | Research2020，，1： | 3 |
| 4 | Black carbon emissions in China显示文摘 | David G. Streets Shalini Gupta Stephanie T. Waldhoff Michael Q. Wang Tami C. Bond Bo Yiyun | 2001 | Atmospheric Environment2001，，25： | 2 |
| 5 | Black carbon emissions in China显示文摘 | David G. Streets Shalini Gupta Stephanie T. Waldhoff Michael Q. Wang Tami C. Bond Bo Yiyun | 2001 | Atmospheric Environment2001，，25： | 2 |
| 6 | PDGFRαreporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair显示文摘The outer coverings of the skeleton,which is also known as the periosteum,are arranged in concentric layers and act as a reservoir for tissue-specific bone progenitors.The cellular heterogeneity within this tissue depot is being increasingly recognized.Here,inducible PDGFRαreporter animals were found to mark a population of cells within the periosteum that act as a stem cell reservoir for periosteal appositional bone formation and fracture repair.During these processes,PDGFRαreporter^(+)progenitors give rise to Nestin+periosteal cells before becoming osteoblasts and osteocytes.The diphtheria toxin-mediated ablation of PDGFRαreporter^(+)cells led to deficits in cortical bone formation during homeostasis and a diminutive hard callus during fracture repair.After ossicle transplantation,both mouse PDGFRαreporter^(+)periosteal cells and human Pdgfrα+periosteal progenitors expand,ossify,and recruit marrow to a greater extent than their counterpart periosteal cells,whereas PDGFRαreporter^(−)periosteal cells exhibit a predisposition to chondrogenesis in vitro.Total RNA sequencing identified enrichment of the secreted factors Fermt3 and Ptpn6 within PDGFRαreporter^(+)periosteal cells,which partly underlie the osteoblastogenic features of this cell population. | Jiajia Xu Yiyun Wang Zhu Li Ye Tian Zhao Li Amy Lu Ching-Yun Hsu Stefano Negri Cammy Tang Robert J.Tower Carol Morris Aaron W.James | 2022 | Bone Research2022，10，1： | 2 |
| 7 | An Exploration of Teaching Class of Mixed Ability显示文摘There has been a long time of debate between the two teaching approaches of homogenous grouping and heterogeneous grouping.Here in the essay,we explored both of the two teaching approaches in Yunnan Province of China whereas the puzzle lies in the question of which method can achieve a relatively-better result in English classes of Yunnan.Some possible solutions are promoted based on the data and analysis collected from a survey. | DUAN Lifang SHI Yun WANG Yiyun | 2020 | Sino-US English Teaching2020，17，4： | 1 |
| 8 | Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery显示文摘There is a continuing quest to rationally fabricate polymeric biomaterials with both high transfection efficiency and minimal toxicity for the emerging opportunities in small interfering RNA(siRNA)delivery.Recently,this goal was promoted highly by developing a robust and efficient strategy to facilitate polymer-mediated RNAi using natural polyphenols with multiple phenol groups that could condense siRNA effectively into negatively charged nanoparticles(NPs).Further coating of these NPs with cationic polymers of low molecular weight enabled their intracellular siRNA delivery.Inspired by the structural and functional features of natural polyphenols,we aimed to further the development of low molecular weight polycatechols as a new class of efficient and biocompatible polymers for siRNA delivery in our current study.The fabricated polycatechols have benefits of requiring only one-step fabrication toward efficient siRNA nanoformulations.Moreover,they could deliver siRNA into cells and silence target genes both in vitro and in vivo.The resulting polycatechol/siRNA formulations were also functionally competent,demonstrating a successful,profound downregulation of a proinflammatory enzyme to attenuate chronic intestinal inflammation in an intestinal injury model.This study provides a new approach in chemistry for the development of efficient synthetic polymers for therapeutic siRNA delivery. | Wanwan Shen Ruojun Wang Qianqian Fan Xiao Gao Hui Wang Yang Shen Yiwen Li Yiyun Cheng | 2020 | CCS Chemistry2020，2，3： | 1 |
| 9 | Microsatellite-centromere mapping in large yellow croaker (Pseudosciaenacrocea) using gynogenetic diploid families显示文摘 | U Yiyun CAI Mingyi WANG Zhiyong | 2008 | Mar Biotechnol2008，10，1： | 1 |
