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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-producing cells in vitro显示文摘Bckground 干细胞,有能力区分进生产胰岛素的房间(欧洲电脑生产厂商) ,将为移植提供小岛房间的潜在地无限的来源并且减轻可获得性和 allogeneic 拒绝的主要限制。因此,干细胞的利用为糖尿病 mellitus (DM ) 正在成为最有希望的治疗。这里,我们学习了糖尿病的病人的骨头的区别能力导出髓的间充质的干细胞( MSC )并且测试了使用 MSC 的可行性因为房间 replacement.Methods 骨头导出髓的 MSC 从 10 个 DM 病人被获得( 5 打 1 DM , 5 打 2 DM )并且在一个三阶段的协议下面导致了到欧洲电脑生产厂商。MSC 的代表性的房间表面抗原表示侧面被流动 cytometric 分析分析。反向的抄写聚合酶链反应(RT-PCR ) 被执行检测与胰腺的房间开发和功能有关的多重基因。欧洲电脑生产厂商的身份被形态学, ditizone 染色和 immunocytochemistry 的分析说明。由这些房间的胰岛素的版本被 MSC 的 immunoradioassay.Results 流动 cytometric 分析在 3 显示出的经过证实这些房间表示了 CD29 (98.28%) 的高水平, CD44 (99.56%) 和 CD106 (98.34%) 。典型像小岛的房间簇在协议(18 天) 的结束被观察。染色的 Ditizone 和为胰岛素的 immunohistochemistry 两个都是积极的。在舞台 2 点的这些区分的房间(10 天) 表示了 nestin,胰腺的十二指肠的 homeobox-1 (PDX-1 ) , Neurogenin3, Pax4,胰岛素, glucagon,但是(18 天) 在舞台 3 点,我们观察了 PDX-1 的高表示,胰岛素, glucagon。胰岛素被这些房间以从 DM 病人的 .Conclusions 骨头导出髓的 MSC 能在 vitro 在某些条件下面区分进功能的欧洲电脑生产厂商的一种调整方式(P0.05 ) 响应葡萄糖刺激的不同集中分泌。用糖尿病的病人的自己的骨头,导出髓的 MSC 将作为为房间代替的自体同源的欧洲电脑生产厂商的来源是可行的。 | SUN Yu CHEN Li HOU Xin-guo HOU Wei-kai DONG Jian-jun SUN Lei TANG Kuan-xiao WANG Bin SONG Jun LI Hui WANG Ke-xin | 2007 | Chinese Medical Journal2007，，9： | 57 |
| 3 | Comparative Study between Robotic Total Thyroidectomy with Central Lymph Node Dissection via Bilateral Axillo-breast Approach and Conventional Open Procedure for Papillary Thyroid Microcarcinoma显示文摘 | Qing-Qing He Jian Zhu Da-Yong Zhuang Zi-Yi Fan Lu-Ming Zheng Peng Zhou Lei Hou Fang Yu Yan-Ning Li Lei Xiao Xue-Feng Dong Gao-Feng Ni | 2016 | Chinese Medical Journal2016，，18： | 42 |
| 4 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 5 | Analysis of risk factors for polypoid lesions of gallbladder among health examinees显示文摘AIM: To investigate the prevalence and risk factors of polypoid lesions of gallbladder (PLG) among the health examinees in the Shanghai region, China. METHODS: A total of 11 816 subjects who underwent health examinations in our hospital between August 2010 and February 2011 were analyzed retrospectively. Among them, there were 7174 men and 4642 women. PLG was diagnosed by the real-time ultrasonography. Those with the body mass index (BMI) ≥ 28 were considered to be obese. Blood biochemical indices were detected with the fully automatic biochemical analyzer and hepatitis B surface antigen (HBsAg) was tested by the automated enzyme immunoassay. The correlations between the prevalence of PLG and age, sex, BMI, serum cholesterol (T-Cho), triglycerides (TG),blood sugar, HBsAg, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), gallstone and fatty liver were investigated. After univariate analysis of 11 variables, stepwise logistic regression analysis was performed to explore the risk factors of PLG. RESULTS: There was a significant difference in sex, T-Cho, HBsAg, HDL-C, LDL-C and fatty liver between the PLG-positive group and the PLG-negative group (332/163 vs 6842/4479, P = 0.003; 22/473 vs 295/11 026, P =0.013; 92/403 vs 993/10 328, P = 0.001; 47/448 vs 332/10 989, P = 0.001; 32/463 vs 381/10 940, P = 0.001; 83/412 vs 3260/8061, P = 0.001). No significant difference was found in the age, BMI, TG, blood sugar and gallstone between the two groups (47.3 ± 26 vs 45.1 ± 33, P = 0.173; 59/436 vs 1097/10 224, P = 0.102; 52/443 vs 982/10 339, P = 0.158; 17/478 vs 295/11 026, P = 0.26; 24/471 vs 395/10 926, P = 0.109). Logistic regression analysis showed that the sex, HBsAg and HDL-C were independent risk factors for the development of PLG in a descending order of HDL-C > HBsAg > sex. CONCLUSION: In healthy people, the male gender, positive HBsAg, and low HDL-C confer higher risks of PLG development. | Hua-Li Yang Hui-Fang Shen Yu Wang Xin-Gang Gu Jian-Min Qin Pei-Hao Yin Qi Li Lei Kong Li-Li Hou | 2012 | World Journal of Gastroenterology2012，18，23： | 24 |
