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| 1 | Current Control Strategy of Chain Circuit STATCOM显示文摘在链式静止同步补偿器(static synchronous compen-sator,STATCOM)小信号交流模型的基础上,提出简化的STATCOM电流控制闭环系统;分别对典型Ⅰ型、典型Ⅱ型控制系统的电流调节器进行参数优化及比较,分析表明,对于电流阶跃响应,系统处于线性控制状态时超调量相对百分比不变,处于限幅非线性状态时超调量绝对值不变;采用比例调节器的典型I型系统稳态精度稍差,但动态控制精度较高,适合用于链式STATCOM工程装置;在a-b-c坐标系下仿真表明,应用优化设计的典型Ⅰ型系统控制参数,链式STATCOM输出电流可以快速跟踪参考值变化,具有良好的稳定性和跟踪精度。 | WANG Xuan FU Jian TENG Letian SUN Lijing ZHAO Ruibin WU Shouyuan DENG Zhanfeng | 2012 | 中国电机工程学报2012，32，12： | 15 |
| 2 | Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors显示文摘Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.Herein,we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective. | Shenghua Gao Tianguang Huang Letian Song Shujing Xu Yusen Cheng Srinivasulu Cherukupalli Dongwei Kang Tong Zhao Lin Sun Jian Zhang Peng Zhan Xinyong Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 5 |
| 3 | Hd1,Ghd7,and DTH8 synergistically determine the rice heading date and yield-related agronomic traits显示文摘Heading date determines the seasonal and regional adaptation of rice(Oryza sativa L.)varieties and is mainly controlled by photoperiod sensitivity(PS).The core heading date genes Hd1,Ghd7,DTH8,and PRR37 act synergistically in regulating the PS.In this study,we systematically analyze the heading date,PS,and agronomic traits of eight homozygous lines with various combinations of Hd1,Ghd7,and DTH8 alleles in the prr37 background under long-day(LD)and short-day(SD)conditions,respectively.We find that Hd1 alone promotes heading,regardless of the day length.However,under LDs,Hd1 suppresses flowering,in coordination with functional Ghd7 or with Ghd7 and DTH8.These loci cooperate to negatively regulate the Ehd1-Hd3 a/RFT1 pathway and delay heading.Under SDs,Hd1 competes with various heading suppressors to promote heading.Therefore,the dual function of Hd1 is vital for PS.The lines carrying Hd1 alone show reduced plant height with fewer primary and secondary branches in panicles.Lines carrying Ghd7 and DTH8(with hd1)show delayed heading and improve agronomic traits.Overall,our results reveal the regulation of rice PS flowering by the core heading date genes and their effects on agronomic traits,providing valuable information for the selection of rice varieties for adaptation to different light and temperature conditions. | Kangli Sun Minghui Huang Wubei Zong Dongdong Xiao Chen Lei Yanqiu Luo Yingang Song Shengting Li Yu Hao Wanni Luo Bingqun Xu Xiaotong Guo Guangliang Wei Letian Chen Yao-Guang Liu Jingxin Guo | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 4 | Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities显示文摘Twenty-two new limonoids,mufolinoids A—V(1—22),including six rings A,B-seco limonoids(1—6),twelve ring A-seco limonoids(7—18),four ring-intact limonoids(19—22),together with thirteen known compounds(23—35)were isolated from Munronia unifoliolata.Their structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray diffraction and calculations of ECD and NMR technologies.Compounds 24,25,33,34 could be significantly reversed the multidrug resistance of MCF-7/doxorubicin(DOX)cells,and the reversal fold(RF)was much higher than that of positive drug Verapamil.Compounds 24,28,and 29 exhibited significant anti-inflammatory activity with the IC50 values in the range of 17.7—39.4μmol/L.Furthermore,compound 29 could markedly inhibit the release of IL-1βby inhibiting the initiation and assembly of NLRP3 inflammasome,which demonstrates the great potential of limonoids as an anti-inflammatory agent. | Yunpeng Sun Qiurong Li Letian Cui Pengfei Tang Yongyi Li Lingyi Kong Jun Luo | 2022 | Chinese Journal of Chemistry2022，40，1： | 1 |
| 5 | Cross-scene passive human activity recognition using commodity WiFi显示文摘With the development of the Internet of Things(IoT)and the popularization of commercial WiFi,researchers have begun to use commercial WiFi for human activity recognition in the past decade.However,cross-scene activity recognition is still difficult due to the different distribution of samples in different scenes.To solve this problem,we try to build a cross-scene activity recognition system based on commercial WiFi.Firstly,we use commercial WiFi devices to collect channel state information(CSI)data and use the Bi-directional long short-term memory(BiLSTM)network to train the activity recognition model.Then,we use the transfer learning mechanism to transfer the model to fit another scene.Finally,we conduct experiments to evaluate the performance of our system,and the experimental results verify the accuracy and robustness of our proposed system.For the source scene,the accuracy of the model trained from scratch can achieve over 90%.After transfer learning,the accuracy of cross-scene activity recognition in the target scene can still reach 90%. | Yuanrun FANG Fu XIAO Biyun SHENG Letian SHA Lijuan SUN | 2022 | Frontiers of Computer Science2022，16，1： | 1 |
