|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer显示文摘BACKGROUND Neoadjuvant chemotherapy is currently recommended as preoperative treatment for locally advanced rectal cancer(LARC);however,evaluation of treatment response to neoadjuvant chemotherapy is still challenging.AIM To create a multi-modal radiomics model to assess therapeutic response after neoadjuvant chemotherapy for LARC.METHODS This retrospective study consecutively included 118 patients with LARC who underwent both computed tomography(CT)and magnetic resonance imaging(MRI)before neoadjuvant chemotherapy between October 2016 and June 2019.Histopathological findings were used as the reference standard for pathological response.Patients were randomly divided into a training set(n=70)and a validation set(n=48).The performance of different models based on CT and MRI,including apparent diffusion coefficient(ADC),dynamic contrast enhanced T1 images(DCE-T1),high resolution T2-weighted imaging(HR-T2WI),and imaging features,was assessed by using the receiver operating characteristic curve analysis.This was demonstrated as area under the curve(AUC)and accuracy(ACC).Calibration plots with Hosmer-Lemeshow tests were used to investigate the agreement and performance characteristics of the nomogram.RESULTS Eighty out of 118 patients(68%)achieved a pathological response.For an individual radiomics model,HR-T2WI performed better(AUC=0.859,ACC=0.896)than CT(AUC=0.766,ACC=0.792),DCE-T1(AUC=0.812,ACC=0.854),and ADC(AUC=0.828,ACC=0.833)in the validation set.The imaging performance for extramural venous invasion detection was relatively low in both the training(AUC=0.73,ACC=0.714)and validation(AUC=0.578,ACC=0.583)sets.The multi-modal radiomics model reached an AUC of 0.925 and ACC of 0.886 in the training set,and an AUC of 0.93 and ACC of 0.875 in the validation set.For the clinical radiomics nomogram,good agreement was found between the nomogram prediction and actual observation.CONCLUSION A multi-modal nomogram using traditional imaging features and radiomics of preoperative CT and MRI adds accuracy to the prediction of treatment outcome,and thus contributes to the personalized selection of neoadjuvant chemotherapy for LARC. | Zheng-Yan Li Xiao-Dong Wang Mou Li Xi-Jiao Liu Zheng Ye Bin Song Fang Yuan Yuan Yuan Chun-Chao Xia Xin Zhang Qian Li | 2020 | World Journal of Gastroenterology2020，26，19： | 7 |
| 2 | Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice显示文摘瞄准:EGFR TKI 和 VEGFR TKI 的联合治疗可以生产一个更大的治疗学的好处并且克服 EGFR 导致 TKI 的抵抗。然而,以前的研究显示出那 EGFR TKI erlotinib 的联合(嗯) 与 VEGFR TKI, sunitinib (苏) 没与 non-small-cell 肺癌症(NSCLC ) 在病人改进全面幸存。在这研究,我们检验了 anticancer 效果嗯,在 A549 人的 NSCLC 异种皮移植老鼠的治疗的苏和他们的联合,并且进行的 PK/PD 当模特儿和模拟优化剂量 regimen.Methods:嗯(20, 50 mg· kg −1·d−1) 或苏(5, 10, 20 mg· kg −1·d−1) 独自一个,或他们的联合予忍受 A549 肿瘤 22 天的 BALB/c 裸体老鼠被以。肿瘤尺寸和身体重量每天被记录。试验性的数据被用来开发在不同剂量政体描述在血浆集中和肿瘤抑制之间的量的关系的 PK/PD 模特儿。模特儿进一步被评估并且验证,并且过去常预言不同联合政体的功效并且选择最佳的 regimen.Results:在里面联合组的 vivo anticancer 功效比独自管理的任何一个药的强壮得多。一个 PK/PD 模特儿与一个联合索引被开发(φ) 4.4,揭示强壮的 synergistic 效果在之间嗯并且苏。模特儿模拟在不同剂量政体预言了肿瘤生长,并且证明苏的剂量在联合处理起了一个明确的作用,并且建议了那更低的剂量嗯( ≤ ; 5 mg· ; kg −1·d−1)并且调整苏的剂量可能为临床的 research.Conclusion 产出更好的剂量政体:试验性的数据并且建模证实 synergistic anticancer 效果嗯并且在 A549 异种皮移植鼠标的处理的苏。当模特儿的 PK/PD 和模拟决定的最佳的剂量政体能在未来被使用现出症状之前的潜为临床的申请学习并且提供一本参考书。 | Jing-yun LI Yu-peng REN Yin YUAN Shuang-min JI Shu-pei ZHOU Li-jie WANG Zhen-zhen MOU Liang LI Wei LU Tian-yan ZHOU | 2016 | Acta Pharmacologica Sinica2016，37，7： | 7 |