| 6 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 7 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 8 | Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the second most deadly cancer worldwide.1 Cirrhosis of different causes predisposes patients to HCC,increasing the annual HCC incidence by 2%–4%.1 The development of cirrhosis facilitates a series of genetic or epigenetic changes,resulting in the formation of dysplastic nodules,a premalignant stage in HCC.1 HCC diagnosis at an early stage contributes to an improved prognosis with the possibility of curative treatment.Due to the low accuracy of current diagnostic methods,it is urgently needed to explore new non-invasive strategies for early HCC diagnosis in cirrhotic patients. | Lei Chen Ghassan K.Abou-Alfa Bo Zheng Jing-Feng Liu Jian Bai Lu-Tao Du Yun-Song Qian Rong Fan Xiao-Long Liu Lin Wu Jin-Lin Hou Hong-Yang Wang The PreCar Team | 2021 | Cell Research2021，31，5： | 20 |
| 9 | BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity显示文摘基础编辑() ,包含 cytidine 脱氨基酶和催化地有缺点的 Cas9,广泛地被用来执行基础编辑。然而,狭窄的编辑窗口是限制它的实用程序。这里,我们开发了依照到由熔化 10 的 U (T) 范围(加) 的更大的 C 为招募 GCN4 肽拷贝到 nCas9 (D10A ) 的编程作为基础编辑命名的一种新编辑技术 scFv-APOBEC-UGI-GB1 到目标地点。新系统完成与一扇拓宽的窗户的基础编辑,导致一个增加的指向染色体的范围。有趣地,新系统很产出更少讨厌的 indels 和 non-C-to-T 变换。我们也通过站 codons (iSTOP ) 的正式就职越过整个染色体在基因混乱表明了它的潜在的使用。一起拿,加系统与编辑窗口和提高的忠实增加提供一个新编辑工具。 | Wen Jiang Songjie Feng Shisheng Huang Wenxia Yu Guanglei Li Guang Yang Yajing Liu Yu Zhang Lei Zhang Yu Hou Jia Chen Jieping Chen Xingxu Huang | 2018 | Cell Research2018，28，8： | 20 |
| 10 | Temporal variations and source apportionment of volatile organic compounds at an urban site in Shijiazhuang, China显示文摘Shijiazhuang,the city with the worst air quality in China,is suffering from severe ozone pollution in summer.As the key precursors of ozone generation,it is necessary to control the Volatile Organic Compounds(VOCs)pollution.To have a better understanding of the pollution status and source contribution,the concentrations of 117 ambient VOCs were analyzed from April to August 2018 in an urban site in Shijiazhuang.Results showed that the monthly average concentration of total VOCs was 66.27 ppbv,in which,the oxygenated VOCs(37.89%),alkanes(33.89%),and halogenated hydrocarbons(13.31%)were the main composite on.Eight major sources were identified using Positive Matrix Factorization modeling with an accurate VOCs emission inventory as inter-complementary methods revealed that the petrochemical industry(26.24%),other industrial sources(15.19%),and traffic source(12.24%)were the major sources for ambient VOCs in Shijiazhuang.The spatial distributions of major industrial activities emissions were identified by using geographic information statistics system,which illustrated the VOCs was mainly from the north and southeast of Shijiazhuang.The inverse trajectory analysis using Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)and Potential Source Contribution Function(PSCF)clearly demonstrated the features of pollutant transport to Shijiazhuang.These findings can provide references for local governments regarding control strategies to reduce VOCs emissions. | Yanan Guan Lei Wang Shujuan Wang Yihao Zhang Jieying Xiao Xiaoli Wang Erhong Duan Li'an Hou | 2020 | Journal of Environmental Sciences2020，32，11： | 19 |
| 11 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 12 | Component Analysis and Free Radicals Scavenging Activity of Physalis alkekengi L. Polysaccharide显示文摘A crude polysaccharide was extracted from Physalis alkekengi L. fruit. HPLC was used for the component analysis of the polysaccharide. The results indicate that Physalis alkekengi L. polysaccharide(PAP) was composed of rhamnose, xylose, arabinose, galactose, and glucose. Free radicals scavenging activity of PAP was studied through 3 free radicals scavenging tests. PAP exhibited high scavenging effects on OH and DPPH radicals, and both the scavenging rates were about 80%. The scavenging rate of O2 radical was about 22%. | CHENG Ying-kun LI Lei MENG Zhao-kun HOU A-li WU Yu-jie TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，2： | 18 |
