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| 1 | Inhibitory effects of saikosaponin-d on CCl_4-induced hepatic fibrogenesis in rats显示文摘AIM: To investigate the suppressive effect of saikosaponin-d (SSd) on hepatic fibrosis in rats induced by CCl4 injections in combination with alcohol and high fat, low protein feeding and its relationship with the expression of nuclear factor-κB (NF-κB), tumor necrosis factor-alpha (TNF-α) and interleukins-6 (IL-6). METHODS: Hepatic fibrosis models were induced by subcutaneous injection of CCl4 at a dosage of 3 mL/kg in rats. At the same time, rats in treatment groups were injected intraperitoneally with SSd at different doses (1.0, 1.5 and 2.0 mg/kg) once daily for 6 wk in combination with CCl4, while the control group received olive oil instead of CCl4. At the end of the experiment, rats were anesthetized and killed (except for 8 rats which died during the experiment; 2 from the model group, 3 in high-dose group, 1 in medium-dose group and 2 in low- dose group). Hematoxylin and eosin (HE) staining and Van Gieson staining were used to examine the changes in liver pathology. The levels of alanine aminotransferase (ALT), triglyeride (TG), albumin (ALB), globulin (GLB), hyaluronic acid (HA) and laminin (LN) in serum and the content of hydroxyproline (HYP) in liver were measured by biochemical examinations and radioimmuneoassay, respectively. In addition, the expression of TNF-α and IL-6 in liver homogenate was evaluated by enzyme- linked immunosorbent assay (ELISA) and the levels of NF-κBp65 and I-κBα in liver tissue were analyzed by Western blotting. RESULTS: Both histological examination and Van Gieson staining demonstrated that SSd could attenuate the area and extent of necrosis and reduce the scores of liver fibrosis. Similarly, the levels of ALT, TG, GLB, HA, andLN in serum, and the contents of HYP, TNF-α and IL-6 in liver were all significantly increased in model group in comparison with those in control group. Whereas, the treatment with SSd markedly reduced all the above parameters compared with the model group, especially in the medium group (ALT: 412 ± 94.5 IU/L vs 113.76 ± 14.91 IU/L, TG: 0.95 ± 0.16 mmol/L vs 0.51 ± 0.06 mmol/L, GLB: 35.62 ± 3.28 g/L vs 24.82 ± 2.73 g/L, HA: 42.15 ± 8.25 ng/mL vs 19.83 ± 3.12 ng/mL, LN: 27.56 ± 4.21 ng/mL vs 13.78 ± 2.57 ng/mL, HYP: 27.32 ± 4.32 μg/mg vs 16.20 ± 3.12 μg/mg, TNF-α: 4.38 ± 0.76 ng/L vs 1.94 ± 0.27 ng/L, IL-6: 28.24 ± 6.37 pg/g vs 12.72 ± 5.26 pg/g, respectively, P < 0.01). SSd also decreased ALB in serum (28.49 ± 4.93 g/L vs 37.51 ± 3.17 g/L, P < 0.05). Moreover, the expression of NF-κB p65 in the liver of treated groups was lower than that in model groups while the expression of I-κBα was higher in treated group than in model group (P < 0.01). The expression of NF-κBp65 and TNF-α had a positive correlation with the level of HA in serum of rats after treatment with CCl4 (r = 0.862, P < 0.01; r = 0.928, P < 0.01, respectively). CONCLUSION: SSd attenuates CCl4-induced hepatic fibrosis in rats, which may be related to its effects of hepato-protective and anti-inflammation properties, the down-regulation of liver TNF-α, IL-6 and NF-κBp65 expression and the increased I-κBα activity in liver. | Shuang-Suo Dang Bao-Feng Wang Yan-An Cheng Ping Song Zhen-Guo Liu Zong-Fang Li | 2007 | World Journal of Gastroenterology2007，13，4： | 41 |
| 2 | A Review on Lithium-ion Power Battery Thermal Management Technologies and Thermal Safety显示文摘Lithium-ion power battery has become one of the main power sources for electric vehicles and hybrid electric vehicles because of superior performance compared with other power sources. In order to ensure the safety and improve the performance, the maximum operating temperature and local temperature difference of batteries must be maintained in an appropriate range. The effect of temperature on the capacity fade and aging are simply investigated. The electrode structure, including electrode thickness, particle size and porosity, are analyzed. It is found that all of them have significant influences on the heat generation of battery. Details of various thermal management technologies, namely air based, phase change material based, heat pipe based and liquid based, are discussed and compared from the perspective of improving the external heat dissipation. The selection of different battery thermal management(BTM) technologies should be based on the cooling demand and applications, and liquid cooling is suggested being the most suitable method for large-scale battery pack charged/discharged at higher C-rate and in high-temperature environment. The thermal safety in the respect of propagation and suppression of thermal runaway is analyzed. | AN Zhoujian JIA Li DING Yong DANG Chao LI Xuejiao | 2017 | Journal of Thermal Science2017，26，5： | 41 |