| 6 | Elodexanthones A—J, Isoprenylated Xanthone Derivatives with Diverse Skeletons and Bioactivities from Hypericum elodeoides显示文摘Elodexanthones A—J (1—10), two pairs of rearranged isoprenylated xanthone enantiomers with an unprecedent 6/6/5/6 tetracyclic core (1—2) along with seven new isoprenylated xanthones (3—9) and a pair of phenylpropanoid xanthones (10), were purified and enantio-separated from the whole plant of Hypericum elodeoides. Their structures including absolute configurations were characterized by the comprehensive analysis of NMR, HRESIMS, NMR calculations, and ECD calculations. Through Bayer-Villiger oxidation, Claisen condensation and electrophilic addition, the rearranged skeletons of elodexanthones A—B (1—2) were generated from isoprenylated xanthone precursors. The bioactivities evaluation exhibited that compounds 3, 5, 8—10 showed anti-inflammatory activity with the IC_(50) values in the range of 9.53—34.39 μmol/L, and compounds 3—7, and 9 showed notable α-glucosidase inhibitory activity (IC_(50): 6.02—257.11 μmol/L). | Yanbing Mu Yaqi Li Qiji Li Wenjun Xu Yunpeng Sun Siyuan Wang Letian Cui Lingyi Kong Jun Luo | 2022 | Chinese Journal of Chemistry2022，40，24： | 1 |
| 7 | Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors显示文摘The main protease(M^(pro))of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle.The covalent M^(pro)inhibitor nirmatrelvir(in combination with ritonavir,a pharmacokinetic enhancer)and the non-covalent inhibitor ensitrelvir have shown efficacy in clinical trials and have been approved for therapeutic use.Effective antiviral drugs are needed to fight the pandemic,while non-covalent M^(pro)inhibitors could be promising alternatives due to their high selectivity and favorable druggability.Numerous non-covalent M^(pro)inhibitors with desirable properties have been developed based on available crystal structures of M^(pro).In this article,we describe medicinal chemistry strategies applied for the discovery and optimization of non-covalent M^(pro)inhibitors,followed by a general overview and critical analysis of the available information.Prospective viewpoints and insights into current strategies for the development of non-covalent M^(pro)inhibitors are also discussed. | Letian Song Shenghua Gao Bing Ye Mianling Yang Yusen Cheng Dongwei Kang Fan Yi Jin-Peng Sun Luis Menéndez-Arias Johan Neyts Xinyong Liu Peng Zhan | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 8 | Mufolinin A,an unprecedented ring A-seco 10-ethyllimonoid from Munronia unifoliolata显示文摘Mufolinin A(1),a ring A-seco rearranged limonoid with an unprecedented ethyl at C-10 and novel 6/6/6/5 fused-ring skeleton,together with three new potential precursors(ring A-seco limonoids,2–4)were isolated from Munronia unifoliolata.Their structures and absolute configurations were confirmed by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),X-ray crystallography,electronic circular dichroism(ECD)calculations and NMR calculations with DP4+analyses.The unprecedented ethyl group of 1 was hypothesized to be derived from methyl migration and ring reduction rearrangement of ring A-seco limonoid 4.Compounds 2 and 4 showed significant multidrug resistance(MDR)reversal activities in MCF-7/DOX cells with reversal fold(RF)values of 13.1 and 8.0,respectively. | Yunpeng Sun Letian Cui Qiurong Li Pengfei Tang Yongyi Li Wenjun Xu Jun Luo Lingyi Kong | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 9 | Progress and Challenges Toward Effective Flexible Perovskite Solar Cells显示文摘The demand for building-integrated photovoltaics and portable energy systems based on flexible photovoltaic technology such as perovskite embedded with exceptional flexibility and a superior power-to-mass ratio is enormous.The photoactive layer,i.e.,the perovskite thin film,as a critical component of flexible perovskite solar