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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Colonic duplication in an adult mimicking a tumor of pancreas显示文摘Duplications of the alimentary tract are uncommon congenital malformations that can present diagnostic difficulties. We report a rare case of a cystic colonic duplication in a female adult. Preoperative investigations were suggestive of pancreatic tumor. The diagnosis was established based on the histopathological examination of the resected specimen. We concluded that, though uncommon, intestinal duplication should be considered in differential diagnosis of abdominal mass. | Fabiana Pirani Carneiro Maria de Nazareth Sobreira Ana Emília B de Azevedo Andréa Pedrosa Ribeiro Alves Karina Martins Campos | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 3 | Excellent mechanical properties of three-dimensionally ordered macroporous nickel photonic crystals 显示文摘 | Lia Y Maa B Zhao J | 2011 | J Alloys Compds2011，509，2： | 1 |
| 4 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 5 | Life-cycle As- sessment of Biodiesel Production from Algal显示文摘 | LARDON L HEI~LIAS A SIALVE B | 2009 | Environmental Science & Technology2009，43，17： | 1 |
| 6 | Resistance to the Soybean Aphid in Soybean Germplasm显示文摘 | Curtis B Hilla Yah Lia | 2004 | Crop Science2004，44，： | 1 |
| 7 | The effect of surface roughness on early in vivo plague colonization on titanium显示文摘 | LIA R SILCIA F EUGENIO B | 1997 | J Periodanntol1997，68，： | 1 |
| 8 | Isorhapontigenin, a new resveratrol analog, attenuates cardiac hypertrophy via blocking signaling transduction pathways 显示文摘 | H - L Lia A - B Wang Y Huang | 2005 | Free Radical Biology & Medicine2005，38，2： | 1 |
| 9 | Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers显示文摘AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat livers.METHODS: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93 M diet, and animals in the experimental group received an Atkins-based diet(59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies. We expressed the data as mean ± standard deviation(sd) assuming unpaired and parametric data; we analyzed differences using the student's t-test. statistical significance was set at P < 0.05.RESULTS: We found that plasma alanine aminotransferase and aspartate aminotransferase levels were significantly higher in the experimental group than in the control group. According to flow cytometry, the percentages of nonviable cells were 11.67% ± 1.12% for early apoptosis, 12.07% ± 1.11% for late apoptosis, and 7.11% ± 0.44% for non-apoptotic death in the experimental diet group and 3.73% ± 0.50% for early apoptosis, 5.67% ± 0.72% for late apoptosis, and 3.82% ± 0.28% for non-apoptotic death in the control diet group. The mean percentage of early apoptosis was higher in the experimental diet group than in the control diet group. Immunohistochemistry for autophagy was negative in both groups. sinusoidal dilation around the central vein and small hepatocytes was only observed in the experimental diet group, and fibrosis was not identified by hematoxylin-eosin or Trichrome Masson staining in either group.CONCLUSION: Eight weeks of an experimental diet resulted in cellular and histopathological lesions in rat livers. Apoptosis was our principal finding; elevated plasma transaminases demonstrate hepatic lesions. | Maria Emília L Monteiro Analucia R Xavier Felipe L Oliveira Porphirio JS Filho Vilma B Azeredo | 2016 | World Journal of Gastroenterology2016，22，22： | 1 |
| 10 | Treatment of oily wastewater by organic-inorganic composite tubular ultrafihration(UF) membranes 显示文摘 | Lia Y S Yana L Xiang C B | 2012 | Desalination2012，196，： | 1 |
| 11 | Provider payment methods and health worker motivation in community-based health insurance: A mixed-methods study显示文摘 | Paul Jacob Robyn Till B?rnighausen Aurélia Souares Adama Traoré Brice Bicaba Ali Sié Rainer Sauerborn | 2014 | Social Science & Medicine2014，，： | 1 |
| 12 | Comparison of different methods for DNA-free RNA isolation from SK-N-MC neuroblastoma显示文摘 | Lucélia Tavares Paula M Alves Ricardo B Ferreira | | 0，，： | 1 |
| 13 | Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor显示文摘 | Lia B P Fournier A E GrandPr T el al | 2002 | Science2002，297，5584： | 1 |
| 14 | DL-3-n-butylphthalide protects endothelial cells against oxidative/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro显示文摘 | Lia L Zhang B Tao Y | 2009 | Brain Res2009，1290，： | 1 |
| 15 | The effect of surface roughness on early in vivo plague colonization on titanium显示文摘 | Lia R Silcia F Eugenio B | 1997 | J Periodanntol1997，68，： | 1 |
| 16 | Precipitation of bovine rotavirus by polyethylene glycol (PEG) and its applica- tion to produce polyclonal and monoclonal antibodies 显示文摘 | Lia V Q F Gubio S C Patricia A B | 2005 | J Virol Methods2005，123，2： | 1 |
| 17 | Drinking and drinking patterns and health status in the general population of five areas of China 显示文摘 | Hao W Su Z Lia B | 2004 | Alcohol Alcohol2004，39，1： | 1 |
| 18 | Fabrication and characterization of transparent conductive ZnO:Al thin films prepared by direct current magnetron sputtering with highly conductive ZnO(ZnAl2O4) ceramic target显示文摘 | Lia D Yao B L | 2003 | Journal of Crystal Growth2003，247，： | 1 |
| 19 | The effect of surface roughness on early in vivo plaque colonization on titanium显示文摘 | Lia R Silvia F Eugenio B | 1997 | Periodontol1997，68，： | 1 |
| 20 | A concrete slatted floor sys- tem for separation of faeces and urine in pig houses显示文摘 | Yea Z Lia B Cheng B | 2007 | Biosystems Engineering2007，98，2： | 1 |
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