| 3 | Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats显示文摘背景中国药在 hepatoprotective 治疗起一个重要作用。这研究被进行在长期的肝的 injury.Methods 的一个老鼠模型调查 emodin 和距骨多糖( APS )的保护的效果长期的肝的损害被一个星期包含40%碳四氯化物( CCI4 )两次的一个橄榄油答案的皮下注射的注射导致,除了在为 12 个星期的喝的水广告 libitum 的79.5% maizena ,20%脂肪,0.5%胆固醇,和10%酒精的一本食谱。同时,老鼠暴露于 emodin 的不同集中(40 mg ????????????????????? 洠汥楬畴 ??????????????瀠敲業浵刮獥汵獴 吗?? | DANG Shuang-suo ZHANG Xin JIA Xiao-li CHENG Yan-an SONG Ping LIU En-qi HE Qian LI Zong-fang | 2008 | Chinese Medical Journal2008，，11： | 34 |
| 4 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 5 | Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen≤1500 IU/mL:An observational study显示文摘BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)patients.AIM To evaluate the efficacy and safety of add-on peginterferonα-2a(peg-IFNα-2a)to an ongoing NA regimen in CHB patients.METHODS In this observational study,195 CHB patients with HBsAg≤1500 IU/m L,hepatitis B e antigen(HBeAg)-negative(including HBeAg-negative patients or HBeAg-positive patients who achieved HBeAg-negative after antiviral treatment with NA)and hepatitis B virus-deoxyribonucleic acid<1.0×10^2 IU/mL after over 1 year of NA therapy were enrolled between November 2015 and December2018 at the Second Affiliated Hospital of Xi'an Jiaotong University,China.Patients were given the choice between receiving either peg-IFNα-2a add-on therapy to an ongoing NA regimen(add-on group,n=91)or continuous NA monotherapy(monotherapy group,n=104)after being informed of the benefits and risks of the peg-IFNα-2a therapy.Total therapy duration of peg-IFNα-2a was 48 wk.All patients were followed-up to week 72(24 wk after discontinuation of peg-IFNα-2a).The primary endpoint was the proportion of patients with HBsAg clearance at week 72.RESULTS Demographic and baseline characteristics were comparable between the two groups.Intention-to-treatment analysis showed that the HBsAg clearance rate in the add-on group and monotherapy group was 37.4%(34/91)and 1.9%(2/104)at week 72,respectively.The HBsAg seroconversion rate in the add-on group was 29.7%(27/91)at week 72,and no patient in the monotherapy group achieved HBsAg seroconversion at week 72.The HBsAg clearance and seroconversion rates in the add-on group were significantly higher than in the monotherapy group at week 72(P<0.001).Younger patients,lower baseline HBsAg concentration,lower HBsAg concentrations at weeks 12 and 24,greater HBsAg decline from baseline to weeks 12 and 24 and the alanine aminotransferase≥2×upper limit of normal during the first 12 wk of therapy were strong predictors of HBsAg clearance in patients with peg-IFNα-2a add-on treatment.Regarding the safety of the treatment,4.4%(4/91)of patients in the add-on group discontinued peg-IFNα-2a due to adverse events.No severe adverse events were noted.CONCLUSION Peg-IFNα-2a as an add-on therapy augments HBsAg clearance in HBeAg-negative CHB patients with HBsAg≤1500 IU/m L after over 1 year of NA therapy. | Feng-Ping Wu Ying Yang Mei Li Yi-Xin Liu Ya-Ping Li Wen-Jun Wang Juan-Juan Shi Xin Zhang Xiao-Li Jia Shuang-Suo Dang | 2020 | World Journal of Gastroenterology2020，26，13： | 27 |