cells(F-PSCs),still faces long-term stability issues when deformation occurs due to encountering temperature changes that also affect intrinsic rigidity.This literature investigation summarizes the main factors responsible for the rapid destruction of F-PSCs.We focus on long-term mechanical stability of F-PSCs together with the recent research protocols for improving this performance.Furthermore,we specify the progress in F-PSCs concerning precise design strategies of the functional layer to enhance the flexural endurance of perovskite films,such as internal stress engineering,grain boundary modification,self-healing strategy,and crystallization regulation.The existing challenges of oxygen-moisture stability and advanced encapsulation technologies of F-PSCs are also discussed.As concluding remarks,we propose our viewpoints on the large-scale commercial application of F-PSCs. | Xiongjie Li Haixuan Yu Zhirong Liu Junyi Huang Xiaoting Ma Yuping Liu Qiang Sun Letian Dai Shahzada Ahmad Yan Shen Mingkui Wang | 2023 | Nano-Micro Letters2023，15，11： | 0 |
| 10 | Experimental and model investigations of SPS casing treatment on a two-stage compressor显示文摘This paper will first carry out experimental investigations on a test compressor which is a large-scale,two-stage and low-speed axial one to evaluate the participation of a novel casing treatment(stall precursor-suppressed casing treatment,SPS CT).The compressor performance for its pressure rise characteristics and efficiency are tested and illustrated.Besides,the time-averaged steady and the time-resolved unsteady measurement in this paper finally lead to some further analyses about the stall evolution of this compressor tending to uncover the process of the stall evolution and the mechanism of the SPS CT.The overall performance results indicate that the SPS CT can extend the compressor stall margin by 3%e11%with very limited efficiency loss.And the mechanism for such casing treatment has also been revealed as stall-precursor suppression by observing the evolution of the inception waves.In addition,modeling work have been conducted subject to the effects of SPS CT on the test two-stage axial compressor.The compressor stability model is able to investigate the effects of different geometrical parameters on the compressor stability and then make an optimal design for the SPS CT when it is applied on the test compressor. | Xu Dong Letian Zhang Dakun Sun Xiaofeng Suna | 2021 | Propulsion and Power Research2021，10，1： | 0 |
| 11 | Smart Design and Manufacturing the Welded Q350 Steel Frames via Lifecycle Management Strategy of Digital Twin显示文摘Artificial intelligent aided design and manufacturing have been recognized as one kind of robust data-driven and data-intensive technologies in the integrated computational material engi-neering(ICME)era.Motivated by the dramatical developments of the services of China Railway High-speed series for more than a decade,it is essential to reveal the foundations of lifecycle man-agement of those trains under environmental conditions.Here,the smart design and manufacturing of welded Q350 steel frames of CR200J series are introduced,presenting the capability and opportu-nity of ICME in weight reduction and lifecycle management at a cost-effective approach.In order to address the required fatigue life time enduring more than 9×10^(6)km,the response of optimized frames to the static and the dynamic loads are comprehensively investigated.It is highlighted that the maximum residual stress of the optimized welded frame is reduced to 69 MPa from 477 MPa of previous existing one.Based on the measured stress and acceleration from the railways,the fatigue life of modified frame under various loading modes could fulfil the requirements of the lifecycle man-agement.Moreover,our recent developed intelligent quality control strategy of welding process mediated by machine learning is also introduced,envisioning its application in the intelligent weld-ing. | Letian Fan Xinchao Wang Yongsheng Chen Li Wang Shumi Liu Yuanfei Wang Xinwei Li Kun Du Jia Zhang Xingyu Gao Feng Sun Haifeng Song William Yi Wang Jinshan Li | 2023 | Journal of Beijing Institute of Technology2023，32，4： | 0 |
