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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | International Society for Peritoneal D:Peritoneal dialysis-related infections recommendations:2010 update显示文摘 | Li PK Szeto CC Piraino B | 2010 | Perit Dial Int2010，30，4： | 1 |
| 3 | Prevalence of sileng kidney disease in Hong Kong: the screening for Hong Kong asymptomatic renal population and valuation(SHARE) program显示文摘 | Li PK Kwan BC Leung CB | 2005 | Kidney Int Suppl2005，67，94： | 1 |
| 4 | Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus显示文摘 | Hsu PK Li AF Wang YC | 2008 | J Thorac Cardiovasc Surg2008，135，5： | 1 |
| 5 | Asymptomatic isolated microscopic haematuria : Long - term follow - up 显示文摘 | Chow KM Kwan BC Li PK | 2004 | Q J Med2004，97，11： | 1 |
| 6 | Prognostic indicators of IgA nephropathy in the Chinese-clinical and pathological perspectives显示文摘 | Li PK Ho KK Szeto CC | 2002 | Nephrol Dial Transplant2002，17，： | 1 |
| 7 | A prescription survey in a hospital hypertension outpatient clinic显示文摘 | Lee PK Li RK Chan JC | 1997 | Br J Clin Pharmacol1997，44，6： | 1 |
| 8 | Direct, fixed time kinetic assaysfor β-hydroxybutyrate and acetoacetate with a centrifugal analyzer or a computer backedpectrophotometer显示文摘 | Li PK Lee JT | 1980 | Clin Chim1980，26，12： | 1 |
| 9 | The cost barrier to peritoneal dialysis in the developing world - an Asian perspective 显示文摘 | Li PK Chow KM | 2001 | Petit Dial Int2001，21，3： | 1 |
| 10 | Peritoneal dialysisrelated infections recommendations:2010 update显示文摘 | Li PK Szeto CC Piraino B | | 0，，： | 1 |
| 11 | Asian Chronic Kidney Disease (CKD) Best Practice Recommendations-Positional Statements for Early Detection of CKD from Asian Forum for CKD Initiatives (AFCKDI)显示文摘 | Li PK Chow KM Matsuo S | | 0，，： | 1 |
| 12 | Early chnges in myocardial antioxidant enzymes in rats treated with adriamycin显示文摘 | Danelisen I Singal PK | 2002 | Mol Cell Biochem2002，232，12： | 1 |
| 13 | Tenascin-C is expressed in maerophage-rich human coronary atherosclerotie plaqu显示文摘 | Wallner K Li C Shah PK | 1999 | Cir- culation1999，99，10： | 1 |
| 14 | Hong Kong study using valsartan in IgA nephropathy (HKVIN):a double-blind,randomized,placebocontrolled study显示文摘 | Li PK Leung CB Chow KM | | 0，，05： | 1 |
| 15 | Peritoneal dialysis related infections recommendations: 2010 update 显示文摘 | Li PK Szeto CC Piraino B | 2010 | Perit Dial Int2010，30，4： | 1 |
| 16 | Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia显示文摘 | Leung KT Li KK Sun SS Chan PK | 2008 | Carcinogenesis2008，29，3： | 1 |
| 17 | Phytoremediation technology:hyperac cumulation metals in plants显示文摘 | Padmavathiamma PK Li LY | 2007 | Water Air and Soil pollution2007，184，14： | 1 |
| 18 | High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions显示文摘 | Chan PK Li WH Chan MY | 1999 | J Med Virol1999，59，2： | 1 |
| 19 | Review article:New-onset diabetes after trans- plantation显示文摘 | Chow KM Li PK | 2008 | Nephrology2008，13，8： | 1 |
| 20 | Melamine toxicity and the kidney显示文摘 | Hau AK Kwan TH Li PK | 2009 | J Am Soc Nephrol2009，20，2： | 1 |
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