| 3 | Original article Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial显示文摘 | ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG Xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun SHI Shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong SUN Jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 4 | Grain refinement and macrosegregation behavior of direct chill cast Al-Zn-Mg-Cu alloy under combined electromagnetic fields显示文摘The combined electromagnetic fields were achieved by the application of an alternating magnetic field and a stationary magnetic field and were used during direct chill(DC) casting process to control the microstructure and macrosegregation of an Al-Zn-Mg-Cu alloy. Ingot microstructures were analyzed under an optical microscope(Leica DMR). The composition at different locations in the ingots was measured with inductively coupled plasma mass spectrometry(ICP) method. The results showed that the grain structure is transformed from dendrite to equiaxed structure and significantly refined with the application of combined electromagnetic fields. The uniformity of microstructure is also greatly improved. The combined electromagnetic fields show a significant effect on the distribution of elements. The negative macrosegregation in the centre area of the ingot is obviously reduced. | Yu-bo Zuo Xu-dong Liu Chao Sun Sen-sen Yuan Dan Mou Zhan-zhi Li Jian-zhong Cui | 2015 | China Foundry2015，12，5： | 1 |
| 5 | A new isotope of protactinium:239Pa显示文摘 | S. Yuan W. Yang W. Mou X. Zhang Z. Li X. Yu J. Gu Y. Guo Z. Gan H. Liu J. Guo | 1995 | Zeitschrift für Physik A Hadrons and Nuclei1995，，3： | 1 |
| 6 | Spectrometric study of α-methylene aromatic araminenone and aminoketone显示文摘Thirteenα-methylene aromatic araminenone and fourα-methylene aromatic aminoketones were prepared by modified Mannich reaction.On the basis of isotopic labeling,a plausible way of cleavage was proposed for the formation of the M^+-17 fragment peak in the MS of theα-methylene aromatic araminenone and aminoketones.The characteristic chemical shift of the olefinic protons in ~1H NMR is also discussed. | Li Yuan Mou Zi Yun Lin Li Ya Zhu Xiao Tian Liang | 2007 | Chinese Chemical Letters2007，18，10： | 1 |
| 7 | Improving security of a chaotic encryption approach 显示文摘 | LI Shu - jun MOU Xuan - qin CAI Yuan - long | 2001 | Physics Letters A2001，290，34： | 1 |
| 8 | Rapid Detection of Rifampin-resistant Clinical Isolates of Mycobacterium tuberculosis by Reverse Dot Blot Hybridization显示文摘Objective A PCR-reverse dot blot hybridization(RDBH) assay was developed for rapid detection of rpo B gene mutations in ‘hot mutation region' of Mycobacterium tuberculosis(M. tuberculosis). Methods 12 oligonucleotide probes based on the wild-type and mutant genotype rpoB sequences of M. tuberculosis were designed to screen the most frequent wild-type and mutant genotypes for diagnosing RIF resistance. 300 M. tuberculosis clinical isolates were detected by RDBH, conventional drug-susceptibility testing(DST) and DNA sequencing to evaluate the RDBH assay. Results The sensitivity and specificity of the RDBH assay were 91.2%(165/181) and 98.3%(117/119), respectively, as compared to DST. When compared with DNA sequencing, the accuracy, positive predictive value(PPV) and negative predictive value(NPV) of the RDBH assay were 97.7%(293/300), 98.2%(164/167), and 97.0%(129/133), respectively. Furthermore, the results indicated that the most common mutations were in codons 531(48.6%), 526(25.4%), 516(8.8%), and 511(6.6%), and the combinative mutation rate was 15(8.3%). One and two strains of insertion and deletion were found among all strains, respectively. Conclusion Our findings demonstrate that the RDBH assay is a rapid, simple and sensitive method for diagnosing RIF-resistant tuberculosis. | GUO Qian YU Yan ZHU Yan Ling ZHAO Xiu Qin LIU Zhi Guang ZHANG Yuan Yuan LI Gui Lian WEI Jian Hao WU Yi Mou WAN Kang Lin | 2015 | Biomedical and Environmental Sciences2015，28，1： | 1 |
| 9 | A simple AuNPs-based colorimetric aptasensor for chlorpyrifos detection显示文摘In this work, a simple gold nanoparticles(Au NPs) based colorimetric biosensor was developed for chlorpyrifos(Chl) detection using an aptamer as the capture probe. The Chl-aptamer with low dissociation constant(Kd) of 58.59 ± 6.08 nmol/L was selected by ss DNA library immobilized systematic evolution of ligands by enrichment(SELEX). In the absence of Chl, the Chl-aptamer acted as the stabilizer for Au NPs in salt solution. In the presence of Chl, the highly specific Chl-aptamer bound with Chl targets immediately,thus a self-aggregation of Au NPs induced by salt was