| 6 | Deep soil water infiltration and its dynamic variation in the shifting sandy land of typical deserts in China显示文摘Soil moisture is the key resource constraint in arid ecosystems, and has been a focus of research on restoration. However, quantitative studies on the contribution of rainfall to deep soil rainfall infiltration are lacking. In this study, we used the YWB-01 Deep Soil Infiltration Water Recorder which had been invented by ourselves to measure the quantity of rain infiltration into deep soil, 150 cm below ground, in four locations in China: Mu Us Sandy Land and Ulan Buh, Tengger, and Badan Jilin deserts over a 2-year period. We found:(1) Deep soil rainfall infiltration decreased progressively from east to west and from semiarid to arid areas, with two locations completely lacking rainfall infiltration. Heavy rain was important to deep soil infiltration in shifting sandy land of arid and semiarid areas.(2) Seasonal variation of infiltration was correlated with rainfall, with a time lag that was less apparent in areas with more rainfall.(3) For single intense rainfall events, infiltration maximums occurred 40–55 h after the rainfall, during which the infiltration rates increased rapidly before reaching a peak, and then decreased slowly. Continuous infiltration could last about 150 h. Rainfall infiltration was determined by the combined action of intensity, quantity and duration. Rainfall with low intensity, long duration, and large quantity was most favorable for deep soil infiltration. Our results can be used in water resource assessments and protection during eco-restoration in the arid and semiarid areas in China. | YANG WenBin TANG JinNian LIANG HaiRong DANG HongZhong LI Wei | 2014 | Science China Earth Sciences2014，57，8： | 21 |
| 7 | Angiopoiesis and bone regeneration via co expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo显示文摘 | Chen ZHANG Kun-zheng WANG Hui QIANG Yi-lun TANG Qian LI Miao LI Xiao-qian DANG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 20 |
| 8 | Surveillance-based evidence:elimination of schistosomiasis as a public health problem in the Peoples’Republic of China显示文摘Background:A steady progress on schistosomiasis control in the Peoples’Republic of China(P.R.China)was achieved and broadened into the twelve-year medium and long term national plan(MLNP)which marled the implementation of an integrated control strategy across all endemic areas in P.R.China in 2004.To understand the endemic trends of schistosomiasis to assess the effectiveness of an integrated strategy,we conducted an analysis of schistosomiasis surveillance data spanned from 2005 to 2015.Methods:The schistosomiasis sentinel surveillance data from sentinel sites were collected and analyzed from 2005 to 2015.In these sentinel sites,residents aged 6 years or above were screened annually by indirect hemagglutination assay(IHA),while only antibody positives were followed by stool examination either Kato-katz method(KK)and/or hatching technique(HT).Domestic animals raised in sentinel sites were examined by HT for confirming the infection of schistosomes.Snail investigation was conducted each year through systematic sampling method combined with environmental sampling method.The snails collected from field were tested by microscopic dissection method.The infection rates of schistosomes in residents,domestic animals and snails,as well as the indicators reflecting the snails’distribution were calculated and analyzed.ANOVA analysis was used to examine the changes of the number of eggs per gram feces in population and Chi-square test was used to examine any change in proportions among groups.Results:A total of 148902 residents from sentinel sites attended this study and 631676 blood samples were examined by IHA test during the 11 covered years.The annual average antibody positive rates presented a significant decrease trends,from 17.48%(95%CI:17.20–17.75%)in 2005 to 5.93%(95%CI:5.71–6.15%)(χ2=8890.47,P<0.001)in 2015.During 2005–2015,the average infection rate of schistosomes in residents declined from 2.07%(95%CI:1.96–2.17%)to 0.13%(95%CI:0.09–0.16%),accompanied by significant decrease of infection intensity in population.In 2015,the stool positives were only found in farmers,fishermen and boatmen with infection rate of 0.16%(95%CI:0.11–0.20%),0.17%(95%CI:0–0.50%)respectively.The infection rate of schistosomes in domestic animals dropped from 9.42%(538/5711,95%CI:8.66–10.18%)to 0.08%(2/2360,95%CI:0–0.20%)from 2005 to 2015.Infections were found in eight species of domestic animals at the beginning of surveillance while only two cattle were infected in 2015.Totally 98 ha of new snail habitats were found,while 94.90%(93/98)distributed in lake and marshland regions.The percentage of frames with snails decreased from 