| 13 | Renewed profile of the Mesozoic magmatism in Korean Peninsula: Regional correlation and broader implication for cratonic destruction in the North China Craton显示文摘Widespread Mesozoic magmatism occurs in the Korean Peninsula(KP). The status quo is poles apart between the northern and southern parts in characterizing its distribution and nature, with the nearly absence of any related information in North Korea. We have the opportunity to have conducted geological investigations in North Korea and South Korea during the past ten years through international cooperation programs. This led to the revelation of a number of granitoids and related volcanic rocks and thus facilitates the comparison with those in East China and Japan. Mesozoic granitoids in the KP can be divisible into three age groups: the Triassic group with a peak age of ~220 Ma, the Jurassic one of ~190–170 Ma and the late Early Cretaceous one of ~110 Ma. The Triassic intrusions include syenite, calc-alkaline to alkaline granite and minor kimberlite in the Pyeongnam Basin of North Korea. They have been considered to form in post-orogenic settings related to the Central Asian Orogenic Belt(CAOB) or the Dabie-Sulu Orogenic Belt(DSOB). The Jurassic granitoids constitute extensive occurrence in the KP and are termed as the Daebo-period magmatism. They correlate well with coeval counterparts in NE China encompassing the northeastern part of the North China Craton(NCC) and the eastern segment of the CAOB. They commonly consist of biotite or two-mica granites and granodiorites, with some containing small dark diorite enclaves. On one hand, Early Jurassic to early Middle Jurassic magmatic rocks are rare in most areas of the NCC, whilst Middle-Late Jurassic ones are not developed in the KP. On the other hand, both NCC and KP host abundant Cretaceous granites. However, the present data revealed contrasting age peaks, with ~130–125 Ma in the NCC and ~110–105 Ma in the KP. Cretaceous granites in the KP comprise the dominant biotite granites and a few amphibole granites. The former exhibit mildly fractionated REE patterns and zircon εHf(t) values from ?15 to ?25, whereas the latter feature strongly fractionated REE patterns and zircon εHf(t) values from ?10 to ?1. Both granites contain inherited zircons of ~1.8–1.9 or ~2.5 Ga. These geochemical characters testify to their derivation from re-melting distinct protoliths in ancient basement. Another Cretaceous magmatic sub-event has been entitled as the Gyeongsang volcanism, which is composed of bimodal calc-alkaline volcanic rocks of 94–55 Ma and granitic-hypabyssal granitic bodies of 72–70 Ma. Synthesizing the Mesozoic magmatic rocks across the KP, NCC and Japan can lead to the following highlights:(1) All Triassic granites in the NCC, KP and Japan have similar characteristics in petrology, chronology and geochemistry. Therefore, the NCC, KP and Japan tend to share the same tectonic setting during the Triassic, seemingly within the context of Indosinian orogensis.(2) Jurassic to earliest Cretaceous magmatic rocks in the NCC seem to define two episodes: episode A from 175 to 157 Ma and episode B from 157 to 135 Ma. Jurassic magmatic rocks in the KP span in age mainly from 190 to 170 Ma, whereas 160–135 Ma ones are rare. With the exception of ~197 Ma Funatsu granite, Jurassic magmatic rocks are absent in Japan.(3) Cretaceous granites in the KP have a peak age of ~110, ~20 Ma younger than those in the NCC, while Japan is exempt from ~130–100 Ma granites.(4) The spatial-temporal distribution and migratory characteristics of theJurassic-Cretaceous magmatic rocks in Japan, KP, and NE China-North China indicate that the subduction of the Paleo-Pacific plate might not be operative before Late Cretaceous(~130–120 Ma).(5) Late Cretaceous magmatic rocks(~90–60 Ma) occur in the southwestern corner of the KP and also in Japan, coinciding with the metamorphic age of ~90–70 Ma in the Sanbagawa metamorphic belt of Japan. The magmatic-metamorphic rock associations and their spatial distribution demonstrate the affinities of sequentially subduction zone, island arc and back-arc basin from Japan to Korea, arguing for the Pacific plate subduction during Late Cretaceous.(6) This study raises another possibility that the Mesozoic cratonic destruction in the NCC, which mainly occurred during ~150–120 Ma, might not only be due to the subduction of the Paleo-Pacific Plate, but also owe much to the intraplate geodynamic forces triggered by other adjacent continental plates like the Eurasian and Indian plates. | ZHAI MingGuo ZHANG YanBin ZHANG XiaoHui WU Fu Yuan PENG Peng LI Qiu Li HOU QuanLin LI TieSheng ZHAO Lei | 2016 | Science China(Information Sciences)2016，59，12： | 16 |
