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| 1 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 2 | Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs显示文摘AIM To study the effect of cholecystokinin-octapeptide(CCK-8)and secretin on contractileactivity of isolated gastric muscle strips inguinea pigs.METHODS Each isolated gastric muscle stripwas suspended in a tissue chamber containing5 mL Krebs solution constantly warmed by waterjacked at 37℃ and supplied with a mixed gas of95% O2 and 5% CO2 After incubating for lhunder 1 g tension,varied concentrations of CCK-8 and secretin were added respectively in thetissue chamber and the contractile response wasmeasured isometrically on ink-writing recorders.RESULTS CCK-8 could increase①all regionalcircular and longitudinal muscular tension at rest(fundus LM 19.7%±2.1%,P<0.01;fundus CM16.7%±2.2%,P<0.01;gastric body LM 16.8%±2.3%,P<0.01;body CM 12.7%±2.6%,P<0.01;antrum LM 12.3%±1.3%,P<0.01;antrum CM 16.7%±4.5%,P<0.01;pylous CM12.7%±5.0%,P<0.05);②contractilefrequencies of body LM,both LM and CM ofantrum and pylorus CM(5.1/min±0.2/min to5.6/min±0.2/min,5.9/min±0.2/min to 6.6/min±0.l/min,5.4/min±0.3/min to 6.3/min±0.4/rain,1.3/min±0.2/min to 2.3/min±0.3/min,respectively,P<0.05);③the mean contractileamplitude of antral circular muscle(58.6%±18.4%,P<0.05)and ④the motility index ofpylorus CM(145.0%±23.8%,P<0.01),butdecrease the mean contractile amplitude ofgastric body and antral LM(-10.3%±3.3%,-10.5%±4.6%,respectively,P<0.05).All the CCK-8 effects were not blocked by atropine orindomethacin.Secretin had no effect on gastricsmooth muscle activity.CONCLUSION CCK-8 possessed bothexcitatory and inhibitory action on contractileactivity of different regions of stomach in guineapigs.Its action was not mediated via cholinergicM receptor and endogenous prostagiandinreceptor, | Li W Zheng TZ Qu SY | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 3 | Visualizing the microtubule-associated protein tau in the nucleus显示文摘Although tau is mainly known as an axonal microtubule-associated protein,many studies indicate that it is not restricted to this subcellular compartment.Assessing tau’s subcellular distribution,however,is not trivial as is evident from transgenic mouse studies.When human tau is over-expressed,it can be immunohistochemically localized to axons and the somatodendritic domain,modeling what is found in neurodegenerative diseases such as Alzheimer’s disease.Yet,in wild-type mice,despite its abundance,tau is difficult to visualize even in the axon.It is even more challenging to detect this protein in the nucleus,where tau has been proposed to protect DNA from damage.To establish a framework for future studies into tau’s nuclear functions,we compared several methods to visualize endogenous nuclear tau in cell lines and mouse brain.While depending on the fixation and permeabilization protocol,we were able to detect nuclear tau in SH-SY5Y human neuroblastoma cells,we failed to do so in N2a murine neuroblastoma cells.As a second method we used subcellular fractionation of mouse tissue and found that in the nucleus tau is mainly present in a hypophosphorylated form.When either full-length or truncated human tau was expressed,both accumulated in the cytoplasm,but were also found in the nuclear fraction.Because subcellular fractionation methods have their limitations,we finally isolated nuclei to probe for nuclear tau and found that the nuclei were free of cytoplasmic contamination.Together our analysis identifies several protocols for detecting tau in the nucleus where it is found in a less phosphorylated form. | LU Jing LI Ting HE RongQiao BARTLETT Perry F GTZ Jürgen | 2014 | Science China(Life Sciences)2014，57，4： | 11 |
| 4 | Surgical treatment of pectus excavatum:30 years 398 patients of experiences 显示文摘 | Hu TZ Li Y Liu WY | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 5 | Surgical treatment of pectus excavatum: 3 years 398 patients of experiences 显示文摘 | Hu TZ Li Y Liu WY | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 6 | Effect of asiaticoside on hypertrophic scar in the rabbit ear model显示文摘 | Xie JL Qi SH Li TZ | 2009 | J Cutan Pathol2009，36，： | 1 |
| 7 | Computed tomography in hepatolenticular degeneration(Wilson's disease)显示文摘 | Chen XR Shen TZ Li NZ | 1983 | Comput Radiol1983，7，： | 1 |
| 8 | NF-Kappa B activation is required for the development of cardiac hypertrophy in vivo 显示文摘 | LI YH HA TZ GAO X | 2004 | Am J Physiol Heart Circ Physiol2004，287，4： | 1 |
| 9 | Advanced glycation end products (AGEs) and their receptor (RAGE) induce apoptosis of periodontal ligament fibroblasts显示文摘 | Li DX Deng TZ Lv J | 2014 | Braz J Med Bioi Res2014，47，12： | 1 |
| 10 | DNMT inhibitors and HDAC inhibitors regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo 显示文摘 | Yi TZ Li J Han X | 2012 | Chemotherapy2012，58，1： | 1 |
| 11 | New flavonol glycosides and new xanthone from Polygala japonica显示文摘 | Li TZ Zhang WD Yang GJ | 2006 | J Asian Nat Prod Res2006，8，5： | 1 |
| 12 | NR2A-containing NMDA receptors are re- quired for LTP induction in rat dorsolateral striatum in vitro 显示文摘 | Li P Li YH Han TZ | 2009 | Brain Res2009，1274，： | 1 |
| 13 | Inhibiting early activation of tissue nuclear factor-kB and nuclear factor interleukin 6 with (1→)-β-D-glucan increases long-term survival in polymicrobial sepsis 显示文摘 | Williams DL Ha TZ Li CF | 1999 | Surgery1999，126，1： | 1 |
| 14 | Effect of asiaticoside on hypertrophic scar in the rabbit ear model显示文摘 | Xie JL Qi SH Li TZ | 2009 | J Cutan Patho12009，36，2： | 1 |
| 15 | Alterations of nitric oxide synthase expression with aging and hypertension in rats 显示文摘 | Tz chong chou Mao Hsiung yen Chi yuan li | 2007 | Hypertension2007，31，： | 1 |
| 16 | 131I-Recombinant Human EGF Has Antitumor Effects Against MCF-7 Human Breast Cancer Xenografts With Low Levels of EGFR显示文摘 | LI YC XU WY TAN TZ | 2004 | Nucl Med Biol2004，31，4： | 1 |
| 17 | New flavonol glycosides and new xanthone from Polygala japonica显示文摘 | Li TZ Zhang WD Yang GJ | 2006 | Journal of Asian natural prod- ucts research2006，8，5： | 1 |
| 18 | Morphine post conditioning protects against reperfusion injury in the isolated rat hearts显示文摘 | Chen ZL Li TZ Zhang BX | 2008 | Surg Res2008，145，： | 1 |
| 19 | Characteristics, development and mapping of Gossypium hirsutum derived EST-SSRs in allotetraploid cotton 显示文摘 | Han ZG Wang CB Song XL Guo WZ Gou JY Li CH Chen XY Zhang TZ | 2006 | Theor Appl Genet2006，112，3： | 1 |
| 20 | Effect of Dan Shen on isolated gastric muscle strips in rats 显示文摘 | Zheng TZ Li W Qu Sy | 1992 | WJG1992，，4： | 1 |
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