16.96%(56884/335391,95%CI:16.83–17.09%)in 2005 to 4.28%(18121/423755,95%CI:4.22–4.34%)in 2014,with a slightly increase in 2015.Meanwhile,the infection rate of schistosomes in snails was decreased from 0.26%(663/256531,95%CI:0.24–0.28%)to zero during 2005–2015.Conclusions:The infection rate of schistosomes declined significantly,providing evidence that the goal of the MLNP was achieved.Elimination of schistosomiasis as a public health problem defined as WHO was also reached in P.R.China nationwide.Surveillance-response system should be improved and strengthened to realize the final goal of schistosomiasis elimination. | Jing Xu Shi-Zhu Li Li-Juan Zhang Robert Bergquist Hui Dang Qiang Wang Shan Lv Tian-Ping Wang Dan-Dan Lin Jian-Bing Liu Guang-Hui Ren Kun Yang Yang Liu Yi Dong Shi-Qing Zhang Xiao-Nong Zhou | 2020 | Infectious Diseases of Poverty2020，9，3： | 20 |
| 9 | Effects of music therapy on depression and duration of hospital stay of breast cancer patients after radical mastectomy显示文摘背景乳癌在世界范围的女人之中仍然是最重要的癌症。疾病本身和治疗可以在病人是的心理井和生活的质量上有深刻影响。消沉在乳癌病人是普通的并且影响治疗学的效果以及延长医院停留的持续时间。然而,很少研究在激进的乳房切除术以后与乳癌在女病人的医院停留的消沉和持续时间上报导了音乐治疗的有效性。120 个对象被招募到这临床的试用并且随机分配了试验性的组(n=60 ) 到二 groups.The 的方法根据平淡的护理照顾收到了音乐治疗,而控制组(n=60 ) 仅仅收到了平淡的护理照顾。整个干预时间从在到化疗的医院的承认的第三次的激进的乳房切除术以后的第一天。人口统计的特征和消沉的数据被分别地使用一般问询表和 Zung 自我等级消沉规模(ZSDS ) 的中国版本收集。一预告测验(在激进的乳房切除术前的日子) 并且三测试以后(在来自医院的分泌物前的日子,第二和第三录取到为化疗的医院) 被利用。医院停留的持续时间在激进的乳房切除术以后从第一天被计算到日子从医院排出。结果所有题目的吝啬的消沉分数是 37.19 ???????? 记 ? 记 ? | ZHOU Kai-na LI Xiao-mei YAN Hong DANG Shao-nong WANG Duo-lao | 2011 | Chinese Medical Journal2011，，15： | 16 |
| 10 | Studies on Fixed-depth Control of Supercavitating Vehicles显示文摘 | LI Dai-Jin LUO Kai ZHANG Yu-Wen DANG Jian-Jun | 2010 | 自动化学报2010，36，3： | 15 |
| 11 | The dominant driving force for supercontinent breakup: Plume push or subduction retreat?显示文摘Understanding the dominant force responsible for supercontinent breakup is crucial for establishing Earth's geodynamic evolution that includes supercontinent cycles and plate tectonics. Conventionally,two forces have been considered: the push by mantle plumes from the sub-continental mantle which is called the active force for breakup, and the dragging force from oceanic subduction retreat which is called the passive force for breakup. However, the relative importance of these two forces is unclear. Here we model the supercontinent breakup coupled with global mantle convection in order to address this question. Our global model features a spherical harmonic degree-2 structure, which includes a major subduction girdle and two large upwelling(superplume) systems. Based on this global mantle structure,we examine the distribution of extensional stress applied to the supercontinent by both subsupercontinent mantle upwellings and subduction retreat at the supercontinent peripheral. Our results show that:(1) at the center half of the supercontinent, plume push stress is ~3 times larger than the stress induced by subduction retreat;(2) an average hot anomaly of no higher than 50 K beneath the supercontinent can produce a push force strong enough to cause the initialization of supercontinent breakup;(3) the extensional stress induced by subduction retreat concentrates on a ~600 km wide zone on the boundary of the supercontinent, but has far less impact to the interior of the supercontinent. We therefore conclude that although circum-supercontinent subduction retreat assists supercontinent breakup, sub-supercontinent mantle upwelling is the essential force. | Nan Zhang Zhuo Dang Chuan Huang Zheng-Xiang Li | 2018 | Geoscience Frontiers2018，9，4： | 15 |
| 12 | Research on unloading nonlinear mechanical characteristics of jointed rock masses显示文摘Geological environments of rock mass projects are always very complicated, and further investigations on rock mechanical characteristics are needed. There are considerable distinctions in rock mechanical characteristics under unloading and loading conditions. A series of tests are conducted to study the stress-strain relationship of rock masses under loading and unloading conditions. Also, the anisotropy, the size effect, and the rheological property of unloading rock mass are investigated. The tests presented in the paper include model test and granite rheological