| 14 | Effect of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors显示文摘OBJECTIVE:To evaluate the effects of electric acupoint stimulation on gastrointestinal hormones and motility among geriatric postoperative patients with gastrointestinal tumors,and to explore an efficient and noninvasive method for postoperative recovery of bowel functions.METHODS:Forty patients were randomly and evenly assigned into a regular nursing care group(RNC) and an acupoint electric stimulation group(AES).Patients in the RNC group received regular nursing care and patients in the AES group received regular nursing care plus electric stimulation of acupoints.The serum levels of gastrin(GAS),motilin(MOT),and cholecystokinin(CCK),and an electrogastrogram(EGG) of all the patients were evaluated on the first,third,and fifth day after surgery.The time to first flatus after surgery and the number of patients with side effects such as abdominal pain,abdominal distention,and diarrhea were recorded.RESULTS:There were significant differences between the two groups in GAS,MOT,EGG,time to first flatus,abdominal pain,abdominal distention,and diarrhea(P < 0.05).CONCLUSION:Electric stimulation on acupoints could increase levels of GAS and MOT,promote the recovery of gastrointestinal functions,and decrease complications among postoperative senile patients with gastrointestinal tumors. | Hou Lili Xu Lei Shi Yan Gu Fen | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 15 |
| 15 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 16 | Health-related quality of life in gastroesophageal reflux patients with noncardiac chest pain: Emphasis on the role of psychological distress显示文摘AIM To investigate the effects of depression and anxiety on health-related quality of life(QoL)in gastroesophageal reflux disease(GERD)patients and those suffering from cardiac(CCP)and noncardiac(NCCP)chest pain in Wuhan,China.METHODS In this cross-sectional study,a total of 358 consecutive patients with GERD were enrolled in Wuhan,China,of which 176 subjects had complaints of chest pain.Those with chest pain underwent coronary angiography and were divided into a CCP group(52 cases)and NCCP group(124 cases).Validated GERD questionnaires were completed,and the 36-item Short-Form Health Survey and Hospital Anxiety/Depression Scale were used for evaluation of Qo L and psychological symptoms,respectively.RESULTS There were similar ratios and levels of depression and anxiety in GERD with NCCP and CCP.However,the QoL was obviously lower in GERD with CCP than NCCP(48.34±17.68 vs 60.21±20.27,P<0.01).In the GERD-NCCP group,rather than the GERD-CCP group,the physical and mental QoL were much poorer in subjects with depression and/or anxiety than those without anxiety or depression.Anxiety and depression had strong negative correlations with both physical and mental health in GERD-NCCP(all P<0.01),but only a weak relationship with mental components of QoL in GERD-CCP.CONCLUSION High levels of anxiety and depression may be more related to the poorer QoL in GERD patients with NCCP than those with CCP.This highlights the importance of evaluation and management of psychological impact for improving QoL in GERD-NCCP patients. | Lei Zhang Lei Tu Jie Chen Jun Song Tao Bai Xue-Lian Xiang Rui-Yun Wang Xiao-Hua Hou | 2017 | World Journal of Gastroenterology2017，23，1： | 14 |
| 17 | A retrospective comparison of the modified tension band technique and the parallel titanium cannulated lag screw technique in transverse patella fracture显示文摘 | Wang Chengxue Tan Lei Qi Baochang Hou Xiangfeng Huang Yulong Zhang Haipeng Yu Tiecheng | 2014 | Chinese Journal of Traumatology2014，17，4： | 14 |