| 12 | Unraveling the Effect of Stacking Configurations on Charge Transfer in WS_(2) and Organic Semiconductor Heterojunctions显示文摘Photoinduced interfacial charge transfer plays a critical role in energy conversion involving van der Waals(vdW)heterostructures constructed of inorganic nanostructures and organic materials.However,the effect of molecular stacking configurations on charge transfer dynamics is less understood.In this study,we demonstrated the tunability of interfacial charge separation in a type-Ⅱ heterojunction between monolayer(ML)WS_(2) and an organic semiconducting molecule[2-(3″′,4′-dimethyl-[2,2′:5′,2′:5″,2″′-quaterthiophen]-5-yl)ethan-1-ammonium halide(4Tm)]by rational design of relative stacking configurations.The assembly between ML-WS_(2) and the 4Tm molecule forms a face-to-face stacking when 4Tm molecules are in a selfaggregation state.In contrast,a face-to-edge stacking is observed when 4Tm molecule is incorporated into a 2D organic-inorganic hybrid perovskite lattice.The face-to-face stacking was proved to be more favorable for hole transfer from WS_(2) to 4Tm and led to interlayer excitons(IEs)emission.Transient absorption measurements show that the hole transfer occurs on a time scale of 150 fs.On the other hand,the face-to-edge stacking resulted in much slower hole transfer without formation of IEs.This inefficient hole transfer occurs on a similar time scale as A exciton recombination in WS_(2),leading to the formation of negative trions.These investigations offer important fundamental insights into the charge transfer processes at organic−inorganic interfaces. | Shuchen Zhang Dewei Sun Jiaonan Sun Ke Ma Zitang Wei Jee Yung Park Aidan H.Coffey Chenhui Zhu Letian Dou Libai Huang | 2023 | Precision Chemistry2023，1，7： | 0 |
| 13 | Remarkable mechanochromism and force-induced thermally activated delayed fluorescence enhancement from white-light-emitting organic luminogens with aggregation-induced emission显示文摘The development of organic materials with white-light emission and thermally activated delayed fluorescence(TADF)properties in the solid state remain a challenge.Herein,a series of white-light-emitting organic luminogens have been developed and are found to show aggregation-induced delayed fluorescence(AIDF)characteristics.The AIDF emitters present dual-emission consisted of prompt fluorescence and TADF in the crystalline state.Their white-light emissions can be easily tuned by altering the chemical structure and connecting position of the heterocyclic aromatic substituent.Under the stimuli of mechanical force and solvent vapor,the compounds exhibit remarkable and reversible mechanochromism,in which their emission colors are switchable between white and yellow.Upon grinding,they also display linearly tunable luminescence colors,as well as force-induced TADF enhancement,which may be associated with the more compact molecular packing and the restriction of intramolecular motions.The results from time-resolved emission scanning and theoretical calculation suggest that the dual-emission of the AIDF luminogens likely results from the twisted intramolecular charge transfer transitions of the molecules,and the reversible mechanochromism properties probably stem from the interconversion of the quasi-axial and the quasi-equatorial conformations. | Yitao Zheng Lingqi Zuo Letian Zhang Zihao Huang Shufeng Li Zhan Yang Zhu Mao Suilian Luo Cong Liu Fengqiang Sun Guang Shi Zhenguo Chi Bingjia Xu | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
| 14 | Genome-scale CRISPRi screening:A powerful tool in engineering microbiology显示文摘Deciphering gene function is fundamental to engineering of microbiology.The clustered regularly interspaced short palindromic repeats(CRISPR)system has been adapted for gene repression across a range of hosts,creating a versatile tool called CRISPR interference(CRISPRi)that enables genome-scale analysis of gene function.This approach has yielded significant advances in the design of genome-scale CRISPRi libraries,as well as in applica-tions of CRISPRi screening in medical and industrial microbiology.This review provides an overview of the recent progress made in pooled and arrayed CRISPRi screening in microorganisms and highlights representative studies that have employed this method.Additionally,the challenges associated with CRISPRi screening are discussed,and potential solutions for optimizing this strategy are proposed. | Letian Sun Ping Zheng Jibin Sun Volker F.Wendisch Yu Wang | 2023 | Engineering Microbiology2023，3，3： | 0 |
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