displayed. The fabricated colorimetric aptasensor exhibited an excellent sensitivity for Chl detection with the LOD as low as 14.46 nmol/L. In addition, the aptasensor was applied to test Chl in tap water, cucumber and cabbage samples, the excellent recoveries with acceptable RSD values below 5% demonstrated that the method can be considered as a promising tool for simple, rapid Chl detection. | Yuan Liu Taotao Li Gaojian Yang Yan Deng Xianbo Mou Nongyue He | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 10 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 11 | Theγ-decay of a new neutron-rich nucleus175Er显示文摘 | Zhang Xueqian Yuan Shuanggui Yang Weifan Li Zongwei Mou Wantong Yu Xian Zhong Jiquan | 1996 | Zeitschrift für Physik A: Hadrons and Nuclei1996，，4： | 1 |
| 12 | Absolute Measurement of 99Tc Standard Solution显示文摘99Tc is a pure beta decay radionuclide with a long half-life T1/2=2.111×105 a. The beta ray has a maximum energy of 293.7 keV. The detected efficiency in 4π proportional counter can be well traced by 60Co with the 4πβ-γ digital coincidence method. There existed a disadvantage of lost of | CHEN Xi-lin ZHENG Ya-ming WU Yong-le YAO Shun-he LU Xiao-xia YUAN Da-qing YANG Chun-li LIU De-min FANG Quan LI Mou CHANG Yong-fu | 2010 | Annual Report of China Institute of Atomic Energy2010，，1： | 0 |
| 13 | Multi-functional stainless steel composite frames stabilize the sodium metal battery显示文摘The sodium(Na)metal battery has the prospect of promising high energy density and sustainable tech-nology for low-cost energy storage.However,the soft texture and high reactivity of Na cause it easy to structure collapse and produce side reactions with organic electrolytes.Inspired by ancient Chinese ar-chitecture,a structural engineering strategy is introduced to conquer the above issues.PVDF film-covered stainless steel mesh(SMPF)embedded in the obverse of Na metal to form a“self-limiting”Na/electrolyte interface and bare stainless steel mesh(SM)with high electronic conductivity embedded in the reverse of Na metal to form a uniformly electronic distributed Na/collector interface.Based on the electric field simulation and in-situ optical tests,the well-designed structure of the SM@Na@SMPF electrode can re-strict the dendrite growth and slow down the bubbles release.The above strategies provide important technical support for the large-scale application of flexible Na metal batteries. | Laiping Li Yusheng Luo Wenlu Yuan Peizhi Mou Qi Wu Lin Zhang Yong Chen Jie Shu Liyuan Zhang | 2023 | Journal of Materials Science & Technology2023，，18： | 0 |
| 14 | Observation of New Nuclide ^(239)Pa显示文摘A new nuclide ^(239)Pa was produced by 50MeV/u ^(18)O bombardment of natural uranium via multi-nucleon transfer reactions(^(238)U-lp+2n).Protactinium was chemically separated from the uranium target and other produced elements.Then in that chemical fraction the growth and decay of ^(239)U gamma rays were observed,identifying the ^(239)U parent as ^(239)Pa.Subsequent to ^(239)Pa β^(-) decay,with a half-life of 106±30min,gamma rays of 522.0,562.0,638.5 and 681.0keV were also observed. | YUAN Shuang-gui YANG Wei-fan MOU Wan-tong ZHANG Xue-qian LI Zong-wei | 1996 | Chinese Physics Letters1996，13，12： | 0 |
| 15 | High-static-low-dynamic stiffness isolator based on an electromagnetic negative stiffness spring with long linear stroke显示文摘Negative stiffness mechanisms can improve low-frequency vibration isolation performance and have been widely used in the vibration isolation of precision equipment. However, the negative stiffness mechanism usually introduces a nonlinear stiffness,resulting in a nonlinear response and worsening the vibration isolation performance, especially under large amplitude vibration.In this paper, an electromagnetic spring with linear negative stiffness(ESLNS) is proposed, in which the antagonistic ampere forces of the energized coils are used to generate negative stiffness within a long linear stroke. The magnetic field distribution is improved through the design of the magnetic circuit, thereby