| 18 | Electrical stimulation of acupoint combinations against deep venous thrombosis in elderly bedridden patients after major surgery显示文摘OBJECTIVE:To compare the effects of electrical stimulation of different acupoint combinations among postoperative bedridden elderly patients on hemorheology and deep venous blood flow velocity and investigate the role of electrical stimulation against deep vein thrombosis(DVT).METHODS:From November 2010 to October 2011,a total of 160 elderly bedridden patients after major surgery were divided into the conventional care group,invigorating and promoting Qi group,blood-activating and damp-eliminating group,and acupoint-combination stimulation group.Whole blood viscosity,plasma viscosity,D-dimer levels,lower limb skin temperature,lower limb circumference,and flow velocities of the external iliac vein,femoral vein,popliteal vein,and deep calf veins in all patients were documented and compared among the four groups.RESULTS:Whole blood viscosity,plasma viscosity,D-dimer levels,and lower limb circumference were significantly reduced in the blood-activating and damp-eliminating group compared with the conventional care group(P<0.05) and were almost equal to those in the acupoint-combination stimulation group(P>0.05).Lower limb venous flow velocities were accelerated in the invigorating and promoting Qi group compared with the other groups,excluding the acupoint-combination stimulation group(P<0.05).CONCLUSION:Hemorheological indices in postoperative bedridden elderly patients were improved after combined electrical stimulation at Yinlingquan(SP 9) and Sanyinjiao(SP 6).Combined electrical stimulation at Zusanli(ST 36) and Taichong(LR 3),on the other hand,accelerated lower limb venous flow. | Lili Hou Cuiping Chen Lei Xu PeihaoYin Wen Peng | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 13 |
| 19 | Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2显示文摘(HER2 ) 背景人的表皮的生长因素 2 是最重要的预言因素之一,但是仅仅乳癌病人 HER2 的 25%-30% 是积极的。是否有另外的分子的标记,能被用来预言在 HER2 否定 patients.This 学习的预后和复发与侵略乳癌在 281 个病人与临床的结果调查了 cyclin A2 和 HER2 层次的关联以便识别 cyclin A2 是否能在 HER2 用作一个预示的因素,是未知的染色的否定 patients.Methods Immunohistochemical 被用来在 281 个病人检测 cyclin A2 和 HER2 表示。Cyclin A2。并且 HER2 基因扩大在 12 个病人用基因分析和 RT-PCR 被分析。风险和幸存估计用木头等级, Kaplan-Meier,和考克斯回归分析被分析;有幸存的 cyclin A2 和 HER2 一致性与更高的 cyclin A2 用 Kappa analysis.Results 病人被分析, HER2 表情有显著地更短的没有疾病的幸存时期(P=0.047 和 P=0.05,分别地) 。Kappa 分析执行了那 cyclin A2, HER2 显示出一个低 Kappa 索引(kappa=0.37 ) ,允许我们断定 cyclin A2 和 HER2 检测不同病理。基因分析和 RT-PCR 证明 cyclin A2 是在有早恶化的病人的 upregulated;平均增加是 3.69-2.74 fold.Conclusions Cyclin A2, HER2 与增长和高复发被联系,特别地当联合时。Cyclin A2 被原子染色容易检测并且可能是为在 HER2 否定病人的复发风险的有用 biomarker。 | LI Hui-ping JI Jia-fu HOU Kuan-yong LEI Yu-tao ZHAO Hong-mei WANG Jing ZHENG Jie LIU Jian-ying WANG Mo-pei XIAO Yu WANG You-fan LU You-yong SUN Yan | 2010 | Chinese Medical Journal2010，，4： | 12 |
| 20 | Profile improvement during CO_2 flooding in ultra-low permeability reservoirs显示文摘Gas flooding such as CO2 flooding may be effectively applied to ultra-low permeability reservoirs, but gas channeling is inevitable due to low viscosity and high mobility of gas and formation heterogeneity. In order to mitigate or prevent gas channeling, ethylenediamine is chosen for permeability profile control. The reaction mechanism of ethylenediamine with CO2, injection performance, swept volume, and enhanced oil recovery were systematically evaluated. The reaction product of ethylenediamine and CO2 was a white solid or a light yellow viscous liquid, which would mitigate or prevent gas channeling. Also, ethylenediamine could be easily injected into ultra-low permeability cores at high temperature with protective ethanol slugs. The core was swept by injection of 0.3 PV ethylenediamine. Oil displacement tests performed on heterogeneous models with closed fractures, oil recovery was significantly enhanced with injection of ethylenediamine. Experimental results showed that using ethylenediamine to plug high permeability layers would provide a new research idea for the gas injection in fractured, heterogeneous and ultra-low permeability reservoirs. This technology has the potential to be widely applied in oilfields. | Zhao Fenglan Zhang Lei Hou Jirui Cao Shujun | 2014 | Petroleum Science2014，11，2： | 12 |
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