test, which are conducted considering geological condition, rock mass structure, in-situ stress field of the permanent shiplock of the Three Gorges Project. The main differences between loading and unloading rock masses are stress paths, yield criteria, deformation and strength parameters, etc.. Different structural plane directions affect unloading rock mass evidently. With increasing size, the tensile strength, the compressive strength, the deformation modulus, the Poisson's ratio and the anisotropy of rock mass all decrease. For sandstone samples with parallel bedding planes, the cohesion c increases but the internal friction angle ? decreases under unloading condition when compared with the values under loading condition. While for samples with vertical bedding planes, the trend is adverse. The rheological property of rocks has close relationship with the tensile stresses of rock masses. When the sandstone samples are tested under high stress condition, their rheological properties are very obvious with the unloading of confining pressure, and three typical rheological stages are shown. Rheological rate changes with the variations in axial stress and confining pressure. | Jianlin Li Lehua Wang Xingxia Wang Ruihong Wang Zhuang Cheng Li Dang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，4： | 15 |
| 13 | Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function显示文摘 | Ping Lu Fu-chuang Zhang Shu-wen Qian Xi Li Zhao-meng Cui Yong-jun Dang Qi-qun Tang | 2016 | Cell Research2016，26，10： | 15 |
| 14 | Gas-kinetic unified algorithm for computable modeling of Boltzmann equation and application to aerothermodynamics for falling disintegration of uncontrolled Tiangong-No.1 spacecraft显示文摘How to solve the hypersonic aerothermodynamics around large-scale uncontrolled spacecraft during falling disintegrated process from outer space to earth,is the key to resolve the problems of the uncontrolled Tiangong-No.1 spacecraft reentry crash.To study aerodynamics of spacecraft reentry covering various flow regimes,a Gas-Kinetic Unified Algorithm(GKUA)has been presented by computable modeling of the collision integral of the Boltzmann equation over tens of years.On this basis,the rotational and vibrational energy modes are considered as the independent variables of the gas molecular velocity distribution function,a kind of Boltzmann model equation involving in internal energy excitation is presented by decomposing the collision term of the Boltzmann equation into elastic and inelastic collision terms.Then,the gas-kinetic numerical scheme is constructed to capture the time evolution of the discretized velocity distribution functions by developing the discrete velocity ordinate method and numerical quadrature technique.The unified algorithm of the Boltzmann model equation involving thermodynamics non-equilibrium effect is presented for the whole range of flow regimes.The gas-kinetic massive parallel computing strategy is developed to solve the hypersonic aerothermodynamics with the processor cores 500~45,000 at least 80%parallel efficiency.To validate the accuracy of the GKUA,the hypersonic flows are simulated including the reentry Tiangong-1 spacecraft shape with the wide range of Knudsen numbers of 220~0.00005 by the comparison of the related results from the DSMC and N-S coupled methods,and the low-density tunnel experiment etc.For uncontrolling spacecraft falling problem,the finite-element algorithm for dynamic thermalforce coupling response is presented,and the unified simulation of the thermal structural response and the hypersonic flow field is tested on the Tiangong-1 shape under reentry aerodynamic environment.Then,the forecasting analysis platform of end-of-life largescale spacecraft flying track is established on the basis of ballistic computation combined with reentry aerothermodynamics and deformation failure/disintegration. | Zhi-Hui Li Ao-Ping Peng Qiang Ma Lei-Ning Dang Xiao-Wei Tang Xue-Zhou Sun | 2019 | Advances in Aerodynamics2019，1，1： | 14 |