| 10 | Beyond fundamental resonance mode:high-order multi-band ALN PMUT for in vivo photoacoustic imaging显示文摘This paper reports on an aluminum nitride(AlN)piezoelectric micromachined ultrasound transducer(PMUT)array for photoacoustic(PA)imaging,where the high-order resonance modes of the PMUT are utilized to improve imaging resolution.A flexural vibration mode(FVM)PMUT is fabricated and applied in a photoacoustic imaging(PAI)system.Specifically,the microelectromechanical system(MEMS)-based PMUT is suitable for PA endoscopic imaging of blood vessels and bronchi due to its miniature size and high sensitivity.More importantly,AlN is a nontoxic material,which makes it harmless for biomedical applications.In the PAI system,the AlN PMUT array is used to detect PA signals,and the acousto–mechanical response is designed and optimized at the PMUT’s fundamental resonance.In this work,we focus on the high-order resonance performance of the PMUT PAI beyond the fundamental resonance.The acoustic and electrical responses of the PMUT’s high-order resonance modes are characterized and analyzed.The fundamental and three high-order resonance bandwidths are 2.2,8.8,18.5,and 48.2 kHz.Compared with the resolution at the fundamental resonance mode,the resolutions at third-and fourth-order resonance modes increase by 38.7%and 76.9%in a phantom experiment.The high-order resonance modes of the AlN PMUT sensor array provide higher central frequency and wider bandwidth for PA signal detection,which increase the resolution of PAI compared to the PMUT working at the fundamental resonance mode. | Junxiang Cai Yiyun Wang Daohuai Jiang Songsong Zhang Yuandong Alex Gu Liang Lou Fei Gao Tao Wu | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 11 | A pointer logic and certifying compiler显示文摘 | Yiyun Chen Lin Ge Baojian Hua Zhaopeng Li Cheng Liu Zhifang Wang | 2007 | Frontiers of Computer Science in China2007，，3： | 1 |
| 12 | S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery显示文摘Photocleavable hydrogels are of great importance in the field of controlled drug delivery,stem cell fate regulation,surface patterning,and intelligent devices.However,the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions.Herein,we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages.The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light,and the degradation kinetics could be significantly promoted by hydrogen peroxide.Correspondingly,the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment.This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and ondemand drug release properties. | Changping Wang Chongyi Liu Qiyao Wei Lei Yang Peng Yang Yiwen Li Yiyun Cheng | 2020 | Research2020，，1： | 1 |
| 13 | 30-modeling numerical solutions of electromagnetic behaviorof HTSC bulk above permanent magnetic guideway 显示文摘 | Lu Yiyun Wang Jiasu Wang Suyu | 2008 | Journal of Superconductivity and Novel Magnetism2008，21，46： | 1 |
| 14 | Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues显示文摘Human osteogenic progenitors are not precisely defined,being primarily studied as heterogeneous multipotent cell populations and termed mesenchymal stem cells(MSCs).Notably,select human pericytes can develop into bone-forming osteoblasts.Here,we sought to define the differentiation potential of CD146 f human pericytes from skeletal and soft tissue sources,with the underlying goal of defining cell surface markers that typify an osteoblastogenic pericyte.CD146+CD31~CD45_pericytes were derived by fluorescence-activated cell sorting from human periosteum,adipose,or dermal tissue.Periosteal CD146+CD31—CD45 cells retained canonical features of pericytes/MSC.Periosteal pericytes demonstrated a striking tendency to undergo osteoblastogenesis in vitro and skeletogenesis in vivo,while soft tissue pericytes did not readily.Transcriptome analysis revealed higher CXCR4 signaling among periosteal pericytes in comparison to their soft tissue counterparts,and CXCR4 chemical inhibition abrogated ectopic ossification by periosteal pericytes.Conversely,enrichment of CXCR4+pericytes or stromal cells identified an osteoblastic/non-adipocytic precursor cell.In sum,human skeletal and soft tissue pericytes differ in their basal abilities to form bone.Diversity exists in soft tissue pericytes,however,and CXCR4+pericytes represent an osteoblastogenic,non-adipocytic cell precursor.Indeed,enrichment for CXCR4-expressing stromal cells is a potential new tactic for skeletal tissue engineering. | Jiajia Xu Dongqing Li Ching-Yun Hsu Ye Tian Leititia Zhang Yiyun Wang Robert J.Tower Leslie Chang Carolyn A.Meyers Yongxing Gao Kristen Broderick Carol Morris Jody E.Hooper Sridhar Nimmagadda Bruno Peault Aaron W.James | 2020 | Bone Research2020，8，3： | 1 |