increasing the stiffness generation efficiency. The stiffness can be adjusted bidirectionally by current within the range of positive and negative stiffness. An electromagnetic stiffness model was established based on the equivalent magnetic circuit method. Experimental measurements verified the accuracy of the model and proved the linearity of the electromagnetic spring. A vibration isolator with high static and low dynamic stiffness(HSLDS) based on the ESLNS is designed and tested. The experimental results prove that the introduction of the ESLNS can effectively expand the isolation frequency band without changing the equilibrium position. Moreover, the vibration isolator with ESLNS does not produce nonlinear response. The proposed electromagnetic spring with linear negative stiffness extends the application range of HSLDS isolators to a large amplitude vibration environment. | YUAN ShuJin WU YaJun SONG DaiPing PU HuaYan MOU LiSheng HOU Lei ZHAO JingLei LI XuePing LUO Jun WU Jie HUANG XiaoXu | 2024 | Science China(Technological Sciences)2024，67，3： | 0 |
| 16 | Decay Study of the Neutron-Rich Nucleus ^(175)Er | Zhang Xueqian Yuan Shuanggui Yang Weifan Mou Wantong Li Zongwei Luo Yixiao Zhong Jiquan Institute of Modern Physics,the Chinese Academy of Sciences,Lanzhou 730000 | 1997 | Chinese journal of nuclear physics1997，，1： | 0 |
| 17 | Spectrometric Study of α-Phenylcinnamic Acids显示文摘Fourteen substituted α-phenylcinnamic acids were prepared by the classical Perkin condensation. A plausible way of cleavage was involved in the formation of the specific fragment peaks in the MS of the α-phenylcinnamic acids . The characteristic chemical shift of the olefinic proton in HNMR is also | Xin HE Li Yuan MOU Zi Yun LIN Li Ya ZHU Xiao Tian LIANG (Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College . Beijing 100050 ) | 1997 | Chinese Chemical Letters1997，8，10： | 0 |
| 18 | Using endogenous glycogen as relaxation agent for imaging liver metabolism by MRI显示文摘Glycogen plays essential roles in glucose metabolism.Imaging glycogen in the liver,the major glycogen reservoir in the body,may shed new light on many metabolic disorders.^(13)C magnetic resonance spectroscopy(MRS)has become the mainstream method for monitoring glycogen in the body.However,the equipment of special hard-ware to standard clinical magnetic resonance imaging(MRI)scanners limits its clinical applications.Herein,we utilized endogenous glycogen as a T_(2)-based relaxation contrast agent for imaging glycogen metabolism in the liver in vivo.The in vitro results demonstrated that the transverse relaxation rate of glycogen strongly correlates with the concentration,pH,and field strength.Based on the Swift-Connick theory,we characterized the exchange property of glycogen and measured the exchange rate of glycogen as 31,847 Hz at 37°C.Besides,the viscosity and echo spacing showed no apparent effect on the transverse relaxation rate.This unique feature enables vi-sualization of glycogen signaling in vivo through T_(2)-weighted MRI.Two hours-post intraperitoneal injection of glucagon,a clinical drug to promote glycogenolysis and gluconeogenesis,the signal intensity of the mice’s liver increased by 1.8 times from the T_(2)-weighted imaging experiment due to the decomposition of glycogen.This study provides a convenient imaging strategy to non-invasively investigate glycogen metabolism in the liver,which may find clinical applications in metabolic diseases. | Shizhen Chen Mou Jiang Yaping Yuan Baolong Wang Yu Li Lei Zhang Zhong-Xing Jiang Chaohui Ye Xin Zhou | 2023 | Fundamental Research2023，3，4： | 0 |
| 19 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 20 | Preliminary Observation of Possible New γ-rays of ^(236)Pa显示文摘PreliminaryObservationofPossibleNewγ-raysof^(236)Pa￥FangKeming;YangWeifan;YuanShuanggui;ShenShuifa;MouWantong;LiZongweiandZha?.. | Fang Keming Yang Weifan Yuan Shuanggui Shen Shuifa Mou Wantong Li Zongwei and Zhang Xueqian | 1996 | IMP & HIRFL Annual Report1996，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员