| 15 | Investigation of gas content of organic-rich shale:A case study from Lower Permian shale in southern North China Basin,central China显示文摘Measuring gas content is an essential step in estimating the commerciality of gas reserves. In this study,eight shale core samples from the Mouye-1 well were measured using a homemade patented gas desorption apparatus to determine their gas contents. Due to the air contamination that is introduced into the desorption canister, a mathematical method was devised to correct the gas quantity and quality.Compared to the chemical compositions of desorbed gas, the chemical compositions of residual gas are somewhat different. In residual gas, carbon dioxide and nitrogen record a slight increase, and propane is first observed. This phenomenon may be related to the exposure time during the transportation of shale samples from the drilling site to the laboratory, as well as the differences in the mass, size and adsorptivity of different gas molecules. In addition to a series of conventional methods, including the USBM direct method and the Amoco Curve Fit(ACF) method, which were used here for lost gas content estimation, a Modified Curve Fit(MCF) method, based on the 'bidisperse' diffusion model, was established to estimate lost gas content. By fitting the ACF and MCF models to gas desorption data, we determined that the MCF method could reasonably describe the gas desorption data over the entire time period, whereas the ACF method failed. The failure of the ACF method to describe the gas desorption process may be related to its restrictive assumption of a single pore size within shale samples. In comparison to the indirect method, this study demonstrates that none of the three methods studied in this investigation(USBM, ACF and MCF) could individually estimate the lost gas contents of all shale samples and that the proportion of free gas relative to total gas has a significant effect on the estimation accuracy of the selected method. When the ratio of free gas to total gas is lower than 45%, the USBM method is the best for estimating the lost gas content, whereas when the ratio ranges from 45% to 75% or is more than 75%, the ACF and MCF methods, are the best options respectively. | Wei Dang Jin-Chuan Zhang Xuan Tang Xiao-Liang Wei Zhong-Ming Li Cheng-Hu Wang Qian Chen Chong Liu | 2018 | Geoscience Frontiers2018，9，2： | 14 |
| 16 | Changes in count and function of splenic lymphocytes from patients with portal hypertension显示文摘AIM: To investigate changes in numbers and proliferative function of splenic lymphocytes in patients with hypersplenism due to portal hypertension (PH), to provide evidence for further study of immune status of the spleen during PH. METHODS: Twelve spleens from patients with hypersplenism due to PH served as the PH group, and four spleens from cases of traumatic spleen rupture were regarded as the control group. After weighing the spleen, lymphocytes were separated and counted using a cell counting plate to calculate the lymphocyte count per gram of spleen tissue (relative quantity) and total lymphocyte count in whole spleen (absolute quantity). The immunohistochemical SP method was used to observe the density and distribution of lymphocytes in the spleen. The MTT method was used to observe changes in lymphocyte proliferative function. RESULTS: As compared to the control group, the splenic lymphocytes in the PH group showed that: (1) There was no difference in distribution but a significant decreasein density; (2) the number of lymphocytes per gram of spleen (relative quantity) decreased significantly (0.822 ± 0.157) × 108 vs (1.174 ± 0.254) × 108, P < 0.01]; (3) with the significant increase in the weight of the PH spleen (832.6 ± 278.2 g vs 211.7 ± 85.6 g, P < 0.01), the total quantity of lymphocytes (absolute quantity) increased significantly (0.685 ± 0.072) × 1011 vs (0.366 ± 0.057) × 1011, P < 0.01]; and (4) the proliferative function of lymphocytes was enhanced: T lymphocytes, (0.022 ± 0.005 vs 0.015 ± 0.003, P < 0.05), and B lymphocytes (0.034 ± 0.006 vs 0.023 ± 0.001, P < 0.01). CONCLUSION: Although lymphocyte density in the spleen decreased in patients with PH, the total quantity of lymphocytes increased because spleen weight increased greatly, along with the proliferating function. With respect to changes in lymphocytes, PH spleens may still have immune function, although it may be disordered. However, complete evaluation of the immune function of the spleen in PH requires more research. | Zong-Fang Li Shu Zhang Gao-Bo Lv Ying Huang Wei Zhang Song Ren Jun Yang Shuang-Suo Dang | 2008 | World Journal of Gastroenterology2008，14，15： | 13 |