| 15 | Catechol-Based Polymers with High Efficacy in Cytosolic Protein Delivery显示文摘Polymers have been widely proposed as carriers for cytosolic protein delivery despite multiple barriers such as protein binding,cell internalization,and endosome escape during cytosolic delivery.Inspired by the strong binding affinity of natural polyphenols with proteins and cell membranes,herein we propose polyphenol modification to improve the efficacy of the protein delivery of cationic polymers.Catecholmodified dendrimers with balanced hydrophobic and hydrogen-bonding interactions show the highest efficacy for various cargo proteins and peptides while the pyrogallol-grafted ones exhibit the lowest efficacy due to increased ligand hydrophilicity.The catechol-based polymers efficiently deliver various bioactive proteins into the cytosol of live cells,exerting biofunctions after intracellular release,and successfully transmittingα-chymotrypsin into tumor cells in vivo to inhibit tumor growth.This study proves that polycatechols can serve as a family of highly efficient carriers for delivery of macromolecular biopharmaceuticals. | Zhe Zhang Xin Gao Yanwen Li Jia Lv Hui Wang Yiyun Cheng | 2023 | CCS Chemistry2023，5，6： | 1 |
| 16 | A genetic map of large yellow croaker Pseudosciaena crocea显示文摘 | Yue Ning Xiande Liu Zhi Yong Wang Wei Guo Yiyun Li Fangjing Xie | 2007 | Aquaculture2007，，1： | 1 |
| 17 | Deciphering Brain Complexity Using Single-cell Sequencing显示文摘The human brain contains billions of highly differentiated and interconnected cells that form intricate neural networks and collectively control the physical activities and high-level cognitive functions,such as memory,decision-making,and social behavior.Big data is required to decipher the complexity of cell types,as well as connectivity and functions of the brain.The newly developed single-cell sequencing technology,which provides a comprehensive landscape of brain cell type diversity by profiling the transcriptome,genome,and/or epigenome of individual cells,has contributed substantially to revealing the complexity and dynamics of the brain and providing new insights into brain development and brain-related disorders.In this review,we first introduce the progresses in both experimental and computational methods of single-cell sequencing technology.Applications of single-cell sequencing-based technologies in brain research,including cell type classification,brain development,and brain disease mechanisms,are then elucidated by representative studies.Lastly,we provided our perspectives into the challenges and future developments in the field of single-cell sequencing.In summary,this mini review aims to provide an overview of how big data generated from single-cell sequencing have empowered the advancements in neuroscience and shed light on the complex problems in understanding brain functions and diseases. | Quanhua Mu Yiyun Chen Jiguang Wang | 2019 | Genomics, Proteomics & Bioinformatics2019，17，4： | 1 |
| 18 | Meta‐Analysis of Factors Which Influence Delirium Following Cardiac Surgery显示文摘 | Yiyun Lin Jian Chen Zhinong Wang | 2012 | Journal of Cardiac Surgery2012，，4： | 1 |
| 19 | Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice显示文摘According to the proportion of 1:1, konjac flour and mulberry leaf powder are compounded into a kind of dietary fiber source(KMCP). It is found to be good for anti-inflammation. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In our work, the effect of KMCP on allergic rhinitis(AR)induced by ovalbumin(OVA)was investigated. We found that the number of nasal rubbing and sneezing, the eosinophil(EOS)count in the nasal mucosa, and the serum levels of histamine(HIS), OVA-specific immunoglobulin E(OVA-sIgE)and interleukin-4(IL-4)were decreased, and the histopathological changes of nasal mucosa were inhibited. Additionally, the experiments further proved that the KMCP treatment could exert substantial effects on short-chain fatty acids(SCFAs)metabolism in the cecum as well. Overall findings suggest that KMCP could suppress the inflammatory response in AR mice, and serve as a novel curative therapeutic for AR without side effects. | Yiyun Zhang Jinxing Wang Qi Zhang Liling Deng Siyao Miao Geng Zhong | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 20 | 继发胶质母细胞瘤基因突变全景图指导下的靶向MET的脑肿瘤临床试验显示文摘文章简介低级别胶质瘤几乎全部会进展到高级别的继发胶质母细胞瘤,且该进展过程的机制并不明晰,也没有阻止进展的治疗手段。通过研究188例继发胶质母细胞瘤的基因突变全景图. | Huimin Hu Quanhua Mu Zhaoshi Bao Yiyun Chen Yanwei Liu Jing Chen Kuanyu Wang Zheng Wang Yoonhee Nam Biaobin Jiang Jason K.Sa.Hee-Jin Cho Nam-Gu Her Chuanbao Zhang Zheng Zhao Ying Zhang Fan Zeng Fan Wu Xun Kang Yuqing Liu Zenghui Qian Zhiliang Wang Ruoyu Huang Qiangwei Wang Wei Zhang Xiaoguang Qiu Wenbin Li Do-Hyun Nam 樊小龙 王吉光 江涛 | 2019 | 科学新闻2019，0，2： | 0 |
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