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| 1 | Throughput Gain of Random Wireless Networks with Physical-Layer Network Coding显示文摘This study analyzes the impact of Physical-layer Network Coding (PNC) on the throughput of a large random wireless network,including one-dimensional and two-dimensional networks.Three different transmission schemes,(1) a traditional flow-based scheme,(2) a network coding scheme,and (3) the PNC scheme are compared to show that the PNC scheme improves wireless network throughput by a constant factor without changing the scaling law compared to the traditional flow-based and network coding schemes.Furthermore,PNC can reduce the effect of interference for the one-dimensional networks,and has a tighter throughput bound for the two-dimensional network. | Xican Yang Jian Li Changliang Xie Li Li | 2012 | Tsinghua Science and Technology2012，17，2： | 3 |
| 2 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 3 | On parameters in grey model GM(1, 1)显示文摘 | Li Xican | 1998 | The J of Grey System1998，10，2： | 1 |
| 4 | Protective effect against hydroxyl-induced DNA damage and antioxidant activity of Radix Glycyrrhizae (Liquorice Root)显示文摘 | Li Xican Chen Weikang Chen Dongfeng | 2013 | Adv Pharm Bull2013，3，1： | 1 |
| 5 | Improved pyrogallol autoxidation method:a reliable and cheap superoxide-scavenging assay suitable for all antioxidants显示文摘 | Li Xican | 2012 | Journal of Agricultural and Food Chemistry2012，60，25： | 1 |
| 6 | Improved pyrogallol autoxidation method:areli- able and cheap superoxide- scavenging assay suitable for all antioxidants 显示文摘 | Xican Li | 2012 | Food Chem2012，60，25： | 1 |
| 7 | Onparameters in grey model GM(1, 1)显示文摘 | Li Xican | 1998 | The Journal of Grey System1998，10，2： | 1 |
| 8 | On parameter in grey model GM(1,1)显示文摘 | Li Xican | 1998 | The J of Grey System1998，10，2： | 1 |
| 9 | Improved pyrogallol autoxidation method:a reliable and cheap superoxide- scavenging assay suitable for all antioxidant显示文摘 | Li Xican | 2012 | Journal of Agriculture and Food Chemistry2012，60，25： | 1 |
| 10 | Antioxidant activity and mechanism of Rhizoma Cimicifugae 显示文摘 | Xican Li Jing Lin Yaoxiang Gao | 2012 | Chemistry Central Journal2012，6，1： | 1 |
| 11 | Solvent effects and improvements in the deoxyribose degradation assay for hydroxyl radicalscavenging显示文摘 | Xican Li | 2013 | Food Chemistry2013，141，3： | 1 |
| 12 | Antioxidant activity and mechanism of protocatechuic acid in vitro显示文摘 | LI Xican WANG Xiaozhen CHEN Dongfeng | 2011 | Functional Foods in Health and Disease2011，1，7： | 1 |
| 13 | The Soil Organic Matter Content Grey Relationship Inversion Pattern Based on HyperSpectral Technique显示文摘 | LI XICAN YU TAO WANG XIAO | 2011 | Grey Systems:Theory and Application2011，1，3： | 1 |
| 14 | The Pattern of Multiple Attribute and Multiple Dimension Grey Decision Making 显示文摘 | LI Xican WANG Jing WANG Fang | 2007 | The Journal of Grey System2007，20，3： | 1 |
| 15 | Improved Pyrogallol Autoxidation Method: A Reliable and Cheap Superoxide-Scavenging Assay Suitable for All Antioxidants显示文摘 | Xican Li | 2012 | Agric Food Chem2012，60，： | 1 |
| 16 | Author correction to‘Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects’[Acta Pharmaceutica Sinica B 13(2023)2138-2151]显示文摘The authors regret that there are some misplaced figure numbers in the body of this article due to negligence in the layout and proofreading of the figures.Although it does not affect the conclusion,it is an obvious error.The authors have now modified as below.The authors apologize for any inconvenience caused to the journal and readers. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 17 | Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs显示文摘A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria.Compound 33a(IMBZ18G)is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant(MDR)Gram-negative strains,with a highly druglike nature.The checkerboard assay reveals its significant synergistic effect withβ-lactamase inhibitor avibactam,and the MIC values against MDR enterobacteria were reduced up to 4—512folds.X-ray co-crystal and chemoproteomic assays indicate that the anti-MDR bacteria effect of 33a results from the dual inhibition of the common PBP3 and some class A and Cβ-lactamases.Accordingly,preclinical studies of 33a alone and 33a-avibactam combination as potential innovative candidates are actively going on,in the treatment ofβ-lactamase-producing MDR Gram-negative bacterial infections. | Zhiwen Li Zhihao Guo Xi Lu Xican Ma Xiukun Wang Rui Zhang Xinxin Hu Yanxiang Wang Jing Pang Tianyun Fan Yonghua Liu Sheng Tang Haigen Fu Jingpu Zhang Yinghong Li Xuefu You Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 18 | N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties:Design,synthesis and antitubercular activity显示文摘Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents.Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates(MIC:<0.002-0.030 μg/mL).Compounds 2f,5e and 5g display acceptable safety and pharmacokinetic profiles,opening a new direction for further development. | Linhu Li Apeng Wang Bin Wang Mingliang Liu Kai Lv Zeyu Tao Chao Ma Xican Ma Bing Han Aoyu Wang Yu Lu | 2020 | Chinese Chemical Letters2020，31，2： | 0 |
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