| 2 | Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2显示文摘The combination of immune checkpoint blockade(ICB)with chemotherapy significantly improves clinical benefit of cancer treatment.Since chemotherapy is often associated with adverse events,concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy.However,whether these ancillary drugs could impede immunotherapy remains unknown.Here,we showed that∆9-tetrahydrocannabinol(THC),the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea,reduced the therapeutic effect of PD-1 blockade.The endogenous cannabinoid anandamide(AEA)also impeded antitumor immunity,indicating an immunosuppressive role of the endogenous cannabinoid system(ECS). | Xinxin Xiong Siyu Chen Jianfei Shen Hua You Han Yang Chao Yan Ziqian Fang Jianeng Zhang Xiuyu Cai Xingjun Dong Tiebang Kang Wende Li Penghui Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 3 | Synthesis,formation mechanism,and intrinsic physical properties of several As/P-containing MAX phases显示文摘321 phases are an atypical series of MAX phases,in which A=As/P,with superior elastic properties,fea-turing in the MA-triangular-prism bilayers in the crystal structure.Until now,besides Nb 3 As 2 C,the pure phases of the other 321 compounds have not been realized,hampering the study of their intrinsic prop-erties.Here,molten-salt sintering(MSS)and solid-state synthesis(SSS)were applied to synthesize As/P-containing 321 phases and 211 phases.Analyzing the phase composition of the end-product via multiple-phase Rietveld refinement,we found that MSS can effectively improve the purity of P-containing MAX phases,with the phase content up to 99%in Nb_(3)P_(2)C and 75.4(5)%in Nb 2 PC.In contrast,MSS performed poorly on As-containing MAX phases,only 8.9(4)%for Nb 3 As 2 C and 64(2)%for Nb 2 AsC,as opposed to the pure phases obtained by SSS.The experimental analyses combined with first-principles calculations reveal that the dominant formation route of Nb_(3)P_(2)C is through NbP+Nb+C→Nb_(3)P_(2)C.Moreover,we found that the benefits of MSS on P-containing MAX phases are on the facilitation of three consid-ered chemical reaction routes,especially on Nb 2 PC+NbP→Nb_(3)P_(2)C.Furthermore,the intrinsic physical properties and Fermi surface topology of two 321 phases consisting of electron,hole,and open orbits are revealed theoretically and experimentally,in which the electron carriers are dominant in electrical trans-port.The feasible synthesis methods and the formation mechanism are instructive to obtain high-purity As/P-containing MAX phases and explore new MAX phases.Meanwhile,the intrinsic physical properties will give great support for future applications on 321 phases. | Hongxiang Chen Sheng Li Jun Deng Zhilong Zhang Jianeng Huang Fa Chang Li Huang Shixuan Du Pinqiang Dai | 2023 | Journal of Materials Science & Technology2023，，2： | 0 |
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