| 17 | Spatial-temporal Characteristics of Land Subsidence Corresponding to Dynamic Groundwater Funnel in Beijing Municipality,China显示文摘Due to long-term over-exploitation of groundwater in Beijing Municipality,regional groundwater funnels have formed and land subsidence has been induced.By combining a groundwater monitoring network,GPS monitor-ing network data,radar satellite SAR data,GIS and other new technologies,a coupled process model based on the dy-namic variation of groundwater and the deformation response of land subsidence has been established.The dynamic variation of groundwater funnels and the land subsidence response process were analyzed systematically in Beijing.Study results indicate that current groundwater funnel areas are distributed mainly in the southwest of Shunyi District,the northeast of Chaoyang District and the northwest of Tongzhou District,with an average decline rate of groundwa-ter level of 2.66 m/yr and a maximum of 3.82 m/yr in the center of the funnels.Seasonal and interannual differences exist in the response model of land subsidence to groundwater funnels with uneven spatial and temporal distribution,where the maximum land subsidence rate was about-41.08 mm/yr and the area with a subsidence rate greater than 30 mm/yr was about 1637.29 km2.Although a consistency was revealed to exist between a groundwater funnel and the spatial distribution characteristics of the corresponding land subsidence funnel,this consistency was not perfect.The results showed that the response model of land subsidence to the dynamic variation of groundwater was more revealing when combining conventional technologies with InSAR,GIS,GPS,providing a new strategy for environmental and hydrogeological research and a scientific basis for regional land subsidence control. | CHEN Beibei GONG Huili LI Xiaojuan LEI Kunchao ZHANG Youquan LI Jiwei GU Zhaoqin DANG Yanan | 2011 | Chinese Geographical Science2011，21，6： | 13 |
| 18 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 19 | A novel synthesis strategy to improve cycle stability of LiNio.8Mno.1Co0.1O2 at high cut-off voltages through core-shell structuring显示文摘Nickel-rich cathode materials have attracted considerable interest because of their high specific capacities,voltage ranges,and low cost.However,serious capacity attenuation and poor rate performance limit their application.This study proposes a novel strategy to improve the cycle stability of the nickel-rich LiNi0.sCo0.1Mn0.1O2(NCM811)layer material by designing core-shell LiNio.sCoo.1 Mno.102(CS-NCM811).CS-NCM811 is designed by the characteristic reaction between dimethylglyoxime(C4H8N2O2)and nickel ion to form Ni(C4H7N2O2)2-The CS-NCM811 is characterized with high nickel content in its core and high manganese content on its surface,leading to a high capacity and excellent cycle stability.The capacity retention of CS-NCM811 was 72.8%,much higher than that of NCM811(47.1%)after 500 cycles at a rate of 5 C.Not only is this method a no vel strategy to desig n high capacity cathode materials but also provides some new in sights into the cycle stability of nickel-rich layered cathode materials. | Kang Wu Qi Li Rongbin Dang Xin Deng Minmin Chen Yu Lin Lee Xiaoling Xiao Zhongbo Hu | 2019 | Nano Research2019，12，10： | 12 |
| 20 | Mechanisms of improvement of left ventricle remodeling by transplanting two kinds of autologous bone marrow stem cells in pigs显示文摘背景在尖锐心肌的梗塞( AMI )以后的很多心肌的房间的坏死导致心脏的功能和移植能改进的室 remodeling.Stem 房间的减少在 AMI 以后的心脏的功能,但是包含的机制一直不是完全学习试图在改变的室上经由冠的动脉调查自体同源的骨头髓 mononuclear 房间( BM-MNC )和 rnesenchymal 干细胞( MSC )的移植的效果的在场的 understood.The 控制组,简单梗塞模型组, BM-MNC 移植组,和 MSC 移植当有 AMI 的一个缩小的猪的模型被建立时, 90 纪录的 group.At ,自体同源的 BM-MNC 的移植(( 4.7ntraoperative ,并且手术后)被评估, compared.The 病态和死亡结果在二 groups.The 后续结果被比较,在二组织的 surgery.Results 与外科手术前的高风险的侧面有病人的类似的百分比以后。 | LI Shu-ren QI Xiao-yong HU Fu-li ZHANG Jian-qing WANG Tian-hong DANG Yi MENG Cun-liang LIU Hui-liang LI Ying-xiao WU Di DONG Jie XUN Li-ying GAO Li-hui JIN Fu-chang | 2008 | Chinese Medical Journal2008，，23： | 12 |
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